Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0222 | 0.0843 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0236 | 0.2025 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 0.0222 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0212 | 0.18 | 0.8837 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0093 | 0.0023 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0359 | 0.0359 |
Plasmodium falciparum | thioredoxin reductase | 0.0093 | 0.0667 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0222 | 0.1024 |
Schistosoma mansoni | ferritin light chain | 0.0035 | 0.0117 | 0.019 |
Echinococcus multilocularis | tumor protein p63 | 0.1076 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0035 | 0.0111 | 0.0388 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0035 | 0.0111 | 0.1677 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0041 | 0.0171 | 0.0641 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0035 | 0.0111 | 0.0388 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0041 | 0.0171 | 0.0171 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0041 | 0.0171 | 0.0279 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0129 | 0.0129 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0035 | 0.0117 | 0.2077 |
Plasmodium falciparum | glutathione reductase | 0.0093 | 0.0667 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.032 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0078 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0292 | 0.2558 | 0.2558 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0032 | 0.0089 | 0.0089 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.0111 | 0.0116 |
Toxoplasma gondii | thioredoxin reductase | 0.0093 | 0.0667 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0035 | 0.0117 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0176 | 0.0626 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0032 | 0.0089 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0359 | 0.0359 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.032 | 0.0523 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0041 | 0.0171 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0153 | 0.0432 |
Trichomonas vaginalis | ferritin, putative | 0.0035 | 0.0117 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0158 | 0.1278 | 0.2086 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0041 | 0.0171 | 0.0171 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.032 | 0.0523 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0093 | 0.0667 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0057 | 0.032 | 0.1857 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0078 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0093 | 0.0023 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0102 | 0.0371 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0041 | 0.0171 | 0.0171 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0057 | 0.032 | 0.1227 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0032 | 0.0089 | 0.0145 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0236 | 0.2025 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0093 | 0.0667 | 1 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0023 | 0.006 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0093 | 0.0667 | 0.0667 |
Brugia malayi | RNA binding protein | 0.0057 | 0.032 | 0.1227 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0212 | 0.18 | 0.8837 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0117 | 0.019 |
Schistosoma mansoni | apoferritin-2 | 0.0035 | 0.0117 | 0.019 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0222 | 0.2313 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 0.0222 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0152 | 0.0567 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0668 | 0.6127 | 0.6127 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.025 | 0.1258 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.0393 | 0.0642 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0035 | 0.0117 | 0.0143 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0117 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0222 | 0.1024 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0093 | 0.0023 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0222 | 0.2313 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0506 | 0.1956 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0035 | 0.0117 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0465 | 0.3088 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0129 | 0.0129 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0032 | 0.0089 | 0.0319 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.025 | 0.0951 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0117 | 0.019 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0212 | 0.18 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0078 |
Echinococcus granulosus | ferritin | 0.0035 | 0.0117 | 0.0117 |
Leishmania major | trypanothione reductase | 0.0093 | 0.0667 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0212 | 0.18 | 0.8837 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0093 | 0.0667 | 0.0667 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0212 | 0.18 | 0.8837 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0032 | 0.0089 | 0.0089 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0222 | 0.0555 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0035 | 0.0117 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0222 | 0.2313 |
Schistosoma mansoni | apoferritin-2 | 0.0035 | 0.0117 | 0.019 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0093 | 0.0023 |
Echinococcus multilocularis | ferritin | 0.0035 | 0.0117 | 0.0117 |
Mycobacterium tuberculosis | Probable reductase | 0.0212 | 0.18 | 0.8837 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0041 | 0.0171 | 0.0279 |
Echinococcus multilocularis | expressed protein | 0.0035 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0222 | 0.1024 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0668 | 0.6127 | 0.6127 |
Schistosoma mansoni | hypothetical protein | 0.0292 | 0.2558 | 0.4175 |
Brugia malayi | hypothetical protein | 0.0292 | 0.2558 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0292 | 0.2558 | 0.4175 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 0.0222 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0041 | 0.0171 | 0.0171 |
Entamoeba histolytica | hypothetical protein | 0.0292 | 0.2558 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.025 | 0.1258 |
Schistosoma mansoni | ferritin | 0.0035 | 0.0117 | 0.019 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0222 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 0.0222 | 0.0691 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 0.0222 | 0.0691 |
Echinococcus multilocularis | tar DNA binding protein | 0.0057 | 0.032 | 0.032 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.0222 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0222 | 0.0843 |
Loa Loa (eye worm) | glutathione reductase | 0.0093 | 0.0667 | 0.4802 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 0.0222 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0035 | 0.0117 | 0.019 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0212 | 0.18 | 0.882 |
Echinococcus granulosus | tar DNA binding protein | 0.0057 | 0.032 | 0.032 |
Onchocerca volvulus | 0.0158 | 0.1278 | 1 | |
Brugia malayi | glutathione reductase | 0.0093 | 0.0667 | 0.2584 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.025 | 0.0951 |
Entamoeba histolytica | hypothetical protein | 0.0292 | 0.2558 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0222 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0102 | 0.0167 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0093 | 0.0667 | 0.2985 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0041 | 0.0171 | 0.0279 |
Brugia malayi | TAR-binding protein | 0.0057 | 0.032 | 0.1227 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0035 | 0.0117 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0057 | 0.032 | 0.1857 |
Trypanosoma brucei | trypanothione reductase | 0.0093 | 0.0667 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0292 | 0.2558 | 0.2558 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.032 | 0.0523 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0093 | 0.0667 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0057 | 0.032 | 0.1857 |
Entamoeba histolytica | hypothetical protein | 0.0292 | 0.2558 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0236 | 0.2025 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0111 | 0.0078 |
Echinococcus granulosus | expressed protein | 0.0035 | 0.0117 | 0.0117 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0035 | 0.0111 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0222 | 0.0843 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0236 | 0.2025 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0222 | 0.0555 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0093 | 0.0667 | 0.4802 |
Schistosoma mansoni | tar DNA-binding protein | 0.0057 | 0.032 | 0.0523 |
Entamoeba histolytica | hypothetical protein | 0.0292 | 0.2558 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0668 | 0.6127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0194 | 0.0783 |
Brugia malayi | Thioredoxin reductase | 0.0093 | 0.0667 | 0.2584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.