Detailed information for compound 759606

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 274.254 | Formula: C12H11FN6O
  • H donors: 2 H acceptors: 4 LogP: 0.75 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=C(C(=O)N)C(n2c(N1)nnn2)c1ccccc1F
  • InChi: 1S/C12H11FN6O/c1-6-9(11(14)20)10(7-4-2-3-5-8(7)13)19-12(15-6)16-17-18-19/h2-5,10H,1H3,(H2,14,20)(H,15,16,18)
  • InChiKey: YYOAUDLWEQMLDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0051 0.0219 0.0484
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0124 0.1083
Onchocerca volvulus 0.0054 0.0233 0.1665
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0327 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0425
Schistosoma mansoni nuclear hormone receptor 0.007 0.0331 0.0685
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Onchocerca volvulus 0.0246 0.1387 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0263 0.1486 0.3293
Loa Loa (eye worm) inositol-1 0.0041 0.0158 0.0351
Echinococcus granulosus lamin dm0 0.0107 0.055 0.055
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0215 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.011 0.0852
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0331 0.0331
Mycobacterium ulcerans hypothetical protein 0.0023 0.0048 0.111
Brugia malayi MH2 domain containing protein 0.0051 0.0215 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.009 0.07
Brugia malayi nuclear hormone receptor 0.0033 0.0109 0.0241
Onchocerca volvulus 0.007 0.0327 0.2343
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.112 0.2482
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0017 0.0037
Brugia malayi Pre-SET motif family protein 0.003 0.0087 0.0193
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0077 0.067
Echinococcus granulosus cathepsin l1 0.0054 0.0233 0.0233
Schistosoma mansoni nuclear receptor 0.0033 0.0109 0.0225
Brugia malayi nuclear receptor RXR 0.0033 0.0109 0.0241
Onchocerca volvulus 0.0054 0.0233 0.1665
Loa Loa (eye worm) nuclear factor I 0.0028 0.0079 0.0174
Treponema pallidum NADH oxidase 0.0017 0.0014 0.5
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0014 0.0036
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.1036 0.2296
Brugia malayi MH2 domain containing protein 0.0051 0.0215 0.0476
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0233 0.2896
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0046 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0822 0.4838 1
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1143 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0331 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.007 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0331 0.0734
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0109 0.0764
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0233 0.0233
Onchocerca volvulus 0.0032 0.0103 0.0723
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.007 0.0327 0.0725
Onchocerca volvulus 0.0054 0.0233 0.1665
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.1036 0.2296
Plasmodium falciparum glutathione reductase 0.0017 0.0014 0.0032
Onchocerca volvulus 0.0033 0.0109 0.0764
Plasmodium vivax vivapain-3 0.0028 0.0077 0.1773
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0409 0.0409
Brugia malayi Cathepsin L-like precursor 0.0054 0.0233 0.0517
Echinococcus multilocularis cathepsin L 0.0028 0.0077 0.0077
Schistosoma mansoni smad1 5 8 and 0.0051 0.0215 0.0444
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0327 0.1245
Plasmodium falciparum glutathione reductase 0.005 0.0211 0.5516
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0048 0.0564
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0371 0.3251
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0371 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0158 0.1952
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0077 0.0925
Loa Loa (eye worm) cysteine protease 0.0054 0.0233 0.0517
Schistosoma mansoni lamin 0.0107 0.055 0.1136
Mycobacterium tuberculosis Conserved protein 0.007 0.0327 0.1245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Plasmodium falciparum thioredoxin reductase 0.0017 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0103
Brugia malayi Cathepsin L-like precursor 0.0054 0.0233 0.0517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0327 0.0725
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0077 0.0925
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.016 0.1242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0502 0.1038
Schistosoma mansoni hypothetical protein 0.0083 0.0409 0.0845
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0331 0.0734
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0233 0.2043
Brugia malayi beta-lactamase family protein 0.007 0.0327 0.0725
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0014 0.0014
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0014 0.0026
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0077 0.0158
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0003 0.0023
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0077 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.011 0.0852
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.0233 0.615
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.016 0.016
Schistosoma mansoni cathepsin s 0.0018 0.0017 0.0035
Schistosoma mansoni cpg binding protein 0.0032 0.0103 0.0213
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0327 0.0725
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0331 0.0734
Mycobacterium leprae conserved hypothetical protein 0.007 0.0327 0.447
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.096
Toxoplasma gondii thioredoxin reductase 0.005 0.0211 0.5502
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0188 0.1036 0.9064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0331 0.0734
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0077 0.067
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0133 0.0294
Loa Loa (eye worm) hypothetical protein 0.0036 0.0127 0.028
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0077 0.067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Loa Loa (eye worm) hypothetical protein 0.003 0.0087 0.0193
Loa Loa (eye worm) hypothetical protein 0.0107 0.055 0.1218
Brugia malayi MH2 domain containing protein 0.0746 0.4387 0.9721
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.016 0.1399
Leishmania major hypothetical protein, conserved 0.0077 0.0371 0.3251
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0106
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0124 0.1083
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0017 0.0037
Leishmania major cathepsin L-like protease 0.0205 0.1143 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0048 0.111
Onchocerca volvulus 0.0054 0.0233 0.1665
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0077 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Leishmania major trypanothione reductase 0.005 0.0211 0.1844
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0331 0.0331
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0263 0.1486 0.3293
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0033 0.0109 0.0109
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0233 0.0483
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0331 0.0734
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Leishmania major hypothetical protein, conserved 0.007 0.0327 0.2864
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0048 0.111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0107 0.055 0.1218
Brugia malayi hypothetical protein 0.0767 0.4513 1
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0109 0.0225
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0219 0.0219
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0331 0.0331
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0327 0.0725
Entamoeba histolytica cysteine protease, putative 0.0054 0.0233 0.2896
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0109 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.096
Echinococcus multilocularis cysteine protease 0.0054 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.007 0.0327 0.0725
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0331 0.0734
Echinococcus multilocularis lamin 0.0107 0.055 0.055
Entamoeba histolytica hypothetical protein 0.0148 0.0799 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0331 0.0734
Brugia malayi MH1 domain containing protein 0.0051 0.0215 0.0476
Brugia malayi steroid hormone receptor 0.007 0.0331 0.0734
Brugia malayi ecdysteroid receptor 0.007 0.0331 0.0734
Leishmania major cathepsin L-like protease 0.0054 0.0233 0.2043
Loa Loa (eye worm) ctsf protein 0.0054 0.0233 0.0517
Schistosoma mansoni Smad4 0.0023 0.0046 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0158 0.1386
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0037
Schistosoma mansoni zinc finger protein 0.0033 0.0109 0.0225
Brugia malayi cathepsin L-like precursor 0.0036 0.0127 0.028
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0109 0.0241
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.1036 0.1036
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0158 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0087 0.0087
Plasmodium falciparum thioredoxin reductase 0.005 0.0211 0.5516
Schistosoma mansoni smad 0.0023 0.0046 0.0096
Brugia malayi hypothetical protein 0.0077 0.0371 0.0823
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Loa Loa (eye worm) intermediate filament protein 0.0107 0.055 0.1218
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0331 0.0331
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0158 0.1231
Echinococcus granulosus Smad4 0.0051 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0077 0.067
Schistosoma mansoni intermediate filament proteins 0.0107 0.055 0.1136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0502 0.1038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0233 0.1814
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0077 0.0925
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0294
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0233 0.1665
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0158 0.0158
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0331 0.0685
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0253 0.056
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0327 0.1245
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0158 0.1386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0178 0.1387
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0327 0.2543
Brugia malayi follicle stimulating hormone receptor 0.0254 0.1433 0.3176
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0077 0.067
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0178 0.1562
Brugia malayi Cathepsin L-like precursor 0.0054 0.0233 0.0517
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0331 0.2373
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0371 0.3251
Onchocerca volvulus 0.007 0.0327 0.2343
Schistosoma mansoni coup transcription factor 0.007 0.0331 0.0685
Mycobacterium ulcerans beta-lactamase 0.007 0.0327 1
Mycobacterium ulcerans lipase LipD 0.007 0.0327 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0014 0.0124
Brugia malayi hypothetical protein 0.0037 0.0133 0.0294
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0294
Schistosoma mansoni survival motor neuron protein 0.0157 0.0849 0.1754
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0014 0.0031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0331 0.0685
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0211 0.0211
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0409 0.0906
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1143 1
Schistosoma mansoni hypothetical protein 0.0083 0.0409 0.0845
Onchocerca volvulus 0.023 0.1287 0.9278
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0502 0.1113
Mycobacterium leprae Probable lipase LipE 0.007 0.0327 0.447
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0673 1
Brugia malayi Cathepsin L-like precursor 0.0054 0.0233 0.0517
Loa Loa (eye worm) fibroinase 0.0054 0.0233 0.0517
Echinococcus multilocularis smad 0.0051 0.0215 0.0215
Leishmania major cathepsin L-like protease 0.0054 0.0233 0.2043
Loa Loa (eye worm) Smad1 0.0051 0.0215 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.1433 0.3176
Schistosoma mansoni hypothetical protein 0.0083 0.0409 0.0845
Echinococcus multilocularis GPCR, family 2 0.0083 0.0409 0.0409
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0077 0.067
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.111
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0003 0.0023
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0133 0.0133
Trichomonas vaginalis esterase, putative 0.007 0.0327 0.2543
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0133 0.0274
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0331 0.0685
Brugia malayi hypothetical protein 0.0033 0.0109 0.0241
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0233 0.0517
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0109 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.0233 0.0517
Schistosoma mansoni alpha-glucosidase 0.0162 0.0879 0.1817
Plasmodium vivax unspecified product 0.0018 0.0017 0.0108
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0109 0.0764
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0294
Plasmodium vivax hypothetical protein, conserved 0.007 0.0327 0.8765
Onchocerca volvulus 0.0107 0.055 0.395
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0371 1
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0133 0.0294
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0109 0.0241
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0133 0.0274
Onchocerca volvulus 0.003 0.0087 0.0608
Onchocerca volvulus 0.007 0.0327 0.2343
Loa Loa (eye worm) hypothetical protein 0.005 0.0207 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Echinococcus multilocularis neuropeptide s receptor 0.0482 0.2799 0.2799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0069 0.0535
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0109 0.0241
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0003 0.0026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Echinococcus granulosus GPCR family 2 0.0083 0.0409 0.0409
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0087 0.2042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.096
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.016 0.1242
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0132 0.1351
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0178 0.0396
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0037 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.007 0.0547
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.0331 0.2373
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.2661 0.2661
Onchocerca volvulus 0.007 0.0331 0.2373
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0003 0.0023
Leishmania major cathepsin L-like protease 0.0054 0.0233 0.2043
Loa Loa (eye worm) hypothetical protein 0.007 0.0327 0.0725
Plasmodium vivax glutathione reductase, putative 0.005 0.0211 0.5516
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0331 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0077 0.067
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0037
Onchocerca volvulus 0.0023 0.0048 0.0325
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0084 0.0655
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0178 0.1562
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0331 0.0685
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0109 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.011 0.0852
Schistosoma mansoni cpg binding protein 0.0034 0.0114 0.0236
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0087 0.0087
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1036 0.1036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0127 0.028
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Echinococcus granulosus dnaJ subfamily B 0.0459 0.2661 0.2661
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0117 0.0117
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0109 0.0109
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0178 0.0396
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0233 0.0233
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0013 0.0022
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0003 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0331 0.0734
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0178 0.1562
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1036 0.1036
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.016 0.197
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0014 0.0124
Echinococcus granulosus survival motor neuron protein 1 0.0767 0.4513 0.4513
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0109 0.0241
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0109 0.0241
Mycobacterium ulcerans hypothetical protein 0.007 0.0327 1
Onchocerca volvulus 0.0054 0.0233 0.1665
Brugia malayi Smad1 0.0051 0.0215 0.0476
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0003 0.0023
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0077 0.1773
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0215 0.0215
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0215 0.0476
Plasmodium vivax unspecified product 0.0028 0.0077 0.1773
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0014 0.0124
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0178 0.0178
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0003 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.0246 0.1387 0.2866
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0014 0.0036
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0233 0.0483
Loa Loa (eye worm) hypothetical protein 0.0036 0.0127 0.028
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0014 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0427
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0109 0.0225
Onchocerca volvulus 0.0033 0.0109 0.0764
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0014 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0822 0.4838 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0109 0.0109
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0077 0.0371 0.0823
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1143 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0331 0.0734
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0211 0.5516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.016 0.197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Echinococcus granulosus lamin 0.0107 0.055 0.055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0106
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0158 0.1231
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Echinococcus multilocularis cpg binding protein 0.0034 0.0114 0.0114
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0331 0.0685
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0331 0.0734
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0046 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Loa Loa (eye worm) hypothetical protein 0.005 0.0207 0.0458
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.0331 0.0685
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0048 0.0564
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0127 0.0261
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0048 0.0564
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0327 0.2543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0127 0.0983
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0029
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0133 0.0133
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0331 0.0685
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0327 0.2543
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0014 0.0124
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0253 0.056
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0103 0.0228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.018
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0215 0.0215
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0109 0.0225
Mycobacterium tuberculosis Conserved protein 0.007 0.0327 0.1245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0017 0.0148
Schistosoma mansoni smad 0.0051 0.0215 0.0444
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0014 0.0124
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0003 0.0026
Brugia malayi Cathepsin L-like precursor 0.0054 0.0233 0.0517
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0003 0.0023
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0046 0.0313
Loa Loa (eye worm) beta-lactamase 0.007 0.0327 0.0725
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0596 0.2292
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.016 0.1242
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0046 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0087 0.018
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.016 0.1242
Leishmania major cathepsin L-like protease 0.0205 0.1143 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0106
Echinococcus granulosus neuropeptide s receptor 0.0482 0.2799 0.2799
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0003 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0327 0.0676
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.111
Onchocerca volvulus 0.0107 0.055 0.395
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.016 0.1399
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.0331 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0331 0.0734
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Onchocerca volvulus 0.0157 0.0849 0.6112
Echinococcus granulosus neuropeptide receptor A26 0.0482 0.2799 0.2799
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Schistosoma mansoni hypothetical protein 0.0751 0.4417 0.9129
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0331 0.0734
Brugia malayi MH1 domain containing protein 0.0051 0.0215 0.0476
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0158 0.4626
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0294
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0419
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0331 0.0331
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.011 0.2673
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0331 0.0734
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0327 0.1245
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0211 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0077 0.0077
Brugia malayi nuclear receptor NHR-88 0.007 0.0331 0.0734
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0046 0.0103
Schistosoma mansoni hypothetical protein 0.018 0.0987 0.2041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.011 0.0852
Brugia malayi Cathepsin L-like precursor 0.0054 0.0233 0.0517
Brugia malayi hypothetical protein 0.0033 0.0109 0.0241
Entamoeba histolytica hypothetical protein 0.0148 0.0799 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0596 0.2292
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0109 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Schistosoma mansoni smad1 5 8 and 0.0051 0.0215 0.0444
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0127 0.028
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0014 0.0124
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0014 0.011
Brugia malayi CXXC zinc finger family protein 0.0032 0.0103 0.0228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0409 0.0409
Echinococcus multilocularis cysteine protease 0.0054 0.0233 0.0233
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0178 0.1562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0219 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0327 0.1245
Brugia malayi MH1 domain containing protein 0.0028 0.0079 0.0174
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0327 0.0327
Trypanosoma cruzi cruzipain precursor, putative 0.0205 0.1143 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0233 0.1814
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0077 0.0925
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Schistosoma mansoni alpha-glucosidase 0.0162 0.0879 0.1817
Trypanosoma brucei trypanothione reductase 0.005 0.0211 0.1844
Echinococcus granulosus cysteine protease 0.0028 0.0077 0.0077
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0046 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0482 0.2799 0.2799
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0211 0.1844
Schistosoma mansoni Smad4 0.0051 0.0215 0.0444
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.111
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0799 0.0799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0127 0.0983
Loa Loa (eye worm) glutathione reductase 0.005 0.0211 0.0467
Schistosoma mansoni nuclear receptor 0.0033 0.0109 0.0225
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0109 0.0109
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0178 0.1387
Brugia malayi Inositol-1 0.0041 0.0158 0.0351
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0158 0.1386
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.088 0.5191 0.5191
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0596 0.2292
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Onchocerca volvulus 0.0036 0.0127 0.0893
Schistosoma mansoni hypothetical protein 0.0459 0.2661 0.55
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0037
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0083 0.0409 0.0906
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0109 0.0241
Brugia malayi beta-lactamase 0.007 0.0327 0.0725
Schistosoma mansoni hypothetical protein 0.0157 0.0849 0.1754
Plasmodium vivax vivapain-2 0.0054 0.0233 0.615
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.016 0.1242
Brugia malayi conserved hypotetical protein 0.0033 0.0109 0.0241
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0029
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0215 0.0444
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0003 0.0026
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0178 0.1562
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.011 0.0852
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.016 0.1242
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0331 0.0734
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0109 0.0225
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0029
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.016 0.1242
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0021 0.0188
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0077 0.0158
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0233 0.0517
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0046 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0331 0.2373
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0294
Schistosoma mansoni Smad4 0.0023 0.0046 0.0096
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0014 0.0029
Schistosoma mansoni inositol monophosphatase 0.0041 0.0158 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Loa Loa (eye worm) hypothetical protein 0.007 0.0327 0.0725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.018
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0157 0.0849 0.1881
Echinococcus multilocularis Smad4 0.0051 0.0215 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0178 0.1387
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.016 0.1242
Brugia malayi ecdysone receptor 0.0033 0.0109 0.0241
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0751 0.4417 0.4417
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0409 0.0409
Brugia malayi tailless protein 0.0033 0.0109 0.0241
Entamoeba histolytica hypothetical protein 0.0148 0.0799 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0139 0.1082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0048 0.0158
Brugia malayi Pre-SET motif family protein 0.0202 0.112 0.2482
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0327 0.0676
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0409 0.0906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0077 0.0595
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0327 0.2864
Plasmodium vivax SET domain protein, putative 0.003 0.0087 0.2068
Echinococcus granulosus intermediate filament protein 0.0107 0.055 0.055
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.007 0.0327 0.0725
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0502 0.0502
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0017 0.0037
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.0233 0.615
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0158 0.1386
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0596 0.8774
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0003 0.0023
Schistosoma mansoni lamin 0.0107 0.055 0.1136
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0419
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0158 0.1231
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0014 0.0032
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0132 0.0486
Toxoplasma gondii ABC1 family protein 0.007 0.0327 0.8761
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0106
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0003 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0444 0.2576 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0109 0.0241
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0331 0.0331
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0117 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.0148 0.0799 0.1651
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0017 0.0148
Brugia malayi nuclear receptor RXR 0.0037 0.0133 0.0294
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0751 0.4417 0.4417
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0014 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.0746 0.4387 0.9721
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0331 0.0685
Loa Loa (eye worm) hypothetical protein 0.0767 0.4513 1
Entamoeba histolytica hypothetical protein 0.0148 0.0799 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0331 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Echinococcus granulosus FTZ F1 alpha 0.007 0.0331 0.0331
Leishmania major cathepsin L-like protease 0.0054 0.0233 0.2043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0109 0.0109
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0178 0.0369
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0178 0.1562
Brugia malayi intermediate filament protein 0.0107 0.055 0.1218
Echinococcus granulosus cpg binding protein 0.0034 0.0114 0.0114
Loa Loa (eye worm) DR-78 0.0033 0.0109 0.0241
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0331 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Echinococcus multilocularis thyroid hormone receptor alpha 0.0822 0.4838 0.4838
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Brugia malayi nuclear receptor NHR-67 0.0033 0.0109 0.0241
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0327 0.2864
Schistosoma mansoni alpha glucosidase 0.0042 0.016 0.033
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0409 0.0409
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0014 0.0124
Loa Loa (eye worm) hypothetical protein 0.018 0.0987 0.2188
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.0233 0.0233
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0673 0.259
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0673 0.259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0502 0.0502
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0077 0.017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0133 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0371 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0048 0.0158
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0211 0.0467
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0178 0.2205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0799 0.0799
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0327 0.1245
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0233 0.1665
Loa Loa (eye worm) hypothetical protein 0.007 0.0331 0.0734
Brugia malayi Cathepsin L-like precursor 0.0036 0.0127 0.028
Schistosoma mansoni hypothetical protein 0.0035 0.0117 0.0242
Brugia malayi Calcitonin receptor-like protein seb-1 0.0263 0.1486 0.3293
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0178 0.2205
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0331 0.0331
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0048 0.111
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0109 0.0241
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0502 0.1113
Trichomonas vaginalis set domain proteins, putative 0.023 0.1287 1
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0127 0.1552
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0331 0.0331
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0233 0.0233
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0331 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0014 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0371 1
Toxoplasma gondii cathepsin CPL 0.0054 0.0233 0.6138
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0014 0.011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0331 0.0734
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0109 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0331 0.0734
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0233 0.2896
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0502 0.0502
Echinococcus multilocularis tumor protein p63 0.1682 1 1
Brugia malayi beta-lactamase family protein 0.007 0.0327 0.0725
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.016 0.4076
Brugia malayi MH1 domain containing protein 0.0028 0.0079 0.0174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0327 0.1245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Schistosoma mansoni hypothetical protein 0.0083 0.0409 0.0845
Loa Loa (eye worm) hypothetical protein 0.0105 0.0538 0.1192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0425
Loa Loa (eye worm) hypothetical protein 0.0246 0.1387 0.3073
Brugia malayi Cathepsin L-like precursor 0.0036 0.0127 0.028
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0158 0.0158
Plasmodium vivax vivapain-2 0.0054 0.0233 0.615
Brugia malayi MH2 domain containing protein 0.0023 0.0046 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0427
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0327 0.1245
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0215 0.0476
Schistosoma mansoni cpg binding protein 0.0034 0.0114 0.0236
Brugia malayi hypothetical protein 0.005 0.0208 0.0461
Loa Loa (eye worm) MH2 domain-containing protein 0.0746 0.4387 0.9721
Echinococcus multilocularis lamin dm0 0.0107 0.055 0.055
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0124 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0427
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0419
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0371 0.3251
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0327 0.2543
Trypanosoma brucei glucosidase, putative 0.0042 0.016 0.1399
Onchocerca volvulus 0.0109 0.0561 0.4034
Brugia malayi hypothetical protein 0.0037 0.0133 0.0294
Leishmania major cathepsin L-like protease 0.0054 0.0233 0.2043
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.0233 0.615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0069 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0425
Echinococcus multilocularis survival motor neuron protein 1 0.0767 0.4513 0.4513
Schistosoma mansoni inositol monophosphatase 0.0041 0.0158 0.0327
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0331 0.0734
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0331 0.0734
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0327 1
Leishmania major cysteine peptidase A (CPA) 0.0054 0.0233 0.2043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0055 0.0427
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0673 0.259
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0233 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0331 0.0331
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0077 0.0925
Giardia lamblia GTOR 0.0045 0.0178 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0331 0.0734
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0331 0.0331
Brugia malayi nuclear receptor NHR-88 0.0033 0.0109 0.0241
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0109 0.0109
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0799 0.1651
Echinococcus granulosus smad 0.0051 0.0215 0.0215
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0014 0.0124
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0263 0.1486 0.3293
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0014 0.0124
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0046 0.0046
Echinococcus granulosus cathepsin L 0.0028 0.0077 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0331 0.0734
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0282 0.7503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0205 0.1143 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0502 0.1038
Brugia malayi nuclear hormone receptor 0.007 0.0331 0.0734
Echinococcus granulosus cathepsin l1 0.0036 0.0127 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0233 0.1814
Schistosoma mansoni smad1 5 8 and 0.0051 0.0215 0.0444
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0409 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.007 0.0547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0077 0.0595
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.016 0.0354
Onchocerca volvulus 0.0054 0.0233 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.011 0.0852
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0158 0.4036
Plasmodium vivax vivapain-1 0.0028 0.0077 0.1773
Mycobacterium tuberculosis Conserved protein 0.007 0.0327 0.1245
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0326 0.0674
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0596 0.2292
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0014 1
Brugia malayi Intermediate filament tail domain containing protein 0.0107 0.055 0.1218
Onchocerca volvulus Cathepsin F homolog 0.0054 0.0233 0.1665
Brugia malayi glutathione reductase 0.005 0.0211 0.0467
Leishmania major cathepsin L-like protease 0.0205 0.1143 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0162 0.0879 0.7691
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.016 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.016 0.1399
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0327 0.2543
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0077 0.0925
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0331 0.0734
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0233 0.1814
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0596 0.2292
Entamoeba histolytica cysteine protease, putative 0.0028 0.0077 0.0925
Echinococcus multilocularis musashi 0.0107 0.055 0.055
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0517
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0109 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0327 0.2864
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.016 0.1242
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0331 0.0734
Mycobacterium tuberculosis Probable reductase 0.0114 0.0596 0.2292
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0331 0.0331
Brugia malayi Thioredoxin reductase 0.005 0.0211 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.011 0.0852
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0048 0.111
Brugia malayi hypothetical protein 0.0148 0.0799 0.177
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.0233 0.0233
Onchocerca volvulus 0.0054 0.0233 0.1665
Brugia malayi latrophilin 2 splice variant baaae 0.018 0.0987 0.2188
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0241

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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