Detailed information for compound 762306

Basic information

Technical information
  • TDR Targets ID: 762306
  • Name: 6-chloro-9-(3-diethylamino-2-hydroxypropyl)-3 ,4-dihydro-2H-carbazol-1-one
  • MW: 348.867 | Formula: C19H25ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CC(Cn1c2ccc(cc2c2c1C(=O)CCC2)Cl)O)CC
  • InChi: 1S/C19H25ClN2O2/c1-3-21(4-2)11-14(23)12-22-17-9-8-13(20)10-16(17)15-6-5-7-18(24)19(15)22/h8-10,14,23H,3-7,11-12H2,1-2H3
  • InChiKey: WJHALUUIKUOUNA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-9-(3-diethylamino-2-hydroxy-propyl)-3,4-dihydro-2H-carbazol-1-one
  • EU-0077917

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.0425 0.0425
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0974 0.2708
Echinococcus multilocularis lamin dm0 0.0113 0.1504 0.2256
Schistosoma mansoni lamin 0.0113 0.1504 0.2256
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0222 0.0222
Onchocerca volvulus 0.005 0.0443 0.0862
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0121 0.0181
Echinococcus multilocularis ferritin 0.0061 0.0627 0.094
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0304 0.0304
Schistosoma mansoni ferritin 0.0061 0.0627 0.094
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0121 0.0181
Brugia malayi cytoplasmic intermediate filament protein 0.006 0.0618 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0121 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0703 0.1055
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0703 0.1055
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0387 0.6143 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0222 0.0616
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0222 0.0574
Brugia malayi Importin beta-1 subunit 0.0032 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0033 0.0163 0.0244
Schistosoma mansoni smad1 5 8 and 0.0042 0.0304 0.0456
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0145 0.6554
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0061 0.0627 0.1201
Brugia malayi RNA, U transporter 1 0.0092 0.1159 0.1159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.129 0.1935
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.2071 0.3106
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0121 0.0121
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0113 0.0183
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0121 0.0197
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0041 0.0107
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.5465 0.5465
Entamoeba histolytica hypothetical protein 0.0146 0.2071 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0236 0.3597 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0443 0.0443
Echinococcus multilocularis expressed protein 0.0061 0.0627 0.094
Echinococcus granulosus tumor protein p63 0.0342 0.5386 0.8766
Onchocerca volvulus 0.0032 0.0132 0.003
Echinococcus multilocularis smad 0.0042 0.0304 0.0456
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0155 0.2218 0.5918
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.129 0.1935
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0121 0.0197
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0236 0.3597 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0222 0.0574
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0121 0.0121
Leishmania major importin beta-1 subunit, putative 0.0026 0.0041 0.1859
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0121 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0121 0.0121
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.2071 0.3106
Loa Loa (eye worm) hypothetical protein 0.0111 0.1469 0.1469
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0132 0.0198
Echinococcus multilocularis Smad4 0.0042 0.0304 0.0456
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0145 0.0218
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0121 0.0181
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0236 0.3597 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0974 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0121 0.0121
Loa Loa (eye worm) transcription factor SMAD2 0.0614 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0113 0.1504 0.1504
Loa Loa (eye worm) RNA binding protein 0.0065 0.0703 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0121 0.0121
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.2071 0.3371
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0121 0.0181
Loa Loa (eye worm) hypothetical protein 0.0052 0.0482 0.0482
Schistosoma mansoni ferritin 0.0061 0.0627 0.094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0425 0.0425
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0121 0.0181
Echinococcus granulosus peptidase Clp S14 family 0.0155 0.2218 0.3611
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Brugia malayi beta-lactamase family protein 0.0037 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0033 0.0163 0.0163
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0155 0.2218 0.5916
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0121 0.0121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0121 0.0181
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0145 0.6554
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0054 0.0517 0.0775
Schistosoma mansoni smad 0.0042 0.0304 0.0456
Brugia malayi MH1 domain containing protein 0.0042 0.0304 0.0304
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0121 0.0197
Brugia malayi Smad1 0.0042 0.0304 0.0304
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0121 0.0181
Echinococcus multilocularis lamin 0.0113 0.1504 0.2256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.129 0.21
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0703 0.1055
Echinococcus granulosus expressed protein 0.0061 0.0627 0.102
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0121 0.0181
Brugia malayi hypothetical protein 0.0146 0.2071 0.2071
Onchocerca volvulus 0.0252 0.3856 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0222 0.0222
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0 0.5
Mycobacterium ulcerans bacterioferritin BfrA 0.0061 0.0627 0.1201
Schistosoma mansoni intermediate filament proteins 0.0113 0.1504 0.2256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0222 0.0222
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0121 0.0181
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.0236 0.3597 0.3597
Schistosoma mansoni thyroid hormone receptor 0.0418 0.6669 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0132 0.0132
Echinococcus granulosus snurportin 1 0.0347 0.5465 0.8896
Trichomonas vaginalis esterase, putative 0.0037 0.0222 0.0574
Schistosoma mansoni hypothetical protein 0.0146 0.2071 0.3106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0132 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0121 0.0121
Echinococcus granulosus lamin dm0 0.0113 0.1504 0.2449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0121 0.0121
Brugia malayi MH2 domain containing protein 0.0042 0.0304 0.0304
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0304 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0121 0.0121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0222 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0132 0.0198
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.0145
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0236 0.3597 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0132 0.0368
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0236 0.3597 0.5
Mycobacterium ulcerans bacterioferritin BfrB 0.0061 0.0627 0.1201
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0121 0.0181
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0222 0.0574
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0121 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0703 0.1055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0121 0.0181
Echinococcus granulosus lamin 0.0113 0.1504 0.2449
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0121 0.0121
Brugia malayi MH1 domain containing protein 0.0042 0.0304 0.0304
Echinococcus multilocularis peptidase Clp (S14 family) 0.0155 0.2218 0.3326
Schistosoma mansoni ferritin light chain 0.0061 0.0627 0.094
Brugia malayi Pre-SET motif family protein 0.0221 0.3339 0.3339
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0121 0.0181
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0222 0.0574
Echinococcus granulosus ferritin 0.0061 0.0627 0.102
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0703 0.1055
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0132 0.0198
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0222 0.0361
Echinococcus granulosus Smad4 0.0042 0.0304 0.0495
Toxoplasma gondii hypothetical protein 0.0081 0.0974 0.2708
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0222 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0121 0.0121
Echinococcus granulosus intermediate filament protein 0.0113 0.1504 0.2449
Loa Loa (eye worm) hypothetical protein 0.0037 0.0222 0.0222
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0425 0.0425
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0236 0.3597 1
Brugia malayi intermediate filament protein 0.0113 0.1504 0.1504
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0121 0.0121
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0703 0.0703
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0061 0.0627 0.1201
Schistosoma mansoni coup transcription factor 0.0031 0.0121 0.0181
Entamoeba histolytica hypothetical protein 0.0146 0.2071 1
Loa Loa (eye worm) intermediate filament protein 0.0113 0.1504 0.1504
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0121 0.0181
Schistosoma mansoni thyroid hormone receptor 0.0418 0.6669 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0121 0.0181
Brugia malayi RNA binding protein 0.0065 0.0703 0.0703
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0703 0.0703
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0121 0.0181
Brugia malayi beta-lactamase 0.0037 0.0222 0.0222
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0113 0.1504 0.1504
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0121 0.0181
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0145 0.0404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.129 0.1935
Schistosoma mansoni hypothetical protein 0.0347 0.5465 0.8195
Brugia malayi beta-lactamase family protein 0.0037 0.0222 0.0222
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0041 0.0107
Schistosoma mansoni peptidase Clp (S14 family) 0.0236 0.3597 0.5394
Brugia malayi nuclear hormone receptor 0.0031 0.0121 0.0121
Onchocerca volvulus 0.0113 0.1504 0.3703
Brugia malayi steroid hormone receptor 0.0031 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0146 0.2071 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0054 0.0517 0.0841
Brugia malayi ecdysteroid receptor 0.0031 0.0121 0.0121
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0304 0.0456
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0121 0.0197
Schistosoma mansoni apoferritin-2 0.0061 0.0627 0.094
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0163 0.0163
Trichomonas vaginalis set domain proteins, putative 0.0252 0.3856 1
Brugia malayi MH2 domain containing protein 0.0042 0.0304 0.0304
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0121 0.0121
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0222 0.0332
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0703 0.0703
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0041 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0121 0.0121
Onchocerca volvulus 0.0113 0.1504 0.3703
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0236 0.3597 1
Schistosoma mansoni hypothetical protein 0.0387 0.6143 0.9212
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0146 0.2071 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0304 0.0495
Loa Loa (eye worm) hypothetical protein 0.0037 0.0222 0.0222
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0061 0.0627 0.1201
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0132 0.0215
Schistosoma mansoni smad1 5 8 and 0.0042 0.0304 0.0456
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0304 0.0456
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0121 0.0197
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0121 0.0197
Loa Loa (eye worm) hypothetical protein 0.0054 0.0517 0.0517
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0121 0.0121
Loa Loa (eye worm) MH2 domain-containing protein 0.0614 1 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0145 0.0404
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0236 0.3597 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0121 0.0197
Loa Loa (eye worm) hypothetical protein 0.0052 0.0482 0.0482
Schistosoma mansoni ferritin 0.0061 0.0627 0.094
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0304 0.0456
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.3596 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0132 0.0198
Brugia malayi Probable ClpP-like protease 0.0236 0.3597 0.3597
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0121 0.0181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0121 0.0121
Schistosoma mansoni apoferritin-2 0.0061 0.0627 0.094
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0121 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0222 1
Schistosoma mansoni Smad4 0.0042 0.0304 0.0456
Schistosoma mansoni lamin 0.0113 0.1504 0.2256
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.129 0.129
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0121 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Onchocerca volvulus 0.0037 0.0222 0.0269
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Echinococcus granulosus importin subunit beta 1 0.0032 0.0145 0.0236
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0236 0.3597 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.006 0.0618 0.0618
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.3339 0.3339
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0222 0.0332
Schistosoma mansoni importin beta-1 0.0032 0.0145 0.0218
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0222 1
Onchocerca volvulus 0.0037 0.0222 0.0269
Loa Loa (eye worm) hypothetical protein 0.0037 0.0222 0.0222
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0703 0.1055
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0222 0.0616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.129 0.1935
Onchocerca volvulus 0.0037 0.0222 0.0269
Echinococcus multilocularis thyroid hormone receptor alpha 0.0418 0.6669 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0222 0.0222
Schistosoma mansoni smad1 5 8 and 0.0042 0.0304 0.0456
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0155 0.2218 0.5918
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0236 0.3597 0.5394
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0425 0.0425
Trichomonas vaginalis ferritin, putative 0.0061 0.0627 0.1626
Brugia malayi nuclear receptor NHR-88 0.0031 0.0121 0.0121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0121 0.0197
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0081 0.0974 0.2229
Entamoeba histolytica hypothetical protein 0.0026 0.0041 0.0199
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0041 0.1859
Loa Loa (eye worm) Smad1 0.0042 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0113 0.1504 0.1504
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0974 0.2708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0121 0.0121
Echinococcus granulosus tar DNA binding protein 0.0065 0.0703 0.1145
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0236 0.3597 1
Echinococcus granulosus smad 0.0042 0.0304 0.0495
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0443 0.0664
Schistosoma mansoni ferritin light chain 0.0061 0.0627 0.094
Schistosoma mansoni ferritin 0.0061 0.0627 0.094
Brugia malayi TAR-binding protein 0.0065 0.0703 0.0703
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0222 0.0574
Loa Loa (eye worm) beta-lactamase 0.0037 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0121
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0121 0.0121
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0236 0.3597 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0222 0.0222
Leishmania major hypothetical protein, conserved 0.0037 0.0222 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0132 0.0368
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.129 0.21
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0236 0.3597 0.5855
Echinococcus multilocularis snurportin 1 0.0347 0.5465 0.8195
Echinococcus multilocularis tumor protein p63 0.0342 0.5386 0.8075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0121 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.129 0.1935
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0387 0.6143 0.9212
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0304 0.0304
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0132 0.0198
Echinococcus multilocularis musashi 0.0113 0.1504 0.2256
Plasmodium falciparum importin beta, putative 0.0032 0.0145 0.0404

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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