Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0331 | 0.1405 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0309 | 0.1214 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0053 | 0.0309 | 0.0509 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0165 | 0.1323 | 0.4309 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0235 | 0.0877 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0312 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0121 | 0.0923 | 0.6911 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0189 | 0.0176 |
Echinococcus multilocularis | expressed protein | 0.0037 | 0.0169 | 0.0169 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.0309 | 0.1006 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0134 | 0.1044 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.0309 | 0.1006 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0053 | 0.0309 | 0.2312 |
Leishmania major | trypanothione reductase | 0.0053 | 0.0312 | 0.1162 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0166 | 0.1336 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0121 | 0.0923 | 0.8349 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0312 | 0.0312 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.0309 | 0.1006 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0189 | 0.0176 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0053 | 0.0309 | 0.2312 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0174 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0309 | 0.1214 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0312 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0331 | 0.1078 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0316 | 0.2684 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0121 | 0.0923 | 0.6911 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0134 | 0.1044 | 0.782 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.0309 | 0.2312 |
Entamoeba histolytica | hypothetical protein | 0.0358 | 0.3069 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0039 | 0.0189 | 0.1414 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.0312 | 0.2334 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.0161 | 0.0599 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0053 | 0.0309 | 0.0509 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.0309 | 0.2312 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0312 | 0.1241 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0054 | 0.0323 | 0.1203 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0053 | 0.0309 | 0.2312 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0312 | 0.1162 |
Mycobacterium ulcerans | hypothetical protein | 0.0053 | 0.0309 | 0.2312 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.0161 | 0.9534 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.017 | 0.1269 |
Entamoeba histolytica | hypothetical protein | 0.0358 | 0.3069 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 0.1336 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.0235 | 0.0877 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.0309 | 0.2312 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0134 | 0.1044 | 0.782 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.2684 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0051 | 0.0294 | 0.9438 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0316 | 0.2684 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0358 | 0.3069 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0039 | 0.0189 | 0.6058 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0121 | 0.0923 | 0.6911 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0358 | 0.3069 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0169 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.017 | 0.1269 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0121 | 0.0923 | 0.6911 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0312 | 0.0312 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0053 | 0.0309 | 0.2312 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0053 | 0.0309 | 0.0509 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0039 | 0.0189 | 0.6058 |
Onchocerca volvulus | 0.0165 | 0.1323 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.1183 | 0.4408 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.0309 | 0.115 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.0309 | 0.115 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.1323 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0312 | 0.1016 |
Echinococcus multilocularis | tumor protein p63 | 0.1127 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0039 | 0.0189 | 0.1414 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0312 | 0.1016 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0331 | 0.1405 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.0309 | 0.2312 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0312 | 0.1241 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.1183 | 0.4408 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0312 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0036 | 0.0161 | 0.5155 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0134 | 0.1044 | 0.782 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0121 | 0.0923 | 0.6911 |
Trichomonas vaginalis | rotamase, putative | 0.0037 | 0.0169 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0189 | 0.0176 |
Schistosoma mansoni | rotamase | 0.0037 | 0.0169 | 0.0549 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.017 | 0.1269 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0189 | 0.0176 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0174 | 0.0566 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0036 | 0.0161 | 0.0599 |
Treponema pallidum | NADH oxidase | 0.0018 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0312 | 1 |
Echinococcus granulosus | expressed protein | 0.0037 | 0.0169 | 0.0169 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0331 | 0.1078 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0036 | 0.0161 | 0.0599 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0149 | 0.1183 | 0.4408 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0358 | 0.3069 | 0.3069 |
Brugia malayi | hypothetical protein | 0.0358 | 0.3069 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0358 | 0.3069 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0358 | 0.3069 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0358 | 0.3069 | 0.3069 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0312 | 0.1162 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0174 | 0.0566 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0121 | 0.0923 | 0.6911 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0189 | 0.0176 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.0161 | 0.0599 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.0235 | 0.0877 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0039 | 0.0189 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.017 | 0.1269 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0312 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0235 | 0.0877 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0037 | 0.0169 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0309 | 0.1214 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.0309 | 0.115 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.2684 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0053 | 0.0309 | 0.2312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.