Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0161 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0739 | 0.4935 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0195 | 0.0233 |
Entamoeba histolytica | hypothetical protein | 0.0317 | 0.2738 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0052 | 0.0316 | 0.2362 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0317 | 0.2738 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0306 | 0.1137 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.0306 | 0.0306 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0316 | 0.1156 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0039 | 0.0195 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0176 | 0.1313 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0306 | 0.4134 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.0239 | 0.0888 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0324 | 0.1349 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.0905 | 0.6754 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0316 | 0.1279 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0176 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0171 | 0.0623 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0316 | 0.1156 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0306 | 0.1116 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0316 | 0.2362 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.0905 | 0.6754 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0195 | 0.0233 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0161 | 0.0598 |
Brugia malayi | hypothetical protein | 0.0317 | 0.2738 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0316 | 0.1279 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0035 | 0.0161 | 0.0598 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0039 | 0.0195 | 0.6395 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0316 | 0.2362 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.0905 | 0.6754 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0324 | 0.1185 |
Schistosoma mansoni | rotamase | 0.0036 | 0.0168 | 0.0615 |
Echinococcus granulosus | expressed protein | 0.0036 | 0.0168 | 0.0168 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0306 | 0.1137 |
Echinococcus multilocularis | expressed protein | 0.0036 | 0.0168 | 0.0168 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.1187 | 0.4415 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.0239 | 0.0888 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0171 | 0.0018 |
Treponema pallidum | NADH oxidase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.1113 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0316 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0739 | 0.4935 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1325 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.0316 | 0.0604 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0306 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0052 | 0.0316 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0324 | 0.1349 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0171 | 0.0623 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.0161 | 0.9538 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0739 | 0.4935 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0195 | 0.0233 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0312 | 0.2689 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0052 | 0.0316 | 0.2362 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0317 | 0.2738 | 0.2738 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.0316 | 0.2362 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0052 | 0.0316 | 0.2362 |
Entamoeba histolytica | hypothetical protein | 0.0317 | 0.2738 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0039 | 0.0195 | 0.1459 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0306 | 0.1137 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0316 | 0.1177 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0039 | 0.0195 | 0.6395 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0316 | 0.1177 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.1024 | 0.7643 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.1024 | 0.7643 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0117 | 0.0905 | 0.8317 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0312 | 0.2689 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0148 | 0.1187 | 0.4415 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0168 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0317 | 0.2738 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0306 | 0.1116 |
Onchocerca volvulus | 0.0163 | 0.1325 | 1 | |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.0905 | 0.6754 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0195 | 0.0233 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0316 | 0.2362 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0176 | 0.1313 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0195 | 0.0233 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0035 | 0.0161 | 0.2173 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0306 | 0.1186 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.134 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0176 | 0.1313 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.0298 | 0.4027 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0052 | 0.0316 | 0.2362 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0239 | 0.0888 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.0316 | 0.0604 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0052 | 0.0316 | 0.2362 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.0316 | 0.1177 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.0905 | 0.6754 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0035 | 0.0161 | 0.0598 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0163 | 0.1325 | 0.4841 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0099 | 0.0739 | 0.4935 |
Entamoeba histolytica | hypothetical protein | 0.0317 | 0.2738 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0053 | 0.0327 | 0.1214 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.2689 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.0905 | 0.6754 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.1024 | 0.7643 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.1024 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0306 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.0168 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.0306 | 0.2281 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0039 | 0.0195 | 0.1459 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.0316 | 0.2362 |
Toxoplasma gondii | hypothetical protein | 0.0099 | 0.0739 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.0316 | 0.1156 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0306 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0306 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0317 | 0.2738 | 0.2738 |
Schistosoma mansoni | hypothetical protein | 0.0317 | 0.2738 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0306 | 0.1186 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0324 | 0.1185 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0036 | 0.0168 | 0.0615 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.1187 | 0.4415 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0239 | 0.0888 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.134 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.2689 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.