Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 6.4 | Antagonist activity against alpha-1 adrenergic receptor of rat anococcygeus muscle. | ChEMBL. | 2562854 |
Kd (functional) | = 8 | Antagonism of rat alpha-2 adrenergic receptor from rat vas deferens | ChEMBL. | 2562854 |
pA2 (functional) | = 6.4 | Antagonist activity against alpha-1 adrenergic receptor of rat anococcygeus muscle. | ChEMBL. | 2562854 |
pA2 (functional) | = 8 | Antagonism of rat alpha-2 adrenergic receptor from rat vas deferens | ChEMBL. | 2562854 |
Ratio (binding) | = 40 | Ratio of pA2 values at alpha-1 and alpha-2 adrenergic receptors. | ChEMBL. | 2562854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.