Detailed information for compound 760183

Basic information

Technical information
  • TDR Targets ID: 760183
  • Name: 2-(2-methoxyphenyl)-N-(2-propan-2-ylphenyl)ac etamide
  • MW: 283.365 | Formula: C18H21NO2
  • H donors: 1 H acceptors: 1 LogP: 3.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CC(=O)Nc1ccccc1C(C)C
  • InChi: 1S/C18H21NO2/c1-13(2)15-9-5-6-10-16(15)19-18(20)12-14-8-4-7-11-17(14)21-3/h4-11,13H,12H2,1-3H3,(H,19,20)
  • InChiKey: BSAJMTZEZNRWPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-isopropylphenyl)-2-(2-methoxyphenyl)acetamide
  • 2-(2-methoxyphenyl)-N-(2-propan-2-ylphenyl)ethanamide
  • ST012105
  • Oprea1_409587
  • ZINC00121838

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0012 0.0013
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0053 0.0071
Mycobacterium tuberculosis Probable lipase LipD 0.0144 0.1377 0.1069
Schistosoma mansoni tar DNA-binding protein 0.0131 0.123 0.1653
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.027 0.0363
Schistosoma mansoni thyroid hormone receptor 0.027 0.2782 0.374
Brugia malayi MH1 domain containing protein 0.0031 0.0127 0.014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0314 0.0347
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0057 0.041 0.0551
Echinococcus granulosus mothers against decapentaplegic 5 0.0057 0.041 0.0551
Loa Loa (eye worm) RNA binding protein 0.0131 0.123 0.1356
Schistosoma mansoni tar DNA-binding protein 0.0131 0.123 0.1653
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0444 0.3165
Mycobacterium tuberculosis Probable lipase LipE 0.0144 0.1377 0.1069
Mycobacterium ulcerans lipase LipD 0.0144 0.1377 1
Schistosoma mansoni importin beta-1 0.0029 0.0096 0.0129
Echinococcus multilocularis Smad4 0.0057 0.041 0.0454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.027 0.0363
Echinococcus granulosus beta LACTamase domain containing family member 0.0144 0.1377 0.1851
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0643 0.4625
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0419 0.0564
Onchocerca volvulus 0.0144 0.1377 0.2716
Brugia malayi beta-lactamase family protein 0.0144 0.1377 0.1518
Plasmodium vivax importin-beta 2, putative 0.0029 0.0096 0.0618
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0053 0.0058
Echinococcus multilocularis snurportin 1 0.0307 0.3187 0.3534
Brugia malayi Pre-SET motif family protein 0.0418 0.4428 0.4882
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0053 0.2479
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0053 0.0058
Echinococcus granulosus Smad4 0.0057 0.041 0.0551
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0028 0.0031
Entamoeba histolytica hypothetical protein 0.0036 0.0176 1
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0053 0.0298
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0012 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.7438 0.8248
Schistosoma mansoni hypothetical protein 0.0033 0.0144 0.0194
Brugia malayi MH2 domain containing protein 0.0057 0.041 0.0452
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0053 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0144 0.1377 1
Schistosoma mansoni Smad4 0.0057 0.041 0.0551
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0036 0.0047
Echinococcus multilocularis tumor protein p63 0.0351 0.3676 0.4077
Entamoeba histolytica hypothetical protein 0.0023 0.0036 0.1456
Mycobacterium tuberculosis Conserved protein 0.0144 0.1377 0.1069
Loa Loa (eye worm) TAR-binding protein 0.0131 0.123 0.1356
Loa Loa (eye worm) hypothetical protein 0.0144 0.1377 0.1518
Mycobacterium tuberculosis Probable esterase LipL 0.0144 0.1377 0.1069
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0345 0.0463
Schistosoma mansoni tar DNA-binding protein 0.0131 0.123 0.1653
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0176 0.0237
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0314 0.0347
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0096 0.0107
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0053 0.0298
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0028 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0144 0.1377 0.1851
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0643 0.4625
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.027 0.0363
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0144 0.0159
Brugia malayi MH2 domain containing protein 0.0836 0.907 1
Schistosoma mansoni smad1 5 8 and 0.0057 0.041 0.0551
Schistosoma mansoni ran 0.0021 0.0012 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0643 0.4625
Schistosoma mansoni Smad4 0.0025 0.006 0.008
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0643 0.0865
Loa Loa (eye worm) transcription factor SMAD2 0.0836 0.907 1
Brugia malayi MH1 domain containing protein 0.0057 0.041 0.0452
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0144 0.1377 0.1069
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0347 0.0467
Echinococcus granulosus smad 0.0057 0.041 0.0551
Schistosoma mansoni hypothetical protein 0.0023 0.0028 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.027 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.1377 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0643 0.5
Schistosoma mansoni smad 0.0057 0.041 0.0551
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.0047
Toxoplasma gondii hypothetical protein 0.0027 0.0075 0.0464
Trichomonas vaginalis set domain proteins, putative 0.0476 0.507 1
Echinococcus granulosus snurportin 1 0.0307 0.3187 0.4285
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0643 0.0865
Loa Loa (eye worm) hypothetical protein 0.0144 0.1377 0.1518
Echinococcus multilocularis thyroid hormone receptor alpha 0.027 0.2782 0.3085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0444 0.0597
Leishmania major hypothetical protein, conserved 0.0144 0.1377 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0337 0.5149
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0053 0.0071
Schistosoma mansoni smad1 5 8 and 0.0057 0.041 0.0551
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0025 0.006 0.0118
Brugia malayi mothers against decapentaplegic homolog 3 0.0025 0.006 0.0066
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0053 0.0081
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0053 0.0298
Entamoeba histolytica hypothetical protein 0.0036 0.0176 1
Trypanosoma brucei hypothetical protein, conserved 0.0144 0.1377 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.006 0.0066
Leishmania major importin beta-1 subunit, putative 0.0023 0.0036 0.0175
Leishmania major hypothetical protein, conserved 0.005 0.0337 0.2381
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0144 0.1377 0.1851
Toxoplasma gondii ABC1 family protein 0.0144 0.1377 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0053 0.0645
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.006 0.0444 0.0489
Echinococcus granulosus tumor protein p63 0.0351 0.3676 0.4942
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0337 0.2381
Loa Loa (eye worm) beta-lactamase 0.0144 0.1377 0.1518
Brugia malayi Importin beta-1 subunit 0.0029 0.0096 0.0106
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.025 0.2559 0.344
Brugia malayi hypothetical protein 0.0033 0.0138 0.0153
Brugia malayi RNA, U transporter 1 0.0082 0.0685 0.0755
Brugia malayi hypothetical protein 0.005 0.0337 0.0371
Loa Loa (eye worm) MH2 domain-containing protein 0.0836 0.907 1
Mycobacterium tuberculosis Probable hydrolase 0.0144 0.1377 0.1069
Schistosoma mansoni smad 0.0025 0.006 0.008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0444 0.0492
Loa Loa (eye worm) hypothetical protein 0.0078 0.0643 0.0709
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.027 0.0299
Schistosoma mansoni ran 0.0021 0.0012 0.0016
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0643 0.0713
Loa Loa (eye worm) nuclear factor I 0.0031 0.0127 0.014
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0053 0.0058
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0337 0.2381
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0066
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0444 0.0597
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.025 0.2559 0.2837
Loa Loa (eye worm) hypothetical protein 0.0051 0.0347 0.0383
Brugia malayi MH2 domain containing protein 0.0025 0.006 0.0066
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0096 0.0618
Onchocerca volvulus 0.0476 0.507 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0096 0.0106
Loa Loa (eye worm) hypothetical protein 0.0048 0.0314 0.0347
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.027 0.0298
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0096 0.0618
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0036 0.0175
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.9018 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.123 0.1653
Brugia malayi RNA binding protein 0.0131 0.123 0.1356
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.027 0.0298
Echinococcus granulosus tar DNA binding protein 0.0131 0.123 0.1653
Entamoeba histolytica hypothetical protein 0.0036 0.0176 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0144 0.1377 0.1518
Schistosoma mansoni hypothetical protein 0.025 0.2559 0.344
Schistosoma mansoni smad1 5 8 and 0.0057 0.041 0.0551
Loa Loa (eye worm) hypothetical protein 0.0144 0.1377 0.1518
Schistosoma mansoni tar DNA-binding protein 0.0131 0.123 0.1653
Plasmodium falciparum importin beta, putative 0.0029 0.0096 0.1336
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0337 0.2381
Onchocerca volvulus 0.0144 0.1377 0.2716
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.0047
Onchocerca volvulus 0.0144 0.1377 0.2716
Onchocerca volvulus 0.006 0.0444 0.0875
Echinococcus multilocularis smad 0.0057 0.041 0.0454
Brugia malayi hypothetical protein 0.0036 0.0176 0.0194
Loa Loa (eye worm) hypothetical protein 0.0144 0.1377 0.1518
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0337 0.2381
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0075 0.0464
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.4428 0.4882
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0053 0.0298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.027 0.0363
Echinococcus multilocularis beta LACTamase domain containing family member 0.0144 0.1377 0.1527
Trichomonas vaginalis penicillin-binding protein, putative 0.0144 0.1377 0.2698
Mycobacterium ulcerans beta-lactamase 0.0144 0.1377 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0643 0.5
Plasmodium vivax SET domain protein, putative 0.006 0.0444 0.3165
Mycobacterium leprae Probable lipase LipE 0.0144 0.1377 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0057 0.041 0.0452
Brugia malayi TAR-binding protein 0.0131 0.123 0.1356
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0144 0.1377 0.1069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0314 0.0347
Trichomonas vaginalis penicillin-binding protein, putative 0.0144 0.1377 0.2698
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0144 0.1377 1
Loa Loa (eye worm) Smad1 0.0057 0.041 0.0452
Schistosoma mansoni Smad4 0.0025 0.006 0.008
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.123 0.1356
Echinococcus multilocularis mothers against decapentaplegic 5 0.0057 0.041 0.0454
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0144 0.1377 0.1069
Brugia malayi MH1 domain containing protein 0.0031 0.0127 0.014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0643 0.4363
Mycobacterium tuberculosis Conserved protein 0.0144 0.1377 0.1069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0444 0.0597
Echinococcus granulosus importin subunit beta 1 0.0029 0.0096 0.0129
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0144 0.1377 0.1518
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0345 0.207
Echinococcus granulosus mothers against decapentaplegic 2 0.0025 0.006 0.008
Echinococcus multilocularis mothers against decapentaplegic 2 0.0025 0.006 0.0066
Brugia malayi MH1 domain containing protein 0.0057 0.041 0.0452
Mycobacterium ulcerans hypothetical protein 0.0144 0.1377 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0337 0.5149
Schistosoma mansoni hypothetical protein 0.0307 0.3187 0.4285
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0053 0.0298
Loa Loa (eye worm) hypothetical protein 0.005 0.0337 0.0371
Echinococcus multilocularis mothers against decapentaplegic 6 0.0025 0.006 0.0066
Trichomonas vaginalis chaperonin, putative 0.0025 0.0053 0.0081
Echinococcus granulosus microtubule associated protein 2 0.0689 0.7438 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.027 0.0363
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0643 0.5
Brugia malayi MH2 domain containing protein 0.0057 0.041 0.0452
Brugia malayi Pre-SET motif family protein 0.006 0.0444 0.0489
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0345 0.0382
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0643 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0444 0.0597
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.1377 0.2698
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0053 0.0058
Brugia malayi Probable ClpP-like protease 0.0078 0.0643 0.0709
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0053 0.0071
Echinococcus granulosus mothers against decapentaplegic 6 0.0025 0.006 0.008
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0096 0.0618
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0176 0.0195
Trichomonas vaginalis esterase, putative 0.0144 0.1377 0.2698
Loa Loa (eye worm) MH2 domain-containing protein 0.0057 0.041 0.0452
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.1377 0.2698
Onchocerca volvulus 0.0051 0.0347 0.0685
Entamoeba histolytica hypothetical protein 0.0036 0.0176 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.123 0.1356
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0144 0.0159
Mycobacterium tuberculosis Conserved protein 0.0144 0.1377 0.1069
Echinococcus multilocularis tar DNA binding protein 0.0131 0.123 0.1364
Schistosoma mansoni thyroid hormone receptor 0.027 0.2782 0.374
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0444 0.0492
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.3187 0.3514
Echinococcus granulosus TGF beta signal transducer SmadC 0.0057 0.041 0.0551
Loa Loa (eye worm) hypothetical protein 0.0144 0.1377 0.1518
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0176 0.0237
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0337 0.2381
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0075 0.1004
Loa Loa (eye worm) hypothetical protein 0.0144 0.1377 0.1518
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0643 1
Brugia malayi Smad1 0.0057 0.041 0.0452
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.7438 1
Trichomonas vaginalis D-aminoacylase, putative 0.0144 0.1377 0.2698
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0144 0.1377 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0057 0.041 0.0454
Schistosoma mansoni hypothetical protein 0.0036 0.0176 0.0237
Brugia malayi beta-lactamase 0.0144 0.1377 0.1518
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0053 1
Brugia malayi beta-lactamase family protein 0.0144 0.1377 0.1518
Mycobacterium leprae conserved hypothetical protein 0.0144 0.1377 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0444 0.0597
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.1377 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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