Detailed information for compound 760872

Basic information

Technical information
  • TDR Targets ID: 760872
  • Name: propan-2-yl 2-[(8-chloro-4-oxo-2,3-dihydro-1H -cyclopenta[c]chromen-7-yl)oxy]acetate
  • MW: 336.767 | Formula: C17H17ClO5
  • H donors: 0 H acceptors: 2 LogP: 3.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)COc1cc2oc(=O)c3c(c2cc1Cl)CCC3)C
  • InChi: 1S/C17H17ClO5/c1-9(2)22-16(19)8-21-15-7-14-12(6-13(15)18)10-4-3-5-11(10)17(20)23-14/h6-7,9H,3-5,8H2,1-2H3
  • InChiKey: XQCNKACEGJJUCC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isopropyl 2-[(8-chloro-4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]acetate
  • 2-[(8-chloro-4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]acetic acid isopropyl ester
  • 2-[(8-chloro-4-keto-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]acetic acid isopropyl ester
  • propan-2-yl 2-[(8-chloro-4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]ethanoate
  • ChemDiv3_003808
  • Oprea1_417844
  • ZINC04038845
  • EU-0046308
  • UNM000000654801
  • IDI1_021718
  • ST5188168

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0072 0.0404
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0165 1
Entamoeba histolytica hypothetical protein 0.011 0.1137 0.8585
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0092 0.0869 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0328 0.4252 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0036 0.0072 0.0031
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0072 0.0404
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0032 0.001
Leishmania major hypothetical protein, conserved 0.0042 0.0165 0.0777
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0092 0.0869 0.6421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0797 0.2314
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0165 0.0748
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0165 0.0478
Onchocerca volvulus 0.0093 0.0891 0.6701
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0165 0.0748
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0123 0.1314 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0324
Toxoplasma gondii propionate-CoA ligase 0.0036 0.0072 0.0404
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.1084 0.1136
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0123 0.1314 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0032 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0032 0.001
Schistosoma mansoni hypothetical protein 0.0414 0.5489 0.5869
Schistosoma mansoni tar DNA-binding protein 0.0328 0.4252 0.454
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0032 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0092 0.0869 0.1992
Schistosoma mansoni thyroid hormone receptor 0.0447 0.5966 0.6381
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0036 0.0072 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0032 0.001
Mycobacterium leprae Probable lipase LipE 0.0042 0.0165 0.0748
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0072 0.0208
Loa Loa (eye worm) TAR-binding protein 0.0328 0.4252 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0246 0.0517
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0123 0.1314 0.3811
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0032 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0165 0.0324
Mycobacterium ulcerans acyl-CoA synthetase 0.0123 0.1314 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Brugia malayi beta-lactamase family protein 0.0042 0.0165 0.0324
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0036 0.0072 0.004
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0072 0.0104
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0036 0.0072 0.0208
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0072 0.0031
Loa Loa (eye worm) hypothetical protein 0.0092 0.0869 0.1992
Loa Loa (eye worm) hypothetical protein 0.0123 0.1314 0.3043
Entamoeba histolytica hypothetical protein 0.011 0.1137 0.8585
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0036 0.0072 0.0208
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0072 0.0208
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0165 1
Schistosoma mansoni alpha-glucosidase 0.0139 0.1543 0.1628
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0032 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0165 0.0133
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0165 0.0478
Echinococcus multilocularis tumor protein p63 0.0728 1 1
Loa Loa (eye worm) oxidoreductase 0.0036 0.0072 0.0104
Brugia malayi beta-lactamase 0.0042 0.0165 0.0324
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0032 0.0005
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0068 0.0036
Mycobacterium tuberculosis Conserved protein 0.0042 0.0165 0.0478
Echinococcus granulosus microtubule associated protein 2 0.0682 0.9333 0.9331
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0123 0.1314 0.3811
Loa Loa (eye worm) beta-lactamase 0.0042 0.0165 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0123 0.1314 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0414 0.5489 0.5475
Brugia malayi RNA recognition motif domain containing protein 0.0328 0.4252 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0032 0.001
Brugia malayi nuclear hormone receptor 0.0033 0.0032 0.001
Onchocerca volvulus 0.0042 0.0165 0.1035
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0036 0.0072 0.0404
Schistosoma mansoni transcription factor LCR-F1 0.011 0.1137 0.1192
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0246 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0032 0.001
Mycobacterium ulcerans hypothetical protein 0.0042 0.0165 0.0748
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Entamoeba histolytica hypothetical protein 0.011 0.1137 0.8585
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0072 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0165 0.0147
Echinococcus multilocularis tar DNA binding protein 0.0328 0.4252 0.4234
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0032 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0072 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0072 0.0208
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0032 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0123 0.1314 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Schistosoma mansoni coup transcription factor 0.0033 0.0032 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0032 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0123 0.1314 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0072 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0032 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0032 0.0005
Echinococcus granulosus tar DNA binding protein 0.0328 0.4252 0.4234
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0324
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0032 0.0005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1864 0.4346
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1864 0.4346
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.9333 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.1137 0.1109
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0165 0.0478
Onchocerca volvulus 0.0042 0.0165 0.1035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0032 0.001
Onchocerca volvulus 0.0036 0.0072 0.031
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0517
Schistosoma mansoni tar DNA-binding protein 0.0328 0.4252 0.454
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.0104
Loa Loa (eye worm) RNA binding protein 0.0328 0.4252 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0165 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0068 0.0095
Mycobacterium ulcerans beta-lactamase 0.0042 0.0165 0.0748
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0165 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0072 0.0404
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0072 0.0104
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0092 0.0869 0.2522
Plasmodium falciparum acyl-CoA synthetase 0.0092 0.0869 1
Schistosoma mansoni alpha glucosidase 0.0036 0.0068 0.0043
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.9333 0.9331
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0072 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0032 0.001
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0068 0.0095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0032 0.001
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0414 0.5489 0.5475
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0072 0.0404
Loa Loa (eye worm) hypothetical protein 0.0092 0.0869 0.1992
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0123 0.1314 0.3043
Brugia malayi TAR-binding protein 0.0328 0.4252 1
Brugia malayi beta-lactamase family protein 0.0042 0.0165 0.0324
Loa Loa (eye worm) hypothetical protein 0.0092 0.0869 0.1992
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0036 0.0072 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0123 0.1314 0.3043
Entamoeba histolytica acyl-coA synthetase, putative 0.0123 0.1314 1
Schistosoma mansoni tar DNA-binding protein 0.0328 0.4252 0.454
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0032 0.001
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0072 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0165 1
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0165 0.0478
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0072 0.0104
Entamoeba histolytica hypothetical protein 0.011 0.1137 0.8585
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.1137 0.1109
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0032 0.0005
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0036 0.0072 0.004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0123 0.1314 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0123 0.1314 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0107 0.1084 0.2501
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0036 0.0072 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0165 0.0147
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0797 0.2314
Mycobacterium ulcerans hypothetical protein 0.0123 0.1314 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0165 0.0748
Mycobacterium ulcerans acyl-CoA synthetase 0.0123 0.1314 1
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0032 0.001
Trichomonas vaginalis esterase, putative 0.0042 0.0165 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1864 0.1838
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0165 0.0133
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0072 0.0404
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0797 0.2314
Onchocerca volvulus 0.0107 0.1084 0.8212
Mycobacterium tuberculosis Conserved protein 0.0042 0.0165 0.0478
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0072 0.0208
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0271 0.3446 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0324
Schistosoma mansoni hypothetical protein 0.011 0.1137 0.1192
Leishmania major 4-coumarate:coa ligase-like protein 0.0123 0.1314 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0072 0.0404
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0165 1
Onchocerca volvulus 0.0036 0.0072 0.031
Mycobacterium ulcerans lipase LipD 0.0042 0.0165 0.0748
Entamoeba histolytica acyl-CoA synthetase, putative 0.0123 0.1314 1
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0032 0.001
Brugia malayi ecdysteroid receptor 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0328 0.4252 0.454
Echinococcus multilocularis thyroid hormone receptor alpha 0.0447 0.5966 0.5953
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0032 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0032 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0032 0.001
Onchocerca volvulus 0.0036 0.0072 0.031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0246 0.0517
Schistosoma mansoni acetyl-CoA synthetase 0.0036 0.0072 0.0047
Toxoplasma gondii ABC1 family protein 0.0042 0.0165 1
Brugia malayi AMP-binding enzyme family protein 0.0123 0.1314 0.3043
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0165 0.0478
Onchocerca volvulus 0.0036 0.0072 0.031
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0165 0.1164
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0165 0.0478
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0072 0.0031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0123 0.1314 1
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0165 0.0478
Brugia malayi AMP-binding enzyme family protein 0.0123 0.1314 0.3043
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0068 0.0036
Brugia malayi steroid hormone receptor 0.0033 0.0032 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0032 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0328 0.4252 0.454
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0165 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0123 0.1314 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0036 0.0072 0.0208
Plasmodium vivax acyl-CoA synthetase, putative 0.0092 0.0869 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0797 0.2314
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0072 0.0104
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0072 0.0208
Brugia malayi nuclear receptor NHR-88 0.0033 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0123 0.1314 0.3043
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0072 0.0104
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0036 0.0072 0.0208
Brugia malayi RNA binding protein 0.0328 0.4252 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0165 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0869 0.1992
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0165 0.0324
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0036 0.0072 0.0208
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1864 0.1838
Schistosoma mansoni alpha-glucosidase 0.0139 0.1543 0.1628
Onchocerca volvulus 0.0123 0.1314 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0123 0.1314 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0324
Mycobacterium tuberculosis Conserved protein 0.0042 0.0165 0.0478
Schistosoma mansoni thyroid hormone receptor 0.0447 0.5966 0.6381
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1864 0.1838
Brugia malayi hypothetical protein 0.011 0.1137 0.2626
Onchocerca volvulus 0.0042 0.0165 0.1035

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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