Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0006 | 0.0322 | 0.0223 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.1152 | 0.1054 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0222 | 0.0114 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0322 | 0.0239 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4393 | 0.4331 |
Onchocerca volvulus | 0.0031 | 0.4393 | 1 | |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.4678 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.4393 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.1152 | 0.1054 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.1152 | 0.2229 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.1152 | 0.1054 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0322 | 0.0239 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.1152 | 0.2086 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.1152 | 0.2086 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0322 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0322 | 0.0239 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.1152 | 0.2086 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.1152 | 0.2086 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0006 | 0.0322 | 0.0215 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1609 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0322 | 0.0239 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4678 | 0.4619 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.1152 | 0.2229 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0006 | 0.0322 | 0.0239 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0222 | 0.0114 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.1152 | 0.2086 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.0222 | 0.0114 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.0925 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.1152 | 0.1054 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0925 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4678 | 0.4619 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.1152 | 0.1054 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1672 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0322 | 0.0239 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.1152 | 0.2086 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.1152 | 0.2086 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.1152 | 0.2086 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.0222 | 0.0114 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.1152 | 0.2229 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0322 | 0.0239 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.4393 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.0222 | 0.0114 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.0322 | 0.0215 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.0925 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.1152 | 0.1054 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.0222 | 0.0114 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0939 | 0.1719 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.8867 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0006 | 0.0322 | 0.0239 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0006 | 0.0322 | 0.0223 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1609 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.4678 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0222 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1152 | 0.2229 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.1152 | 0.2229 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.1152 | 0.1054 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.1152 | 0.2086 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.1152 | 0.2229 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0322 | 0.0239 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.1152 | 0.1054 |
Onchocerca volvulus | 0.0011 | 0.1152 | 0.2229 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.1152 | 0.1054 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0531 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0322 | 0.0239 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.1152 | 0.2229 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.1152 | 0.2086 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.1152 | 0.2229 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.1152 | 0.2086 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0222 | 0.0114 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.