TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 298.318 | Formula: C11H14N4O4S
H donors: 1 H acceptors: 5 LogP: -0.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCCS(=O)(=O)c1cccc2c1[n+]([O-])nc([n+]2[O-])N
InChi: 1S/C11H14N4O4S/c1-2-3-7-20(18,19)9-6-4-5-8-10(9)15(17)13-11(12)14(8)16/h4-6H,2-3,7H2,1H3,(H2,12,13)
InChiKey: LFWIGDFMGQLTGB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0196	0.0209
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0059	0.2134	0.2134
Loa Loa (eye worm)	hypothetical protein	0.004	0.1156	0.1229
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.011	0.4732	0.9555
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0024	0.0359	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0059	0.2134	0.2134
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0024	0.0359	0.0523
Schistosoma mansoni	amidase	0.0202	0.9405	0.9405
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0059	0.2134	0.2134
Echinococcus granulosus	FTZ F1 alpha	0.0059	0.2134	0.2134
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0059	0.2134	0.2269
Echinococcus multilocularis	FTZ F1 alpha	0.0059	0.2134	0.2134
Brugia malayi	nuclear receptor NHR-88	0.0028	0.054	0.0575
Schistosoma mansoni	loxhd1	0.0021	0.0196	0.0196
Schistosoma mansoni	nuclear hormone receptor	0.0059	0.2134	0.2134
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0059	0.2134	0.2269
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0711	0.0711
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0078	0.3092	0.6305
Brugia malayi	Amidase family protein	0.0024	0.0359	0.0381
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0059	0.2134	0.2269
Loa Loa (eye worm)	phosphatidylinositol 3	0.0035	0.0882	0.0938
Onchocerca volvulus	Protein ultraspiracle homolog	0.0059	0.2134	1
Schistosoma mansoni	polycystin 1-related	0.0021	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Schistosoma mansoni	lipoxygenase	0.0021	0.0196	0.0196
Onchocerca volvulus		0.0028	0.054	0.2533
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0059	0.2134	0.2134
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0711	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0059	0.2134	0.2269
Loa Loa (eye worm)	nuclear hormone receptor	0.0028	0.054	0.0575
Brugia malayi	Nuclear hormone receptor E75	0.0028	0.054	0.0575
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0038	0.1053	0.1053
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0028	0.054	0.0575
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0059	0.2134	0.2269
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0161	0.7289	0.7289
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0196	0.0209
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0711	0.0756
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.054	0.054
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0059	0.2134	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0711	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.5471	0.5471
Schistosoma mansoni	fatty-acid amide hydrolase	0.0202	0.9405	0.9405
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0059	0.2138	0.2138
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0059	0.2134	0.2134
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0202	0.9405	0.9405
Brugia malayi	conserved hypotetical protein	0.0028	0.054	0.0575
Brugia malayi	nuclear receptor RXR	0.0028	0.054	0.0575
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0059	0.2134	0.2134
Brugia malayi	hypothetical protein	0.0031	0.0711	0.0756
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0196	0.0196
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0059	0.2134	0.2134
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.054	0.054
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.004	0.1141	0.0227
Schistosoma mansoni	RAR-like nuclear receptor	0.0059	0.2134	0.2134
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0059	0.2134	0.2134
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0024	0.0359	0.0523
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0114	0.4904	0.5214
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0028	0.054	0.054
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0059	0.2134	0.2134
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0059	0.2134	0.2134
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0038	0.1053	0.8882
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0028	0.054	0.0575
Schistosoma mansoni	rab6-interacting	0.0021	0.0196	0.0196
Brugia malayi	photoreceptor-specific nuclear receptor	0.0059	0.2134	0.2269
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0078	0.3092	0.6305
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.1141	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0196	0.0196
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0114	0.4904	1
Brugia malayi	ecdysone receptor	0.0028	0.054	0.0575
Brugia malayi	tailless protein	0.0028	0.054	0.0575
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0024	0.0359	0.0523
Brugia malayi	Doublecortin family protein	0.0021	0.0196	0.0209
Mycobacterium ulcerans	carboxylesterase, LipT	0.0152	0.6859	1
Onchocerca volvulus		0.0021	0.0196	0.092
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.1141	0.2326
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.054	0.054
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0214	1	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0196	0.0196
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0196	0.0196
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0038	0.1053	0.2148
Echinococcus granulosus	ubiquitin specific protease 41	0.004	0.1141	0.1141
Brugia malayi	Steroid receptor seven-up type 2	0.0059	0.2134	0.2269
Schistosoma mansoni	zinc finger protein	0.0028	0.054	0.054
Schistosoma mansoni	rab6-interacting	0.0021	0.0196	0.0196
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0024	0.0359	0.0359
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.5471	0.5471
Brugia malayi	Nuclear hormone receptor E75	0.0028	0.054	0.0575
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.01	0.4214	0.448
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.004	0.1141	0.1213
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.004	0.1141	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0059	0.2134	0.2269
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.054	0.054
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0031	0.0711	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0059	0.2134	0.2269
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0055	0.191	1
Schistosoma mansoni	lipoxygenase	0.0059	0.2138	0.2138
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0202	0.9405	0.9405
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0059	0.2134	0.2269
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0024	0.0359	0.0359
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.054	0.054
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0035	0.0882	0.1151
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.054	0.054
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0184	0.8486	0.8486
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0114	0.4904	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0191	0.8818	0.9376
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.054	0.054
Loa Loa (eye worm)	steroid hormone receptor	0.0059	0.2134	0.2269
Brugia malayi	nuclear hormone receptor	0.0028	0.054	0.0575
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0024	0.0359	0.0359
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0114	0.4904	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Brugia malayi	amidase	0.0202	0.9405	1
Onchocerca volvulus		0.0028	0.054	0.2533
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1141	0.2326
Loa Loa (eye worm)	DR-78	0.0028	0.054	0.0575
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0059	0.2134	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0059	0.2134	0.2269
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0028	0.054	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Echinococcus multilocularis	nuclear receptor nhr 48	0.0028	0.054	0.054
Brugia malayi	hypothetical protein	0.0028	0.054	0.0575
Loa Loa (eye worm)	hypothetical protein	0.004	0.1141	0.1213
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.004	0.1141	0.1141
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0114	0.4904	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0059	0.2134	0.2134
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0059	0.2134	0.2269
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0059	0.2134	0.2269
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.1141	0.172
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0059	0.2134	0.2134
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0024	0.0359	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0059	0.2134	0.2134
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0196	0.0196
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0074	0.2865	0.3046
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.004	0.1141	0.1141
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0091	0.3722	0.6931
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0711	0.0756
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0028	0.054	0.054
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0028	0.054	0.054
Echinococcus granulosus	thyroid hormone receptor alpha	0.0028	0.054	0.054
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0711	0.0756
Brugia malayi	nuclear receptor RXR	0.0031	0.0711	0.0756
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.2134	0.2269
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0202	0.9405	0.9405
Loa Loa (eye worm)	hypothetical protein	0.0202	0.9405	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0059	0.2134	0.2269
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0024	0.0359	0.0359
Echinococcus multilocularis	RUN	0.0021	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0024	0.0359	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0059	0.2134	0.2134
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0059	0.2138	0.2138
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0059	0.2134	0.2269
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0059	0.2134	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Echinococcus multilocularis	ubiquitin specific protease 41	0.004	0.1141	0.1141
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0059	0.2134	0.2269
Brugia malayi	hypothetical protein	0.0021	0.0196	0.0209
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.004	0.1141	0.1141
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0059	0.2134	0.2269
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0024	0.0359	0.0523
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0038	0.1053	0.2148
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.054	0.054
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.004	0.1141	0.1141
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0059	0.2134	0.2134
Schistosoma mansoni	tyrosine kinase	0.0158	0.7144	0.7144
Echinococcus granulosus	RUN	0.0021	0.0196	0.0196
Brugia malayi	nuclear receptor NHR-67	0.0028	0.054	0.0575
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0028	0.054	0.0575
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0031	0.0711	0.0756
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0059	0.2134	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0059	0.2134	0.2134
Brugia malayi	nuclear receptor NHR-88	0.0059	0.2134	0.2269
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0214	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0059	0.2134	0.2134
Brugia malayi	Amidase family protein	0.0024	0.0359	0.0381
Onchocerca volvulus	Bile acid receptor homolog	0.0059	0.2134	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0074	0.2865	0.2865
Brugia malayi	nuclear hormone receptor family member odr-7	0.0028	0.054	0.0575
Schistosoma mansoni	thyroid hormone receptor	0.0184	0.8486	0.8486
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0038	0.1053	0.2148
Brugia malayi	nuclear hormone receptor	0.0059	0.2134	0.2269
Schistosoma mansoni	hypothetical protein	0.0125	0.5471	0.5471
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.004	0.1141	0.4654
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Schistosoma mansoni	hypothetical protein	0.0021	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0711	0.0756
Schistosoma mansoni	fatty-acid amide hydrolase	0.0024	0.0359	0.0359
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0114	0.4904	1
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0024	0.0359	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0059	0.2134	0.2134
Echinococcus granulosus	nuclear receptor nhr 48	0.0028	0.054	0.054
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0038	0.1053	0.1528
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0038	0.1053	0.112
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0196	0.0209
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.1141	0.172
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0031	0.0711	0.0711
Schistosoma mansoni	nuclear receptor nhr-48	0.0028	0.054	0.054
Loa Loa (eye worm)	amidase	0.0024	0.0359	0.0381
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0059	0.2134	0.2269
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0024	0.0359	0.5
Schistosoma mansoni	coup transcription factor	0.0059	0.2134	0.2134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0059	0.2134	0.2269
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0074	0.2865	0.2865
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0024	0.0359	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.004	0.1141	0.1141
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.005	0.1683	0.1637
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.1141	0.2326
Onchocerca volvulus		0.0059	0.2134	1
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0024	0.0359	0.0359
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0028	0.054	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0074	0.2865	0.3046
Brugia malayi	orphan nuclear receptor NR2E1	0.0028	0.054	0.0575
Loa Loa (eye worm)	amidase	0.0024	0.0359	0.0381
Entamoeba histolytica	hypothetical protein	0.0091	0.3722	0.6931
Brugia malayi	hypothetical protein	0.0028	0.054	0.0575
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0028	0.054	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0196	0.0196
Brugia malayi	putative amidase	0.0024	0.0359	0.0381
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0059	0.2134	0.2269
Brugia malayi	steroid hormone receptor	0.0059	0.2134	0.2269
Brugia malayi	hypothetical protein	0.0021	0.0196	0.0209
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0031	0.0711	0.0711
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0024	0.0359	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0059	0.2134	0.2269
Schistosoma mansoni	nuclear receptor	0.0028	0.054	0.054
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0114	0.4904	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0059	0.2134	0.2134
Brugia malayi	hypothetical protein	0.0031	0.0711	0.0756
Onchocerca volvulus		0.0021	0.0196	0.092
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Schistosoma mansoni	retinoic acid receptor RXR	0.0059	0.2134	0.2134
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0161	0.7289	0.7289
Loa Loa (eye worm)	hypothetical protein	0.0028	0.054	0.0575
Brugia malayi	ecdysteroid receptor	0.0059	0.2134	0.2269
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.004	0.1141	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0711	0.0756
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0059	0.2134	0.2269
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0024	0.0359	0.0523
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0028	0.054	0.054
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0202	0.9405	0.9405
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0152	0.6859	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0028	0.054	0.054
Schistosoma mansoni	nuclear receptor	0.0028	0.054	0.054
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2134	0.2269
Schistosoma mansoni	thyroid hormone receptor	0.0184	0.8486	0.8486

Activities

Activity type	Activity value	Assay description	Source	Reference
C10 (functional)	= 8.31 uM	Concentration required to reduce plating efficiency to 10 percent of controls, under hypoxic conditions in mouse SCCVII tumor cells.	ChEMBL.	12502371
C10 (functional)	= 175 uM	Concentration required to reduce plating efficiency to 10 percent of controls, under aerobic conditions in mouse SCCVII tumor cells.	ChEMBL.	12502371
HCR (functional)	= 21.1	Intraexperimental difference between the hypoxic and aerobic cytotoxicity	ChEMBL.	12502371
RHT (functional)	= 1.2	Intraexperimental ratio of hypoxic TPZ C10 to hypoxic BTO C10 in mouse SCCVII tumor cells.	ChEMBL.	12502371

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 76309