Detailed information for compound 762394

Basic information

Technical information
  • TDR Targets ID: 762394
  • Name: 2-amino-4-(4-bromophenyl)-7,7-dimethyl-1-morp holin-4-yl-5-oxo-6,8-dihydro-4H-quinoline-3-c arbonitrile
  • MW: 457.364 | Formula: C22H25BrN4O2
  • H donors: 1 H acceptors: 2 LogP: 3.53 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)N(N2CCOCC2)C2=C(C1c1ccc(cc1)Br)C(=O)CC(C2)(C)C
  • InChi: 1S/C22H25BrN4O2/c1-22(2)11-17-20(18(28)12-22)19(14-3-5-15(23)6-4-14)16(13-24)21(25)27(17)26-7-9-29-10-8-26/h3-6,19H,7-12,25H2,1-2H3
  • InChiKey: AOEJMORQEPPZFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(4-bromophenyl)-7,7-dimethyl-1-morpholino-5-oxo-6,8-dihydro-4H-quinoline-3-carbonitrile
  • 2-amino-4-(4-bromophenyl)-5-keto-7,7-dimethyl-1-morpholino-6,8-dihydro-4H-quinoline-3-carbonitrile
  • AN-919/40736440

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0358 0.2398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0343 0.3993
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0417 0.0406
Schistosoma mansoni ferritin 0.0078 0.0725 0.0997
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0141 0.0097
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.0358 0.4211
Schistosoma mansoni Smad4 0.0052 0.04 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0141 0.0105
Mycobacterium leprae conserved hypothetical protein 0.008 0.0749 0.004
Echinococcus granulosus peptidase Clp S14 family 0.0377 0.4417 0.6409
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0624 0.0583
Brugia malayi isocitrate dehydrogenase 0.005 0.0369 0.0354
Mycobacterium ulcerans hypothetical protein 0.008 0.0749 0.0602
Schistosoma mansoni intermediate filament proteins 0.0055 0.044 0.058
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Schistosoma mansoni lamin 0.0055 0.044 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0223 0.222
Brugia malayi hypothetical protein 0.0265 0.3038 0.3266
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0141 0.0141
Plasmodium vivax glutathione reductase, putative 0.014 0.1491 0.1742
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0141 0.0105
Brugia malayi steroid hormone receptor 0.0031 0.0141 0.0105
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.0358 0.1059
Loa Loa (eye worm) hypothetical protein 0.008 0.0749 0.0769
Echinococcus multilocularis Smad4 0.0052 0.04 0.0358
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0624 0.085
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0749 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0141 0.0105
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0575 0.6867 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.005 0.0369 0.115
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.04 0.0389
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0198 0.2206 0.284
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0343 0.03
Loa Loa (eye worm) isocitrate dehydrogenase 0.005 0.0369 0.0354
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.005 0.0369 0.0476
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0575 0.6867 0.6853
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0141 0.0141
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0086 0.0042
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.0358 0.0459
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0141 0.0097
Schistosoma mansoni ferritin 0.0078 0.0725 0.0997
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0193 0.1773
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.288 0.3094
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0624 0.0633
Onchocerca volvulus 0.008 0.0749 1
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0123 0.0086
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0749 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0223 0.222
Echinococcus multilocularis thyroid hormone receptor alpha 0.0418 0.4926 0.4904
Echinococcus multilocularis lamin 0.0055 0.044 0.0398
Loa Loa (eye worm) MH2 domain-containing protein 0.0765 0.921 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0749 0.1034
Brugia malayi beta-lactamase family protein 0.008 0.0749 0.0769
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Toxoplasma gondii ABC1 family protein 0.008 0.0749 0.0834
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0369 0.115
Onchocerca volvulus 0.008 0.0749 1
Echinococcus multilocularis expressed protein 0.0078 0.0725 0.0684
Echinococcus multilocularis isocitrate dehydrogenase 0.005 0.0369 0.0326
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.005 0.0369 0.0018
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.005 0.0369 0.002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.04 0.0522
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0369 0.0326
Mycobacterium ulcerans bacterioferritin BfrA 0.0078 0.0725 0.0564
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0032
Schistosoma mansoni hypothetical protein 0.0387 0.4542 0.6592
Brugia malayi MH2 domain containing protein 0.0052 0.04 0.0389
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0107 0.0506
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0749 0.0708
Loa Loa (eye worm) RNA binding protein 0.0253 0.288 0.3094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0141 0.0105
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0749 1
Brugia malayi Probable ClpP-like protease 0.0575 0.6867 0.7444
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0141 0.0105
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0343 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0749 0.4149
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0141 0.0105
Brugia malayi RNA binding protein 0.0253 0.288 0.3094
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0141 0.0141
Schistosoma mansoni lamin 0.0055 0.044 0.058
Mycobacterium leprae Probable lipase LipE 0.008 0.0749 0.004
Brugia malayi beta-lactamase 0.008 0.0749 0.0769
Brugia malayi MH2 domain containing protein 0.0765 0.921 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0749 0.0769
Schistosoma mansoni smad1 5 8 and 0.0052 0.04 0.0522
Loa Loa (eye worm) hypothetical protein 0.008 0.0749 0.0769
Brugia malayi MH1 domain containing protein 0.0029 0.0113 0.0075
Brugia malayi Smad1 0.0052 0.04 0.0389
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0078 0.0725 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0193 0.1773
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0141 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.0178
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0358 0.1059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0141 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0343 0.3993
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0749 0.0769
Trichomonas vaginalis esterase, putative 0.008 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Entamoeba histolytica hypothetical protein 0.0265 0.3038 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.032 0.3714 0.5844
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.1491 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0749 0.0682
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.288 0.3094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0141 0.0097
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0387 0.4542 0.4518
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0141 0.0097
Schistosoma mansoni ets-related 0.0213 0.2391 0.344
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0141 0.0105
Mycobacterium ulcerans bacterioferritin BfrB 0.0078 0.0725 0.0564
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.032 0.3714 0.4867
Treponema pallidum bacterioferrin (TpF1) 0.0078 0.0725 0.0564
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Brugia malayi MH1 domain containing protein 0.0052 0.04 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0749 0.4149
Schistosoma mansoni smad 0.0052 0.04 0.0522
Toxoplasma gondii hypothetical protein 0.0198 0.2206 0.3017
Loa Loa (eye worm) intermediate filament protein 0.0055 0.044 0.0432
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0198 0.0168
Schistosoma mansoni transcription factor LCR-F1 0.0265 0.3038 0.4388
Echinococcus multilocularis smad 0.0052 0.04 0.0358
Schistosoma mansoni gabp alpha 0.007 0.0624 0.085
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.0358 0.0247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0417 0.0406
Echinococcus multilocularis thioredoxin glutathione reductase 0.0141 0.1499 0.1461
Brugia malayi Ets-domain containing protein 0.007 0.0624 0.0633
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0141 0.0141
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0749 0.0682
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0141 0.1366
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.032 0.3714 0.5844
Schistosoma mansoni hypothetical protein 0.0265 0.3038 0.4388
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0749 0.0682
Mycobacterium tuberculosis Putative ferredoxin reductase 0.032 0.3714 0.5844
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0198 0.2206 0.284
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0749 0.0682
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.044 0.0432
Echinococcus multilocularis peptidase Clp (S14 family) 0.0377 0.4417 0.4393
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0343 0.0943
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0387 0.4542 0.6592
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0343 0.2299
Loa Loa (eye worm) glutathione reductase 0.014 0.1491 0.1579
Schistosoma mansoni ferritin 0.0078 0.0725 0.0997
Loa Loa (eye worm) hypothetical protein 0.008 0.0749 0.0769
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Echinococcus granulosus intermediate filament protein 0.0055 0.044 0.058
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0343 0.0943
Schistosoma mansoni ferritin light chain 0.0078 0.0725 0.0997
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0107 0.0506
Mycobacterium tuberculosis Conserved protein 0.008 0.0749 0.0682
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.04 0.0358
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0141 0.0105
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0034 0.0226
Mycobacterium tuberculosis Conserved protein 0.008 0.0749 0.0682
Mycobacterium ulcerans lipase LipD 0.008 0.0749 0.0602
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0749 0.5025
Trypanosoma brucei isocitrate dehydrogenase, putative 0.005 0.0369 0.2475
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0369 0.0264
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0749 1
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.0358 0.4211
Echinococcus multilocularis lamin dm0 0.0055 0.044 0.0398
Entamoeba histolytica hypothetical protein 0.0265 0.3038 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.04 0.0522
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.0369 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0141 0.0105
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0369 0.115
Trypanosoma brucei trypanothione reductase 0.014 0.1491 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0046
Schistosoma mansoni apoferritin-2 0.0078 0.0725 0.0997
Brugia malayi Thioredoxin reductase 0.014 0.1491 0.1579
Echinococcus granulosus lamin dm0 0.0055 0.044 0.058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0141 0.0105
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0356 0.4156 0.6613
Schistosoma mansoni tar DNA-binding protein 0.0253 0.288 0.4156
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0141 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0141 0.0141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0417 0.0406
Brugia malayi ecdysteroid receptor 0.0031 0.0141 0.0105
Brugia malayi MH1 domain containing protein 0.0029 0.0113 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0343 0.0943
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0358 0.1059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0141 0.0141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0358 0.2398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0141 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0141 0.0105
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.005 0.0369 0.0476
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0749 0.0682
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0749 0.0682
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0032
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0575 0.6867 1
Loa Loa (eye worm) TAR-binding protein 0.0253 0.288 0.3094
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0141 0.0105
Loa Loa (eye worm) fli-1 protein 0.0213 0.2391 0.2561
Entamoeba histolytica hypothetical protein 0.0265 0.3038 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0749 0.0769
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0123 0.0086
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0198 0.2206 0.284
Mycobacterium tuberculosis Probable oxidoreductase 0.0356 0.4156 0.6613
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0075
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0141 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0223 0.222
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.04 0.0522
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0141 0.0141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0141 0.0141
Mycobacterium tuberculosis Conserved protein 0.008 0.0749 0.0682
Brugia malayi glutathione reductase 0.014 0.1491 0.1579
Loa Loa (eye worm) hypothetical protein 0.0053 0.0417 0.0406
Loa Loa (eye worm) hypothetical protein 0.0575 0.6867 0.7444
Plasmodium falciparum thioredoxin reductase 0.014 0.1491 0.1742
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0223 0.222
Loa Loa (eye worm) thioredoxin reductase 0.014 0.1491 0.1579
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0078 0.0725 0.0639
Plasmodium vivax thioredoxin reductase, putative 0.014 0.1491 0.1742
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0208 0.0178
Brugia malayi TAR-binding protein 0.0253 0.288 0.3094
Brugia malayi MH1 domain containing protein 0.0052 0.04 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Loa Loa (eye worm) hypothetical protein 0.0054 0.0428 0.0418
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.0358 0.1059
Loa Loa (eye worm) hypothetical protein 0.0055 0.044 0.0432
Schistosoma mansoni thyroid hormone receptor 0.0418 0.4926 0.7155
Schistosoma mansoni coup transcription factor 0.0031 0.0141 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0749 0.1034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0141 0.0141
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.0358 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0141 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0253 0.288 0.4156
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.005 0.0369 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.044 0.0432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0141 0.0105
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0377 0.4417 0.6012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0141 0.0097
Mycobacterium tuberculosis Probable dehydrogenase 0.032 0.3714 0.5844
Schistosoma mansoni ferritin 0.0078 0.0725 0.0997
Loa Loa (eye worm) Smad1 0.0052 0.04 0.0389
Schistosoma mansoni smad1 5 8 and 0.0052 0.04 0.0522
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0141 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0749 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0103 0.0455
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.0358 0.0247
Echinococcus granulosus Smad4 0.0052 0.04 0.0522
Loa Loa (eye worm) hypothetical protein 0.006 0.0498 0.0496
Leishmania major trypanothione reductase 0.014 0.1491 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.032 0.3714 0.5844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0193 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.015 0.114
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0513 0.6101 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0141 0.0105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0141 0.0105
Brugia malayi MH2 domain containing protein 0.0052 0.04 0.0389
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0749 0.0682
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0105
Schistosoma mansoni smad1 5 8 and 0.0052 0.04 0.0522
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0141 0.0097
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Echinococcus multilocularis ferritin 0.0078 0.0725 0.0684
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0223 0.1498
Loa Loa (eye worm) transcription factor SMAD2 0.0765 0.921 1
Onchocerca volvulus 0.0031 0.0141 0.1366
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0343 0.0943
Brugia malayi beta-lactamase family protein 0.008 0.0749 0.0769
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.0358 0.0459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0141 0.0105
Echinococcus granulosus tar DNA binding protein 0.0253 0.288 0.4156
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0141 0.1366
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.0358 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0141 0.0105
Schistosoma mansoni ferritin light chain 0.0078 0.0725 0.0997
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0137 0.0953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0223 0.222
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.0369 0.2475
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0141 0.1366
Echinococcus granulosus ferritin 0.0078 0.0725 0.0997
Mycobacterium ulcerans beta-lactamase 0.008 0.0749 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0343 0.3993
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0265 0.3038 0.3007
Loa Loa (eye worm) nuclear factor I 0.0029 0.0113 0.0075
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0575 0.6867 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0377 0.4417 0.7069
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0343 0.0438
Plasmodium falciparum glutathione reductase 0.014 0.1491 0.1742
Schistosoma mansoni apoferritin-2 0.0078 0.0725 0.0997
Brugia malayi Fli-1 protein 0.0213 0.2391 0.2561
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0749 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0193 0.1773
Loa Loa (eye worm) hypothetical protein 0.008 0.0749 0.0769
Brugia malayi Isocitrate dehydrogenase 0.005 0.0369 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0103 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0107 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0253 0.288 0.4156
Onchocerca volvulus 0.0055 0.044 0.5614
Loa Loa (eye worm) beta-lactamase 0.008 0.0749 0.0769
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.04 0.0358
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0198 0.0168
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0343 0.0326
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0749 0.1034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Schistosoma mansoni tar DNA-binding protein 0.0253 0.288 0.4156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0193 0.1773
Plasmodium vivax hypothetical protein, conserved 0.008 0.0749 0.0602
Brugia malayi intermediate filament protein 0.0055 0.044 0.0432
Entamoeba histolytica hypothetical protein 0.0265 0.3038 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0193 0.1773
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.0358 0.2398
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0141 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.0007
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0078 0.0725 0.0639
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.04 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0141 0.0105
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0086 0.0062
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Toxoplasma gondii thioredoxin reductase 0.014 0.1491 0.1946
Schistosoma mansoni thyroid hormone receptor 0.0418 0.4926 0.7155
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0141 0.0141
Echinococcus granulosus thioredoxin glutathione reductase 0.0141 0.1499 0.2132
Echinococcus multilocularis musashi 0.0055 0.044 0.0398
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0356 0.4156 0.6613
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0141 0.0105
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0198 0.2206 0.2412
Echinococcus granulosus smad 0.0052 0.04 0.0522
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0141 0.0141
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.0358 0.2398
Onchocerca volvulus 0.008 0.0749 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0575 0.6867 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0369 0.0326
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0377 0.4417 0.7069
Brugia malayi nuclear receptor NHR-88 0.0031 0.0141 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0253 0.288 0.4156
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0749 1
Schistosoma mansoni hypothetical protein 0.0037 0.0208 0.024
Echinococcus granulosus lamin 0.0055 0.044 0.058
Echinococcus multilocularis tar DNA binding protein 0.0253 0.288 0.2848
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0141 0.0105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0141 0.0141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0358 0.1059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0193 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.0007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.014 0.1491 0.1974
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0141 0.0141
Onchocerca volvulus 0.0055 0.044 0.5614
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0356 0.4156 0.5586
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0575 0.6867 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0265 0.3038 0.4388
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0141 0.0141
Trichomonas vaginalis ferritin, putative 0.0078 0.0725 0.9635
Loa Loa (eye worm) hypothetical protein 0.008 0.0749 0.0769
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.0369 0.0326
Leishmania major hypothetical protein, conserved 0.008 0.0749 0.4149
Mycobacterium tuberculosis Probable reductase 0.032 0.3714 0.5844
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0141 0.0141
Echinococcus granulosus expressed protein 0.0078 0.0725 0.0997
Brugia malayi nuclear hormone receptor 0.0031 0.0141 0.0105
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.005 0.0369 0.0326
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0343 0.0326
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0343 0.2299
Schistosoma mansoni peptidase Clp (S14 family) 0.0575 0.6867 1
Brugia malayi Ets-domain containing protein 0.007 0.0624 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0141 0.0105
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.0358 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0358 0.1059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0257 0.2726
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0141 0.0097

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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