Detailed information for compound 758961

Basic information

Technical information
  • TDR Targets ID: 758961
  • Name: N-(4-methoxyphenyl)-4-(4-methyl-3-piperidin-1 -ylsulfonylphenyl)phthalazin-1-amine
  • MW: 488.601 | Formula: C27H28N4O3S
  • H donors: 1 H acceptors: 4 LogP: 4.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Nc1nnc(c2c1cccc2)c1ccc(c(c1)S(=O)(=O)N1CCCCC1)C
  • InChi: 1S/C27H28N4O3S/c1-19-10-11-20(18-25(19)35(32,33)31-16-6-3-7-17-31)26-23-8-4-5-9-24(23)27(30-29-26)28-21-12-14-22(34-2)15-13-21/h4-5,8-15,18H,3,6-7,16-17H2,1-2H3,(H,28,30)
  • InChiKey: JRDHTASKNWPANF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methoxyphenyl)-4-[4-methyl-3-(1-piperidylsulfonyl)phenyl]phthalazin-1-amine
  • N-(4-methoxyphenyl)-4-[4-methyl-3-(1-piperidylsulfonyl)phenyl]-1-phthalazinamine
  • (4-methoxyphenyl)-[4-(4-methyl-3-piperidinosulfonyl-phenyl)phthalazin-1-yl]amine
  • N-(4-methoxyphenyl)-4-(4-methyl-3-piperidin-1-ylsulfonyl-phenyl)phthalazin-1-amine
  • STK043770
  • Oprea1_556801

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0166 0.1819 0.5286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0569
Brugia malayi glutathione reductase 0.0048 0.0453 0.0819
Brugia malayi Bromodomain containing protein 0.0009 0.0008 0.0007
Echinococcus multilocularis dna polymerase kappa 0.002 0.0131 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.0283
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0941 0.1709
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0131 0.0283
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.154 0.1537
Onchocerca volvulus 0.0098 0.104 0.1519
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0037 0.0033
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0854 0.2586
Echinococcus granulosus geminin 0.0166 0.1819 0.3311
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.0283
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.013 0.1407 0.2559
Loa Loa (eye worm) pyruvate kinase 0.0137 0.1487 0.2706
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0015 0.0033
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0257
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0131 0.016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.13 0.8403
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0092 0.017
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.0283
Echinococcus granulosus zinc finger protein 0.0009 0.0008 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0601 0.1739
Loa Loa (eye worm) pyruvate kinase-PB 0.0096 0.1007 0.183
Mycobacterium tuberculosis Conserved protein 0.0036 0.0316 0.0909
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0131 0.0121
Echinococcus multilocularis pyruvate kinase 0.007 0.0715 0.0711
Plasmodium vivax pyruvate kinase 2, putative 0.007 0.0715 0.4735
Trypanosoma brucei pyruvate kinase 1, putative 0.0137 0.1487 1
Onchocerca volvulus 0.0036 0.0316 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0316 0.0908
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.154 0.1537
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0411 0.466 0.8493
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0316 0.1792
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0453 0.2585
Trichomonas vaginalis glutaminase, putative 0.0299 0.3364 0.6227
Trichomonas vaginalis set domain proteins, putative 0.0475 0.5402 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0279 0.0275
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0037 0.006
Echinococcus granulosus dna polymerase kappa 0.002 0.0131 0.0233
Giardia lamblia Pyruvate kinase 0.0137 0.1487 1
Echinococcus multilocularis pyruvate kinase 0.007 0.0715 0.0711
Onchocerca volvulus 0.006 0.0601 0.0666
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.154 0.2802
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0114 0.0376
Mycobacterium ulcerans hypothetical protein 0.0036 0.0316 0.0683
Loa Loa (eye worm) acetyltransferase 0.0305 0.3437 0.6263
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0114 0.02
Brugia malayi Pyruvate kinase, muscle isozyme 0.0137 0.1487 0.2706
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.116 0.4341
Mycobacterium leprae Probable pyruvate kinase PykA 0.0137 0.1487 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0131 0.0121
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0092 0.017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0453 0.1466
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0316 0.0909
Schistosoma mansoni hypothetical protein 0.0281 0.3154 0.9176
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.116 0.4341
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0036 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0601 0.0597
Loa Loa (eye worm) hypothetical protein 0.0137 0.1487 0.2706
Schistosoma mansoni cpg binding protein 0.0033 0.0279 0.0801
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.013 0.1407 0.1403
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0131 0.0502
Trypanosoma brucei unspecified product 0.002 0.0131 0.0502
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0131 0.0283
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0131 0.0372
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0041 0.0381 0.0688
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0316 0.0683
Mycobacterium ulcerans beta-lactamase 0.0036 0.0316 0.0683
Entamoeba histolytica hypothetical protein 0.0266 0.2977 1
Mycobacterium tuberculosis Probable reductase 0.0109 0.116 0.4341
Brugia malayi beta-lactamase family protein 0.0036 0.0316 0.0569
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0941 0.1742
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.13 0.4913
Schistosoma mansoni cpg binding protein 0.0031 0.0258 0.0742
Schistosoma mansoni zinc finger protein 0.0009 0.0008 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0685 0.1984
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0131 0.016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.104 0.189
Schistosoma mansoni hypothetical protein 0.013 0.1407 0.4086
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0114 0.0088
Schistosoma mansoni ap endonuclease 0.0018 0.0114 0.032
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0137 0.1487 0.5673
Giardia lamblia Pyruvate kinase 0.007 0.0715 0.4466
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0584
Toxoplasma gondii pyruvate kinase PyK1 0.0137 0.1487 1
Plasmodium vivax pyruvate kinase, putative 0.0137 0.1487 1
Leishmania major DNA polymerase eta, putative 0.002 0.0131 0.0283
Loa Loa (eye worm) pyruvate kinase 0.0137 0.1487 0.2706
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.154 0.4473
Trypanosoma brucei pyruvate kinase 1 0.0137 0.1487 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.13 0.4913
Leishmania major DNA polymerase kappa, putative 0.002 0.0131 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0114 0.0066
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0131 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.154 0.4473
Loa Loa (eye worm) hypothetical protein 0.0411 0.466 0.8493
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0453 0.0449
Loa Loa (eye worm) glutathione reductase 0.0048 0.0453 0.0819
Brugia malayi Pre-SET motif family protein 0.0418 0.4735 0.863
Loa Loa (eye worm) hypothetical protein 0.013 0.1407 0.2559
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.0008 0.0007
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0316 0.0909
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0092 0.0225
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0316 0.0683
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0015 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0114 0.0154
Mycobacterium ulcerans lipase LipD 0.0036 0.0316 0.0683
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0601 0.1739
Loa Loa (eye worm) hypothetical protein 0.0281 0.3154 0.5747
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0453 0.0819
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0114 0.0154
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0131 0.0243
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0037 0.006
Mycobacterium tuberculosis Conserved protein 0.0036 0.0316 0.0909
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.116 0.4341
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0941 0.6084
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0092 0.0486
Brugia malayi glutaminase DH11.1 0.0299 0.3364 0.6128
Echinococcus granulosus pyruvate kinase 0.007 0.0715 0.1297
Mycobacterium tuberculosis Conserved protein 0.0036 0.0316 0.0909
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0305 0.3437 1
Echinococcus multilocularis pyruvate kinase 0.0137 0.1487 0.1484
Schistosoma mansoni hypothetical protein 0.0166 0.1819 0.5286
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0225
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0092 0.0225
Chlamydia trachomatis pyruvate kinase 0.0137 0.1487 1
Brugia malayi hypothetical protein 0.0482 0.5486 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0258 0.0464
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013 0.1407 0.1403
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0316 0.0909
Plasmodium vivax SET domain protein, putative 0.006 0.0601 0.3957
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0316 0.2011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0569
Leishmania major pyruvate kinase 0.0137 0.1487 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.154 0.4473
Loa Loa (eye worm) glutaminase 2 0.0299 0.3364 0.6128
Echinococcus multilocularis dna polymerase eta 0.002 0.0131 0.0128
Onchocerca volvulus Pyruvate kinase homolog 0.0137 0.1487 0.2389
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0041 0.0068
Schistosoma mansoni pyruvate kinase 0.007 0.0715 0.2071
Entamoeba histolytica hypothetical protein 0.0266 0.2977 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.116 0.4341
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0941 0.6084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0316 0.0569
Loa Loa (eye worm) glutaminase 0.0299 0.3364 0.6128
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0316 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0114 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0114 0.0154
Plasmodium falciparum pyruvate kinase 2 0.007 0.0715 0.4466
Brugia malayi beta-lactamase family protein 0.0036 0.0316 0.0569
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.116 0.7204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0015 0.0011
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0131 0.0502
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0601 0.1739
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0131 0.0062
Entamoeba histolytica pyruvate kinase, putative 0.0096 0.1007 0.312
Loa Loa (eye worm) hypothetical protein 0.0482 0.5486 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0316 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Echinococcus multilocularis zinc finger protein 0.0009 0.0008 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Mycobacterium ulcerans glutaminase 0.0299 0.3364 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0131 0.0233
Brugia malayi pyruvate kinase, muscle isozyme 0.0029 0.0235 0.0422
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0015 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0266 0.2977 0.5424
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0131 0.0243
Brugia malayi beta-lactamase 0.0036 0.0316 0.0569
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0316 0.1603
Loa Loa (eye worm) hypothetical protein 0.0096 0.1007 0.183
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0584
Brugia malayi hypothetical protein 0.0266 0.2977 0.5424
Schistosoma mansoni DNA polymerase eta 0.002 0.0131 0.0372
Schistosoma mansoni survival motor neuron protein 0.0098 0.104 0.3018
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0041 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0316 0.0584
Toxoplasma gondii pyruvate kinase PyKII 0.007 0.0715 0.4466
Trypanosoma cruzi pyruvate kinase 2, putative 0.0137 0.1487 1
Echinococcus granulosus pyruvate kinase 0.0137 0.1487 0.2706
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0092 0.0225
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0131 0.0128
Echinococcus multilocularis pyruvate kinase 0.0108 0.1153 0.1149
Brugia malayi CXXC zinc finger family protein 0.0031 0.0258 0.0464
Entamoeba histolytica hypothetical protein 0.0266 0.2977 1
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.0854 0.5463
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2551 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0114 1
Leishmania major pyruvate kinase 0.0137 0.1487 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1413 0.2571
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0114 0.02
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1413 0.2571
Trichomonas vaginalis pyruvate kinase, putative 0.0137 0.1487 0.2753
Toxoplasma gondii exonuclease III APE 0.0018 0.0114 0.0154
Echinococcus multilocularis pyruvate kinase 0.007 0.0715 0.0711
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0941 0.6274
Echinococcus granulosus pyruvate kinase 0.007 0.0715 0.1297
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0092 0.0486
Schistosoma mansoni transcription factor LCR-F1 0.0266 0.2977 0.8661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0569
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0569
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0569
Brugia malayi Thioredoxin reductase 0.0048 0.0453 0.0819
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0114 0.021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013 0.1407 0.2559
Echinococcus multilocularis survival motor neuron protein 1 0.0482 0.5486 0.5484
Echinococcus granulosus pyruvate kinase 0.007 0.0715 0.1297
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0316 0.0569
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0584
Trichomonas vaginalis esterase, putative 0.0036 0.0316 0.0584
Mycobacterium ulcerans pyruvate kinase 0.0137 0.1487 0.4264
Echinococcus granulosus histone acetyltransferase KAT2B 0.0297 0.3338 0.6082
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0233
Trypanosoma brucei trypanothione reductase 0.0048 0.0453 0.2752
Brugia malayi Calcitonin receptor-like protein seb-1 0.0411 0.466 0.8493
Schistosoma mansoni hypothetical protein 0.0266 0.2977 0.8661
Onchocerca volvulus 0.0036 0.0316 0.0111
Echinococcus multilocularis pyruvate kinase 0.0137 0.1487 0.1484
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0453 0.2945
Schistosoma mansoni bromodomain containing protein 0.0009 0.0008 0.0012
Loa Loa (eye worm) beta-lactamase 0.0036 0.0316 0.0569
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0305 0.3437 0.3435
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0316 0.0909
Loa Loa (eye worm) pyruvate kinase 0.0137 0.1487 0.2706
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0316 0.1603
Loa Loa (eye worm) hypothetical protein 0.006 0.0601 0.1089
Onchocerca volvulus 0.0475 0.5402 1
Brugia malayi pyruvate kinase 0.0029 0.0235 0.0422
Onchocerca volvulus Pyruvate kinase homolog 0.0137 0.1487 0.2389
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.0098 0.104 0.3018
Brugia malayi Latrophilin receptor protein 2 0.013 0.1407 0.2559
Schistosoma mansoni hypothetical protein 0.013 0.1407 0.4086
Schistosoma mansoni ap endonuclease 0.0018 0.0114 0.032
Giardia lamblia DINP protein human, muc B family 0.002 0.0131 0.0283
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0601 0.1739
Leishmania major trypanothione reductase 0.0048 0.0453 0.2585
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0316 0.0584
Trypanosoma cruzi pyruvate kinase 2, putative 0.0137 0.1487 1
Brugia malayi Pre-SET motif family protein 0.006 0.0601 0.1089
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Plasmodium falciparum glutathione reductase 0.0048 0.0453 0.2585
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0114 0.02
Leishmania major hypothetical protein, conserved 0.0036 0.0316 0.1603
Trichomonas vaginalis pyruvate kinase, putative 0.0137 0.1487 0.2753
Schistosoma mansoni bromodomain containing protein 0.0009 0.0008 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0601 0.1089
Echinococcus multilocularis geminin 0.0166 0.1819 0.1816
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0131 0.0283
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0235 0.0422
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0266 0.2977 0.2975
Schistosoma mansoni hypothetical protein 0.013 0.1407 0.4086
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0092 0.0161
Echinococcus multilocularis GPCR, family 2 0.013 0.1407 0.1403
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.116 0.4341
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0568 0.1028
Echinococcus granulosus dna polymerase eta 0.002 0.0131 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0316 0.0909
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013 0.1407 0.2559
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0131 0.0233
Plasmodium falciparum pyruvate kinase 0.0137 0.1487 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.154 0.2802
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0131 0.0502
Schistosoma mansoni hypothetical protein 0.013 0.1407 0.4086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0015 0.0021
Echinococcus granulosus GPCR family 2 0.013 0.1407 0.2559
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Echinococcus granulosus survival motor neuron protein 1 0.0482 0.5486 1
Echinococcus granulosus cpg binding protein 0.0033 0.0279 0.0502
Entamoeba histolytica hypothetical protein 0.0266 0.2977 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0854 0.5463
Schistosoma mansoni pyruvate kinase 0.0137 0.1487 0.432
Brugia malayi PHD-finger family protein 0.0009 0.0008 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0114 0.0154
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0131 0.0372
Plasmodium falciparum thioredoxin reductase 0.0048 0.0453 0.2585
Brugia malayi latrophilin 2 splice variant baaae 0.0281 0.3154 0.5747
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0114 0.0154
Echinococcus granulosus pyruvate kinase 0.0137 0.1487 0.2706
Schistosoma mansoni cpg binding protein 0.0033 0.0279 0.0801
Onchocerca volvulus 0.0036 0.0316 0.0111
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0941 0.1742
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.154 0.2802
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0131 0.0233
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0131 0.0502
Brugia malayi MH2 domain containing protein 0.0131 0.1413 0.2571
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0453 0.0819
Toxoplasma gondii ABC1 family protein 0.0036 0.0316 0.1603
Brugia malayi Pyruvate kinase, M2 isozyme 0.0137 0.1487 0.2706
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0411 0.466 0.8493
Onchocerca volvulus Pyruvate kinase homolog 0.0137 0.1487 0.2389
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0569
Schistosoma mansoni pyruvate kinase 0.0137 0.1487 0.432
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0114 0.021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.4735 0.863
Schistosoma mansoni glutaminase 0.0299 0.3364 0.9785
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0316 0.0909
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0114 0.0633
Plasmodium vivax glutathione reductase, putative 0.0048 0.0453 0.2945
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0601 0.3648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.154 0.2802
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0131 0.0502
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0601 0.0597
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0691 0.429
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0316 0.0569
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.13 0.4913
Brugia malayi acetyltransferase, GNAT family protein 0.0305 0.3437 0.6263
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0316 0.0909
Toxoplasma gondii thioredoxin reductase 0.0048 0.0453 0.2585
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0114 0.011
Loa Loa (eye worm) latrophilin receptor protein 2 0.013 0.1407 0.2559

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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