Detailed information for compound 762001

Basic information

Technical information
  • TDR Targets ID: 762001
  • Name: 1-(4-chlorophenyl)sulfonyl-4-[(2,3-dimethoxyp henyl)methyl]piperazine
  • MW: 410.915 | Formula: C19H23ClN2O4S
  • H donors: 0 H acceptors: 2 LogP: 2.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1OC)CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C19H23ClN2O4S/c1-25-18-5-3-4-15(19(18)26-2)14-21-10-12-22(13-11-21)27(23,24)17-8-6-16(20)7-9-17/h3-9H,10-14H2,1-2H3
  • InChiKey: AEQUHYRXZDUKSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-chlorophenyl)sulfonyl-4-(2,3-dimethoxybenzyl)piperazine
  • 5956-84-3
  • CBMicro_036914
  • 1-(4-Chloro-benzenesulfonyl)-4-(2,3-dimethoxy-benzyl)-piperazine
  • BAS 03050138
  • Oprea1_343379
  • BIM-0037086.P001
  • STK126759
  • Oprea1_758782

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0174 0.1589
Giardia lamblia GTOR 0.0044 0.0458 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0331 0.4451
Trichomonas vaginalis ferritin, putative 0.0017 0.006 0.0029
Echinococcus granulosus smad 0.0041 0.0418 0.0407
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1184 0.1211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.121 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0293 0.0264
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0119 0.1311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0019 0.0173
Loa Loa (eye worm) RNA binding protein 0.0253 0.3547 0.4026
Mycobacterium ulcerans lipase LipD 0.0035 0.0331 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0174 0.1589
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0344
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0458 0.0449
Loa Loa (eye worm) hypothetical protein 0.0204 0.2829 0.3204
Mycobacterium ulcerans hypothetical protein 0.0035 0.0331 1
Schistosoma mansoni ferritin 0.0017 0.006 0.0083
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0418 0.0407
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0458 0.1216
Loa Loa (eye worm) beta-lactamase 0.0035 0.0331 0.0344
Schistosoma mansoni ferritin 0.0017 0.006 0.0083
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0174 0.213
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0418 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0196 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0331 0.3015
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0174 0.6095
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0458 0.6333
Trichomonas vaginalis set domain proteins, putative 0.0691 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3547 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3113 1
Echinococcus granulosus Smad4 0.0041 0.0418 0.0407
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0458 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0458 0.0429
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0331 0.0889
Brugia malayi TAR-binding protein 0.0253 0.3547 0.4026
Schistosoma mansoni ferritin light chain 0.0017 0.006 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0199 0.0169
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0331 0.0889
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0062
Trypanosoma cruzi ISWI complex protein 0.006 0.0706 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0067 0.0808 0.0816
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0458 1
Schistosoma mansoni Smad4 0.0018 0.0085 0.0153
Echinococcus granulosus peregrin 0.0038 0.0371 0.0357
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0331 0.0301
Brugia malayi MH1 domain containing protein 0.0023 0.0149 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0327 0.0297
Plasmodium falciparum phd finger protein, putative 0.0028 0.0233 1
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3547 1
Schistosoma mansoni bromodomain containing protein 0.025 0.35 0.9868
Loa Loa (eye worm) hypothetical protein 0.0299 0.4224 0.4802
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0331 0.0301
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0331 0.4451
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0089 0.1128 0.1152
Mycobacterium tuberculosis Conserved protein 0.0035 0.0331 0.0889
Loa Loa (eye worm) hypothetical protein 0.0279 0.3933 0.4469
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1611 0.1659
Mycobacterium tuberculosis Conserved protein 0.0035 0.0331 0.0889
Loa Loa (eye worm) transcription factor SMAD2 0.0601 0.8671 0.9893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0246 0.0216
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0089 0.1128 0.312
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0331 0.0855
Schistosoma mansoni smad1 5 8 and 0.0041 0.0418 0.1102
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0331 0.0889
Brugia malayi beta-lactamase 0.0035 0.0331 0.0344
Echinococcus granulosus expressed protein 0.0017 0.006 0.0031
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0327 0.4391
Mycobacterium ulcerans beta-lactamase 0.0035 0.0331 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0067 0.0808 0.2211
Echinococcus granulosus tumor protein p63 0.0661 0.9556 1
Brugia malayi MH1 domain containing protein 0.0041 0.0418 0.0444
Brugia malayi hypothetical protein 0.0035 0.0331 0.0344
Brugia malayi beta-lactamase family protein 0.0035 0.0331 0.0344
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.121 0.1238
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0331 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0458 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0293 0.0264
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0233 0.212
Loa Loa (eye worm) hypothetical protein 0.0161 0.2187 0.2469
Schistosoma mansoni Smad4 0.0041 0.0418 0.1102
Schistosoma mansoni hypothetical protein 0.0204 0.2829 0.7959
Schistosoma mansoni smad 0.0018 0.0085 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.1098 0.3037
Schistosoma mansoni hypothetical protein 0.0095 0.121 0.3354
Onchocerca volvulus 0.0087 0.1098 0.1023
Echinococcus multilocularis bloom syndrome protein 0.0021 0.012 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.1098 0.3037
Loa Loa (eye worm) Smad1 0.0041 0.0418 0.0444
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0085 0.0062
Brugia malayi MH2 domain containing protein 0.0041 0.0418 0.0444
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0432 0.0421
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.006 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0236 0.3292 0.3424
Brugia malayi jmjC domain containing protein 0.0042 0.0432 0.046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0236 0.3292 0.3424
Schistosoma mansoni hypothetical protein 0.0122 0.1611 0.4494
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0085 0.0062
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0174 0.6095
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0174 0.213
Loa Loa (eye worm) PHD-finger family protein 0.0081 0.1016 0.1129
Brugia malayi Bromodomain containing protein 0.0151 0.2045 0.2307
Brugia malayi Latrophilin receptor protein 2 0.0095 0.121 0.135
Schistosoma mansoni zinc finger protein 0.006 0.0706 0.192
Loa Loa (eye worm) nuclear factor I 0.0023 0.0149 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0233 0.0202
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0056 0.0072
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0903 0.248
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0321 0.0305
Brugia malayi Pre-SET motif family protein 0.0607 0.8764 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0162 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0154 0.2092 0.5862
Schistosoma mansoni smad1 5 8 and 0.0041 0.0418 0.1102
Loa Loa (eye worm) hypothetical protein 0.0168 0.2298 0.2597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0293 0.0264
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0061 0.0032
Leishmania major hypothetical protein, conserved 0.006 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0532 0.0574
Schistosoma mansoni hypothetical protein 0.0081 0.1016 0.2804
Echinococcus multilocularis peregrin 0.0038 0.0371 0.0357
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0331 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0162 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0344
Brugia malayi Pre-SET motif family protein 0.0087 0.1098 0.1223
Brugia malayi MH1 domain containing protein 0.0041 0.0418 0.0444
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0174 0.213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0327 0.0297
Brugia malayi MH2 domain containing protein 0.0018 0.0085 0.0062
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0344
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.121 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0199 0.0169
Schistosoma mansoni smad1 5 8 and 0.0041 0.0418 0.1102
Echinococcus multilocularis smad 0.0041 0.0418 0.0407
Trypanosoma brucei ISWI complex protein 0.006 0.0706 1
Brugia malayi RNA binding protein 0.0253 0.3547 0.4026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0331 1
Onchocerca volvulus 0.0035 0.0331 0.0249
Mycobacterium leprae Probable lipase LipE 0.0035 0.0331 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0067 0.0808 0.0816
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0085 0.0057
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.1241 0.3441
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.012 0.0103
Loa Loa (eye worm) TAR-binding protein 0.0253 0.3547 0.4026
Brugia malayi MH2 domain containing protein 0.0601 0.8671 0.9893
Schistosoma mansoni hypothetical protein 0.0035 0.0331 0.0854
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0331 0.0344
Schistosoma mansoni apoferritin-2 0.0017 0.006 0.0083
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1611 0.1659
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0397 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0162 0.0132
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0084 0.1051 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0327 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0327 0.0297
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.121 0.1238
Echinococcus granulosus fetal alzheimer antigen falz 0.0089 0.1128 0.1152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0299 0.4224 0.4802
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0344
Brugia malayi beta-lactamase family protein 0.0035 0.0331 0.0344
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3547 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0085 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0293 0.0264
Brugia malayi PHD-finger family protein 0.0098 0.1266 0.1414
Onchocerca volvulus 0.0035 0.0331 0.0249
Brugia malayi MH1 domain containing protein 0.0023 0.0149 0.0135
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0458 0.6333
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.1755 0.181
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0233 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0458 0.0429
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0397 0.0384
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0331 0.0889
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0418 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0196 0.0165
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0418 0.0407
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.121 0.1238
Toxoplasma gondii ABC1 family protein 0.0035 0.0331 0.3015
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0021 0.0195
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1184 0.1211
Echinococcus granulosus zinc finger protein 0.0077 0.0955 0.097
Schistosoma mansoni ferritin light chain 0.0017 0.006 0.0083
Schistosoma mansoni hypothetical protein 0.006 0.0706 0.192
Brugia malayi PHD-finger family protein 0.0028 0.0233 0.0232
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0032
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0458 0.6333
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1755 0.4904
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0233 0.0212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0458 1
Echinococcus granulosus ferritin 0.0017 0.006 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0432 0.1142
Echinococcus granulosus histone lysine methyltransferase setb 0.0154 0.2092 0.2164
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0233 0.0212
Trichomonas vaginalis esterase, putative 0.0035 0.0331 0.0301
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0344
Loa Loa (eye worm) hypothetical protein 0.0154 0.2092 0.236
Onchocerca volvulus Alhambra homolog 0.0028 0.0233 0.015
Echinococcus granulosus bloom syndrome protein 0.0021 0.012 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0162 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0149 0.0135
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.012 0.009
Leishmania major hypothetical protein, conserved 0.0035 0.0331 0.4451
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0331 0.0315
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0331 0.0315
Brugia malayi latrophilin 2 splice variant baaae 0.0204 0.2829 0.3204
Mycobacterium tuberculosis Conserved protein 0.0035 0.0331 0.0889
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.3547 0.4026
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0458 0.6333
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0233 0.212
Echinococcus multilocularis expressed protein 0.0017 0.006 0.0031
Brugia malayi Bromodomain containing protein 0.0038 0.0371 0.0389
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0293 0.2671
Onchocerca volvulus 0.0097 0.1241 0.1166
Schistosoma mansoni zinc finger protein 0.0077 0.0955 0.2629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0162 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0154 0.2092 0.5862
Echinococcus granulosus tar DNA binding protein 0.0253 0.3547 0.3691
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0085 0.0057
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0327 0.4391
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0082 0.0762
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0458 0.6333
Schistosoma mansoni hypothetical protein 0.0095 0.121 0.3354
Echinococcus multilocularis GPCR, family 2 0.0095 0.121 0.1238
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0331 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0162 0.0132
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0331 0.0301
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3547 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0607 0.8764 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.2049 0.2312
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0331 0.0315
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0331 0.0301
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0299 0.4224 0.4802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0293 0.0264
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0061 0.0032
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.012 0.009
Schistosoma mansoni hypothetical protein 0.0095 0.121 0.3354
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0418 0.0407
Schistosoma mansoni smad 0.0041 0.0418 0.1102
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0331 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0364 0.0335
Schistosoma mansoni methyl-cpg binding protein mbd 0.0067 0.0808 0.2211
Loa Loa (eye worm) MH2 domain-containing protein 0.0601 0.8671 0.9893
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0331 0.0889
Schistosoma mansoni apoferritin-2 0.0017 0.006 0.0083
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0327 0.4391
Brugia malayi hypothetical protein 0.0016 0.0047 0.0019
Brugia malayi Smad1 0.0041 0.0418 0.0444
Schistosoma mansoni Smad4 0.0018 0.0085 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0331 0.0854
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.121 0.135
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0233 0.0575
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0142 0.1907 0.197
Trypanosoma cruzi ISWI complex protein 0.006 0.0706 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0087 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0233 0.0232
Brugia malayi hypothetical protein 0.0024 0.0174 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0085 0.0062
Loa Loa (eye worm) RecQ helicase 0.0021 0.012 0.0103
Brugia malayi Calcitonin receptor-like protein seb-1 0.0299 0.4224 0.4802
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0142 0.1907 0.197
Schistosoma mansoni ferritin 0.0017 0.006 0.0083
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0087 0.1098 0.1121
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0418 0.0444
Echinococcus granulosus GPCR family 2 0.0095 0.121 0.1238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0344
Loa Loa (eye worm) hypothetical protein 0.0097 0.1241 0.1386
Onchocerca volvulus 0.0035 0.0331 0.0249
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0458 0.0449
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0432 0.046
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0678 0.0741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0293 0.0264
Echinococcus multilocularis Smad4 0.0041 0.0418 0.0407
Leishmania major hypothetical protein, conserved 0.0024 0.0174 0.213
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0458 0.049
Echinococcus multilocularis zinc finger protein 0.0077 0.0955 0.097
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0085 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0331 0.4451
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0418 0.1102
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0331 0.0889
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1755 0.4904
Loa Loa (eye worm) hypothetical protein 0.0095 0.121 0.135
Schistosoma mansoni tar DNA-binding protein 0.0253 0.3547 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0199 0.0169
Plasmodium vivax SET domain protein, putative 0.0087 0.1098 1
Schistosoma mansoni ferritin 0.0017 0.006 0.0083
Echinococcus multilocularis tumor protein p63 0.0661 0.9556 1
Schistosoma mansoni hypothetical protein 0.0095 0.121 0.3354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0293 0.0264
Loa Loa (eye worm) bromodomain containing protein 0.007 0.0844 0.0931
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0331 0.0855
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0458 0.6333
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.3547 0.4026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0432 0.1142
Schistosoma mansoni bromodomain containing protein 0.0017 0.0064 0.0095
Brugia malayi Bromodomain containing protein 0.0296 0.4183 0.4754
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0331 0.0889
Brugia malayi MH2 domain containing protein 0.0041 0.0418 0.0444
Brugia malayi jmjC domain containing protein 0.0093 0.1184 0.1321
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0154 0.2092 0.2164
Echinococcus multilocularis ferritin 0.0017 0.006 0.0031
Brugia malayi PHD-finger family protein 0.0017 0.0063 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0253 0.3547 0.3691
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0233 0.212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0162 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0331 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.011 0.0091
Schistosoma mansoni hypothetical protein 0.0028 0.0233 0.0575
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.006 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0327 0.0297

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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