Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1982 | 0.563 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1982 | 0.1982 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1982 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1982 | 0.563 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.1982 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.1472 | 0.418 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.352 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.352 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.1472 | 0.418 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1982 | 0.4959 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1472 | 0.3287 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0016 | 0.1472 | 0.3287 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.1472 | 0.418 |
Echinococcus granulosus | lamin | 0.0027 | 0.352 | 1 |
Onchocerca volvulus | 0.0016 | 0.1472 | 0.3287 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0048 | 0.7525 | 0.7525 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1982 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3427 | 0.9695 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1982 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.089 | 0.1382 |
Onchocerca volvulus | 0.0016 | 0.1472 | 0.3287 | |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.1472 | 0.7425 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.1982 | 0.0598 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1982 | 0.1982 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.352 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0016 | 0.1472 | 0.418 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0011 | 0.0468 | 0.2363 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.116 | 0.3295 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.1472 | 0.418 |
Onchocerca volvulus | 0.0016 | 0.1472 | 0.3287 | |
Entamoeba histolytica | cysteine protease, putative | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.1472 | 0.418 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.1472 | 0.418 |
Onchocerca volvulus | Cathepsin F homolog | 0.0016 | 0.1472 | 0.3287 |
Onchocerca volvulus | 0.0016 | 0.1472 | 0.3287 | |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0468 | 0.133 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.352 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.1982 | 0.1982 |
Schistosoma mansoni | lamin | 0.0027 | 0.352 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.1472 | 0.7425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.352 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.352 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0011 | 0.0468 | 0.133 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0016 | 0.1472 | 0.7425 |
Onchocerca volvulus | 0.0016 | 0.1472 | 0.3287 | |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.1472 | 0.418 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.1472 | 0.418 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.1472 | 0.418 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.116 | 0.2266 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.1472 | 0.418 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1982 | 0.563 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Echinococcus granulosus | cathepsin l1 | 0.0011 | 0.0468 | 0.133 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.1472 | 0.3287 |
Schistosoma mansoni | lamin | 0.0027 | 0.352 | 1 |
Onchocerca volvulus | 0.0016 | 0.1472 | 0.3287 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.1982 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1982 | 0.563 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0016 | 0.1472 | 0.7425 |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.1472 | 0.7425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0016 | 0.1472 | 0.418 |
Echinococcus multilocularis | musashi | 0.0027 | 0.352 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0016 | 0.1472 | 0.3287 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1982 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.352 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.089 | 0.2528 |
Onchocerca volvulus | 0.0016 | 0.1472 | 0.3287 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0011 | 0.0468 | 0.2363 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0011 | 0.0468 | 0.133 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.352 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0011 | 0.0468 | 0.2363 |
Onchocerca volvulus | 0.0027 | 0.352 | 1 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.1982 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.352 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1982 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1982 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.089 | 0.2528 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.1472 | 0.418 |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0468 | 0.133 |
Brugia malayi | cathepsin L-like precursor | 0.0011 | 0.0468 | 0.133 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.352 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1982 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1982 | 0.563 |
Loa Loa (eye worm) | ctsf protein | 0.0016 | 0.1472 | 0.3287 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0016 | 0.1472 | 0.418 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0016 | 0.1472 | 0.3287 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0056 | 0.8997 | 0.8997 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.1982 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0797 | 0.1077 |
Onchocerca volvulus | 0.0027 | 0.352 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0797 | 0.1077 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.1472 | 0.3287 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.1472 | 0.418 |
Leishmania major | cathepsin L-like protease | 0.0062 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.1472 | 0.418 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.1472 | 0.418 |
Loa Loa (eye worm) | fibroinase | 0.0016 | 0.1472 | 0.3287 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.1472 | 0.7425 |
Echinococcus granulosus | cathepsin l1 | 0.0016 | 0.1472 | 0.418 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.1472 | 0.7425 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0016 | 0.1472 | 0.1472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.