Detailed information for compound 761510

Basic information

Technical information
  • TDR Targets ID: 761510
  • Name: 5-chloro-2-methoxy-N-(5-propan-2-yl-1,3,4-thi adiazol-2-yl)benzamide
  • MW: 311.787 | Formula: C13H14ClN3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)Nc1nnc(s1)C(C)C)Cl
  • InChi: 1S/C13H14ClN3O2S/c1-7(2)12-16-17-13(20-12)15-11(18)9-6-8(14)4-5-10(9)19-3/h4-7H,1-3H3,(H,15,17,18)
  • InChiKey: LYPLHHRZSFVCLK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-methoxy-benzamide
  • 5-chloro-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-methoxybenzamide
  • 5-Chloro-N-(5-isopropyl-[1,3,4]thiadiazol-2-yl)-2-methoxy-benzamide
  • BAS 05277487
  • ST5021504
  • ZINC00199443
  • EU-0015291

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0125
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0533 0.0533
Schistosoma mansoni thyroid hormone receptor 0.0162 0.2936 0.3663
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0113 0.014
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0878 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0101 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.021 0.0329
Echinococcus multilocularis dnaJ subfamily B 0.042 0.8011 0.8011
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.021 0.026
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0572 0.0745
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0101 0.0101
Schistosoma mansoni coup transcription factor 0.0023 0.021 0.026
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0625 0.0625
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0547 0.0681
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.021 0.026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0996 0.1242
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0778 0.1225
Brugia malayi Bromodomain containing protein 0.0031 0.0384 0.0604
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.005 0.005
Entamoeba histolytica hypothetical protein 0.0039 0.0533 0.5979
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0625 0.0625
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0246 0.0228
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.021 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0424 0.5205
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.1785 0.1785
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.021 0.0329
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0107 0.0008
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0547 0.0681
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.2494 0.2494
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0168 0.0209
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0384 0.0478
Echinococcus granulosus FTZ F1 alpha 0.0023 0.021 0.021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0107 0.0132
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0778 1
Schistosoma mansoni cpg binding protein 0.003 0.0347 0.0431
Schistosoma mansoni lamin 0.003 0.0352 0.0438
Brugia malayi PHD-finger family protein 0.0031 0.0384 0.0604
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0778 0.107
Echinococcus granulosus lamin dm0 0.003 0.0352 0.0352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.021 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0571 0.7204
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0168 0.0105
Schistosoma mansoni hypothetical protein 0.0031 0.0384 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.021 0.0329
Entamoeba histolytica hypothetical protein 0.0039 0.0533 0.5979
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0339 0.6418 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0347 0.0545
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0488 0.0768
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.005 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Leishmania major hypothetical protein, conserved 0.0057 0.0878 0.1229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0372 0.4499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0372 0.4499
Echinococcus granulosus GPCR family 2 0.0017 0.0101 0.0101
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0168 0.1871
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0865 0.9827
Echinococcus multilocularis muscleblind protein 0.0335 0.6338 0.6338
Schistosoma mansoni hypothetical protein 0.0382 0.7257 0.9059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0821 0.1294
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Onchocerca volvulus 0.003 0.0352 0.0423
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0778 0.107
Echinococcus multilocularis geminin 0.0382 0.7257 0.7257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.063 0.8002
Brugia malayi PHD-finger family protein 0.0012 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.021 0.0329
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0384 0.0604
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0878 0.1229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.021 0.021
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0878 0.1229
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0537 0.6743
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.021 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0366 0.4418
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.3582 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0168 0.0105
Brugia malayi hypothetical protein 0.0037 0.0485 0.0763
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0107 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0778 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0778 0.107
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0533 0.0663
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.021 0.021
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0352 0.0554
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0107 0.0166
Brugia malayi hypothetical protein 0.0039 0.0533 0.0839
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.2915 0.4454
Echinococcus multilocularis lamin dm0 0.003 0.0352 0.0352
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0107 0.0166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.021 0.0329
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0168 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0347 0.0545
Onchocerca volvulus 0.003 0.0347 0.0407
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.021 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.3271 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0081 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.021 0.0329
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0537 0.6743
Echinococcus granulosus neuropeptide receptor A26 0.0522 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.021 0.0329
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0335 0.6338 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0101 0.0101
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.021 0.0329
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0537 0.0689
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0125
Loa Loa (eye worm) hypothetical protein 0.003 0.0352 0.0554
Echinococcus multilocularis GPCR, family 2 0.0017 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0519 0.6498
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0457 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0107 0.0008
Brugia malayi nuclear receptor NHR-88 0.0023 0.021 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.021 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.021 0.0329
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0146 0.0229
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0537 0.5609
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0537 0.0689
Schistosoma mansoni thyroid hormone receptor 0.0162 0.2936 0.3663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0519 0.6498
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0335 0.6338 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0313 0.3713
Plasmodium falciparum phd finger protein, putative 0.0031 0.0384 0.4343
Echinococcus multilocularis cpg binding protein 0.0031 0.038 0.038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.021 0.021
Brugia malayi jmjC domain containing protein 0.004 0.0547 0.086
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0572 0.0745
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0537 0.0689
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0102 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0107 0.0916
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0339 0.6415 0.8008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0313 0.3713
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0125
Echinococcus granulosus dnaJ subfamily B 0.042 0.8011 0.8011
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0778 0.107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.021 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0446 0.5501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0313 0.3713
Loa Loa (eye worm) hypothetical protein 0.0057 0.0878 0.1384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.021 0.0329
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.021 0.0329
Echinococcus granulosus cpg binding protein 0.0031 0.038 0.038
Echinococcus multilocularis muscleblind protein 1 0.0335 0.6338 0.6338
Schistosoma mansoni cpg binding protein 0.0031 0.038 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0313 0.3702
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0778 0.107
Mycobacterium ulcerans hypothetical protein 0.0179 0.3271 1
Echinococcus multilocularis X box binding protein 1 0.0339 0.6415 0.6415
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0547 0.086
Loa Loa (eye worm) intermediate filament protein 0.003 0.0352 0.0554
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0778 1
Echinococcus granulosus lamin 0.003 0.0352 0.0352
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0081 0.0126
Schistosoma mansoni lamin 0.003 0.0352 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0519 0.6498
Echinococcus multilocularis neuropeptide s receptor 0.0522 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0342 0.0537
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0384 0.4343
Schistosoma mansoni intermediate filament proteins 0.003 0.0352 0.0438
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.0102
Echinococcus multilocularis musashi 0.003 0.0352 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0519 0.6498
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0168 0.1746
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0778 0.097
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0703 0.0952
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0168 0.0168
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0703 0.0952
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.2936 0.2936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0107 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0519 0.6498
Entamoeba histolytica hypothetical protein 0.0039 0.0533 0.5979
Schistosoma mansoni hypothetical protein 0.0139 0.2494 0.3112
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.2915 0.4454
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0514 0.0514
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0537 0.0689
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.021 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0703 0.0952
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0168 0.1871
Brugia malayi intermediate filament protein 0.003 0.0352 0.0554
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0102 0.1113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0107 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0372 0.4499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0313 0.3702
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0168 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0571 0.7204
Schistosoma mansoni hypothetical protein 0.0382 0.7257 0.9059
Giardia lamblia PHD finger protein 15 0.0031 0.0384 0.3541
Onchocerca volvulus Alhambra homolog 0.0031 0.0384 0.0517
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.006
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.021 0.021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.0102
Schistosoma mansoni ap endonuclease 0.002 0.0168 0.0208
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0168 0.0105
Echinococcus granulosus geminin 0.0382 0.7257 0.7257
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0878 1
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0547 0.0547
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0778 0.107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0908 0.1276
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.021 0.0329
Giardia lamblia GTOR 0.0052 0.0778 1
Brugia malayi nuclear hormone receptor 0.0023 0.021 0.0329
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.021 0.026
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0878 0.1229
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0821 0.1294
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0352 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0519 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0778 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0101 0.0158
Brugia malayi Inositol-1 0.0039 0.0537 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.021 0.0329
Schistosoma mansoni ap endonuclease 0.002 0.0168 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0571 0.7204
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0537 1
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.021 0.0329
Schistosoma mansoni inositol monophosphatase 0.0039 0.0537 0.0669
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0457 0.112
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0102 0.0126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0537 0.6743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.021 0.0329
Brugia malayi steroid hormone receptor 0.0023 0.021 0.0329
Echinococcus granulosus X box binding protein 1 0.0339 0.6415 0.6415
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0107 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0703 0.0952
Brugia malayi hypothetical protein 0.0057 0.0878 0.1384
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0778 0.0778
Onchocerca volvulus 0.003 0.0352 0.0423
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.021 0.021
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0384 0.3635
Loa Loa (eye worm) hypothetical protein 0.0054 0.0821 0.1294
Echinococcus multilocularis neuropeptide receptor A26 0.0522 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0572 0.0745
Brugia malayi jmjC domain containing protein 0.0103 0.1785 0.2815
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0778 0.0778
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0101 0.0158
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.0102
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0107 0.0008
Brugia malayi Muscleblind-like protein 0.0335 0.6338 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0537 0.6054
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0107 0.0008
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0537 0.0537
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.021 0.021
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.6418 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0488 0.0768
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0384 0.3635
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0168 0.0263
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0077
Schistosoma mansoni nuclear hormone receptor 0.0023 0.021 0.026
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0125
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.021 0.026
Loa Loa (eye worm) hypothetical protein 0.0195 0.3582 0.565
Schistosoma mansoni hypothetical protein 0.0037 0.0488 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0519 0.6498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.021 0.0329
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Loa Loa (eye worm) hypothetical protein 0.0054 0.0824 0.1298
Brugia malayi isocitrate dehydrogenase 0.0017 0.0102 0.0159
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.021 0.026
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0266 0.0266
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0537 0.0537
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0384 0.0384
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0107 0.0008
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0001 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0001 0.0001
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0102 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0778 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0571 0.7204
Schistosoma mansoni inositol monophosphatase 0.0039 0.0537 0.0669
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.021 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0107 0.0916
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0537 0.119
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0158
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.021 0.0329
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.2494 0.2494
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0878 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.021 0.026
Entamoeba histolytica hypothetical protein 0.0039 0.0533 0.5979
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0533 0.0533
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0102 0.1113
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0168 0.1746
Brugia malayi ecdysteroid receptor 0.0023 0.021 0.0329
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0107 0.0107
Schistosoma mansoni cpg binding protein 0.0031 0.038 0.0473
Echinococcus multilocularis lamin 0.003 0.0352 0.0352
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.1785 0.1785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0313 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0313 0.3702
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0161 0.2915 0.4454
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.021 0.021
Echinococcus granulosus intermediate filament protein 0.003 0.0352 0.0352
Toxoplasma gondii exonuclease III APE 0.002 0.0168 0.0853
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Echinococcus granulosus peregrin 0.0031 0.0384 0.0384
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0571 0.7204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.021 0.0329
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0329
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0878 1
Schistosoma mansoni hypothetical protein 0.0025 0.0266 0.033
Brugia malayi N-terminal motif family protein 0.0195 0.3582 0.565
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.021 0.026
Schistosoma mansoni hypothetical protein 0.0039 0.0533 0.0663
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.0102
Loa Loa (eye worm) inositol-1 0.0039 0.0537 0.0846
Toxoplasma gondii hypothetical protein 0.0055 0.0841 0.9518
Loa Loa (eye worm) hypothetical protein 0.0031 0.0384 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.021 0.0329
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0102 0.0102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0778 0.1225
Schistosoma mansoni jumonji domain containing protein 0.0082 0.1371 0.171
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0168 0.0263
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.6418 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0168 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0366 0.4418
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0188 0.0136
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0821 0.1294
Echinococcus multilocularis peregrin 0.0031 0.0384 0.0384
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0519 0.5376
Schistosoma mansoni hypothetical protein 0.042 0.8011 1
Echinococcus granulosus muscleblind protein 0.0335 0.6338 0.6338
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0384 0.0384
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.104 0.1639
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0266 0.0266
Leishmania major mitochondrial DNA polymerase beta 0.0339 0.6418 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.021 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0107 0.0916
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.021 0.0329

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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