Detailed information for compound 761773

Basic information

Technical information
  • TDR Targets ID: 761773
  • Name: ZINC01130706
  • MW: 494.359 | Formula: C20H20BrN3O5S
  • H donors: 1 H acceptors: 3 LogP: 2.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=C2C(=NN(C2=O)c2ccc(cc2)S(=O)(=O)N)C)cc(c1OC)Br
  • InChi: 1S/C20H20BrN3O5S/c1-4-29-18-11-13(10-17(21)19(18)28-3)9-16-12(2)23-24(20(16)25)14-5-7-15(8-6-14)30(22,26)27/h5-11H,4H2,1-3H3,(H2,22,26,27)/b16-9-
  • InChiKey: ATGARLLTSONOLL-SXGWCWSVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.6922
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0129 0.0204
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0129 0.0152
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0458 0.0438
Brugia malayi nuclear receptor NHR-88 0.0021 0.0129 0.0204
Brugia malayi nuclear hormone receptor 0.0021 0.0129 0.0204
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0182 0.0162
Onchocerca volvulus 0.0027 0.0274 0.0425
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0129 0.0152
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0795 1
Brugia malayi hypothetical protein 0.0033 0.0401 0.0634
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0463 0.0694
Brugia malayi Inositol-1 0.0036 0.0463 0.0731
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0439 0.0419
Schistosoma mansoni lamin 0.0027 0.0274 0.0356
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0308 0.0288
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0089 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Brugia malayi PHD-finger family protein 0.0029 0.0308 0.0486
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0552 0.0533
Entamoeba histolytica hypothetical protein 0.0036 0.0458 0.6152
Echinococcus multilocularis X box binding protein 1 0.0302 0.6222 0.6214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0089 0.0107
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0089 0.0107
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.2888 0.2873
Toxoplasma gondii hypothetical protein 0.005 0.0765 0.9604
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0832 0.1275
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0413 0.0653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0431 0.6145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0689 1
Onchocerca volvulus 0.0027 0.0274 0.0425
Schistosoma mansoni thyroid hormone receptor 0.0148 0.2888 0.4018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0021 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0439 0.0586
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1728 0.1711
Schistosoma mansoni hypothetical protein 0.0023 0.0182 0.0226
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0129 0.0152
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0129 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0284 0.3945
Echinococcus multilocularis geminin 0.0345 0.7157 0.7151
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0626 0.0951
Brugia malayi intermediate filament protein 0.0027 0.0274 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0129 0.0204
Schistosoma mansoni lamin 0.0027 0.0274 0.0356
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0022 0.0002
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0689 0.067
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0795 0.1217
Schistosoma mansoni hypothetical protein 0.0029 0.0308 0.0402
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0689 0.105
Schistosoma mansoni hypothetical protein 0.0034 0.0413 0.055
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1728 0.1711
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0129 0.0109
Leishmania major mitochondrial DNA polymerase beta 0.031 0.6388 1
Echinococcus multilocularis peregrin 0.0029 0.0308 0.0288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0751 0.1187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.3215 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0431 0.6145
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0463 0.1196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.6922
Brugia malayi jmjC domain containing protein 0.0035 0.0439 0.0694
Loa Loa (eye worm) hypothetical protein 0.0051 0.0795 0.1257
Leishmania major hypothetical protein, conserved 0.0051 0.0795 0.1217
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0022 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0129 0.0204
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0089 0.0867
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0022 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0129 0.0204
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0308 0.0402
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0001
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0463 0.0443
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Echinococcus multilocularis neuropeptide receptor A26 0.0476 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0431 0.6145
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0431 0.5293
Echinococcus granulosus lamin 0.0027 0.0274 0.0254
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0458 0.0613
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0463 0.0443
Giardia lamblia GTOR 0.0046 0.0689 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0689 0.105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0413 0.0653
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.6388 1
Brugia malayi Muscleblind-like protein 0.0307 0.6326 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0089 0.0867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.6922
Mycobacterium ulcerans hypothetical protein 0.0163 0.3215 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0129 0.0109
Echinococcus multilocularis muscleblind protein 0.0307 0.6326 0.6318
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0129 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0129 0.0204
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0129 0.0109
Loa Loa (eye worm) hypothetical protein 0.0029 0.0308 0.0486
Loa Loa (eye worm) inositol-1 0.0036 0.0463 0.0731
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0308 0.3696
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0129 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0129 0.0152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0358 0.5047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0001
Loa Loa (eye worm) hypothetical protein 0.0178 0.3549 0.561
Echinococcus granulosus lamin dm0 0.0027 0.0274 0.0254
Echinococcus multilocularis neuropeptide s receptor 0.0476 1 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0463 0.6614
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0463 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0431 0.6145
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0463 0.5698
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0129 0.0109
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0689 0.105
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0274 0.0434
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0308 0.0486
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0689 0.0936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0129 0.0204
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0129 0.0109
Loa Loa (eye worm) hypothetical protein 0.0307 0.6326 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.6388 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0129 0.0152
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0089 0.0107
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0129 0.0204
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0129 0.0109
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0439 0.0419
Echinococcus multilocularis lamin 0.0027 0.0274 0.0254
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0463 0.6614
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0795 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0129 0.0204
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0484 0.0728
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0129 0.0152
Entamoeba histolytica hypothetical protein 0.0036 0.0458 0.6152
Echinococcus granulosus intermediate filament protein 0.0027 0.0274 0.0254
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0129 0.0109
Schistosoma mansoni hypothetical protein 0.0345 0.7157 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0225 0.3066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0129 0.0109
Loa Loa (eye worm) hypothetical protein 0.0027 0.0274 0.0434
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.2856 0.4454
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0463 0.6614
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0129 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0284 0.3945
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0089 0.102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0226 0.3078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0264 0.0417
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0089 0.0068
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0089 0.014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0021 0.0033
Schistosoma mansoni coup transcription factor 0.0021 0.0129 0.0152
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0089 0.021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0129 0.0204
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0308 0.3696
Schistosoma mansoni ap endonuclease 0.0019 0.0089 0.0096
Echinococcus granulosus geminin 0.0345 0.7157 0.7151
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0129 0.0109
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0972 0.1537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0431 0.6145
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0463 0.6229
Echinococcus granulosus peregrin 0.0029 0.0308 0.0288
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0022 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0795 1
Echinococcus granulosus muscleblind protein 0.0307 0.6326 0.6318
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.2442 0.2427
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0022 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.6922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0278 0.3855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0225 0.3066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0754 0.1191
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0129 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0129 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0689 1
Entamoeba histolytica hypothetical protein 0.0036 0.0458 0.6152
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0463 0.0694
Schistosoma mansoni hypothetical protein 0.0345 0.7157 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0129 0.0109
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.2856 0.4454
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0129 0.0152
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0689 0.1089
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.2442 0.2427
Schistosoma mansoni intermediate filament proteins 0.0027 0.0274 0.0356
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.3549 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0689 0.105
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0159 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0129 0.0204
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.6388 1
Giardia lamblia PHD finger protein 15 0.0029 0.0308 0.3647
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0626 0.0951
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0022 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0795 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0129 0.0109
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0689 0.067
Brugia malayi steroid hormone receptor 0.0021 0.0129 0.0204
Schistosoma mansoni hypothetical protein 0.0036 0.0458 0.0613
Echinococcus multilocularis musashi 0.0027 0.0274 0.0254
Echinococcus multilocularis GPCR, family 2 0.0016 0.0021 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0226 0.3078
Schistosoma mansoni inositol monophosphatase 0.0036 0.0463 0.0619
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0689 0.105
Schistosoma mansoni inositol monophosphatase 0.0036 0.0463 0.0619
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0101 0.0126
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0182 0.0162
Echinococcus granulosus GPCR family 2 0.0016 0.0021 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0001
Brugia malayi hypothetical protein 0.0036 0.0458 0.0724
Schistosoma mansoni thyroid hormone receptor 0.0148 0.2888 0.4018
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0284 0.3945
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0089 0.014
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0484 0.0728
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0129 0.0204
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0381 0.1125
Loa Loa (eye worm) hypothetical protein 0.0307 0.6326 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0129 0.0204
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0089 0.102
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0089 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0458 0.0438
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0795 0.1217
Plasmodium falciparum phd finger protein, putative 0.0029 0.0308 0.3696
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0751 0.1187
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0308 0.3696
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0022 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0129 0.0152
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0021 0.0033
Echinococcus granulosus neuropeptide receptor A26 0.0476 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0431 0.6145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0129 0.0109
Schistosoma mansoni ap endonuclease 0.0019 0.0089 0.0096
Echinococcus granulosus X box binding protein 1 0.0302 0.6222 0.6214
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0021 0.0033
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0308 0.0288
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0129 0.0109
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0439 0.0586
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Echinococcus multilocularis lamin dm0 0.0027 0.0274 0.0254
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0484 0.0728
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0129 0.0204
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0129 0.0204
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0022 0.0034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1308 0.1803
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0001
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.2856 0.4454
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0463 0.0694
Brugia malayi hypothetical protein 0.0051 0.0795 0.1257
Onchocerca volvulus Alhambra homolog 0.0029 0.0308 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0129 0.0204
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0274 0.0434
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0751 0.1187
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0129 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0129 0.0204
Brugia malayi ecdysteroid receptor 0.0021 0.0129 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0278 0.3855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0225 0.3066
Entamoeba histolytica hypothetical protein 0.0036 0.0458 0.6152
Brugia malayi N-terminal motif family protein 0.0178 0.3549 0.561
Brugia malayi Bromodomain containing protein 0.0029 0.0308 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.6922
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0022 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0129 0.0204
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0689 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0129 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0542 0.78
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0626 0.0951
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0089 0.0107
Brugia malayi isocitrate dehydrogenase 0.0016 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0129 0.0204
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0626 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0226 0.3078
Schistosoma mansoni hypothetical protein 0.0302 0.6222 0.869
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0381 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0022 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0129 0.0109
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0689 0.105
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0795 0.1217
Schistosoma mansoni hypothetical protein 0.0127 0.2442 0.3393
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0463 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0689 0.1089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0129 0.0204
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0439 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0431 0.6145
Echinococcus multilocularis muscleblind protein 1 0.0307 0.6326 0.6318
Loa Loa (eye worm) hypothetical protein 0.0049 0.0751 0.1187
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0129 0.0152
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0089 0.0867
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0129 0.0109
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0129 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0226 0.3078
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0021 0.0033
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0001
Brugia malayi jmjC domain containing protein 0.0094 0.1728 0.2731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0336 0.4722
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0274 0.0434
Echinococcus granulosus jumonji domain containing protein 0.004 0.0552 0.0533
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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