Detailed information for compound 763519

Basic information

Technical information
  • TDR Targets ID: 763519
  • Name: methyl 4-[[3-[(4-methoxycarbonylphenyl)carbam oyl]benzoyl]amino]benzoate
  • MW: 432.425 | Formula: C24H20N2O6
  • H donors: 2 H acceptors: 4 LogP: 3.3 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)NC(=O)c1cccc(c1)C(=O)Nc1ccc(cc1)C(=O)OC
  • InChi: 1S/C24H20N2O6/c1-31-23(29)15-6-10-19(11-7-15)25-21(27)17-4-3-5-18(14-17)22(28)26-20-12-8-16(9-13-20)24(30)32-2/h3-14H,1-2H3,(H,25,27)(H,26,28)
  • InChiKey: AUCLLOICHHSKGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[[3-[[(4-methoxycarbonylphenyl)amino]-oxomethyl]phenyl]-oxomethyl]amino]benzoic acid methyl ester
  • 4-[[3-[(4-carbomethoxyphenyl)carbamoyl]benzoyl]amino]benzoic acid methyl ester
  • methyl 4-[[3-[(4-methoxycarbonylphenyl)carbamoyl]phenyl]carbonylamino]benzoate
  • ChemDiv3_006201
  • IDI1_024111
  • Oprea1_576409
  • Oprea1_212777
  • BAS 00451651

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0206 0.0206
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.9083 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0155 0.0269
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.015
Mycobacterium tuberculosis Conserved protein 0.0074 0.1113 0.1225
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0086 0.0175
Brugia malayi chromobox protein homolog 3 0.0077 0.1184 0.2393
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1113 0.1225
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.8633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.249 0.249
Onchocerca volvulus Huntingtin homolog 0.0118 0.2001 0.6094
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0086 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1113 0.1225
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.3546 0.6146
Echinococcus granulosus chromobox protein 2 0.0023 0.0086 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.249 0.249
Schistosoma mansoni hypothetical protein 0.0047 0.0579 0.0579
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.01 0.0202
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0118 0.1985 0.1985
Schistosoma mansoni hypothetical protein 0.0041 0.0446 0.0446
Echinococcus multilocularis zinc finger protein 0.0039 0.0405 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0731 0.1478
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1301 0.2631
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0579 0.0579
Entamoeba histolytica Ran family GTPase 0.0021 0.0057 0.5696
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1184 0.2393
Loa Loa (eye worm) beta-lactamase 0.0074 0.1113 0.1928
Leishmania major hypothetical protein, conserved 0.003 0.0236 0.2124
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0086 0.4137
Loa Loa (eye worm) hypothetical protein 0.0061 0.0849 0.1471
Loa Loa (eye worm) hypothetical protein 0.0149 0.2621 0.4542
Echinococcus multilocularis lamin 0.0026 0.0155 0.0155
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0086 0.0175
Onchocerca volvulus 0.0074 0.1113 0.3267
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.3229 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0206 0.9854
Trichomonas vaginalis ran, putative 0.0021 0.0057 0.0115
Onchocerca volvulus Alhambra homolog 0.0029 0.0206 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.249 0.249
Onchocerca volvulus 0.0048 0.0604 0.1647
Onchocerca volvulus 0.0047 0.0566 0.1526
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.01 0.0202
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0086 0.0776
Echinococcus granulosus chromobox protein 1 0.0138 0.2398 0.2398
Echinococcus multilocularis tar DNA binding protein 0.0196 0.3546 0.3546
Echinococcus multilocularis snurportin 1 0.0307 0.5771 0.5771
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0579 0.1003
Brugia malayi PHD-finger family protein 0.0029 0.0206 0.0416
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1113 0.225
Entamoeba histolytica hypothetical protein 0.0023 0.0086 0.8633
Brugia malayi PHD-finger family protein 0.0049 0.0615 0.1243
Brugia malayi intermediate filament protein 0.0026 0.0155 0.0313
Onchocerca volvulus 0.0074 0.1113 0.3267
Trichomonas vaginalis glutaminase, putative 0.0266 0.4946 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0401 0.0401
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1113 0.5
Brugia malayi Importin beta-1 subunit 0.0029 0.0209 0.0422
Trichomonas vaginalis chromobox protein, putative 0.0138 0.2398 0.4849
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0086 0.0776
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1113 0.225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.249 0.249
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0209 0.1876
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0512
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0579 0.0579
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3546 0.3546
Brugia malayi hypothetical protein 0.0023 0.0086 0.0175
Echinococcus multilocularis chromobox protein 1 0.0138 0.2398 0.2398
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0209 0.1876
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0326 0.0326
Brugia malayi jmjC domain containing protein 0.0094 0.1507 0.3046
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.5771 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1184 0.2051
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0057 0.0057
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0162 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0579 0.0579
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1113 0.1225
Brugia malayi N-terminal motif family protein 0.018 0.3229 0.6528
Echinococcus multilocularis jumonji domain containing protein 0.004 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.015
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0209 0.0209
Echinococcus multilocularis chromobox protein 2 0.0023 0.0086 0.0086
Brugia malayi jmjC domain containing protein 0.0038 0.0401 0.0811
Brugia malayi TAR-binding protein 0.0196 0.3546 0.7171
Brugia malayi SET domain containing protein 0.0023 0.0086 0.0175
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.033 0.0571
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1113 0.1113
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0086 0.0776
Loa Loa (eye worm) hypothetical protein 0.0118 0.2001 0.3468
Schistosoma mansoni hypothetical protein 0.0102 0.1676 0.1676
Onchocerca volvulus 0.0074 0.1113 0.3267
Leishmania major importin beta-1 subunit, putative 0.0023 0.01 0.0899
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0522 0.0522
Trichomonas vaginalis hypothetical protein 0.0023 0.0086 0.0175
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0162 0.0162
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0209 0.1876
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0086 0.0086
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0057 0.0512
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1113 0.225
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1122 0.1122
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1113 1
Loa Loa (eye worm) RNA binding protein 0.0196 0.3546 0.6146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.0175
Brugia malayi hypothetical protein 0.0228 0.4203 0.8498
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0305 0.0305
Brugia malayi CHD4 protein 0.0026 0.0162 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1113 0.1225
Trypanosoma cruzi ISWI complex protein 0.003 0.0236 0.2124
Schistosoma mansoni hypothetical protein 0.0518 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0086 0.4137
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.4203 0.4203
Echinococcus multilocularis lamin dm0 0.0026 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.015
Trichomonas vaginalis esterase, putative 0.0074 0.1113 0.225
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0305 0.0305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1113 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.1049 0.1049
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.8633
Onchocerca volvulus 0.0026 0.0155 0.0218
Schistosoma mansoni glutaminase 0.0266 0.4946 0.4946
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0086 0.0086
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0023 0.0086 0.0086
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1507 0.1507
Echinococcus granulosus tumor protein p63 0.0331 0.6261 0.6261
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0206 0.0206
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0305 0.0305
Onchocerca volvulus 0.0061 0.0849 0.2426
Loa Loa (eye worm) hypothetical protein 0.0139 0.2419 0.4192
Trypanosoma cruzi ISWI complex protein 0.003 0.0236 0.2124
Echinococcus granulosus tar DNA binding protein 0.0196 0.3546 0.3546
Schistosoma mansoni hypothetical protein 0.0047 0.0579 0.0579
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0206 0.0356
Schistosoma mansoni survival motor neuron protein 0.0047 0.0566 0.0566
Echinococcus multilocularis peregrin 0.0033 0.0299 0.0299
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1507 0.1507
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3546 0.3546
Mycobacterium ulcerans glutaminase 0.0266 0.4946 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0566 0.1144
Loa Loa (eye worm) hypothetical protein 0.0048 0.0604 0.1047
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0086 0.0776
Loa Loa (eye worm) hypothetical protein 0.0074 0.1113 0.1928
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1113 0.1113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1113 0.1225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Loa Loa (eye worm) hypothetical protein 0.0074 0.1113 0.1928
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0086 0.0175
Loa Loa (eye worm) hypothetical protein 0.008 0.1238 0.2146
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0086 0.0776
Schistosoma mansoni bromodomain containing protein 0.0125 0.2126 0.2126
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.1184 0.3492
Leishmania major GTP-binding protein, putative 0.0021 0.0057 0.0512
Trichomonas vaginalis importin beta-1, putative 0.0023 0.01 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3546 0.3546
Mycobacterium tuberculosis Conserved protein 0.0074 0.1113 0.1225
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1113 1
Loa Loa (eye worm) hypothetical protein 0.018 0.3229 0.5595
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3546 0.3546
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1113 1
Brugia malayi beta-lactamase 0.0074 0.1113 0.225
Loa Loa (eye worm) hypothetical protein 0.0029 0.0209 0.0362
Echinococcus multilocularis musashi 0.0026 0.0155 0.0155
Brugia malayi RNA, U transporter 1 0.0082 0.1269 0.2565
Schistosoma mansoni ran 0.0021 0.0057 0.0057
Echinococcus granulosus Chromobox protein 3 0.0023 0.0086 0.0086
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0 0.5
Leishmania major hypothetical protein, conserved 0.0074 0.1113 1
Echinococcus granulosus zinc finger protein 0.0039 0.0405 0.0405
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0118 0.1985 0.1985
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0522 0.0522
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0512
Toxoplasma gondii ABC1 family protein 0.0074 0.1113 1
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0446 0.0774
Echinococcus multilocularis geminin 0.0518 1 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0305 0.0305
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0401 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Loa Loa (eye worm) hypothetical protein 0.0047 0.0579 0.1003
Schistosoma mansoni zinc finger protein 0.0039 0.0405 0.0405
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0086 0.0776
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0086 0.4137
Schistosoma mansoni hypothetical protein 0.0307 0.5771 0.5771
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.249 0.249
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1113 0.225
Loa Loa (eye worm) hypothetical protein 0.0084 0.1313 0.2276
Plasmodium falciparum importin beta, putative 0.0029 0.0209 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.2001 0.3468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.249 0.249
Onchocerca volvulus 0.0026 0.0155 0.0218
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0155 0.0269
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0401 0.0401
Schistosoma mansoni chromobox protein 0.0023 0.0086 0.0086
Entamoeba histolytica hypothetical protein 0.0023 0.0086 0.8633
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0731 0.1478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0305 0.0305
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1113 0.225
Echinococcus granulosus snurportin 1 0.0307 0.5771 0.5771
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0 0.5
Echinococcus granulosus GPCR family 2 0.0047 0.0579 0.0579
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0579 0.1171
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.277
Trypanosoma brucei ISWI complex protein 0.003 0.0236 0.2124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1113 0.225
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Loa Loa (eye worm) hypothetical protein 0.0076 0.1145 0.1984
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1113 0.1225
Echinococcus granulosus importin subunit beta 1 0.0029 0.0209 0.0209
Mycobacterium tuberculosis Conserved protein 0.0074 0.1113 0.1225
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.1049 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Loa Loa (eye worm) hypothetical protein 0.0074 0.1113 0.1928
Schistosoma mansoni hypothetical protein 0.0029 0.0206 0.0206
Brugia malayi Heterochromatin protein 1 0.0138 0.2398 0.4849
Schistosoma mansoni chromobox protein 0.0138 0.2398 0.2398
Echinococcus granulosus jumonji domain containing protein 0.004 0.043 0.043
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1113 0.1113
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.1301 0.3866
Schistosoma mansoni hypothetical protein 0.0518 1 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0206 0.1848
Schistosoma mansoni chromobox protein 0.0138 0.2398 0.2398
Loa Loa (eye worm) hypothetical protein 0.0029 0.0206 0.0356
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1113 0.225
Echinococcus granulosus lamin dm0 0.0026 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0228 0.4203 0.7284
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0086 0.0175
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1301 0.2631
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.249 0.249
Brugia malayi hypothetical protein 0.0118 0.2001 0.4046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0305 0.0529
Schistosoma mansoni importin beta-1 0.0029 0.0209 0.0209
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0815 0.1412
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0579 0.0579
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0086 0.0086
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0086 0.0086
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0155 0.0313
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0099
Plasmodium vivax importin-beta 2, putative 0.0029 0.0209 0.1876
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0057 0.0057
Schistosoma mansoni intermediate filament proteins 0.0026 0.0155 0.0155
Loa Loa (eye worm) TAR-binding protein 0.0196 0.3546 0.6146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.2621 0.5299
Loa Loa (eye worm) hypothetical protein 0.0102 0.1676 0.2904
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0086 0.0175
Entamoeba histolytica hypothetical protein 0.0023 0.01 1
Brugia malayi RNA binding protein 0.0196 0.3546 0.7171
Entamoeba histolytica hypothetical protein 0.0023 0.0086 0.8633
Mycobacterium leprae Probable lipase LipE 0.0074 0.1113 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1113 0.1225
Loa Loa (eye worm) glutaminase 0.0266 0.4946 0.8571
Schistosoma mansoni hypothetical protein 0.003 0.0236 0.0236
Mycobacterium ulcerans beta-lactamase 0.0074 0.1113 0.225
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.0175
Schistosoma mansoni ran 0.0021 0.0057 0.0057
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0057 0.0512
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0086 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1676 0.3388
Brugia malayi Bromodomain containing protein 0.0075 0.1142 0.2309
Loa Loa (eye worm) hypothetical protein 0.0074 0.1113 0.1928
Loa Loa (eye worm) hypothetical protein 0.0026 0.0155 0.0269
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.0175
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1113 0.225
Brugia malayi beta-lactamase family protein 0.0074 0.1113 0.225
Echinococcus granulosus lamin 0.0026 0.0155 0.0155
Giardia lamblia PHD finger protein 15 0.0029 0.0206 1
Echinococcus multilocularis chromobox protein 1 0.0138 0.2398 0.2398
Loa Loa (eye worm) helicase 0.0023 0.0086 0.015
Schistosoma mansoni lamin 0.0026 0.0155 0.0155
Echinococcus granulosus peregrin 0.0033 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0074 0.1113 0.1928
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0604 0.0604
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0086 0.0175
Schistosoma mansoni chromobox protein 0.0023 0.0086 0.0086
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0162 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0086 0.0175
Schistosoma mansoni hypothetical protein 0.0047 0.0579 0.0579
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.2621 0.4542
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0401 0.0695
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1113 0.1928
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.015
Schistosoma mansoni lamin 0.0026 0.0155 0.0155
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.2621 0.5299
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.249 0.5035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0252
Mycobacterium ulcerans hypothetical protein 0.0074 0.1113 0.225
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.2729
Loa Loa (eye worm) hypothetical protein 0.0074 0.1113 0.1928
Echinococcus multilocularis GPCR, family 2 0.0047 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1184 0.2393
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0206 0.1848
Echinococcus granulosus chromobox protein 1 0.0138 0.2398 0.2398
Brugia malayi Bromodomain containing protein 0.0033 0.0299 0.0604
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.3546 0.7171
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0162 0.028
Brugia malayi beta-lactamase family protein 0.0074 0.1113 0.225
Echinococcus granulosus Chromo domain 0.0023 0.0086 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0305 0.0305
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0305 0.0305
Schistosoma mansoni tar DNA-binding protein 0.0196 0.3546 0.3546
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0512
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.01 0.0899
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0579 0.1171
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0086 0.0175
Brugia malayi Protein cec-1. 0.0023 0.0086 0.0175
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.2398 0.4156
Echinococcus multilocularis Chromo domain 0.0023 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0049 0.0614 0.1064
Mycobacterium ulcerans lipase LipD 0.0074 0.1113 0.225
Echinococcus multilocularis tumor protein p63 0.0331 0.6261 0.6261
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.4203 0.4203
Schistosoma mansoni hypothetical protein 0.0047 0.0579 0.0579
Schistosoma mansoni zinc finger protein 0.003 0.0236 0.0236
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.249 0.4315
Brugia malayi glutaminase DH11.1 0.0266 0.4946 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0206 0.1848
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0206 0.0206
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1113 0.1113
Trichomonas vaginalis chromobox protein, putative 0.0138 0.2398 0.4849
Schistosoma mansoni hypothetical protein 0.0047 0.0566 0.0566
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.8633
Echinococcus granulosus intermediate filament protein 0.0026 0.0155 0.0155
Onchocerca volvulus Huntingtin homolog 0.0118 0.2001 0.6094
Brugia malayi Bromodomain containing protein 0.0148 0.2587 0.5231
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0086 0.0175
Loa Loa (eye worm) glutaminase 2 0.0266 0.4946 0.8571
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0522 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0086 0.0175

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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