Detailed information for compound 761546

Basic information

Technical information
  • TDR Targets ID: 761546
  • Name: 3-(2-chlorophenyl)-N-[4-(dipropylsulfamoyl)ph enyl]-5-methyl-1,2-oxazole-4-carboxamide
  • MW: 475.988 | Formula: C23H26ClN3O4S
  • H donors: 1 H acceptors: 4 LogP: 4.83 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(S(=O)(=O)c1ccc(cc1)NC(=O)c1c(C)onc1c1ccccc1Cl)CCC
  • InChi: 1S/C23H26ClN3O4S/c1-4-14-27(15-5-2)32(29,30)18-12-10-17(11-13-18)25-23(28)21-16(3)31-26-22(21)19-8-6-7-9-20(19)24/h6-13H,4-5,14-15H2,1-3H3,(H,25,28)
  • InChiKey: KAWKMZHMLOUSLH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(2-chlorophenyl)-N-[4-(dipropylsulfamoyl)phenyl]-5-methyl-isoxazole-4-carboxamide
  • 3-(2-chlorophenyl)-N-[4-(dipropylsulfamoyl)phenyl]-5-methyl-4-isoxazolecarboxamide
  • STK038885

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0199 0.3626 0.5754
Brugia malayi nuclear receptor NHR-88 0.0023 0.021 0.0333
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0171 0.027
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0389 0.0389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.021 0.0333
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0535 0.0688
Schistosoma mansoni hypothetical protein 0.033 0.616 0.7697
Echinococcus multilocularis GPCR, family 2 0.0017 0.0103 0.0103
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.054 0.054
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0344 0.6416 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0494 0.0784
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0763 0.1049
Brugia malayi isocitrate dehydrogenase 0.0017 0.0104 0.0164
Brugia malayi jmjC domain containing protein 0.0105 0.1808 0.2868
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0104 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.01 0.0916
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0832 0.1319
Echinococcus multilocularis neuropeptide receptor A26 0.0529 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.021 0.0333
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0559 0.0727
Schistosoma mansoni cpg binding protein 0.003 0.0344 0.043
Onchocerca volvulus Alhambra homolog 0.0032 0.0389 0.0525
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.021 0.0333
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0862 0.9909
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0763 0.1049
Echinococcus multilocularis muscleblind protein 0.0338 0.6301 0.6301
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.021 0.0262
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0701 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.01 0.0916
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.021 0.0333
Schistosoma mansoni transcription factor LCR-F1 0.004 0.054 0.0674
Entamoeba histolytica hypothetical protein 0.004 0.054 0.6237
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0104 0.0129
Loa Loa (eye worm) inositol-1 0.004 0.0535 0.0848
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0454 0.1107
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.021 0.0333
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0535 0.6873
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0559 0.0727
Schistosoma mansoni ap endonuclease 0.0021 0.0171 0.0213
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0104 0.0104
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0763 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0507 0.6498
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0832 0.1319
Echinococcus multilocularis lamin 0.0031 0.0357 0.0357
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0869 1
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.021 0.0262
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0763 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0906 0.1275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0559 0.7204
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0763 0.1049
Schistosoma mansoni coup transcription factor 0.0023 0.021 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.021 0.0333
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0171 0.0112
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0171 0.192
Echinococcus multilocularis geminin 0.0381 0.715 0.715
Loa Loa (eye worm) hypothetical protein 0.0057 0.0869 0.1378
Echinococcus granulosus cpg binding protein 0.0032 0.0377 0.0377
Schistosoma mansoni cpg binding protein 0.0032 0.0377 0.0471
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0559 0.7204
Echinococcus granulosus geminin 0.0381 0.715 0.715
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.021 0.0333
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0103 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0355 0.4418
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.01 0.0158
Plasmodium falciparum phd finger protein, putative 0.0032 0.0389 0.445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0303 0.3702
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0171 0.1884
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Loa Loa (eye worm) hypothetical protein 0.0338 0.6301 1
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.8003 0.8003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.6416 1
Schistosoma mansoni hypothetical protein 0.0026 0.026 0.0325
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.1053 0.1671
Loa Loa (eye worm) hypothetical protein 0.0032 0.0389 0.0617
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0104 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0055 0.0832 0.1319
Echinococcus multilocularis peregrin 0.0032 0.0389 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0507 0.6498
Schistosoma mansoni jumonji domain containing protein 0.0084 0.1388 0.1734
Echinococcus multilocularis muscleblind protein 1 0.0338 0.6301 0.6301
Brugia malayi intermediate filament protein 0.0031 0.0357 0.0566
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0171 0.1884
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0171 0.027
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0055 0.0835 0.1324
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0763 0.121
Schistosoma mansoni hypothetical protein 0.0032 0.0389 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.01 0.0916
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.021 0.0333
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.026 0.026
Brugia malayi N-terminal motif family protein 0.0199 0.3626 0.5754
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.054 0.054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.021 0.0333
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.01 0.0916
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0389 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.021 0.0333
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0869 0.1217
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.021 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0559 0.7204
Brugia malayi ecdysteroid receptor 0.0023 0.021 0.0333
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.021 0.021
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0171 0.192
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0357 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0304 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0303 0.3702
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.2913 0.4454
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0389 0.3733
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0357 0.0566
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.1808 0.1808
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.021 0.0262
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.01 0.0124
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.018 0.0126
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0104 0.0164
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0535 0.1174
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0869 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.021 0.0333
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0063
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0103 0.0163
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0535 0.5633
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0143 0.2526 0.2526
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.021 0.0333
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0104 0.1144
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0763 0.1049
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0559 0.0727
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.004 0.054 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.021 0.0333
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0104 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0128
Brugia malayi hypothetical protein 0.004 0.054 0.0856
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0389 0.445
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.026 0.026
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0507 0.5275
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.021 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0507 0.6498
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0832 0.1319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.021 0.0333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0357 0.0566
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0171 0.0212
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.3626 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.021 0.021
Leishmania major hypothetical protein, conserved 0.0057 0.0869 0.1217
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.021 0.021
Brugia malayi nuclear hormone receptor 0.0023 0.021 0.0333
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0869 1
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0535 0.0535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0633 0.0633
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0389 0.3733
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.021 0.021
Toxoplasma gondii hypothetical protein 0.0055 0.0838 0.9607
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0763 0.1049
Schistosoma mansoni hypothetical protein 0.0381 0.715 0.8934
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0355 0.4418
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0869 0.1217
Toxoplasma gondii exonuclease III APE 0.0021 0.0171 0.0876
Echinococcus granulosus X box binding protein 1 0.033 0.616 0.616
Schistosoma mansoni hypothetical protein 0.0381 0.715 0.8934
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Schistosoma mansoni intermediate filament proteins 0.0031 0.0357 0.0446
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0128
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0869 1
Brugia malayi PHD-finger family protein 0.0032 0.0389 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.021 0.0333
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0389 0.0389
Brugia malayi hypothetical protein 0.0037 0.0478 0.0757
Brugia malayi Muscleblind-like protein 0.0338 0.6301 1
Schistosoma mansoni inositol monophosphatase 0.004 0.0535 0.0667
Brugia malayi CXXC zinc finger family protein 0.003 0.0344 0.0546
Onchocerca volvulus 0.0031 0.0357 0.0431
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.021 0.0333
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0553 0.0553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0171 0.0112
Echinococcus multilocularis lamin dm0 0.0031 0.0357 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0763 1
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0389 0.0617
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.021 0.0333
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0357 0.0566
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0361 0.4499
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0163
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0763 0.0952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0413 0.5205
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.1808 0.1808
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.021 0.0262
Schistosoma mansoni hypothetical protein 0.0143 0.2526 0.3156
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0559 0.7204
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.01 0.0158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0051 0.0081
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0535 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0617 0.8002
Giardia lamblia PHD finger protein 15 0.0032 0.0389 0.3693
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0237 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.021 0.0333
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.021 0.021
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0633 0.0633
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0993 0.124
Giardia lamblia GTOR 0.0051 0.0763 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0553 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.021 0.0333
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.021 0.0262
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0553 0.0691
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0128
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0426 0.8003 1
Entamoeba histolytica hypothetical protein 0.004 0.054 0.6237
Schistosoma mansoni thyroid hormone receptor 0.0166 0.297 0.3711
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0083 0.013
Brugia malayi hypothetical protein 0.0057 0.0869 0.1378
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0103 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0113 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.021 0.0333
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0535 0.0688
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.021 0.0262
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0143 0.2526 0.2526
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.052 0.052
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.2913 0.4454
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0171 0.0112
Brugia malayi PHD-finger family protein 0.0012 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0701 0.0951
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0701 0.0951
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0171 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0763 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0701 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0507 0.6498
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0171 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0507 0.6498
Entamoeba histolytica hypothetical protein 0.004 0.054 0.6237
Echinococcus multilocularis thyroid hormone receptor alpha 0.0166 0.297 0.297
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0104 0.0006
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0344 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0361 0.4499
Schistosoma mansoni lamin 0.0031 0.0357 0.0446
Echinococcus granulosus lamin dm0 0.0031 0.0357 0.0357
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0104 0.0104
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0553 0.0691
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0051 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.0529 1 1
Echinococcus granulosus intermediate filament protein 0.0031 0.0357 0.0357
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0494 0.0784
Echinococcus granulosus lamin 0.0031 0.0357 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0763 1
Onchocerca volvulus 0.0031 0.0357 0.0431
Schistosoma mansoni cpg binding protein 0.0032 0.0377 0.0471
Echinococcus multilocularis X box binding protein 1 0.033 0.616 0.616
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.021 0.0262
Mycobacterium ulcerans hypothetical protein 0.0181 0.3269 1
Leishmania major mitochondrial DNA polymerase beta 0.0344 0.6416 1
Brugia malayi Bromodomain containing protein 0.0032 0.0389 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0304 0.3713
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0763 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0304 0.3713
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0103 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.6416 1
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0869 0.1217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.021 0.0333
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0763 0.1049
Schistosoma mansoni nuclear hormone receptor 0.0023 0.021 0.0262
Echinococcus granulosus dnaJ subfamily B 0.0426 0.8003 0.8003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0303 0.3702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0434 0.5501
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0104 0.0164
Brugia malayi jmjC domain containing protein 0.0041 0.0553 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0559 0.7204
Brugia malayi Inositol-1 0.004 0.0535 0.0848
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0104 0.0104
Echinococcus multilocularis cpg binding protein 0.0032 0.0377 0.0377
Echinococcus granulosus peregrin 0.0032 0.0389 0.0389
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.021 0.021
Schistosoma mansoni thyroid hormone receptor 0.0166 0.297 0.3711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0507 0.6498
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0535 0.6148
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0535 0.0688
Echinococcus granulosus muscleblind protein 0.0338 0.6301 0.6301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0304 0.3713
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0104 0.1144
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.021 0.0333
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0146 0.0231
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0507 0.6498
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.004 0.054 0.6237
Loa Loa (eye worm) hypothetical protein 0.003 0.0346 0.0549
Echinococcus granulosus GPCR family 2 0.0017 0.0103 0.0103
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.021 0.021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0454 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.021 0.0333
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0083 0.013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0535 0.6873
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0333
Echinococcus granulosus neuropeptide receptor A26 0.0529 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0128
Brugia malayi steroid hormone receptor 0.0023 0.021 0.0333
Loa Loa (eye worm) hypothetical protein 0.0338 0.6301 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.021 0.021
Schistosoma mansoni ap endonuclease 0.0021 0.0171 0.0213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0103 0.0163
Echinococcus granulosus FTZ F1 alpha 0.0023 0.021 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.3269 1
Onchocerca volvulus 0.003 0.0344 0.0393
Echinococcus multilocularis musashi 0.0031 0.0357 0.0357
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0535 0.6873
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.2913 0.4454
Schistosoma mansoni lamin 0.0031 0.0357 0.0446
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.021 0.0333
Schistosoma mansoni inositol monophosphatase 0.004 0.0535 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0361 0.4499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.01 0.0916
Schistosoma mansoni hypothetical protein 0.0038 0.0494 0.0617
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0763 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0104 0.0006
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0763 0.0763

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.