Detailed information for compound 75962

Basic information

Technical information
  • TDR Targets ID: 75962
  • Name: 6-[(3-methylpyridin-2-yl)methoxy]-3-phenyl-[1 ,2,4]triazolo[3,4-a]phthalazine
  • MW: 367.403 | Formula: C22H17N5O
  • H donors: 0 H acceptors: 4 LogP: 3.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccnc1COc1nn2c(nnc2c2c1cccc2)c1ccccc1
  • InChi: 1S/C22H17N5O/c1-15-8-7-13-23-19(15)14-28-22-18-12-6-5-11-17(18)21-25-24-20(27(21)26-22)16-9-3-2-4-10-16/h2-13H,14H2,1H3
  • InChiKey: CHMFFBQMSYJXTP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[(3-methyl-2-pyridyl)methoxy]-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 2 Starlite/ChEMBL References
Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 Starlite/ChEMBL References
Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131775 All targets in OG5_131775
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129441 All targets in OG5_129441
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor Get druggable targets OG5_129441 All targets in OG5_129441
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129441 All targets in OG5_129441
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi excitatory GABA receptor EXP-1A gamma-aminobutyric acid (GABA) A receptor, beta 3 473 aa 441 aa 29.9 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein gamma-aminobutyric acid (GABA) A receptor, gamma 2 467 aa 449 aa 27.6 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein gamma-aminobutyric acid (GABA) A receptor, alpha 2 451 aa 393 aa 25.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0177 0.0218
Schistosoma mansoni netrin receptor unc5 0.0016 0.0077 0.0094
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0063 0.0941 0.1157
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0165 0.0165
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0063 0.0941 0.0941
Mycobacterium ulcerans two component sensor kinase MprB 0.0019 0.0139 0.0951
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0184 0.3147 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0034 0.0407 0.0407
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0165 0.193
Schistosoma mansoni memapsin-2 (A01 family) 0.0417 0.7413 0.9117
Entamoeba histolytica hypothetical protein 0.004 0.0518 0.2898
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0109 0.1786 0.4104
Onchocerca volvulus 0.0135 0.2259 0.2966
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0402 0.1277
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0341 0.042
Schistosoma mansoni DNA polymerase eta 0.0022 0.0177 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.0941 0.1157
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0989 0.0989
Brugia malayi Rhodanese-like domain containing protein 0.0109 0.1786 0.1786
Loa Loa (eye worm) ACC-1 protein 0.0063 0.0941 0.0941
Brugia malayi hypothetical protein 0.0064 0.0951 0.0951
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0941 0.1157
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4351 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0317 0.0317
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0064 0.0951 0.117
Schistosoma mansoni nAChR subunit 0.0063 0.0941 0.1157
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0856 0.2721
Onchocerca volvulus 0.0063 0.0941 0.1235
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0077 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0064 0.0064
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0064 0.0951 0.117
Echinococcus granulosus carbonic anhydrase 0.0086 0.1363 0.1677
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0017 0.009 0.0659
Echinococcus granulosus pikachurin 0.0023 0.0209 0.0257
Brugia malayi Rhodanese-like domain containing protein 0.0109 0.1786 0.1786
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0341 0.0341
Schistosoma mansoni jun-related protein 0.0071 0.1077 0.1324
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0798 0.0982
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0177 0.1335
Trypanosoma brucei lanosterol synthase 0.0152 0.2573 0.8178
Onchocerca volvulus 0.0064 0.0951 0.1249
Schistosoma mansoni ap endonuclease 0.0059 0.0856 0.1053
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0402 0.1277
Trypanosoma cruzi lanosterol synthase, putative 0.0152 0.2573 0.8178
Entamoeba histolytica hypothetical protein 0.004 0.0518 0.2898
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0341 0.042
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0029 0.0317 0.0317
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0019 0.0139 0.0951
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0518 0.0637
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0177 0.1335
Schistosoma mansoni nAChR subunit 0.0063 0.0941 0.1157
Brugia malayi nuclear receptor RXR 0.0064 0.0951 0.0951
Echinococcus multilocularis transcription factor btf3 0.0034 0.0402 0.0494
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0165 0.0525
Entamoeba histolytica rodhanase-like domain containing protein 0.0109 0.1786 1
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0209 0.0209
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0856 0.2721
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0109 0.1786 0.2196
Brugia malayi Cytochrome P450 family protein 0.0015 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0086 0.1363 0.1363
Entamoeba histolytica hypothetical protein 0.004 0.0518 0.2898
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.0941 0.1157
Schistosoma mansoni neurotransmitter gated ion channel 0.0034 0.0407 0.0501
Schistosoma mansoni nAChR subunit 0.0029 0.0317 0.039
Loa Loa (eye worm) hypothetical protein 0.0101 0.163 0.163
Onchocerca volvulus 0.0109 0.1786 0.2344
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0063 0.0941 0.1157
Schistosoma mansoni coup transcription factor 0.0135 0.2259 0.2778
Plasmodium falciparum geranylgeranyltransferase, putative 0.0021 0.0165 0.1212
Loa Loa (eye worm) hypothetical protein 0.0027 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Brugia malayi hypothetical protein 0.0428 0.7618 0.7618
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0021 0.0165 0.0925
Echinococcus granulosus carbonic anhydrase II 0.0184 0.3147 0.387
Echinococcus granulosus glycine receptor subunit beta 0.0063 0.0941 0.1157
Brugia malayi nuclear receptor NHR-67 0.0064 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Brugia malayi tailless protein 0.0064 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Trypanosoma brucei carbonic anhydrase-like protein 0.0184 0.3147 1
Schistosoma mansoni nAChR subunit 0.0063 0.0941 0.1157
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0135 0.2259 0.2778
Brugia malayi photoreceptor-specific nuclear receptor 0.0135 0.2259 0.2259
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.0165 0.038
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0077 0.0094
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0063 0.0941 0.0941
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2781 0.639
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Plasmodium falciparum plasmepsin V 0.0017 0.009 0.0659
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0063 0.0941 0.1157
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0026 0.026 0.026
Toxoplasma gondii aspartyl protease 0.0017 0.009 0.0659
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0177 0.1434
Leishmania major lanosterol synthase, putative 0.0132 0.2191 0.6964
Onchocerca volvulus 0.0029 0.0317 0.0417
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0177 0.0177
Plasmodium falciparum plasmepsin I 0.0017 0.009 0.0659
Brugia malayi nuclear hormone receptor 0.0064 0.0951 0.0951
Trypanosoma cruzi lanosterol synthase, putative 0.0152 0.2573 0.8178
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0856 1
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0951 0.117
Onchocerca volvulus 0.0063 0.0941 0.1235
Echinococcus multilocularis slit 2 protein 0.0023 0.0209 0.0257
Schistosoma mansoni nAChR subunit 0.0029 0.0317 0.039
Echinococcus granulosus dnaJ subfamily B 0.0456 0.8131 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0165 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0096 0.1547 0.1547
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0184 0.3147 0.387
Loa Loa (eye worm) hypothetical protein 0.0071 0.1091 0.1091
Schistosoma mansoni hypothetical protein 0.0189 0.3242 0.3987
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0177 0.0563
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.1286 0.1582
Loa Loa (eye worm) hypothetical protein 0.0021 0.0165 0.0165
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0071 0.1091 0.1342
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0064 0.0951 0.0951
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0034 0.0407 0.0407
Echinococcus multilocularis carbonic anhydrase 0.0086 0.1363 0.1677
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0209
Schistosoma mansoni nuclear receptor nhr-48 0.0064 0.0951 0.117
Loa Loa (eye worm) hypothetical protein 0.0026 0.026 0.026
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0019 0.0139 0.0951
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.2781 0.365
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.0165 0.038
Onchocerca volvulus 0.0109 0.1786 0.2344
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Brugia malayi EGF-like domain containing protein 0.0023 0.0209 0.0209
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0135 0.2259 0.2778
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1091 0.1091
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4351 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0402 0.0923
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0951 0.117
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0135 0.2259 0.2778
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0135 0.2259 0.2778
Loa Loa (eye worm) runx1 0.0054 0.0766 0.0766
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0177 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2942 0.6761
Loa Loa (eye worm) nuclear receptor NHR-67 0.0064 0.0951 0.0951
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0025 0.0243 0.0559
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0951 0.117
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0177 0.0563
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.009 0.009
Leishmania major DNA polymerase eta, putative 0.0022 0.0177 0.0563
Brugia malayi Calcitonin receptor-like protein seb-1 0.0096 0.1547 0.1547
Trypanosoma brucei unspecified product 0.0022 0.0177 0.0563
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.009 0.011
Schistosoma mansoni cathepsin D (A01 family) 0.0017 0.009 0.011
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0063 0.0941 0.1157
Leishmania major farnesyltransferase beta subunit 0.0021 0.0165 0.0525
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0109 0.1786 0.4104
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0402 0.0402
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0109 0.1786 0.4104
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0165 0.0525
Brugia malayi Cation transporter family protein 0.0063 0.0941 0.0941
Echinococcus granulosus thyroid hormone receptor alpha 0.0064 0.0951 0.117
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0856 0.6449
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0177 0.0563
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Echinococcus multilocularis nAChR subunit 0.0063 0.0941 0.1157
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0017 0.009 0.0206
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0063 0.0941 0.0941
Giardia lamblia Prenyltransferase 0.0021 0.0165 0.193
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0135 0.2259 0.2778
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Echinococcus granulosus nAChR subunit 0.0063 0.0941 0.1157
Loa Loa (eye worm) hypothetical protein 0.0428 0.7618 0.7618
Plasmodium vivax aspartyl protease, putative 0.0017 0.009 0.1049
Brugia malayi hypothetical protein 0.004 0.0518 0.0518
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0135 0.2259 0.2259
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0317 0.039
Echinococcus multilocularis lamin dm0 0.0056 0.0811 0.0997
Brugia malayi Death domain containing protein 0.0016 0.0077 0.0077
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0064 0.0951 0.0951
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Plasmodium vivax plasmepsin IV, putative 0.0017 0.009 0.1049
Schistosoma mansoni nAChR subunit 0.0063 0.0941 0.1157
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0177 0.0563
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0941 0.0941
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2781 0.639
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0019 0.0139 0.0951
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0029 0.0317 0.039
Schistosoma mansoni hypothetical protein 0.0086 0.1363 0.1677
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0279 0.0343
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0029 0.0317 0.0317
Schistosoma mansoni lamin 0.0056 0.0811 0.0997
Echinococcus multilocularis carbonic anhydrase 0.0086 0.1363 0.1677
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Plasmodium vivax geranylgeranyltransferase, putative 0.0021 0.0165 0.193
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0019 0.0139 0.5
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.0165 0.1212
Echinococcus granulosus carbonic anhydrase 0.0086 0.1363 0.1677
Giardia lamblia DINP protein human, muc B family 0.0022 0.0177 0.207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0077 0.0077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0856 0.2721
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0951 0.117
Entamoeba histolytica rodhanase-like domain containing protein 0.0109 0.1786 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0063 0.0941 0.1157
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0279 0.0343
Onchocerca volvulus 0.0056 0.0811 0.1064
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0259 0.4531 0.4531
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0341 0.042
Echinococcus multilocularis pikachurin 0.0023 0.0209 0.0257
Schistosoma mansoni hypothetical protein 0.003 0.0341 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2781 0.639
Schistosoma mansoni cpg binding protein 0.0032 0.037 0.0454
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.003 0.0341 0.042
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Brugia malayi orphan nuclear receptor NR2E1 0.0064 0.0951 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0055 0.0175
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0029 0.0317 0.039
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0019 0.0139 0.1046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0135 0.2259 0.2778
Schistosoma mansoni hypothetical protein 0.005 0.0698 0.0859
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0184 0.3147 0.3147
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0856 1
Trichomonas vaginalis cdc25b, putative 0.0109 0.1786 0.4104
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0184 0.3147 1
Loa Loa (eye worm) DR-78 0.0064 0.0951 0.0951
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0402 0.225
Brugia malayi CXXC zinc finger family protein 0.0032 0.037 0.037
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0017 0.009 0.0659
Loa Loa (eye worm) hypothetical protein 0.0086 0.1363 0.1363
Brugia malayi hypothetical protein 0.0064 0.0951 0.0951
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0019 0.0139 0.1046
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0019 0.0139 0.1046
Echinococcus multilocularis GPCR, family 2 0.003 0.0341 0.042
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0856 1
Echinococcus multilocularis jun protein 0.0087 0.1375 0.1691
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0165 0.1212
Trichomonas vaginalis cdc25b, putative 0.0109 0.1786 0.4104
Schistosoma mansoni carbonic anhydrase-related 0.0086 0.1363 0.1677
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0317 0.0317
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.0165 0.0525
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0019 0.0139 0.1046
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0402 0.0923
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2781 0.639
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0063 0.0941 0.1157
Onchocerca volvulus 0.0056 0.0811 0.1064
Echinococcus multilocularis Ankyrin 0.0016 0.0079 0.0098
Loa Loa (eye worm) hypothetical protein 0.023 0.3997 0.3997
Brugia malayi hypothetical protein 0.0029 0.0317 0.0317
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0856 0.2721
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.8131 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.0165 0.0203
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.009 0.009
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0177 0.0563
Schistosoma mansoni acetylcholine receptor subunit beta 0.0029 0.0317 0.039
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1895 0.1895
Toxoplasma gondii hypothetical protein 0.0086 0.1363 1
Onchocerca volvulus 0.0017 0.009 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0135 0.2259 0.2259
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0034 0.0407 0.0501
Plasmodium falciparum plasmepsin X 0.0017 0.009 0.0659
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0086 0.1363 0.1363
Echinococcus granulosus jun protein 0.0087 0.1375 0.1691
Loa Loa (eye worm) hypothetical protein 0.0085 0.1331 0.1331
Brugia malayi MH2 domain containing protein 0.0115 0.1895 0.1895
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0021 0.0165 0.0925
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0177 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0135 0.2259 0.2259
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.0941 0.1157
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4351 1
Onchocerca volvulus 0.0063 0.0941 0.1235
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0079 0.0098
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0063 0.0941 0.1157
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0941 0.0941
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0063 0.0941 0.1157
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0135 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Schistosoma mansoni zinc finger protein 0.0064 0.0951 0.117
Leishmania major carbonic anhydrase-like protein 0.0184 0.3147 1
Echinococcus multilocularis geminin 0.0189 0.3242 0.3987
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0094
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0109 0.1786 0.2196
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0402 0.1277
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0177 0.0407
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0064 0.0202
Loa Loa (eye worm) ACC-1 protein 0.0063 0.0941 0.0941
Onchocerca volvulus Bile acid receptor homolog 0.0135 0.2259 0.2966
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0135 0.2259 0.2778
Loa Loa (eye worm) hypothetical protein 0.0016 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0071 0.1091 0.1091
Loa Loa (eye worm) nuclear hormone receptor 0.0064 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0109 0.1786 0.1786
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0063 0.0941 0.0941
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0811 0.0811
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0177 0.0218
Echinococcus multilocularis glycine receptor subunit beta 0.0063 0.0941 0.1157
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4351 1
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.0165 0.038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.1091 0.1342
Plasmodium falciparum plasmepsin II 0.0017 0.009 0.0659
Echinococcus multilocularis musashi 0.0056 0.0811 0.0997
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0064 0.0951 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0055 0.0175
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0518 0.0637
Leishmania major geranylgeranyltransferase, putative 0.0021 0.0165 0.0525
Plasmodium falciparum plasmepsin VIII, putative 0.0017 0.009 0.0659
Schistosoma mansoni hypothetical protein 0.0269 0.4708 0.579
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0856 0.1968
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0209 0.0257
Leishmania major cytochrome p450-like protein 0.0015 0.0064 0.0202
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Entamoeba histolytica hypothetical protein 0.0034 0.0402 0.225
Loa Loa (eye worm) hypothetical protein 0.003 0.0341 0.0341
Trichomonas vaginalis cdc25c, putative 0.0109 0.1786 0.4104
Leishmania major basic transcription factor 3a, putative 0.0034 0.0402 0.1277
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0135 0.2259 0.2966
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0063 0.0941 0.1157
Loa Loa (eye worm) hypothetical protein 0.0066 0.0989 0.0989
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.009 0.011
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0021 0.0165 0.0203
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0019 0.0139 0.1046
Loa Loa (eye worm) hypothetical protein 0.0071 0.1091 0.1091
Loa Loa (eye worm) hypothetical protein 0.0259 0.4531 0.4531
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Onchocerca volvulus 0.0032 0.037 0.0485
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0811 0.0811
Loa Loa (eye worm) hypothetical protein 0.0055 0.0792 0.0792
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0407 0.0407
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1895 0.1895
Schistosoma mansoni cell polarity protein 0.0023 0.0209 0.0257
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0025 0.0243 0.0559
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Brugia malayi hypothetical protein 0.0029 0.0317 0.0317
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.009 0.009
Brugia malayi Protein kinase domain containing protein 0.0016 0.0077 0.0077
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0019 0.0139 0.5
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0063 0.0941 0.0941
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0135 0.2259 0.2778
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0029 0.0317 0.0317
Plasmodium vivax aspartyl protease, putative 0.0017 0.009 0.1049
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0086 0.1363 0.1363
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Onchocerca volvulus 0.0063 0.0941 0.1235
Schistosoma mansoni cpg binding protein 0.0034 0.0403 0.0496
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0402 0.2947
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Plasmodium falciparum plasmepsin VII 0.0017 0.009 0.0659
Trypanosoma brucei unspecified product 0.0015 0.0055 0.0175
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0086 0.1363 0.1363
Entamoeba histolytica hypothetical protein 0.0034 0.0407 0.2279
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0063 0.0941 0.1157
Schistosoma mansoni lozenge 0.0054 0.0766 0.0942
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0941 0.0941
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0135 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0071 0.1091 0.1091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0019 0.0139 0.0951
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.4351 0.4351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0135 0.2259 0.2259
Toxoplasma gondii aspartyl protease ASP1 0.0017 0.009 0.0659
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0063 0.0941 0.1157
Echinococcus multilocularis dna polymerase eta 0.0022 0.0177 0.0218
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Onchocerca volvulus 0.0029 0.0317 0.0417
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0019 0.0139 0.1046
Echinococcus granulosus lamin dm0 0.0056 0.0811 0.0997
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.0798 0.6011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0951 0.117
Schistosoma mansoni intermediate filament proteins 0.0056 0.0811 0.0997
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0077 0.0094
Schistosoma mansoni slit 0.0023 0.0209 0.0257
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0029 0.0317 0.039
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.009 0.011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0941 0.0941
Echinococcus granulosus slit 2 protein 0.0023 0.0209 0.0257
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0064 0.0064
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0165 0.038
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0269 0.4708 0.579
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0856 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0021 0.0165 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2942 0.6761
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0856 0.0856
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0135 0.2259 0.2778
Brugia malayi Nuclear hormone receptor-like 1 0.0135 0.2259 0.2259
Brugia malayi hypothetical protein 0.0071 0.1091 0.1091
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0334 0.0334
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0465 0.8297 0.8297
Entamoeba histolytica hypothetical protein 0.004 0.0518 0.2898
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0317 0.0317
Echinococcus granulosus dna polymerase eta 0.0022 0.0177 0.0218
Echinococcus granulosus lamin 0.0056 0.0811 0.0997
Schistosoma mansoni ap endonuclease 0.0059 0.0856 0.1053
Echinococcus granulosus cpg binding protein 0.0034 0.0403 0.0496
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Schistosoma mansoni carbonic anhydrase-related 0.0086 0.1363 0.1677
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.0165 0.1212
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2781 0.639
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0063 0.0941 0.1157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0135 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0135 0.2259 0.2778
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0029 0.0317 0.039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0135 0.2259 0.2259
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0077 0.0077
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.0941 0.1157
Mycobacterium leprae Probable two component sensor kinase MprB 0.0019 0.0139 0.5
Loa Loa (eye worm) GABA receptor subunit 0.0034 0.0407 0.0407
Plasmodium vivax aspartyl protease, putative 0.0017 0.009 0.1049
Loa Loa (eye worm) steroid hormone receptor 0.0135 0.2259 0.2259
Schistosoma mansoni nuclear receptor 0.0064 0.0951 0.117
Leishmania major DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Schistosoma mansoni hypothetical protein 0.0066 0.0989 0.1216
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0135 0.2259 0.2259
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0135 0.2259 0.2778
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0177 0.0407
Plasmodium falciparum plasmepsin VI 0.0017 0.009 0.0659
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0941 0.1157
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.1286 0.1582
Echinococcus multilocularis glycine receptor subunit beta 0.0063 0.0941 0.1157
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0139 0.5
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.0407 0.0501
Brugia malayi hypothetical protein 0.0071 0.1091 0.1091
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.0165 0.038
Onchocerca volvulus 0.0428 0.7618 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0025 0.0243 0.0559
Mycobacterium tuberculosis Two component sensor kinase [first part] 0.0014 0.0045 0.0338
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0798 0.9266
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0055 0.0175
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0856 0.1968
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0894 0.6557
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0209
Brugia malayi Steroid receptor seven-up type 2 0.0135 0.2259 0.2259
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0096 0.1547 0.1547
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0165 0.0165
Echinococcus multilocularis nuclear receptor nhr 48 0.0064 0.0951 0.117
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0135 0.2259 0.2259
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0518 0.0637
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0177 0.0177
Loa Loa (eye worm) acetylcholine receptor protein 0.0029 0.0317 0.0317
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0165 0.038
Schistosoma mansoni thyroid hormone receptor 0.0404 0.7184 0.8835
Plasmodium falciparum plasmepsin IX 0.0017 0.009 0.0659
Loa Loa (eye worm) hypothetical protein 0.0086 0.1363 0.1363
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0021 0.0165 0.0165
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0184 0.3147 0.387
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.0177
Echinococcus multilocularis lamin 0.0056 0.0811 0.0997
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.0165 0.193
Entamoeba histolytica rodhanase-like domain containing protein 0.0109 0.1786 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0402 0.4693
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Onchocerca volvulus 0.0034 0.0407 0.0534
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0071 0.1091 0.1091
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0269 0.4708 0.579
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0025 0.0243 0.1457
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0421 0.749 0.9212
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0029 0.0317 0.0317
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0209 0.0257
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0209 0.0209
Brugia malayi Pepsin A precursor 0.0017 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0021 0.0165 0.038
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0798 0.0982
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0165 0.0525
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0063 0.0941 0.0941
Echinococcus granulosus Ankyrin 0.0016 0.0079 0.0098
Plasmodium vivax plasmepsin V, putative 0.0017 0.009 0.1049
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0063 0.0941 0.1157
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0077 0.0101
Mycobacterium ulcerans two component regulator - sensor kinase 0.0019 0.0139 0.0951
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Schistosoma mansoni nAChR subunit 0.0063 0.0941 0.1157
Echinococcus multilocularis carbonic anhydrase II 0.0184 0.3147 0.387
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Brugia malayi Cation transporter family protein 0.0063 0.0941 0.0941
Echinococcus granulosus glycine receptor subunit beta 0.0063 0.0941 0.1157
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0064 0.0064
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0856 0.4794
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0063 0.0941 0.0941
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0135 0.2259 0.2778
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0209 0.0257
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0177 0.0218
Schistosoma mansoni acetylcholine receptor-related 0.0029 0.0317 0.039
Echinococcus granulosus GPCR family 2 0.003 0.0341 0.042
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0086 0.1363 0.1363
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0184 0.3147 0.3147
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0951 0.117
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0177 0.1434
Trichomonas vaginalis receptor histidine kinase, putative 0.0025 0.0243 0.0559
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1027 0.1263
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0019 0.0139 0.0951
Echinococcus granulosus transcription factor btf3 0.0034 0.0402 0.0494
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0064 0.0202
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0856 0.1053
Brugia malayi ecdysteroid receptor 0.0135 0.2259 0.2259
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0077 0.0094
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0109 0.1786 0.4104
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0071 0.1091 0.1091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0941 0.1157
Schistosoma mansoni cpg binding protein 0.0034 0.0403 0.0496
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Onchocerca volvulus Putative nachr subunit 0.0063 0.0941 0.1235
Brugia malayi hypothetical protein 0.0029 0.0317 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0135 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0135 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Onchocerca volvulus 0.0029 0.0317 0.0417
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0135 0.2259 0.2778
Trichomonas vaginalis sensor histidine kinase, putative 0.0025 0.0243 0.0559
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0086 0.1363 0.1363
Brugia malayi hypothetical protein 0.0068 0.1033 0.1033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Schistosoma mansoni lamin 0.0056 0.0811 0.0997
Brugia malayi laminin alpha chain 0.0023 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0101 0.163 0.163
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0063 0.0941 0.1157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0135 0.2259 0.2259
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0165 0.0165
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0071 0.1091 0.1342
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0402 0.2947
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0064 0.0951 0.117
Loa Loa (eye worm) carbonic anhydrase 3 0.0184 0.3147 0.3147
Schistosoma mansoni retinoic acid receptor RXR 0.0135 0.2259 0.2778
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Brugia malayi nuclear hormone receptor family member odr-7 0.0064 0.0951 0.0951
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.009 0.1049
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0165 0.038
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4351 1
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0798 0.0798
Schistosoma mansoni steroid hormone receptor ad4bp 0.0135 0.2259 0.2778
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.0941 0.1157
Onchocerca volvulus 0.0068 0.1033 0.1356
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0021 0.0165 0.0203
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0165 0.0165
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0109 0.1786 0.4104
Schistosoma mansoni thyroid hormone receptor 0.0404 0.7184 0.8835
Schistosoma mansoni transcription factor btf3 0.0034 0.0402 0.0494
Echinococcus multilocularis FTZ F1 alpha 0.0135 0.2259 0.2778
Schistosoma mansoni hypothetical protein 0.003 0.0341 0.042
Toxoplasma gondii exonuclease III APE 0.0059 0.0856 0.6281
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.1375 0.1691
Schistosoma mansoni nAChR subunit 0.0063 0.0941 0.1157
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2781 0.639
Onchocerca volvulus 0.0109 0.1786 0.2344
Brugia malayi nuclear receptor RXR 0.0071 0.1091 0.1091
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.0165 0.1212
Loa Loa (eye worm) hypothetical protein 0.0434 0.7722 0.7722
Echinococcus multilocularis cpg binding protein 0.0034 0.0403 0.0496
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.0165 0.0203
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0021 0.0165 0.0203
Brugia malayi nuclear receptor NHR-88 0.0064 0.0951 0.0951
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1091 0.1091
Schistosoma mansoni nuclear hormone receptor 0.0135 0.2259 0.2778
Onchocerca volvulus 0.0109 0.1786 0.2344
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0798 0.9266
Schistosoma mansoni nuclear receptor 0.0064 0.0951 0.117
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0077 0.0094
Echinococcus granulosus ecdysone induced protein 78C 0.0135 0.2259 0.2778
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0317 0.039
Onchocerca volvulus 0.0063 0.0941 0.1235
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0021 0.0165 0.038
Brugia malayi hypothetical protein 0.0029 0.0317 0.0317
Schistosoma mansoni nAChR subunit 0.0063 0.0941 0.1157
Schistosoma mansoni RAR-like nuclear receptor 0.0135 0.2259 0.2778
Brugia malayi excitatory GABA receptor EXP-1A 0.0063 0.0941 0.0941
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0135 0.2259 0.2259
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0025 0.0243 0.0559
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0856 0.6281
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0019 0.0139 0.1046
Onchocerca volvulus 0.0034 0.0407 0.0534
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0029 0.0317 0.039
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0941 0.0941
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.0798 0.2536
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.0165 0.0525
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0177 0.0993
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0135 0.2259 0.2778
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0063 0.0941 0.1157
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0021 0.0165 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0135 0.2259 0.2259
Brugia malayi Cation transporter family protein 0.0063 0.0941 0.0941
Onchocerca volvulus 0.0064 0.0951 0.1249
Echinococcus multilocularis Protein lozenge 0.0054 0.0766 0.0942
Schistosoma mansoni hypothetical protein 0.004 0.0518 0.0637
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0184 0.3147 0.3147
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0856 0.1053
Brugia malayi nuclear hormone receptor 0.0135 0.2259 0.2259
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0135 0.2259 0.2778
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0951 0.117
Plasmodium vivax aspartyl proteinase, putative 0.0017 0.009 0.1049
Brugia malayi nuclear hormone receptor family member nhr-6 0.0064 0.0951 0.0951
Echinococcus multilocularis ecdysone induced protein 78C 0.0135 0.2259 0.2778
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0077 0.0094
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0063 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Brugia malayi follicle stimulating hormone receptor 0.0465 0.8297 0.8297
Echinococcus multilocularis carbonic anhydrase 0.0086 0.1363 0.1677
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0334 0.0334
Schistosoma mansoni hypothetical protein 0.003 0.0341 0.042
Echinococcus granulosus carbonic anhydrase 0.0086 0.1363 0.1677
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0135 0.2259 0.2778
Echinococcus granulosus dna polymerase kappa 0.0022 0.0177 0.0218
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0811 0.0811
Loa Loa (eye worm) hypothetical protein 0.0056 0.0811 0.0811
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0086 0.1363 0.1363
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0063 0.0941 0.1157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0317 0.0317
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.0941 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0135 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0135 0.2259 0.2259
Brugia malayi nuclear receptor NHR-88 0.0135 0.2259 0.2259
Brugia malayi hypothetical protein 0.0017 0.009 0.009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0135 0.2259 0.2778
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0177 0.0218
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0951 0.0951
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.073 0.073
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0209 0.0209
Onchocerca volvulus 0.0017 0.009 0.0118
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0021 0.0165 0.193
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0407 0.0407
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.1375 0.1691
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.009 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0402 0.0923
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0021 0.0165 0.0203
Brugia malayi Cytochrome P450 family protein 0.0015 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0135 0.2259 0.2259
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2781 0.639
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0135 0.2259 0.2778
Schistosoma mansoni hypothetical protein 0.0456 0.8131 1
Schistosoma mansoni hypothetical protein 0.0071 0.1077 0.1324
Trypanosoma brucei unspecified product 0.0015 0.0055 0.0175
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0084 0.1328 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0404 0.7184 0.8835
Plasmodium falciparum plasmepsin III 0.0017 0.009 0.0659
Echinococcus granulosus nAChR subunit 0.0034 0.0407 0.0501
Loa Loa (eye worm) hypothetical protein 0.0428 0.7618 0.7618
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0019 0.0139 0.0951
Brugia malayi bZIP transcription factor family protein 0.0087 0.1375 0.1375
Brugia malayi hypothetical protein 0.0017 0.009 0.009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0135 0.2259 0.2259
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0341 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.4351 1
Brugia malayi hypothetical protein 0.0029 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0096 0.1547 0.1547
Echinococcus granulosus nuclear receptor nhr 48 0.0064 0.0951 0.117
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0064 0.0202
Onchocerca volvulus 0.0063 0.0941 0.1235
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0177 0.0563
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0798 0.0982
Loa Loa (eye worm) hypothetical protein 0.0063 0.0941 0.0941
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0209 0.0257
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0951 0.1249
Loa Loa (eye worm) hypothetical protein 0.0558 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0071 0.1091 0.1342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0135 0.2259 0.2778
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.0941 0.1157
Brugia malayi ecdysone receptor 0.0064 0.0951 0.0951
Plasmodium falciparum plasmepsin IV 0.0017 0.009 0.0659
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0109 0.1786 0.2196
Toxoplasma gondii aspartyl protease ASP3 0.0017 0.009 0.0659
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0063 0.0941 0.1157
Loa Loa (eye worm) LGC-31 protein 0.0063 0.0941 0.0941
Plasmodium falciparum carbonic anhydrase 0.0086 0.1363 1
Brugia malayi Uncoordinated protein 44 0.0016 0.0077 0.0077
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0063 0.0941 0.0941
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0951 0.117
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0165 0.0525
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0021 0.0165 0.0925
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0063 0.0941 0.1157
Schistosoma mansoni hypothetical protein 0.0189 0.3242 0.3987
Loa Loa (eye worm) hypothetical protein 0.0034 0.0407 0.0407
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.037 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0135 0.2259 0.2259
Onchocerca volvulus Protein ultraspiracle homolog 0.0135 0.2259 0.2966
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0021 0.0165 0.0203
Brugia malayi intermediate filament protein 0.0056 0.0811 0.0811
Brugia malayi steroid hormone receptor 0.0135 0.2259 0.2259
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0856 1
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0021 0.0165 0.0525
Loa Loa (eye worm) hypothetical protein 0.0109 0.1786 0.1786
Echinococcus multilocularis nAChR subunit 0.0034 0.0407 0.0501
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0177 0.0177
Echinococcus granulosus FTZ F1 alpha 0.0135 0.2259 0.2778
Echinococcus granulosus geminin 0.0189 0.3242 0.3987
Brugia malayi beta-NAC-like protein 0.0034 0.0402 0.0402
Schistosoma mansoni carbonic anhydrase 0.0086 0.1363 0.1677
Echinococcus granulosus death domain containing protein 0.0016 0.0077 0.0094
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0021 0.0165 0.1212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0135 0.2259 0.2259
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0025 0.0243 0.0559
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0341 0.0341
Brugia malayi Latrophilin receptor protein 2 0.003 0.0341 0.0341
Brugia malayi conserved hypotetical protein 0.0064 0.0951 0.0951
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.4351 0.4351
Echinococcus granulosus intermediate filament protein 0.0056 0.0811 0.0997
Schistosoma mansoni carbonic anhydrase-related 0.0086 0.1363 0.1677
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0951 0.1249
Loa Loa (eye worm) hypothetical protein 0.0064 0.0951 0.0951

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.88 nM Binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873
Ki (binding) = 0.88 nM Binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873
Ki (binding) = 1 nM Binding affinity for human GABA-A receptor alpha3-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873
Ki (binding) = 1 nM Binding affinity for human GABA-A receptor alpha3-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873
Ki (binding) = 2.3 nM Binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873
Ki (binding) = 2.3 nM Binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873
Ki (binding) = 2.4 nM Binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873
Ki (binding) = 2.4 nM Binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits in L(tk-) cells ChEMBL. 15027873

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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