Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0027 | 0.0231 | 0.0777 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0725 | 0.2442 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0434 | 0.0269 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0323 | 0.0157 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.2766 | 0.2641 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0434 | 0.0844 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.1296 | 0.1936 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.6697 | 0.664 |
Onchocerca volvulus | 0.0031 | 0.0323 | 0.2463 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2766 | 0.413 |
Echinococcus granulosus | lamin | 0.0027 | 0.0231 | 0.0805 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0434 | 0.1231 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.2716 | 0.4055 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.5138 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0024 | 0.0169 | 0.0253 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.1296 | 0.4527 |
Echinococcus multilocularis | GPCR, family 2 | 0.0132 | 0.2864 | 0.9646 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0079 | 0.1524 | 0.5134 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.1296 | 1 |
Schistosoma mansoni | smad | 0.0024 | 0.0169 | 0.0253 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2766 | 0.413 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0079 | 0.1524 | 0.5322 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0231 | 0.0805 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0434 | 0.1726 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.2217 | 0.4314 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.2969 | 0.4433 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0132 | 0.2864 | 0.9646 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0434 | 0.3346 |
Brugia malayi | Fli-1 protein | 0.0239 | 0.5522 | 0.5445 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0434 | 0.0648 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.2217 | 0.4314 |
Onchocerca volvulus | 0.0035 | 0.0434 | 0.539 | |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0434 | 0.1231 |
Schistosoma mansoni | ets-related | 0.0239 | 0.5522 | 0.8245 |
Schistosoma mansoni | hypothetical protein | 0.0286 | 0.6697 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.085 | 0.0626 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0132 | 0.2864 | 0.2741 |
Loa Loa (eye worm) | hypothetical protein | 0.0418 | 1 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0434 | 0.3346 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0302 | 0.7084 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.2513 | 0.4891 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0132 | 0.2864 | 0.2741 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1239 | 0.1089 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0358 | 0.8492 | 0.8466 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.2864 | 0.2741 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.2766 | 0.9316 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0434 | 0.0269 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.2716 | 0.9482 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.2864 | 0.4276 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.2766 | 0.2641 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.025 | 0.1925 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.2217 | 0.4314 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0231 | 0.0344 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0434 | 0.1461 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0231 | 0.0062 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.3121 | 0.4041 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.2864 | 0.4276 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.1296 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0024 | 0.0169 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0434 | 0.0269 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0608 | 0.4686 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.3121 | 0.4041 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0534 | 0.4117 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.2217 | 0.4314 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0434 | 0.3346 |
Onchocerca volvulus | 0.0035 | 0.0434 | 0.539 | |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0434 | 0.0269 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.3524 | 0.6858 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0132 | 0.2864 | 0.9646 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0434 | 0.0269 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0725 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0218 | 0.005 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.1296 | 0.4366 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.025 | 0.1925 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.1296 | 0.4527 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0079 | 0.1524 | 0.1378 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0725 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0434 | 0.0269 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.2217 | 0.4314 |
Echinococcus multilocularis | Smad4 | 0.0024 | 0.0169 | 0.057 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0286 | 0.6697 | 0.664 |
Brugia malayi | Ets-domain containing protein | 0.0079 | 0.1524 | 0.1378 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0534 | 0.0371 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0725 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0608 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.3524 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0434 | 0.0844 |
Schistosoma mansoni | smad1 5 8 and | 0.0024 | 0.0169 | 0.0253 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0434 | 0.1231 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0302 | 0.7084 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 0.7084 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0358 | 0.8492 | 0.8466 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0358 | 0.8492 | 0.8466 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.2766 | 0.2641 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0231 | 0.0805 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0434 | 0.0269 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0132 | 0.2864 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0434 | 0.0269 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0132 | 0.2864 | 0.2741 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0434 | 0.0269 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0231 | 0.0777 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.3121 | 0.4041 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0434 | 0.3346 |
Brugia malayi | RNA binding protein | 0.0128 | 0.2766 | 0.2641 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.2864 | 0.4276 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.2513 | 0.4891 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0434 | 0.0648 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0725 | 0.8557 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.2969 | 0.4433 |
Loa Loa (eye worm) | fli-1 protein | 0.0239 | 0.5522 | 0.5445 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.2513 | 0.4891 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0434 | 0.0844 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0434 | 0.0844 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0725 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0434 | 0.1231 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0434 | 0.0844 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0434 | 0.0269 |
Schistosoma mansoni | lamin | 0.0027 | 0.0231 | 0.0344 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.1296 | 0.1146 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.1296 | 0.1146 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0434 | 0.1515 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0137 | 0.2969 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0725 | 0.1411 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.2766 | 0.2641 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0725 | 0.0438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2766 | 0.413 |
Echinococcus multilocularis | smad | 0.0024 | 0.0169 | 0.057 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.1296 | 0.4366 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.2217 | 0.4314 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0619 | 0.0278 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0024 | 0.0169 | 0.0591 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0024 | 0.0169 | 0.057 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0231 | 0.0062 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0619 | 0.0278 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0434 | 0.0844 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2766 | 0.413 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.2513 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0418 | 1 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0024 | 0.0169 | 0.057 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0725 | 0.0565 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0434 | 0.3346 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0434 | 0.0269 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0608 | 0.4686 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0619 | 0.0278 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0725 | 0.0438 |
Schistosoma mansoni | Smad4 | 0.0024 | 0.0169 | 0.0253 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0534 | 0.4117 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0725 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0725 | 0.2532 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0725 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0534 | 0.804 |
Brugia malayi | follicle stimulating hormone receptor | 0.0231 | 0.533 | 0.525 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.2217 | 0.8821 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0024 | 0.0169 | 0.0591 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0231 | 0.533 | 0.525 |
Schistosoma mansoni | gabp alpha | 0.0079 | 0.1524 | 0.2276 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0231 | 0.0062 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0418 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0024 | 0.0169 | 0.0253 |
Brugia malayi | Ets-domain containing protein | 0.0079 | 0.1524 | 0.1378 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0434 | 0.0844 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.1296 | 0.1936 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0434 | 0.3346 |
Echinococcus granulosus | GPCR family 2 | 0.0132 | 0.2864 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.2766 | 0.9658 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0434 | 0.0844 |
Onchocerca volvulus | 0.0035 | 0.0434 | 0.539 | |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0725 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0534 | 0.0371 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0132 | 0.2864 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0619 | 0.0278 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0231 | 0.0777 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0434 | 0.0844 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0725 | 0.0565 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0434 | 0.0269 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.2766 | 0.2641 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.2766 | 0.413 |
Echinococcus granulosus | smad | 0.0024 | 0.0169 | 0.0591 |
Echinococcus granulosus | Smad4 | 0.0024 | 0.0169 | 0.0591 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0434 | 0.1726 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0231 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.2864 | 0.4276 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0434 | 0.1231 |
Schistosoma mansoni | lamin | 0.0027 | 0.0231 | 0.0344 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 0.7084 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0434 | 0.0844 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.2716 | 0.9147 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0231 | 0.0062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.