Detailed information for compound 762447

Basic information

Technical information
  • TDR Targets ID: 762447
  • Name: 1-(4-ethoxyphenyl)sulfonylbenzotriazole
  • MW: 303.336 | Formula: C14H13N3O3S
  • H donors: 0 H acceptors: 4 LogP: 2.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)S(=O)(=O)n1nnc2c1cccc2
  • InChi: 1S/C14H13N3O3S/c1-2-20-11-7-9-12(10-8-11)21(18,19)17-14-6-4-3-5-13(14)15-16-17/h3-10H,2H2,1H3
  • InChiKey: LRKPYRLXJHFTRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_463848
  • Oprea1_363964
  • ZINC02501811
  • T5579994

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi TAR-binding protein 0.0263 0.3682 1
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0941 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.0941 0.2556
Loa Loa (eye worm) hypothetical protein 0.0077 0.0941 0.2556
Schistosoma mansoni tar DNA-binding protein 0.0263 0.3682 0.3544
Brugia malayi beta-lactamase family protein 0.0077 0.0941 0.2512
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0941 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1692 0.4597
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0941 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0213 0.0522
Loa Loa (eye worm) beta-lactamase 0.0077 0.0941 0.2556
Loa Loa (eye worm) hypothetical protein 0.0077 0.0941 0.2556
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0941 0.0744
Onchocerca volvulus 0.0077 0.0941 1
Mycobacterium leprae Probable lipase LipE 0.0077 0.0941 0.5
Schistosoma mansoni tar DNA-binding protein 0.0263 0.3682 0.3544
Onchocerca volvulus 0.0077 0.0941 1
Echinococcus multilocularis lamin dm0 0.0028 0.0213 0.0213
Echinococcus multilocularis microtubule associated protein 2 0.0691 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0941 0.0941
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.7082 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0941 0.5
Schistosoma mansoni microtubule-associated protein tau 0.0691 1 1
Schistosoma mansoni tar DNA-binding protein 0.0263 0.3682 0.3544
Onchocerca volvulus 0.0077 0.0941 1
Echinococcus multilocularis musashi 0.0028 0.0213 0.0213
Toxoplasma gondii ABC1 family protein 0.0077 0.0941 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0941 0.5
Brugia malayi intermediate filament protein 0.0028 0.0213 0.0522
Brugia malayi RNA binding protein 0.0263 0.3682 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0263 0.3682 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0941 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0941 0.2512
Brugia malayi beta-lactamase 0.0077 0.0941 0.2512
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0941 0.0941
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0213 0.0578
Loa Loa (eye worm) TAR-binding protein 0.0263 0.3682 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0941 0.2556
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0941 0.0744
Loa Loa (eye worm) hypothetical protein 0.0077 0.0941 0.2556
Loa Loa (eye worm) hypothetical protein 0.0028 0.0213 0.0578
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0941 0.5
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0941 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0263 0.3682 1
Mycobacterium ulcerans hypothetical protein 0.0077 0.0941 0.5
Echinococcus multilocularis tar DNA binding protein 0.0263 0.3682 0.3682
Mycobacterium ulcerans lipase LipD 0.0077 0.0941 0.5
Echinococcus granulosus intermediate filament protein 0.0028 0.0213 0.0213
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0941 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0941 0.2556
Loa Loa (eye worm) hypothetical protein 0.0077 0.0941 0.2556
Trichomonas vaginalis esterase, putative 0.0077 0.0941 0.5
Schistosoma mansoni tar DNA-binding protein 0.0263 0.3682 0.3544
Echinococcus multilocularis lamin 0.0028 0.0213 0.0213
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1692 0.4597
Loa Loa (eye worm) RNA binding protein 0.0263 0.3682 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0022 0.0059
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0213 0.0578
Brugia malayi beta-lactamase family protein 0.0077 0.0941 0.2512
Brugia malayi MH2 domain containing protein 0.0128 0.1692 0.4564
Schistosoma mansoni tar DNA-binding protein 0.0263 0.3682 0.3544
Leishmania major hypothetical protein, conserved 0.0077 0.0941 0.5
Echinococcus granulosus lamin 0.0028 0.0213 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0941 0.5
Echinococcus granulosus lamin dm0 0.0028 0.0213 0.0213
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0941 0.5
Mycobacterium ulcerans beta-lactamase 0.0077 0.0941 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0941 0.5
Echinococcus granulosus tar DNA binding protein 0.0263 0.3682 0.3682
Loa Loa (eye worm) hypothetical protein 0.0027 0.0205 0.0558

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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