Detailed information for compound 762091

Basic information

Technical information
  • TDR Targets ID: 762091
  • Name: 5-(5-chlorothiophen-2-yl)-N-[(3,4-dimethoxyph enyl)methylideneamino]-1H-pyrazole-3-carboxam ide
  • MW: 390.844 | Formula: C17H15ClN4O3S
  • H donors: 2 H acceptors: 2 LogP: 3.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C=NNC(=O)c2n[nH]c(c2)c2ccc(s2)Cl)ccc1OC
  • InChi: 1S/C17H15ClN4O3S/c1-24-13-4-3-10(7-14(13)25-2)9-19-22-17(23)12-8-11(20-21-12)15-5-6-16(18)26-15/h3-9H,1-2H3,(H,20,21)(H,22,23)/b19-9+
  • InChiKey: RJJOCCIHQSKLKE-DJKKODMXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(5-chloro-2-thienyl)-N-[(3,4-dimethoxyphenyl)methyleneamino]-1H-pyrazole-3-carboxamide
  • 5-(5-chloro-2-thienyl)-N-[(3,4-dimethoxybenzylidene)amino]-1H-pyrazole-3-carboxamide
  • ST5054236
  • BAS 01859559

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0834 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Brugia malayi Phosphoglycerate kinase 0.0061 0.2497 0.1814
Echinococcus granulosus phosphoglycerate kinase 1 0.0166 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0166 1 1
Schistosoma mansoni phosphoglycerate kinase 0.0166 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0834 0.0834
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0834 0.0086
Entamoeba histolytica phosphoglycerate kinase, putative 0.0166 1 1
Giardia lamblia Phosphoglycerate kinase 0.0166 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.2609 0.2609
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0166 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.2609 0.1936
Leishmania major phosphoglycerate kinase B, cytosolic 0.0166 1 1
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0166 1 0.5
Chlamydia trachomatis phosphoglycerate kinase 0.0166 1 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0834 0.0834
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0834 0.0086
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 1 1
Leishmania major DNA polymerase eta, putative 0.0062 0.2609 0.2005
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Trypanosoma brucei phosphoglycerate kinase 0.0166 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0834 0.0834
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.2609 0.1936
Schistosoma mansoni phosphoglycerate kinase 0.0166 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Echinococcus multilocularis dna polymerase eta 0.0062 0.2609 0.1936
Trypanosoma brucei unspecified product 0.0038 0.0834 0.0834
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0834 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 1 1
Schistosoma mansoni DNA polymerase eta 0.0062 0.2609 0.1936
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.2497 0.1885
Echinococcus granulosus dna polymerase eta 0.0062 0.2609 0.1936
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.2497 0.1885
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.2609 0.2005
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0166 1 0.5
Leishmania major phosphoglycerate kinase C, glycosomal 0.0166 1 1
Echinococcus multilocularis phosphoglycerate kinase 1 0.0166 1 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.2497 0.1885
Plasmodium vivax phosphoglycerate kinase, putative 0.0166 1 0.5
Treponema pallidum phosphoglycerate kinase 0.0166 1 0.5
Leishmania major DNA polymerase kappa, putative 0.0038 0.0834 0.0086
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.2497 0.1885
Mycobacterium ulcerans phosphoglycerate kinase 0.0166 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0834 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Plasmodium falciparum phosphoglycerate kinase 0.0166 1 0.5
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.2497 0.1885
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.2497 0.2497
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0166 1 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 1 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.2497 0.1885
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0834 0.0834
Trypanosoma brucei phosphoglycerate kinase 0.0166 1 1
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.2497 0.2497

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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