Detailed information for compound 762335

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.286 | Formula: C19H12BrN3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N=c2scc(n2C(=N)C1=Cc1ccc(c(c1)Br)O)c1ccccc1
  • InChi: 1S/C19H12BrN3O2S/c20-14-9-11(6-7-16(14)24)8-13-17(21)23-15(12-4-2-1-3-5-12)10-26-19(23)22-18(13)25/h1-10,21,24H/b13-8-,21-17?
  • InChiKey: KMBXPKAPHWMXQS-DBXDWNGZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0217 0.0194
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.0505 0.0483
Loa Loa (eye worm) hypothetical protein 0.0102 0.0676 0.0732
Brugia malayi Fli-1 protein 0.0219 0.1744 0.1929
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2453 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0139 0.0369
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0103 0.0089
Mycobacterium ulcerans beta-lactamase 0.0112 0.0762 0.1503
Brugia malayi MH2 domain containing protein 0.0069 0.037 0.0389
Brugia malayi MH2 domain containing protein 0.0069 0.037 0.0389
Plasmodium falciparum thioredoxin reductase 0.0097 0.0629 0.1222
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0552 0.4786 0.5169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Echinococcus multilocularis peptidase Clp (S14 family) 0.0362 0.3049 0.3032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Echinococcus multilocularis GPCR, family 2 0.0032 0.0038 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0762 0.0828
Loa Loa (eye worm) intermediate filament protein 0.0108 0.0731 0.0794
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0402 0.038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0246 0.1989 0.3127
Loa Loa (eye worm) hypothetical protein 0.0044 0.0146 0.0137
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0217 0.0194
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0103 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0505 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.013 0.0334
Echinococcus granulosus peptidase Clp S14 family 0.0362 0.3049 0.3283
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0552 0.4786 1
Brugia malayi nuclear hormone receptor 0.0083 0.0505 0.0541
Loa Loa (eye worm) glutathione reductase 0.0097 0.0629 0.0679
Schistosoma mansoni hypothetical protein 0.1039 0.9238 0.9236
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0552 0.4786 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0505 0.0483
Echinococcus granulosus tar DNA binding protein 0.04 0.3397 0.3662
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0146 0.0137
Schistosoma mansoni apoferritin-2 0.0087 0.0538 0.0516
Schistosoma mansoni ferritin 0.0087 0.0538 0.0516
Toxoplasma gondii thioredoxin reductase 0.0097 0.0629 0.1222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0088 0.1162
Brugia malayi Ets-domain containing protein 0.0072 0.0402 0.0425
Schistosoma mansoni gabp alpha 0.0072 0.0402 0.038
Brugia malayi nuclear receptor RXR 0.0044 0.0146 0.0137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.0505 0.0483
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0146 0.0123
Brugia malayi hypothetical protein 0.0039 0.0103 0.0089
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1026 0.406
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.0505 0.6527
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.2453 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.0505 0.0541
Loa Loa (eye worm) hypothetical protein 0.0044 0.0146 0.0137
Brugia malayi intermediate filament protein 0.0108 0.0731 0.0794
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0217 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0177 0.2328
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0762 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.0505 0.0483
Loa Loa (eye worm) hypothetical protein 0.0044 0.0146 0.0137
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0103 0.008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0552 0.4786 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.0505 0.0523
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0146 0.0133
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0139 0.0116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.0505 0.0483
Brugia malayi RNA recognition motif domain containing protein 0.04 0.3397 0.3784
Loa Loa (eye worm) hypothetical protein 0.0112 0.0762 0.0828
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0217 0.0351
Brugia malayi nuclear hormone receptor 0.0039 0.0103 0.0089
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0177 0.053
Brugia malayi beta-lactamase 0.0112 0.0762 0.0828
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.013 0.171
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Entamoeba histolytica hypothetical protein 0.0333 0.279 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0762 0.0828
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0066 0.0867
Loa Loa (eye worm) hypothetical protein 0.007 0.0381 0.0401
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0217 0.0693
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0217 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.0505 0.0541
Mycobacterium ulcerans bacterioferritin BfrB 0.0087 0.0538 0.103
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0362 0.3049 0.4835
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0676 0.0732
Onchocerca volvulus 0.0083 0.0505 0.6527
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0221 0.1764 0.3555
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.0505 0.0483
Mycobacterium tuberculosis Conserved protein 0.0112 0.0762 0.1148
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.013 0.171
Onchocerca volvulus 0.011 0.0752 0.9871
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0089 0.0161
Echinococcus granulosus FTZ F1 alpha 0.0083 0.0505 0.0523
Onchocerca volvulus 0.0108 0.0731 0.9587
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0762 0.2962
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0217 0.0693
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.013 0.171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0505 0.0483
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0139 0.0187
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0052 0.022 0.0197
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0146 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0177 0.2328
Schistosoma mansoni nuclear hormone receptor 0.0083 0.0505 0.0483
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0762 1
Brugia malayi MH1 domain containing protein 0.0069 0.037 0.0389
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0177 0.0167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0762 0.1148
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.1488 0.1468
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0217 0.0693
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0217 0.0217
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0103 0.0089
Loa Loa (eye worm) hypothetical protein 0.0052 0.022 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0088 0.1162
Brugia malayi TAR-binding protein 0.04 0.3397 0.3784
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0177 0.0173
Loa Loa (eye worm) fli-1 protein 0.0219 0.1744 0.1929
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0762 0.1148
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0103 0.008
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.0505 0.0523
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0552 0.4786 1
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0762 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0069 0.037 0.0389
Brugia malayi Probable ClpP-like protease 0.0552 0.4786 0.5341
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0103 0.0089
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.005 0.0029
Mycobacterium ulcerans hypothetical protein 0.0112 0.0762 0.1503
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0217 0.0217
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0177 0.0177
Onchocerca volvulus Bile acid receptor homolog 0.0083 0.0505 0.6527
Loa Loa (eye worm) hypothetical protein 0.0106 0.0713 0.0774
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0505 0.0541
Brugia malayi ecdysone receptor 0.0039 0.0103 0.0089
Loa Loa (eye worm) Smad1 0.0069 0.037 0.0389
Brugia malayi nuclear receptor NHR-88 0.0039 0.0103 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.0505 0.0541
Loa Loa (eye worm) hypothetical protein 0.0044 0.0146 0.0137
Echinococcus granulosus GPCR family 2 0.0032 0.0038 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0552 0.4786 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.013 0.171
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0124 0.0308
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0177 0.053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0217 0.0194
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.019 0.1481 0.302
Loa Loa (eye worm) hypothetical protein 0.0044 0.0146 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0505 0.0483
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0552 0.4786 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0139 0.182
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0124 0.0308
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0221 0.1764 0.2763
Onchocerca volvulus 0.0039 0.0103 0.1076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0333 0.279 0.3003
Schistosoma mansoni lamin 0.0108 0.0731 0.071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0505 0.0523
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0015
Echinococcus multilocularis ferritin 0.0087 0.0538 0.0516
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.005 0.0027
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0762 0.1148
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.0505 0.0541
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.0505 0.0523
Schistosoma mansoni thyroid hormone receptor 0.1123 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0246 0.1989 0.3127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0103 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0088 0.1162
Loa Loa (eye worm) nuclear factor I 0.0038 0.009 0.0075
Schistosoma mansoni inositol monophosphatase 0.0043 0.0139 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0114 0.1494
Loa Loa (eye worm) inositol-1 0.0043 0.0139 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2453 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0103 0.0086
Echinococcus multilocularis expressed protein 0.0087 0.0538 0.0516
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0246 0.1989 0.3127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0066 0.0867
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0103 0.1076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0762 0.074
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0103 0.008
Toxoplasma gondii hypothetical protein 0.019 0.1481 0.302
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0069 0.037 0.0347
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0103 0.0086
Schistosoma mansoni smad 0.0069 0.037 0.0347
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0139 0.0125
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1026 0.406
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0762 0.1148
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0103 0.0086
Brugia malayi nuclear receptor NHR-88 0.0083 0.0505 0.0541
Schistosoma mansoni lamin 0.0108 0.0731 0.071
Brugia malayi beta-lactamase family protein 0.0112 0.0762 0.0828
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0505 0.0541
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.02
Loa Loa (eye worm) hypothetical protein 0.0112 0.0762 0.0828
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0762 0.1503
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.013 0.0107
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.0505 0.6527
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0087 0.0538 0.094
Echinococcus granulosus mothers against decapentaplegic 5 0.0069 0.037 0.0376
Schistosoma mansoni intermediate filament proteins 0.0108 0.0731 0.071
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0103 0.1076
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0103 0.0086
Schistosoma mansoni apoferritin-2 0.0087 0.0538 0.0516
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0217 0.0351
Echinococcus multilocularis Smad4 0.0069 0.037 0.0347
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.0505 0.0541
Schistosoma mansoni nuclear receptor 0.0039 0.0103 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0088 0.1162
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0217 0.0194
Loa Loa (eye worm) MH2 domain-containing protein 0.1007 0.8941 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0146 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0762 0.1503
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0177 0.0155
Echinococcus multilocularis lamin dm0 0.0108 0.0731 0.071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0676 0.0732
Brugia malayi hypothetical protein 0.0333 0.279 0.3103
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0552 0.4786 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0402 0.0425
Brugia malayi conserved hypotetical protein 0.0039 0.0103 0.0089
Echinococcus multilocularis smad 0.0069 0.037 0.0347
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Schistosoma mansoni alpha glucosidase 0.0042 0.013 0.0107
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.0505 0.0483
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.019 0.1481 0.295
Mycobacterium leprae Probable lipase LipE 0.0112 0.0762 0.1418
Schistosoma mansoni inositol monophosphatase 0.0043 0.0139 0.0116
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0139 0.0187
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0221 0.1764 0.2763
Schistosoma mansoni coup transcription factor 0.0083 0.0505 0.0483
Schistosoma mansoni hypothetical protein 0.0333 0.279 0.2773
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0139 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0629 0.0933
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0087 0.0538 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0034 0.0451
Schistosoma mansoni ets-related 0.0219 0.1744 0.1725
Plasmodium vivax glutathione reductase, putative 0.0097 0.0629 0.1222
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1039 0.9238 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0762 0.074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0177 0.053
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0103 0.0089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Mycobacterium tuberculosis Conserved protein 0.0112 0.0762 0.1148
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0097 0.0076
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0629 0.2409
Schistosoma mansoni ferritin 0.0087 0.0538 0.0516
Echinococcus granulosus Smad4 0.0069 0.037 0.0376
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0124 0.0308
Echinococcus granulosus expressed protein 0.0087 0.0538 0.0559
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0087 0.0538 0.0787
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0217 0.0194
Brugia malayi RNA binding protein 0.04 0.3397 0.3784
Brugia malayi hypothetical protein 0.0044 0.0146 0.0137
Loa Loa (eye worm) hypothetical protein 0.0112 0.0762 0.0828
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0762 0.1148
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0762 0.1148
Loa Loa (eye worm) MH2 domain-containing protein 0.0069 0.037 0.0389
Schistosoma mansoni alpha-glucosidase 0.0164 0.1245 0.1225
Schistosoma mansoni alpha-glucosidase 0.0164 0.1245 0.1225
Mycobacterium tuberculosis Probable dehydrogenase 0.0221 0.1764 0.2763
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0381 0.0401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0177 0.0173
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.019 0.1481 0.302
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0146 0.0137
Echinococcus granulosus TGF beta signal transducer SmadC 0.0069 0.037 0.0376
Brugia malayi beta-lactamase family protein 0.0112 0.0762 0.0828
Schistosoma mansoni tar DNA-binding protein 0.04 0.3397 0.3382
Loa Loa (eye worm) TAR-binding protein 0.04 0.3397 0.3784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.0505 0.0541
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0103 0.0089
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.0505 0.0483
Mycobacterium ulcerans lipase LipD 0.0112 0.0762 0.1503
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.0505 0.0541
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0103 0.008
Echinococcus multilocularis musashi 0.0108 0.0731 0.071
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0629 0.0607
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0103 0.0089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Schistosoma mansoni smad1 5 8 and 0.0069 0.037 0.0347
Mycobacterium tuberculosis Conserved protein 0.0112 0.0762 0.1148
Onchocerca volvulus 0.0112 0.0762 1
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0762 0.1503
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.02
Schistosoma mansoni ferritin 0.0087 0.0538 0.0516
Echinococcus granulosus lamin dm0 0.0108 0.0731 0.0769
Loa Loa (eye worm) transcription factor SMAD2 0.1007 0.8941 1
Brugia malayi ecdysteroid receptor 0.0083 0.0505 0.0541
Brugia malayi Glycosyl hydrolases family 31 protein 0.0191 0.1488 0.1643
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0505 0.0541
Entamoeba histolytica hypothetical protein 0.0333 0.279 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0552 0.4786 0.4774
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0217 0.0693
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0217 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.013 0.171
Schistosoma mansoni ferritin light chain 0.0087 0.0538 0.0516
Echinococcus granulosus lysosomal alpha glucosidase 0.0191 0.1488 0.159
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.0505 0.0523
Brugia malayi glutathione reductase 0.0097 0.0629 0.0679
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0103 0.008
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0552 0.4786 0.4774
Echinococcus multilocularis tar DNA binding protein 0.04 0.3397 0.3382
Brugia malayi hypothetical protein 0.0039 0.0103 0.0089
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0552 0.4786 1
Brugia malayi Thioredoxin reductase 0.0097 0.0629 0.0679
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.0505 0.0541
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.005 0.0027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.013 0.171
Loa Loa (eye worm) hypothetical protein 0.0552 0.4786 0.5341
Brugia malayi isocitrate dehydrogenase 0.0052 0.0217 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.0505 0.0541
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.0505 0.0483
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0762 0.074
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.0505 0.0523
Schistosoma mansoni thyroid hormone receptor 0.1123 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0505 0.0541
Giardia lamblia GTOR 0.0048 0.0177 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0103 0.0089
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0139 0.0369
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0038 0.0017
Echinococcus granulosus intermediate filament protein 0.0108 0.0731 0.0769
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.0505 0.0483
Echinococcus granulosus smad 0.0069 0.037 0.0376
Trichomonas vaginalis ferritin, putative 0.0087 0.0538 0.7062
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0762 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0052 0.022 0.0214
Brugia malayi Smad1 0.0069 0.037 0.0389
Leishmania major hypothetical protein, conserved 0.0112 0.0762 0.2962
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0089 0.0161
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0177 0.053
Schistosoma mansoni Smad4 0.0069 0.037 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.0505 0.0541
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0505 0.0483
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0058 0.0272 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.013 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0066 0.0867
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0103 0.008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0505 0.0523
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0552 0.4786 1
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0762 1
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0762 0.2962
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0066 0.0867
Schistosoma mansoni tar DNA-binding protein 0.04 0.3397 0.3382
Loa Loa (eye worm) beta-lactamase 0.0112 0.0762 0.0828
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0139 0.0369
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0221 0.1764 0.2763
Loa Loa (eye worm) hypothetical protein 0.0062 0.0306 0.0318
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0191 0.1488 0.1643
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.013 0.0116
Onchocerca volvulus 0.0112 0.0762 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0103 0.008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0217 0.0194
Trypanosoma brucei trypanothione reductase 0.0097 0.0629 0.2409
Onchocerca volvulus 0.0112 0.0762 1
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.0505 0.0483
Loa Loa (eye worm) DR-78 0.0039 0.0103 0.0089
Schistosoma mansoni ferritin light chain 0.0087 0.0538 0.0516
Schistosoma mansoni tar DNA-binding protein 0.04 0.3397 0.3382
Brugia malayi MH1 domain containing protein 0.0038 0.009 0.0075
Loa Loa (eye worm) hypothetical protein 0.0112 0.0762 0.0828
Schistosoma mansoni ferritin 0.0087 0.0538 0.0516
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Brugia malayi steroid hormone receptor 0.0083 0.0505 0.0541
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0087 0.0538 0.0787
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.013 0.171
Loa Loa (eye worm) RNA binding protein 0.04 0.3397 0.3784
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.005 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0066 0.0867
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0217 0.0693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0003 0.0034
Brugia malayi Ets-domain containing protein 0.0072 0.0402 0.0425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.0505 0.0541
Mycobacterium ulcerans bacterioferritin BfrA 0.0087 0.0538 0.103
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0712 0.6252 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.1488 0.1468
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0246 0.1989 0.4036
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.013 0.0334
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0103 0.008
Brugia malayi tailless protein 0.0039 0.0103 0.0089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0676 0.0732
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1171 0.1807
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.0505 0.0483
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0177 0.053
Entamoeba histolytica hypothetical protein 0.0333 0.279 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0762 0.0828
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0505 0.0541
Brugia malayi hypothetical protein 0.0044 0.0146 0.0137
Brugia malayi MH1 domain containing protein 0.0038 0.009 0.0075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.0505 0.0483
Schistosoma mansoni transcription factor LCR-F1 0.0333 0.279 0.2773
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.0505 0.0541
Brugia malayi Inositol-1 0.0043 0.0139 0.013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0146 0.0123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.04 0.3397 0.3784
Brugia malayi MH1 domain containing protein 0.0069 0.037 0.0389
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0177 0.0155
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0629 0.0657
Schistosoma mansoni smad1 5 8 and 0.0069 0.037 0.0347
Schistosoma mansoni nuclear receptor 0.0039 0.0103 0.008
Brugia malayi nuclear receptor RXR 0.0039 0.0103 0.0089
Trichomonas vaginalis esterase, putative 0.0112 0.0762 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Plasmodium falciparum glutathione reductase 0.0097 0.0629 0.1222
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.013 0.012
Echinococcus granulosus ferritin 0.0087 0.0538 0.0559
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0552 0.4786 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0089 0.0161
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0762 0.1418
Echinococcus granulosus lamin 0.0108 0.0731 0.0769
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0139 0.0369
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.005 0.0657
Brugia malayi Intermediate filament tail domain containing protein 0.0108 0.0731 0.0794
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.0505 0.0483
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0139 0.182
Onchocerca volvulus 0.0108 0.0731 0.9587
Entamoeba histolytica hypothetical protein 0.0333 0.279 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0069 0.037 0.0347
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0629 0.0679
Toxoplasma gondii hypothetical protein 0.0048 0.018 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.0505 0.0541
Brugia malayi MH2 domain containing protein 0.1007 0.8941 1
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.005 0.0657
Schistosoma mansoni zinc finger protein 0.0039 0.0103 0.008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0552 0.4786 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.013 0.171
Schistosoma mansoni hypothetical protein 0.007 0.0381 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0066 0.0867
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.2453 1
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.0505 0.0541
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0089
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0038 0.0017
Echinococcus multilocularis lamin 0.0108 0.0731 0.071
Onchocerca volvulus 0.0039 0.0103 0.1076
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1026 0.406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0003 0.0034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0762 0.0828
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0177 0.053
Brugia malayi cytoplasmic intermediate filament protein 0.0058 0.0272 0.028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0038 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0762 0.2962
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0103 0.008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.0505 0.0541
Schistosoma mansoni tar DNA-binding protein 0.04 0.3397 0.3382
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0362 0.3049 0.4835
Loa Loa (eye worm) hypothetical protein 0.0108 0.0731 0.0794
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0505 0.0541
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0139 0.182
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0221 0.1764 0.2763
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0177 0.0177
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0629 0.1222
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0103 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0003 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0066 0.0867
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0124 0.0308
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0069 0.037 0.0347
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0066 0.0034
Leishmania major trypanothione reductase 0.0097 0.0629 0.2409
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.0505 0.0541
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.013 0.012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0108 0.0731 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0025 0.0328
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.019 0.1481 0.302
Treponema pallidum bacterioferrin (TpF1) 0.0087 0.0538 0.103
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0505 0.0541
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0103 0.008
Brugia malayi nuclear receptor NHR-67 0.0039 0.0103 0.0089
Schistosoma mansoni smad1 5 8 and 0.0069 0.037 0.0347
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0333 0.279 0.2773
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0208 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0088 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0177 0.2328
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0139 0.0187
Schistosoma mansoni tar DNA-binding protein 0.04 0.3397 0.3382
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0762 0.0802
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.013 0.0169
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1039 0.9238 0.9236
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Trypanosoma brucei glucosidase, putative 0.0042 0.013 0.0334
Toxoplasma gondii ABC1 family protein 0.0112 0.0762 0.1503
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0217 0.0351
Loa Loa (eye worm) hypothetical protein 0.0083 0.0505 0.0541
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0103 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0103 0.008
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0402 0.0411
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0762 0.1148
Mycobacterium tuberculosis Probable reductase 0.0221 0.1764 0.2763
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.013 0.171
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0362 0.3049 0.6295
Mycobacterium ulcerans hypothetical protein 0.0156 0.1171 0.2366
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0505 0.0541

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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