Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0232 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.4113 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.4113 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.047 | 0.1143 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.047 | 0.1143 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2276 | 0.2276 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.3832 | 0.3832 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.047 | 0.1143 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.047 | 0.1143 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.2276 | 0.2276 |
Brugia malayi | hypothetical protein | 0.0109 | 0.4113 | 0.4113 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.3832 | 0.3832 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.047 | 0.1143 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.047 | 0.1143 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.047 | 0.1143 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2276 | 0.5534 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.047 | 0.1143 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.047 | 0.1143 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.4113 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.3832 | 0.3832 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.3832 | 0.3832 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0232 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.4113 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0109 | 0.4113 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0109 | 0.4113 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.047 | 0.047 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.047 | 0.047 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.047 | 0.047 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0109 | 0.4113 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.047 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.047 | 0.047 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.4113 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.