Detailed information for compound 761777

Basic information

Technical information
  • TDR Targets ID: 761777
  • Name: methyl (4Z)-1-(3,4-dimethoxyphenyl)-4-[(4-flu orophenyl)methylidene]-2-methyl-5-oxopyrrole- 3-carboxylate
  • MW: 397.396 | Formula: C22H20FNO5
  • H donors: 0 H acceptors: 2 LogP: 3.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=C(C)N(C(=O)C1=Cc1ccc(cc1)F)c1ccc(c(c1)OC)OC
  • InChi: 1S/C22H20FNO5/c1-13-20(22(26)29-4)17(11-14-5-7-15(23)8-6-14)21(25)24(13)16-9-10-18(27-2)19(12-16)28-3/h5-12H,1-4H3/b17-11-
  • InChiKey: TWVQEFDGHAKXHB-BOPFTXTBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 1-(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylidene]-2-methyl-5-oxopyrrole-3-carboxylate
  • methyl (4Z)-1-(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylene]-2-methyl-5-oxo-pyrrole-3-carboxylate
  • methyl 1-(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylene]-2-methyl-5-oxo-pyrrole-3-carboxylate
  • 1-(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylene]-2-methyl-5-oxo-3-pyrrolecarboxylic acid methyl ester
  • (4Z)-1-(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylene]-2-methyl-5-oxo-3-pyrrolecarboxylic acid methyl ester
  • 1-(3,4-dimethoxyphenyl)-4-(4-fluorobenzylidene)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester
  • (4Z)-1-(3,4-dimethoxyphenyl)-4-(4-fluorobenzylidene)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester
  • methyl 1-(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylidene]-2-methyl-5-oxo-pyrrole-3-carboxylate
  • methyl (4Z)-1-(3,4-dimethoxyphenyl)-4-[(4-fluorophenyl)methylidene]-2-methyl-5-oxo-pyrrole-3-carboxylate
  • ZINC04699102
  • STK161455

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0127 0.0115
Brugia malayi nuclear hormone receptor 0.002 0.0127 0.0348
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0316 0.3803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0127 0.0348
Echinococcus granulosus geminin 0.0333 0.7205 0.7202
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0771 0.2116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0091 0.0892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0475 0.6922
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0091 0.0124
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0091 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0127 0.0348
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0012 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0218 0.3066
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0022 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0127 0.0159
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1775 0.1765
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0451 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0218 0.3078
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0091 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0218 0.3066
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0151 0.0217
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0681 0.105
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0316 0.3803
Brugia malayi hypothetical protein 0.0032 0.0398 0.1092
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0177 0.0165
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Schistosoma mansoni hypothetical protein 0.0028 0.0316 0.0422
Echinococcus granulosus peregrin 0.0028 0.0316 0.0304
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.3645 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0127 0.0115
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0618 0.0951
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0127 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0127 0.0348
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.6384 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0127 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0127 0.0348
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0127 0.0115
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0742
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.285 0.4454
Schistosoma mansoni coup transcription factor 0.002 0.0127 0.0159
Schistosoma mansoni hypothetical protein 0.0286 0.6142 0.8522
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0022 0.0016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0145 0.296 0.2951
Entamoeba histolytica hypothetical protein 0.0035 0.047 0.6425
Schistosoma mansoni hypothetical protein 0.0033 0.0424 0.0573
Echinococcus multilocularis neuropeptide s receptor 0.0457 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0423 0.6145
Onchocerca volvulus 0.0027 0.0282 0.044
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0127 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0127 0.0348
Loa Loa (eye worm) hypothetical protein 0.0027 0.0282 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0127 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0127 0.0348
Brugia malayi jmjC domain containing protein 0.0034 0.0451 0.1237
Giardia lamblia PHD finger protein 15 0.0028 0.0316 0.381
Echinococcus multilocularis neuropeptide receptor A26 0.0457 1 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0127 0.0159
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0451 0.0439
Plasmodium falciparum phd finger protein, putative 0.0028 0.0316 0.3803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0276 0.3945
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0681 0.1869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0475 0.6922
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.001
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.6384 1
Brugia malayi N-terminal motif family protein 0.0176 0.3645 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0423 0.5193
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0681 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0424 0.1164
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0316 0.0422
Loa Loa (eye worm) hypothetical protein 0.0049 0.0771 0.2116
Echinococcus multilocularis peregrin 0.0028 0.0316 0.0304
Brugia malayi hypothetical protein 0.0035 0.047 0.1291
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0795 0.1228
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0681 0.067
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.285 0.4454
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0127 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0276 0.3945
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0022 0.0014
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0022 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0218 0.3066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0127 0.0115
Schistosoma mansoni ap endonuclease 0.0018 0.0091 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0177 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0534 0.78
Schistosoma mansoni hypothetical protein 0.0333 0.7205 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0316 0.0304
Brugia malayi hypothetical protein 0.005 0.0795 0.218
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0681 0.105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.027 0.3855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.027 0.3855
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0127 0.0115
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.6384 1
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0795 1
Echinococcus granulosus lamin 0.0027 0.0282 0.027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0618 0.0951
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0127 0.0159
Loa Loa (eye worm) hypothetical protein 0.0049 0.0774 0.2124
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0476 0.0728
Echinococcus multilocularis musashi 0.0027 0.0282 0.027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.3209 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0423 0.6145
Echinococcus multilocularis GPCR, family 2 0.0015 0.0022 0.0009
Brugia malayi intermediate filament protein 0.0027 0.0282 0.0773
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0127 0.0348
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0316 0.0304
Brugia malayi ecdysteroid receptor 0.002 0.0127 0.0348
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0795 0.1228
Schistosoma mansoni intermediate filament proteins 0.0027 0.0282 0.0374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0681 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.2508 0.2498
Brugia malayi Bromodomain containing protein 0.0028 0.0316 0.0867
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0127 0.0115
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0618 0.0951
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0013
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.2508 0.2498
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0022 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0127 0.0348
Brugia malayi steroid hormone receptor 0.002 0.0127 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0475 0.6922
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.035 0.5047
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0282 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0328 0.4722
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0127 0.0159
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0127 0.0159
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0451 0.1237
Leishmania major hypothetical protein, conserved 0.005 0.0795 0.1228
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0127 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0091 0.1179
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0127 0.0348
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0022 0.0061
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0091 0.0124
Toxoplasma gondii exonuclease III APE 0.0018 0.0091 0.0892
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0316 0.3803
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0316 0.0867
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0127 0.0348
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0681 0.105
Echinococcus multilocularis X box binding protein 1 0.0286 0.6142 0.6138
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.047 0.0459
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Schistosoma mansoni lamin 0.0027 0.0282 0.0374
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0681 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0795 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0091 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0127 0.0348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0127 0.0115
Echinococcus multilocularis lamin 0.0027 0.0282 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0127 0.0115
Mycobacterium ulcerans hypothetical protein 0.0156 0.3209 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0476 0.0728
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.047 0.0459
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0022 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.047 0.0637
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0771 0.2116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0681 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0618 0.0951
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0451 0.061
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0999 0.274
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0022 0.006
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0022 0.006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0091 0.0079
Giardia lamblia GTOR 0.0045 0.0681 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0127 0.0348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0127 0.0348
Brugia malayi jmjC domain containing protein 0.0093 0.1775 0.4869
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0218 0.3078
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0795 0.1228
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0424 0.1164
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0127 0.0115
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0022 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0282 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0475 0.6922
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0127 0.0159
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0681 0.105
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0022 0.0016
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0127 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0127 0.0348
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0091 0.0892
Schistosoma mansoni thyroid hormone receptor 0.0145 0.296 0.4097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0423 0.6145
Echinococcus granulosus neuropeptide receptor A26 0.0457 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0022 0.0009
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0022 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0091 0.0079
Loa Loa (eye worm) hypothetical protein 0.0028 0.0316 0.0867
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0681 0.067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0091 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0276 0.3945
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0091 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0127 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0475 0.6922
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0127 0.0348
Loa Loa (eye worm) hypothetical protein 0.005 0.0795 0.218
Schistosoma mansoni thyroid hormone receptor 0.0145 0.296 0.4097
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0127 0.0115
Echinococcus multilocularis lamin dm0 0.0027 0.0282 0.027
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0127 0.0159
Schistosoma mansoni lamin 0.0027 0.0282 0.0374
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0091 0.1179
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0681 0.105
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0022 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0218 0.3078
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0476 0.0728
Schistosoma mansoni hypothetical protein 0.0125 0.2508 0.3469
Entamoeba histolytica hypothetical protein 0.0035 0.047 0.6425
Echinococcus granulosus intermediate filament protein 0.0027 0.0282 0.027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0127 0.0348
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0681 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0423 0.6145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0127 0.0348
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0127 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0423 0.6145
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0022 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0127 0.0348
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0282 0.0773
Toxoplasma gondii hypothetical protein 0.0048 0.0757 0.9512
Brugia malayi PHD-finger family protein 0.0028 0.0316 0.0867
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.006
Echinococcus granulosus X box binding protein 1 0.0286 0.6142 0.6138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0218 0.3078
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.6384 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0127 0.0348
Schistosoma mansoni hypothetical protein 0.0035 0.047 0.0637
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.285 0.4454
Loa Loa (eye worm) hypothetical protein 0.002 0.0127 0.0348
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1343 0.185
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0567 0.0555
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0127 0.0348
Echinococcus granulosus jumonji domain containing protein 0.004 0.0567 0.0555
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0093 0.0126
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0681 0.105
Brugia malayi nuclear receptor NHR-88 0.002 0.0127 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0423 0.6145
Schistosoma mansoni ap endonuclease 0.0018 0.0091 0.011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0771 0.2116
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0022 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0681 0.1869
Echinococcus granulosus GPCR family 2 0.0015 0.0022 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0127 0.0115
Entamoeba histolytica hypothetical protein 0.0035 0.047 0.6425
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0127 0.0115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0091 0.0124
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0825 0.1275
Loa Loa (eye worm) hypothetical protein 0.0176 0.3645 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0091 0.025
Schistosoma mansoni hypothetical protein 0.0333 0.7205 1
Entamoeba histolytica hypothetical protein 0.0035 0.047 0.6425
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0127 0.0159
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1775 0.1765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0423 0.6145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0681 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0022 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0127 0.0348
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0013
Onchocerca volvulus 0.0027 0.0282 0.044
Echinococcus multilocularis geminin 0.0333 0.7205 0.7202
Schistosoma mansoni hypothetical protein 0.0022 0.0177 0.0229
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0022 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0012 0.0034
Brugia malayi isocitrate dehydrogenase 0.0015 0.0022 0.0061
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0795 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0451 0.0439
Echinococcus granulosus lamin dm0 0.0027 0.0282 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0127 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0795 1
Onchocerca volvulus Alhambra homolog 0.0028 0.0316 0.0538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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