Detailed information for compound 762330

Basic information

Technical information
  • TDR Targets ID: 762330
  • Name: NCGC00099379-01
  • MW: 395.471 | Formula: C22H21NO4S
  • H donors: 0 H acceptors: 3 LogP: 4.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N(S(=O)(=O)c1ccc(cc1)C)C(=O)c1ccccc1C
  • InChi: 1S/C22H21NO4S/c1-16-8-14-20(15-9-16)28(25,26)23(18-10-12-19(27-3)13-11-18)22(24)21-7-5-4-6-17(21)2/h4-15H,1-3H3
  • InChiKey: OWFADKLXVVAECM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • EU-0077830
  • Oprea1_762210

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0188 0.1364 0.2524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0103 0.0685 0.065
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0117 0.019
Echinococcus granulosus FTZ F1 alpha 0.0103 0.0685 0.065
Loa Loa (eye worm) RNA binding protein 0.0382 0.2903 0.2877
Brugia malayi beta-lactamase family protein 0.0188 0.1364 0.1347
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0253 0.0217
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.014 0.0234
Brugia malayi glutathione reductase 0.0099 0.0655 0.0638
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.0183 0.1325 0.1308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0081
Schistosoma mansoni ferritin 0.0079 0.0495 0.0459
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0129 0.0092
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0129 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0102 0.0065
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0253 0.0217
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.1364 0.3509
Trichomonas vaginalis esterase, putative 0.0188 0.1364 0.3509
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0354 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0103 0.0685 0.065
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0393 0.0357
Schistosoma mansoni apoferritin-2 0.0079 0.0495 0.0459
Trichomonas vaginalis rotamase, putative 0.0033 0.0129 0.0332
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0068 0.0049
Echinococcus multilocularis chromobox protein 1 0.0077 0.0479 0.0443
Echinococcus multilocularis lysine specific demethylase 5A 0.008 0.0503 0.0468
Echinococcus granulosus smad 0.0026 0.0073 0.0036
Brugia malayi RNA, U transporter 1 0.0089 0.0578 0.056
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0103 0.0685 0.0667
Echinococcus multilocularis lamin 0.0191 0.1388 0.1356
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0066 0.0393 0.0357
Loa Loa (eye worm) MH2 domain-containing protein 0.0379 0.2885 0.2859
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0072
Brugia malayi MH1 domain containing protein 0.0026 0.0073 0.0054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.0542 0.0507
Schistosoma mansoni hypothetical protein 0.0022 0.0039 0.0002
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.014 0.0361
Brugia malayi hypothetical protein 0.003 0.0102 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0616 0.0581
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.014 0.0104
Loa Loa (eye worm) hypothetical protein 0.0034 0.0136 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0616 0.0581
Echinococcus multilocularis expressed protein 0.0033 0.0129 0.0092
Mycobacterium ulcerans hypothetical protein 0.0359 0.2726 0.2622
Toxoplasma gondii thioredoxin reductase 0.0099 0.0655 0.0621
Mycobacterium tuberculosis Conserved protein 0.0188 0.1364 0.1317
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0124 0.0087
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.021 0.0201
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0205 0.0357
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0382 0.2903 0.2877
Schistosoma mansoni hypothetical protein 0.0183 0.1325 0.1292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.008 0.0206
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.1274 1 1
Schistosoma mansoni nuclear hormone receptor 0.0103 0.0685 0.065
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.0299 0.0263
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.014 0.0197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.0542 0.0524
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0103 0.0685 0.065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0103 0.0685 0.065
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0073 0.0036
Leishmania major mitochondrial DNA polymerase beta 0.0682 0.5294 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0117 0.0081
Echinococcus multilocularis chromobox protein 1 0.0077 0.0479 0.0443
Trypanosoma brucei trypanothione reductase 0.0099 0.0655 0.121
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0253 0.0217
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.1077 0.1044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.007 0.018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0188 0.1364 0.1317
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0027
Brugia malayi RNA binding protein 0.0382 0.2903 0.289
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0103 0.0685 0.065
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.014 0.0104
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.014 0.0234
Giardia lamblia PHD finger protein 15 0.0066 0.0393 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0835 0.6509 0.6858
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0103 0.0685 0.0667
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0393 0.0357
Mycobacterium leprae conserved hypothetical protein 0.0188 0.1364 0.0914
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0205 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0227 0.0584
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0135 0.0098
Schistosoma mansoni zinc finger protein 0.0048 0.0253 0.0217
Loa Loa (eye worm) transcription factor SMAD2 0.0379 0.2885 0.2859
Onchocerca volvulus 0.0048 0.0253 0.0315
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0027
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0253 0.0315
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0103 0.0685 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.011 0.0283
Echinococcus multilocularis PHD finger protein rhinoceros 0.0066 0.0393 0.0357
Loa Loa (eye worm) hypothetical protein 0.0063 0.0372 0.0336
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.014 0.0361
Onchocerca volvulus 0.0191 0.1388 0.3342
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0079 0.0495 0.0381
Schistosoma mansoni smad1 5 8 and 0.0026 0.0073 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.1364 0.2524
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0253 0.0217
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0518 0.0483
Echinococcus multilocularis expressed conserved protein 0.0107 0.0722 0.0688
Onchocerca volvulus 0.0188 0.1364 0.3276
Mycobacterium ulcerans bacterioferritin BfrA 0.0079 0.0495 0.0359
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1364 0.3509
Echinococcus multilocularis geminin 0.0187 0.1354 0.1322
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.1274 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0453 0.0418
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.014 0.0197
Onchocerca volvulus 0.0191 0.1388 0.3342
Leishmania major importin beta-1 subunit, putative 0.0025 0.007 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0236 0.0608
Echinococcus multilocularis expressed protein 0.0079 0.0495 0.0459
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0205 0.0066
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0096 0.063 0.1163
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.0655 0.0621
Brugia malayi RNA recognition motif domain containing protein 0.0382 0.2903 0.289
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0055 0.0019
Echinococcus granulosus peregrin 0.0066 0.0393 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0382 0.2903 0.2877
Schistosoma mansoni coup transcription factor 0.0103 0.0685 0.065
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.1665 0.1641
Echinococcus granulosus intermediate filament protein 0.0191 0.1388 0.1356
Brugia malayi Steroid receptor seven-up type 2 0.0103 0.0685 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0103 0.0685 0.0667
Echinococcus granulosus ferritin 0.0079 0.0495 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0158
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0439 0.3358 0.3264
Schistosoma mansoni hypothetical protein 0.0047 0.0244 0.0208
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0051 0.0014
Schistosoma mansoni hypothetical protein 0.0085 0.0542 0.0507
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0123 0.0086
Mycobacterium ulcerans esterase/lipase LipP 0.0188 0.1364 0.1241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0135 0.0347
Schistosoma mansoni hypothetical protein 0.0085 0.0542 0.0507
Loa Loa (eye worm) hypothetical protein 0.003 0.0102 0.0065
Brugia malayi tailless protein 0.0048 0.0253 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0227 0.0584
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0253 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.1364 0.2524
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.1274 1 1
Echinococcus granulosus chromobox protein 1 0.0077 0.0479 0.0443
Echinococcus granulosus geminin 0.0187 0.1354 0.1322
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0096 0.063 0.1129
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.0655 0.0621
Schistosoma mansoni steroid hormone receptor ad4bp 0.0103 0.0685 0.065
Echinococcus multilocularis protein dispatched 1 0.0056 0.0313 0.0277
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0479 0.1232
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0205 0.0169
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0835 0.6509 0.6858
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.0685 0.065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0103 0.0685 0.065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.0542 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.021 0.0541
Loa Loa (eye worm) beta-lactamase 0.0188 0.1364 0.1332
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0103 0.0685 0.065
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0022 0.0039 0.0042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.014 0.0104
Brugia malayi nuclear hormone receptor 0.0103 0.0685 0.0667
Schistosoma mansoni nuclear receptor 0.0048 0.0253 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0103 0.0685 0.0667
Mycobacterium tuberculosis Conserved hypothetical protein 0.0359 0.2726 0.2784
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.014 0.2611
Brugia malayi PHD-finger family protein 0.0066 0.0393 0.0374
Schistosoma mansoni hypothetical protein 0.0047 0.0244 0.0208
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0379 0.0343
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0103 0.0685 0.0667
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Echinococcus multilocularis smad 0.0026 0.0073 0.0036
Schistosoma mansoni thyroid hormone receptor 0.1113 0.8718 0.8714
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0037 0.0038
Onchocerca volvulus 0.0188 0.1364 0.3276
Brugia malayi conserved hypotetical protein 0.0048 0.0253 0.0234
Plasmodium vivax hypothetical protein, conserved 0.0188 0.1364 0.1332
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0227 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0103 0.0685 0.0667
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0616 0.0581
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.014 0.0104
Mycobacterium tuberculosis Probable lipase LipE 0.0188 0.1364 0.1317
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.021 0.0541
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.014 0.0234
Schistosoma mansoni hypothetical protein 0.101 0.7901 0.7893
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0052 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0082 0.0212
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0236 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.011 0.0283
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0054 0.0299 0.0263
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0253 0.0234
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0028 0.0072
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.014 0.0197
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0205 0.0528
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0323 0.2436 0.4563
Echinococcus granulosus GPCR family 2 0.0085 0.0542 0.0507
Brugia malayi cytoplasmic intermediate filament protein 0.0102 0.0682 0.0665
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0253 0.0217
Echinococcus multilocularis GPCR, family 2 0.0085 0.0542 0.0507
Schistosoma mansoni hypothetical protein 0.0152 0.1077 0.1044
Schistosoma mansoni cpg binding protein 0.0036 0.015 0.0114
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0518 0.0483
Toxoplasma gondii exonuclease III APE 0.0042 0.0205 0.0169
Loa Loa (eye worm) steroid hormone receptor 0.0103 0.0685 0.065
Brugia malayi ecdysone receptor 0.0048 0.0253 0.0234
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0253 0.0217
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0188 0.1364 0.1317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0379 0.0343
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0268 0.1999 0.1984
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0777 0.076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.0685 0.065
Loa Loa (eye worm) hypothetical protein 0.0114 0.0777 0.0743
Brugia malayi hypothetical protein 0.0152 0.1077 0.106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0616 0.0581
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0188 0.1364 0.1241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0135 0.0347
Mycobacterium tuberculosis Probable lipase LipD 0.0188 0.1364 0.1317
Loa Loa (eye worm) hypothetical protein 0.0085 0.0542 0.0507
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0682 0.5294 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0077 0.0479 0.0444
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0103 0.0685 0.065
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0188 0.1364 0.1317
Mycobacterium tuberculosis Conserved protein 0.0188 0.1364 0.1317
Trichomonas vaginalis set domain proteins, putative 0.0505 0.3886 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.3399 0.3374
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0458 0.0422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0616 0.0581
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0479 0.1232
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.1665 0.1641
Plasmodium falciparum glutathione reductase 0.0099 0.0655 0.0621
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1364 0.3509
Schistosoma mansoni ferritin 0.0079 0.0495 0.0459
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0188 0.1364 0.1347
Schistosoma mansoni intermediate filament proteins 0.0191 0.1388 0.1356
Loa Loa (eye worm) hypothetical protein 0.0092 0.0601 0.0567
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0253 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0109 0.028
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0253 0.0217
Brugia malayi nuclear receptor RXR 0.0054 0.0299 0.0281
Schistosoma mansoni ferritin light chain 0.0079 0.0495 0.0459
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0123 0.0163
Trichomonas vaginalis ferritin, putative 0.0079 0.0495 0.1273
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0103 0.0685 0.065
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1364 0.3509
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0103 0.0685 0.065
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.0299 0.0263
Onchocerca volvulus 0.0048 0.0253 0.0315
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0117 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.008 0.0206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.6313 0.6299
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Trichomonas vaginalis ran, putative 0.0023 0.0051 0.0132
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0205 0.0528
Brugia malayi intermediate filament protein 0.0191 0.1388 0.1372
Schistosoma mansoni ferritin 0.0079 0.0495 0.0459
Schistosoma mansoni nuclear receptor 0.0048 0.0253 0.0217
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0227 0.1713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0103 0.0685 0.065
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0253 0.0217
Brugia malayi Pre-SET motif family protein 0.0064 0.0379 0.0361
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0103 0.0685 0.1466
Echinococcus granulosus beta LACTamase domain containing family member 0.0188 0.1364 0.1332
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0439 0.3358 0.3334
Brugia malayi Pre-SET motif family protein 0.0444 0.3399 0.3386
Plasmodium vivax glutathione reductase, putative 0.0099 0.0655 0.0621
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0227 0.0398
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.0299 0.0263
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0159
Entamoeba histolytica hypothetical protein 0.0152 0.1077 1
Entamoeba histolytica hypothetical protein 0.0152 0.1077 1
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0236 0.0608
Brugia malayi nuclear receptor NHR-67 0.0048 0.0253 0.0234
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0777 0.0743
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0205 0.032
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.007 0.0063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.1364 0.1332
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0073 0.0036
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0154 0.0395
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0682 0.5294 1
Brugia malayi hypothetical protein 0.0054 0.0299 0.0281
Schistosoma mansoni tar DNA-binding protein 0.0382 0.2903 0.2877
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0253 0.0217
Brugia malayi jmjC domain containing protein 0.0021 0.0037 0.0018
Echinococcus multilocularis jumonji domain containing protein 0.0092 0.0598 0.0564
Leishmania major hypothetical protein, conserved 0.003 0.0102 0.0124
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0379 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0154 0.0395
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.1274 1 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0117 0.0099
Schistosoma mansoni ap endonuclease 0.0042 0.0205 0.0169
Brugia malayi nuclear receptor NHR-88 0.0048 0.0253 0.0234
Schistosoma mansoni hypothetical protein 0.0335 0.2535 0.2507
Loa Loa (eye worm) hypothetical protein 0.1274 1 1
Brugia malayi jmjC domain containing protein 0.0021 0.0037 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0103 0.0685 0.065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0072
Brugia malayi chromobox protein homolog 3 0.0043 0.021 0.0192
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0258 0.0222
Plasmodium falciparum phd finger protein, putative 0.0066 0.0393 0.0357
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0123 0.0163
Brugia malayi TAR-binding protein 0.0382 0.2903 0.289
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0072
Schistosoma mansoni gabp alpha 0.0074 0.0458 0.0422
Schistosoma mansoni rotamase 0.0033 0.0129 0.0092
Entamoeba histolytica hypothetical protein 0.0152 0.1077 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0154 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0154 0.0395
Leishmania major GTP-binding protein, putative 0.0023 0.0051 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0393 0.0357
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0096 0.063 0.1129
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.1077 0.1044
Loa Loa (eye worm) hypothetical protein 0.0054 0.0299 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0135 0.0347
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0205 0.0169
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.014 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0379 0.0343
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0103 0.0685 0.065
Loa Loa (eye worm) hypothetical protein 0.0188 0.1364 0.1332
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0102 0.0124
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0051 0.0014
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0055 0.0019
Plasmodium falciparum importin beta, putative 0.0031 0.0117 0.0081
Toxoplasma gondii hypothetical protein 0.011 0.0743 0.0708
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0479 0.0443
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0205 0.0169
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0227 0.0191
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0135 0.0098
Brugia malayi MH2 domain containing protein 0.0379 0.2885 0.2872
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0227 0.0209
Onchocerca volvulus 0.0034 0.0136 0.0003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0299 0.0263
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0227 0.0362
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.101 0.7901 0.7893
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0518 0.0483
Toxoplasma gondii hypothetical protein 0.0439 0.3358 0.3334
Loa Loa (eye worm) PHD-finger family protein 0.0066 0.0393 0.0357
Brugia malayi Ets-domain containing protein 0.0074 0.0458 0.044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0205 0.4511
Mycobacterium ulcerans hypothetical protein 0.0188 0.1364 0.1241
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.014 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0299 0.0263
Echinococcus granulosus chromobox protein 1 0.0077 0.0479 0.0443
Treponema pallidum bacterioferrin (TpF1) 0.0079 0.0495 0.0359
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0205 0.0169
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0102 0.0065
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0227 0.0362
Loa Loa (eye worm) hypothetical protein 0.0113 0.0768 0.0734
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0439 0.3358 0.3013
Trichomonas vaginalis rotamase, putative 0.0032 0.0123 0.0316
Brugia malayi steroid hormone receptor 0.0103 0.0685 0.0667
Brugia malayi nuclear hormone receptor 0.0048 0.0253 0.0234
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0103 0.0685 0.065
Loa Loa (eye worm) hypothetical protein 0.0064 0.0379 0.0343
Echinococcus multilocularis snurportin 1 0.0335 0.2535 0.2507
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.014 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0158
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.014 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0103 0.0685 0.0667
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0205 0.032
Brugia malayi beta-lactamase 0.0188 0.1364 0.1347
Loa Loa (eye worm) hypothetical protein 0.0188 0.1361 0.1329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0103 0.0685 0.065
Schistosoma mansoni hypothetical protein 0.0047 0.0244 0.0208
Echinococcus granulosus PHD finger protein rhinoceros 0.0066 0.0393 0.0357
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0028 0.0072
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.0542 0.0507
Loa Loa (eye worm) hypothetical protein 0.0191 0.1388 0.1356
Echinococcus granulosus cpg binding protein 0.0036 0.015 0.0114
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0251 0.1865 0.1442
Brugia malayi Heterochromatin protein 1 0.0077 0.0479 0.0461
Schistosoma mansoni ap endonuclease 0.0042 0.0205 0.0169
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0253 0.0217
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0117 0.019
Loa Loa (eye worm) hypothetical protein 0.0188 0.1364 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0061 0.0158
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0205 0.0169
Loa Loa (eye worm) hypothetical protein 0.0268 0.1999 0.1969
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0102 0.0124
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0103 0.0685 0.065
Schistosoma mansoni hypothetical protein 0.0187 0.1354 0.1322
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0439 0.3358 0.3334
Plasmodium falciparum thioredoxin reductase 0.0034 0.014 0.0104
Loa Loa (eye worm) hypothetical protein 0.0049 0.0258 0.0222
Entamoeba histolytica hypothetical protein 0.0152 0.1077 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1202 0.9427 1
Brugia malayi MH1 domain containing protein 0.0026 0.0073 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.1364 0.3509
Echinococcus granulosus Smad4 0.0026 0.0073 0.0036
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0253 0.0217
Schistosoma mansoni RAR-like nuclear receptor 0.0103 0.0685 0.065
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.1274 1 1
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.0098
Schistosoma mansoni thyroid hormone receptor 0.1113 0.8718 0.8714
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0253 0.0217
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0458 0.0422
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0154 0.0222
Brugia malayi Bromodomain containing protein 0.0066 0.0393 0.0374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0135 0.0347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0072
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0102 0.0682 0.0648
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.0655 0.0621
Schistosoma mansoni hypothetical protein 0.0085 0.0542 0.0507
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0458 0.0422
Brugia malayi jmjC domain containing protein 0.0021 0.0037 0.0018
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0073 0.0036
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0073 0.0036
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0216 0.1588 0.1557
Onchocerca volvulus Bile acid receptor homolog 0.0103 0.0685 0.1466
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0258 0.0222
Schistosoma mansoni ran 0.0023 0.0051 0.0014
Schistosoma mansoni ferritin 0.0079 0.0495 0.0459
Brugia malayi Nuclear hormone receptor-like 1 0.0103 0.0685 0.0667
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0117 0.0797 0.1446
Schistosoma mansoni tar DNA-binding protein 0.0382 0.2903 0.2877
Entamoeba histolytica hypothetical protein 0.0025 0.007 0.0182
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0253 0.0234
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.1665 0.1641
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0205 0.1501
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0092 0.0601 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0154 0.0395
Loa Loa (eye worm) hypothetical protein 0.0188 0.1364 0.1332
Mycobacterium leprae Probable lipase LipE 0.0188 0.1364 0.0914
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0028 0.0072
Brugia malayi jmjC domain containing protein 0.0216 0.1588 0.1572
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0014
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0253 0.0315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0616 0.0581
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0191 0.1388 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0135 0.0347
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0102 0.0065
Trypanosoma brucei hypothetical protein, conserved 0.0188 0.1364 0.2552
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0103 0.0685 0.065
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0123 0.0696
Loa Loa (eye worm) hypothetical protein 0.0089 0.0574 0.0539
Brugia malayi hypothetical protein 0.0048 0.0253 0.0234
Brugia malayi PHD-finger family protein 0.0024 0.0054 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0103 0.0685 0.0667
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0616 0.0598
Schistosoma mansoni smad 0.0026 0.0073 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0253 0.0217
Brugia malayi CXXC zinc finger family protein 0.0034 0.0135 0.0116
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.1274 1 1
Echinococcus multilocularis peregrin 0.0066 0.0393 0.0357
Brugia malayi Calcitonin receptor-like protein seb-1 0.0268 0.1999 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0135 0.0347
Brugia malayi hypothetical protein 0.0054 0.0299 0.0281
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0268 0.1999 0.1969
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.0542 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0154 0.0395
Mycobacterium ulcerans beta-lactamase 0.0188 0.1364 0.1241
Brugia malayi AF-10 protein 0.0022 0.0039 0.002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0052 0.0015
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.101 0.7901 0.7893
Brugia malayi photoreceptor-specific nuclear receptor 0.0103 0.0685 0.0667
Schistosoma mansoni patched 1 0.0049 0.0258 0.0222
Schistosoma mansoni ran 0.0023 0.0051 0.0014
Echinococcus multilocularis cpg binding protein 0.0036 0.015 0.0114
Onchocerca volvulus 0.0103 0.0685 0.1466
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0258 0.0222
Echinococcus granulosus lysine specific demethylase 5A 0.0082 0.0518 0.0483
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0123 0.0201
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.014 0.0122
Schistosoma mansoni cpg binding protein 0.0036 0.015 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0299 0.0281
Loa Loa (eye worm) hypothetical protein 0.0066 0.0393 0.0357
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0393 0.0357
Echinococcus multilocularis thyroid hormone receptor alpha 0.1113 0.8718 0.8714
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.1665 0.1641
Brugia malayi Ets-domain containing protein 0.0074 0.0458 0.044
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0068 0.0049
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0323 0.2436 0.4584
Plasmodium vivax SET domain protein, putative 0.0064 0.0379 0.0343
Echinococcus granulosus tar DNA binding protein 0.0382 0.2903 0.2877
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.007 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0135 0.0347
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.1274 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0227 0.0191
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0103 0.0685 0.065
Schistosoma mansoni lamin 0.0191 0.1388 0.1356
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.014 0.0197
Echinococcus granulosus importin subunit beta 1 0.0031 0.0117 0.0081
Echinococcus multilocularis protein patched 0.0049 0.0258 0.0222
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0154 0.026
Schistosoma mansoni hypothetical protein 0.0066 0.0393 0.0357
Brugia malayi nuclear receptor RXR 0.0048 0.0253 0.0234
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Brugia malayi CHE-14 protein 0.0049 0.0258 0.0239
Onchocerca volvulus 0.0188 0.1364 0.3276
Brugia malayi ecdysteroid receptor 0.0103 0.0685 0.0667
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.1274 1 1
Echinococcus granulosus expressed protein 0.0079 0.0495 0.0459
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0139 0.0121
Schistosoma mansoni retinoic acid receptor RXR 0.0103 0.0685 0.065
Onchocerca volvulus Protein ultraspiracle homolog 0.0103 0.0685 0.1466
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0079 0.0495 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0129 0.0332
Loa Loa (eye worm) hypothetical protein 0.0089 0.0574 0.0539
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Echinococcus multilocularis ferritin 0.0079 0.0495 0.0459
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.0685 0.065
Brugia malayi Latrophilin receptor protein 2 0.0085 0.0542 0.0524
Loa Loa (eye worm) hypothetical protein 0.0188 0.1364 0.1332
Echinococcus multilocularis FTZ F1 alpha 0.0103 0.0685 0.065
Schistosoma mansoni smad1 5 8 and 0.0026 0.0073 0.0036
Schistosoma mansoni chromobox protein 0.0077 0.0479 0.0443
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.0253 0.0217
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0227 0.0362
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0682 0.5294 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.1364 0.1332
Brugia malayi MH2 domain containing protein 0.0026 0.0073 0.0054
Mycobacterium tuberculosis Probable hydrolase 0.0188 0.1364 0.1317
Brugia malayi MH2 domain containing protein 0.0026 0.0073 0.0054
Schistosoma mansoni hypothetical protein 0.0085 0.0542 0.0507
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.1364 0.1332
Trichomonas vaginalis importin beta-1, putative 0.0025 0.007 0.018
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0251 0.1865 0.1857
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0299 0.0281
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0379 0.0343
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0123 0.0163
Mycobacterium ulcerans lipase LipD 0.0188 0.1364 0.1241
Loa Loa (eye worm) DR-78 0.0048 0.0253 0.0217
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.014 0.0104
Mycobacterium tuberculosis Probable esterase LipL 0.0188 0.1364 0.1317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0159
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0791 0.0757
Schistosoma mansoni hypothetical protein 0.0047 0.0244 0.0208
Onchocerca volvulus 0.0505 0.3886 1
Loa Loa (eye worm) glutathione reductase 0.0099 0.0655 0.0621
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0103 0.0685 0.065
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.0655 0.0621
Loa Loa (eye worm) hypothetical protein 0.0054 0.0299 0.0263
Echinococcus multilocularis peptidase Clp (S14 family) 0.0835 0.6509 0.6496
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0227 0.0362
Giardia lamblia GTOR 0.0045 0.0227 0.5149
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0777 0.0743
Loa Loa (eye worm) intermediate filament protein 0.0191 0.1388 0.1356
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0258 0.0664
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0102 0.0065
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.1274 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0136 0.0952 0.0918
Mycobacterium ulcerans bacterioferritin BfrB 0.0079 0.0495 0.0359
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0174
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.1077 0.1044
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0227 0.0191
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0227 0.0191
Loa Loa (eye worm) hypothetical protein 0.0054 0.0299 0.0263
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.014 0.0104
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0777 0.7078
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0092 0.0601 0.0567
Brugia malayi Fli-1 protein 0.0225 0.166 0.1644
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.2535 0.2507
Mycobacterium tuberculosis Probable reductase 0.0226 0.1665 0.1641
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0096 0.063 0.1129
Loa Loa (eye worm) hypothetical protein 0.0188 0.1364 0.1332
Brugia malayi jmjC domain containing protein 0.0021 0.0037 0.0018
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0253 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0103 0.0685 0.065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Schistosoma mansoni importin beta-1 0.0031 0.0117 0.0081
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0073 0.0036
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0253 0.0217
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.1168 0.1135
Echinococcus multilocularis Smad4 0.0026 0.0073 0.0036
Schistosoma mansoni lamin 0.0191 0.1388 0.1356
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.0253 0.0217
Brugia malayi nuclear receptor NHR-88 0.0103 0.0685 0.0667
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.1274 1 1
Schistosoma mansoni tar DNA-binding protein 0.0382 0.2903 0.2877
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0103 0.0685 0.0667
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.1274 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0251 0.1865 0.1857
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0227 0.1713
Loa Loa (eye worm) hypothetical protein 0.0183 0.1325 0.1292
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0205 0.0187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0835 0.6509 0.6327
Brugia malayi hypothetical protein 0.0048 0.0253 0.0234
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.1274 1 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0051 0.0014
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.1665 0.1231
Schistosoma mansoni jumonji domain containing protein 0.0172 0.1234 0.1202
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0216 0.1588 0.1557
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0188 0.1364 0.1332
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0103 0.0685 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0082 0.0212
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0253 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0103 0.0685 0.0667
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0205 0.007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.0542 0.0507
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0205 0.032
Echinococcus multilocularis lamin dm0 0.0191 0.1388 0.1356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0616 0.0581
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0205 0.0066
Echinococcus granulosus snurportin 1 0.0335 0.2535 0.2507
Schistosoma mansoni ferritin light chain 0.0079 0.0495 0.0459
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.1665 0.1641
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0051 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Loa Loa (eye worm) hypothetical protein 0.006 0.0346 0.031
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.0655 0.1176
Echinococcus granulosus expressed protein 0.0033 0.0129 0.0092
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0253 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0175 0.0449
Toxoplasma gondii ABC1 family protein 0.0188 0.1364 0.1332
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0102 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0082 0.0212
Schistosoma mansoni apoferritin-2 0.0079 0.0495 0.0459
Onchocerca volvulus Alhambra homolog 0.0066 0.0393 0.0688
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0079 0.0495 0.0359
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0258 0.0222
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Brugia malayi jmjC domain containing protein 0.0082 0.0518 0.05
Echinococcus granulosus lamin 0.0191 0.1388 0.1356
Loa Loa (eye worm) hypothetical protein 0.0103 0.0685 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0101 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0103 0.0685 0.065
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0039 0.0002
Schistosoma mansoni ets-related 0.0225 0.166 0.1629
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.0655 0.0554
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0323 0.2436 0.4563
Loa Loa (eye worm) TAR-binding protein 0.0382 0.2903 0.2877
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0379 0.0343
Leishmania major trypanothione reductase 0.0099 0.0655 0.1176
Brugia malayi Intermediate filament tail domain containing protein 0.0191 0.1388 0.1372
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0103 0.0685 0.065
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0117 0.0081
Loa Loa (eye worm) hypothetical protein 0.0054 0.0299 0.0263
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0251 0.1865 0.1857
Echinococcus granulosus expressed conserved protein 0.0107 0.0722 0.0688
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.014 0.0104
Onchocerca volvulus 0.0077 0.0479 0.0918
Loa Loa (eye worm) fli-1 protein 0.0225 0.166 0.1629
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0073 0.0036
Schistosoma mansoni hypothetical protein 0.0187 0.1354 0.1322
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.014 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.0685 0.065
Plasmodium falciparum glutathione reductase 0.0034 0.014 0.0104
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217
Echinococcus granulosus ecdysone induced protein 78C 0.0103 0.0685 0.065
Mycobacterium tuberculosis Conserved protein 0.0188 0.1364 0.1317
Echinococcus multilocularis tar DNA binding protein 0.0382 0.2903 0.2877
Brugia malayi Thioredoxin reductase 0.0099 0.0655 0.0638
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0022 0.0039 0.0002
Schistosoma mansoni chromobox protein 0.0077 0.0479 0.0443
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0022 0.0039 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0159
Echinococcus granulosus peptidase Clp S14 family 0.0835 0.6509 0.6496
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0103 0.0685 0.0667
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0616 0.0581
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0253 0.0217
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0253 0.0217
Echinococcus granulosus lamin dm0 0.0191 0.1388 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0227 0.0584
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0379 0.0343
Echinococcus multilocularis beta LACTamase domain containing family member 0.0188 0.1364 0.1332
Schistosoma mansoni Smad4 0.0026 0.0073 0.0036
Schistosoma mansoni smad1 5 8 and 0.0026 0.0073 0.0036
Echinococcus multilocularis musashi 0.0191 0.1388 0.1356
Schistosoma mansoni peptidase Clp (S14 family) 0.1274 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0253 0.0234
Loa Loa (eye worm) Smad1 0.0026 0.0073 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0103 0.0685 0.0667
Echinococcus granulosus jumonji domain containing protein 0.0092 0.0598 0.0564
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.1168 0.1135
Brugia malayi beta-lactamase family protein 0.0188 0.1364 0.1347
Schistosoma mansoni tar DNA-binding protein 0.0382 0.2903 0.2877
Brugia malayi Smad1 0.0026 0.0073 0.0054
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0073 0.0036
Plasmodium falciparum thioredoxin reductase 0.0099 0.0655 0.0621
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.1274 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0253 0.0217

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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