Detailed information for compound 759569

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.605 | Formula: C24H27NO4S2
  • H donors: 1 H acceptors: 2 LogP: 3.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSCCOC(=C1C(=NC2=C(C1c1ccc(o1)C)C(=O)CC(C2)c1cccs1)C)O
  • InChi: 1S/C24H27NO4S2/c1-4-30-11-9-28-24(27)21-15(3)25-17-12-16(20-6-5-10-31-20)13-18(26)22(17)23(21)19-8-7-14(2)29-19/h5-8,10,16,23,27H,4,9,11-13H2,1-3H3
  • InChiKey: XOCNXEJFCDIOAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Echinococcus multilocularis lamin dm0 0.0054 0.0314 0.0299
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0032 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0785 0.2306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0163 0.0818
Plasmodium vivax glutathione reductase, putative 0.0046 0.0254 0.5428
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0104 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0298 0.1432
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0161 0.3317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0163 0.0818
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0244 0.5202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0163 0.0818
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0272 0.5846
Echinococcus multilocularis tumor protein p63 0.1342 1 1
Schistosoma mansoni lamin 0.0054 0.0314 0.0606
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0015 0.0044
Toxoplasma gondii thioredoxin reductase 0.0046 0.0254 0.5428
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0114 0.0501
Brugia malayi ecdysone receptor 0.0024 0.0092 0.0389
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0114 0.0501
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.025 0.0477
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0216 0.8413
Onchocerca volvulus 0.0047 0.0264 0.1814
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0298 0.1432
Loa Loa (eye worm) acetyltransferase 0.0152 0.105 0.5245
Schistosoma mansoni zinc finger protein 0.0024 0.0092 0.0156
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.025 0.5342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0028 0.0141
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0015 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0314 0.1515
Brugia malayi nuclear hormone receptor 0.0052 0.0298 0.1432
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0781 0.3882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0338 0.7331
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0032 0.0691
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0092 0.0077
Mycobacterium tuberculosis Conserved protein 0.0073 0.0455 0.1337
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0092 0.0077
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0015 0.0044
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0028 0.5
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0272 0.1304
Loa Loa (eye worm) hypothetical protein 0.0053 0.0307 0.1477
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0455 0.1337
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0455 0.223
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0837
Leishmania major hypothetical protein, conserved 0.0073 0.0455 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0023 0.0176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0486
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0298 0.0283
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0092 0.0389
Brugia malayi nuclear hormone receptor 0.0024 0.0092 0.0389
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0378 0.8258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0298 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Echinococcus granulosus microtubule associated protein 2 0.0669 0.4943 0.4935
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0298 0.1432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0113 0.0566
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0028 0.0141
Schistosoma mansoni cellular tumor antigen P53 0.0196 0.1385 0.2781
Plasmodium falciparum thioredoxin reductase 0.0016 0.0028 0.054
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0455 0.2289
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0298 0.0573
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0464 0.3402 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0032 0.0017
Mycobacterium ulcerans glutaminase 0.0277 0.1988 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0298 0.1432
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0298 0.1432
Schistosoma mansoni thyroid hormone receptor 0.0551 0.4054 0.8195
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0455 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0455 0.5716
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0378 0.8258
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0028 0.0293
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0298 0.0573
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0015 0.0044
Schistosoma mansoni nuclear receptor 0.0024 0.0092 0.0156
Onchocerca volvulus 0.0073 0.0455 0.3211
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.018 0.3758
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0455 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0111 0.0556
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.0084
Brugia malayi Augmenter of liver regeneration 0.0034 0.0161 0.074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0028 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0272 0.5846
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0032 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0298 0.0283
Trichomonas vaginalis esterase, putative 0.0073 0.0455 0.2289
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0272 0.1304
Onchocerca volvulus 0.0073 0.0455 0.3211
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0244 0.1227
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0244 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0455 0.223
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0697 0.8857
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0028 0.0013
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0028 0.0293
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0272 0.1304
Loa Loa (eye worm) hypothetical protein 0.0073 0.0455 0.223
Leishmania major hypothetical protein, conserved 0.0034 0.0161 0.3317
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0254 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0111 0.0556
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0092 0.056
Echinococcus granulosus lamin dm0 0.0054 0.0314 0.0299
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0113 0.0566
Treponema pallidum NADH oxidase 0.0016 0.0028 0.5
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.025 0.0235
Onchocerca volvulus 0.0016 0.0032 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0093 0.0467
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.105 0.5245
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0272 0.1304
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0455 0.223
Schistosoma mansoni lamin 0.0054 0.0314 0.0606
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.025 0.5342
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0028 0.0293
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0272 0.3342
Onchocerca volvulus 0.0073 0.0455 0.3211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0113 0.0566
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0298 0.0283
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0092 0.0077
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0272 0.1304
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0015 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0298 0.1432
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0455 0.2289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0023 0.0115
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.018 0.3754
Echinococcus multilocularis thyroid hormone receptor alpha 0.0551 0.4054 0.4044
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0028 0.054
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0272 0.1304
Schistosoma mansoni coup transcription factor 0.0052 0.0298 0.0573
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0455 0.1337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.018 0.0906
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0298 0.0573
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0032 0.0159
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0375
Trichomonas vaginalis glutaminase, putative 0.0277 0.1988 1
Leishmania major cathepsin L-like protease 0.0063 0.0378 0.8258
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0272 0.1304
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.018 0.6916
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0032 0.0691
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0455 0.1337
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0032 0.0017
Plasmodium falciparum glutathione reductase 0.0046 0.0254 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0298 0.0283
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0697 0.2048
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0126 0.056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Onchocerca volvulus 0.0054 0.0314 0.2181
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0501
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0092 0.0389
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0161 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0413
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0032 0.0642
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0092 0.0077
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0697 0.2048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0451
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0455 0.2289
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0455 0.1337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Loa Loa (eye worm) fibroinase 0.0016 0.0032 0.0084
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0161 0.3317
Onchocerca volvulus 0.0024 0.0092 0.056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0032 0.0642
Brugia malayi steroid hormone receptor 0.0052 0.0298 0.1432
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0298 0.0573
Onchocerca volvulus 0.0054 0.0314 0.2181
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.025 0.5342
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0092 0.0077
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0032 0.0375
Onchocerca volvulus 0.0048 0.0272 0.1877
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0455 0.0441
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0015 0.0044
Loa Loa (eye worm) glutaminase 2 0.0277 0.1988 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1651 0.1638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0023 0.0115
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0272 0.08
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0413
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0032 0.0691
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0028 0.0293
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0092 0.0389
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0697 0.2048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0298 0.0283
Schistosoma mansoni glutaminase 0.0277 0.1988 0.4003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0028 0.0293
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0028 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.025 0.0235
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0298 0.0573
Mycobacterium tuberculosis Conserved protein 0.0073 0.0455 0.1337
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0114 0.0099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0254 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0093 0.0466
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0161 0.3317
Brugia malayi nuclear receptor RXR 0.0024 0.0092 0.0389
Giardia lamblia GTOR 0.0045 0.025 1
Loa Loa (eye worm) beta-lactamase 0.0073 0.0455 0.223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.025 0.1258
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.025 0.1191
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0023 0.0115
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0314 0.1515
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0272 0.1304
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0272 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0314 0.1515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.018 0.0906
Onchocerca volvulus 0.0016 0.0032 0.012
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0455 0.1337
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0084
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0314 0.1515
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0028 0.054
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0455 0.1337
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0032 0.0034
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.018 1
Mycobacterium ulcerans lipase LipD 0.0073 0.0455 0.223
Onchocerca volvulus 0.0052 0.0298 0.2062
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0092 0.056
Loa Loa (eye worm) hypothetical protein 0.0073 0.0455 0.223
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0092 0.0389
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.005 0.0798
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0015 0.0076
Schistosoma mansoni hypothetical protein 0.0499 0.3664 0.7405
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0272 0.5846
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0028 0.0293
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0032 0.012
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0161 0.3317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.018 0.0906
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0298 0.0283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0015 0.0044
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0092 0.0389
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0028 0.0013
Brugia malayi nuclear receptor NHR-67 0.0024 0.0092 0.0389
Leishmania major trypanothione reductase 0.0046 0.0254 0.5428
Brugia malayi conserved hypotetical protein 0.0024 0.0092 0.0389
Brugia malayi hypothetical protein 0.0024 0.0092 0.0389
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0023 0.0176
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0161 0.0146
Brugia malayi intermediate filament protein 0.0054 0.0314 0.1515
Onchocerca volvulus 0.0196 0.1385 1
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.0048 0.0272 0.1304
Mycobacterium tuberculosis Conserved protein 0.0073 0.0455 0.1337
Echinococcus multilocularis cysteine protease 0.0016 0.0032 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0486
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0023 0.0008
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0375
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0092 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0023 0.0115
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0028 0.0082
Loa Loa (eye worm) cysteine protease 0.0016 0.0032 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.4943 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0272 0.3342
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0455 0.2289
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0092 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0455 0.223
Brugia malayi beta-lactamase 0.0073 0.0455 0.223
Loa Loa (eye worm) DR-78 0.0024 0.0092 0.0389
Brugia malayi glutaminase DH11.1 0.0277 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0455 0.223
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0015 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0298 0.1432
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0032 0.0375
Brugia malayi nuclear receptor NHR-88 0.0024 0.0092 0.0389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0028 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0298 0.0283
Brugia malayi hypothetical protein 0.0232 0.1651 0.8293
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0272 0.1304
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0298 0.1432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.025 0.9137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Loa Loa (eye worm) hypothetical protein 0.0232 0.1651 0.8293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0163 0.0818
Loa Loa (eye worm) ctsf protein 0.0016 0.0032 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0298 0.2062
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.025 0.9137
Onchocerca volvulus 0.0016 0.0032 0.012
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0375
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0486
Brugia malayi ecdysteroid receptor 0.0052 0.0298 0.1432
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0028 0.0065
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0023 0.0008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0028 0.0026
Mycobacterium ulcerans hypothetical protein 0.0073 0.0455 0.223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0163 0.0818
Echinococcus granulosus intermediate filament protein 0.0054 0.0314 0.0299
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0785 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0781 0.3882
Brugia malayi glutathione reductase 0.0046 0.0254 0.121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0501
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0455 0.1337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0093 0.0467
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.018 0.3758
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0163 0.0818
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.1018 0.1004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0093 0.0466
Echinococcus multilocularis lamin 0.0054 0.0314 0.0299
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0298 0.1432
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0298 0.0283
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0298 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0298 0.1432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0032 0.012
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0092 0.0077
Loa Loa (eye worm) hypothetical protein 0.0073 0.0455 0.223
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0298 0.1432
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0298 0.1432
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.0084
Schistosoma mansoni hypothetical protein 0.0047 0.0264 0.0504
Brugia malayi tailless protein 0.0024 0.0092 0.0389
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0298 0.2062
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.105 0.1036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0126 0.056
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0092 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.013 0.0655
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0298 0.0283
Schistosoma mansoni survival motor neuron protein 0.0047 0.0264 0.0504
Loa Loa (eye worm) hypothetical protein 0.0048 0.0272 0.1304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Schistosoma mansoni intermediate filament proteins 0.0054 0.0314 0.0606
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0114 0.0099
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0028 0.0293
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0837
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0028 0.0293
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.025 0.5342
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0298 0.0283
Brugia malayi nuclear receptor NHR-88 0.0052 0.0298 0.1432
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0298 0.0573
Entamoeba histolytica cysteine protease, putative 0.0016 0.0032 0.0642
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0032 0.0084
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0092 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0298 0.1432
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.025 0.1191
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0298 0.2062
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0032 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0697 0.2048
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.025 0.5342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0298 0.1432
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Brugia malayi MH2 domain containing protein 0.0116 0.0781 0.3882
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.0084
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0028 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Brugia malayi nuclear receptor RXR 0.0027 0.0114 0.0501
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0244 0.5202
Onchocerca volvulus 0.0016 0.0032 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Plasmodium vivax vivapain-2 0.0016 0.0032 0.0375
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.4943 0.4935
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0092 0.0389
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0023 0.0176
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0785 0.2306
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0092 0.0077
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.018 0.3758
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0455 0.0893
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0375
Echinococcus granulosus cathepsin l1 0.0016 0.0032 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0298 0.1432
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.0084
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0032 0.0017
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0092 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.018 0.0906
Brugia malayi beta-lactamase family protein 0.0073 0.0455 0.223
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0092 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0093 0.0467
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0244 0.5202
Brugia malayi hypothetical protein 0.0024 0.0092 0.0389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0455 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0032 0.0017
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0499 0.3664 0.3654
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Plasmodium vivax vivapain-2 0.0016 0.0032 0.0375
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0455 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0032 0.0159
Plasmodium falciparum glutathione reductase 0.0016 0.0028 0.054
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1651 0.1638
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0092 0.0077
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0023 0.0176
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0114 0.0201
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Brugia malayi Thioredoxin reductase 0.0046 0.0254 0.121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0298 0.1432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0298 0.1432
Onchocerca volvulus 0.0024 0.0092 0.056
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0028 0.0065
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0023 0.0176
Brugia malayi hypothetical protein 0.0027 0.0114 0.0501
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0298 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.02 0.1007
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0023 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0254 0.121
Mycobacterium leprae Probable lipase LipE 0.0073 0.0455 0.5716
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0032 0.0017
Echinococcus granulosus lamin 0.0054 0.0314 0.0299
Echinococcus multilocularis musashi 0.0054 0.0314 0.0299
Trypanosoma brucei trypanothione reductase 0.0046 0.0254 0.5428
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0161 0.074
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0254 0.0746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0165 0.0486
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0501
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0114 0.0201
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0254 0.5428
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0092 0.0156
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Onchocerca volvulus 0.0016 0.0032 0.012
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0298 0.1432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0298 0.1432
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0298 0.0283
Mycobacterium tuberculosis Probable reductase 0.0105 0.0697 0.2048
Loa Loa (eye worm) hypothetical protein 0.0048 0.0272 0.1304
Schistosoma mansoni thyroid hormone receptor 0.0551 0.4054 0.8195
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0028 0.0293
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0015 0.0044
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0161 0.6112
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0272 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0092 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.025 0.1258
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0455 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0298 0.0283
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.018 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0023 0.0115
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.018 0.0837
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0073 0.0455 0.223
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0092 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0163 0.0818
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0028 0.0293
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0278 0.5971
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.105 0.21
Leishmania major cathepsin L-like protease 0.0063 0.0378 0.8258
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0298 0.0283
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0092 0.0389
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0455 0.0441
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0023 0.0176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0272 0.08
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0093 0.0466
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0375
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0298 0.0283
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0216 0.781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0298 0.1432
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0298 0.1432
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0785 0.2306
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0092 0.0156
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0378 0.8258
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0501
Onchocerca volvulus 0.0016 0.0032 0.012
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.025 0.5342
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0023 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0028 0.0293
Onchocerca volvulus 0.0016 0.0032 0.012
Brugia malayi beta-lactamase family protein 0.0073 0.0455 0.223
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0455 0.2289
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0378 0.8258
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0092 0.0077
Toxoplasma gondii ABC1 family protein 0.0073 0.0455 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0264 0.126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.025 0.1258
Loa Loa (eye worm) glutathione reductase 0.0046 0.0254 0.121
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0216 0.8464
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0837
Mycobacterium ulcerans beta-lactamase 0.0073 0.0455 0.223
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0023 0.0039
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0499 0.3664 0.3654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0093 0.0467
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0378 0.8258
Brugia malayi hypothetical protein 0.0027 0.0114 0.0501
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0298 0.0573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0298 0.0283
Toxoplasma gondii cathepsin CPL 0.0016 0.0032 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0138 0.0692
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.0084
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0161 0.3317
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0298 0.1432
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0298 0.0283
Schistosoma mansoni nuclear receptor 0.0024 0.0092 0.0156
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0104 0.0089
Plasmodium falciparum thioredoxin reductase 0.0046 0.0254 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.0196 0.1385 0.6946
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0114 0.0501
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0244 0.1227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0298 0.1432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.018 0.0906
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0272 0.1304
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0161 0.3317
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0028 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0032 0.0159
Leishmania major cathepsin L-like protease 0.0063 0.0378 0.8258
Loa Loa (eye worm) hypothetical protein 0.0052 0.0298 0.1432
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.0084
Loa Loa (eye worm) glutaminase 0.0277 0.1988 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0028 0.0293
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0697 0.2048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0501
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0163 0.335
Echinococcus multilocularis cysteine protease 0.0016 0.0032 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0092 0.0389
Mycobacterium ulcerans hypothetical protein 0.0048 0.0272 0.1304
Loa Loa (eye worm) hypothetical protein 0.0073 0.0455 0.223
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.007 0.1245
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0032 0.0159
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0298 0.0573
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0272 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0015 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0298 0.1432
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0254 0.5428
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0161 0.3317

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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