Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0333 | 1 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0147 | 0.3444 | 0.8344 |
Onchocerca volvulus | Matrilysin homolog | 0.009 | 0.1424 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.013 | 0.2847 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.013 | 0.2847 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0333 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.013 | 0.2847 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0333 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0098 | 0.1709 | 0.1709 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0147 | 0.3444 | 0.8344 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.013 | 0.2847 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.015 | 0.3563 | 0.3563 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0333 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.015 | 0.3563 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.013 | 0.2847 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.013 | 0.2847 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.009 | 0.1424 | 0.3998 |
Leishmania major | dihydroorotate dehydrogenase | 0.0333 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0333 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.013 | 0.2847 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0096 | 0.1648 | 0.1403 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.3563 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0333 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.009 | 0.1424 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.3563 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.015 | 0.3563 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0333 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0333 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0333 | 1 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.015 | 0.3563 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0333 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0098 | 0.1709 | 0.4798 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.013 | 0.2847 | 0.2847 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0333 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0057 | 0.0285 | 0.0285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.