Detailed information for compound 763831

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.341 | Formula: C17H20F3NO3
  • H donors: 0 H acceptors: 2 LogP: 2.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCC(=O)N1CCCC(C1)C(=O)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C17H20F3NO3/c1-24-9-7-15(22)21-8-3-5-13(11-21)16(23)12-4-2-6-14(10-12)17(18,19)20/h2,4,6,10,13H,3,5,7-9,11H2,1H3
  • InChiKey: XMUSMVBSZKGOAI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.5951 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0533 0.68
Echinococcus multilocularis musashi 0.0027 0.024 0.0377
Mycobacterium tuberculosis Conserved protein 0.0035 0.0415 0.0512
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.1406 0.1805
Loa Loa (eye worm) hypothetical protein 0.0206 0.4262 0.5471
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0094 0.0278
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0466 0.0577
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0114 0.0114
Mycobacterium ulcerans flavoprotein disulfide reductase 0.005 0.0756 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Leishmania major cathepsin L-like protease 0.0127 0.2479 0.8556
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0114 0.0345
Echinococcus multilocularis thioredoxin glutathione reductase 0.0145 0.2881 0.4521
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0676 0.1496
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0114 0.0128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0533 0.1809
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Brugia malayi MH2 domain containing protein 0.0363 0.7789 1
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0415 0.0533
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0756 0.2587
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0415 0.0533
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.4 0.6715
Trichomonas vaginalis mercuric reductase, putative 0.005 0.0756 0.1252
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0533 0.4172
Loa Loa (eye worm) hypothetical protein 0.0053 0.082 0.1053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.1773 0.2783
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.0294
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0301 0.6406 0.8224
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0185 0.0291
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Leishmania major cathepsin L-like protease 0.0127 0.2479 0.8556
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Loa Loa (eye worm) hypothetical protein 0.0035 0.0415 0.0533
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0331 0.0519
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0533 0.1809
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0145 0.2881 0.3648
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0331 0.0425
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0182 0.0434
Echinococcus multilocularis cysteine protease 0.0033 0.0377 0.0592
Echinococcus multilocularis geminin 0.0181 0.3697 0.58
Brugia malayi beta-lactamase family protein 0.0035 0.0415 0.0533
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0182 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0331 0.0425
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0457 0.0587
Loa Loa (eye worm) Smad1 0.0025 0.0185 0.0238
Leishmania major cathepsin L-like protease 0.0127 0.2479 0.8556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Echinococcus granulosus expressed protein 0.0017 0.0013 0.002
Schistosoma mansoni ap endonuclease 0.004 0.0533 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.005 0.0756 0.247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0331 0.0425
Brugia malayi Fli-1 protein 0.024 0.5024 0.645
Plasmodium falciparum thioredoxin reductase 0.0145 0.2881 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0415 0.0533
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0415 0.0677
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Loa Loa (eye worm) hypothetical protein 0.0037 0.0466 0.0599
Echinococcus multilocularis ferritin 0.0017 0.0013 0.002
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0377 0.0678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Plasmodium falciparum pyruvate kinase 0.0037 0.0466 0.1576
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0331 0.0425
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0331 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0331 0.0551
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.1257 0.1973
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0015 0.0019
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0377 0.1015
Onchocerca volvulus 0.0033 0.0377 0.0678
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0331 0.0331
Schistosoma mansoni ran 0.0021 0.0094 0.0094
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0415 0.0512
Leishmania major DNA polymerase eta, putative 0.0022 0.0114 0.0069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0015 0.0015
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0466 0.0599
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0331 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Loa Loa (eye worm) beta-lactamase 0.0035 0.0415 0.0533
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.2479 0.8596
Schistosoma mansoni hypothetical protein 0.0181 0.3697 0.3697
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.2479 0.8596
Schistosoma mansoni hypothetical protein 0.0072 0.1257 0.1257
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0331 0.0519
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0415 0.0415
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0676 0.0867
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Echinococcus multilocularis smad 0.0025 0.0185 0.0291
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0367 0.7875 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.005 0.0756 0.2375
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.0582
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0756 0.2587
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.0582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0015 0.0015
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0331 0.0519
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.033 0.7047 0.8947
Echinococcus granulosus importin subunit beta 1 0.0028 0.0261 0.041
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0756 1
Trypanosoma brucei trypanothione reductase 0.0145 0.2881 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0185 0.0291
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0233
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.005 0.0756 0.2587
Schistosoma mansoni hypothetical protein 0.0291 0.6173 0.6173
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.3935 0.6175
Trypanosoma cruzi trypanothione reductase, putative 0.0145 0.2881 1
Loa Loa (eye worm) transcription factor SMAD2 0.0363 0.7789 1
Toxoplasma gondii exonuclease III APE 0.004 0.0533 0.168
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0676 0.106
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.033 0.7047 0.8947
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0331 0.0519
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.2231 0.7733
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0756 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0261 0.041
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0377 0.0678
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.5951 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0331 0.0331
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0213 0.0274
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.1406 0.2206
Schistosoma mansoni hypothetical protein 0.0095 0.1773 0.1773
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0377 0.0484
Echinococcus granulosus pyruvate kinase 0.0037 0.0466 0.0732
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0415 0.0651
Mycobacterium tuberculosis Conserved protein 0.0035 0.0415 0.0512
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.005 0.0756 0.2587
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0415 0.0415
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0377 0.2918
Brugia malayi mbt repeat family protein 0.0047 0.0676 0.0867
Onchocerca volvulus 0.0033 0.0377 0.0678
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0466 0.0599
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0094 0.0148
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0331 0.0551
Echinococcus granulosus pyruvate kinase 0.0037 0.0466 0.0732
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0114 0.0178
Onchocerca volvulus 0.0033 0.0377 0.0678
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0533 0.0662
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.1406 0.2206
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0367 0.7875 1
Echinococcus granulosus smad 0.0025 0.0185 0.0291
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 0.0582
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0415 0.0512
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.5951 0.764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0331 0.0425
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0676 0.106
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0466 0.0764
Mycobacterium leprae Probable lipase LipE 0.0035 0.0415 0.0512
Echinococcus granulosus lamin dm0 0.0027 0.024 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.5038 0.7905
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2587
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Schistosoma mansoni gabp alpha 0.0079 0.1406 0.1406
Echinococcus multilocularis pyruvate kinase 0.0029 0.029 0.0455
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0059 0.0155
Schistosoma mansoni hypothetical protein 0.0095 0.1773 0.1773
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0331 0.0425
Plasmodium vivax thioredoxin reductase, putative 0.0145 0.2881 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0377 0.0592
Loa Loa (eye worm) MBCTL1 0.0053 0.082 0.1053
Brugia malayi Cathepsin L-like precursor 0.0022 0.013 0.0167
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0331 0.0519
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Echinococcus granulosus cathepsin l1 0.0033 0.0377 0.0592
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.013 0.0167
Loa Loa (eye worm) fibroinase 0.0033 0.0377 0.0484
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0093
Brugia malayi cathepsin L-like precursor 0.0022 0.013 0.0167
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0331 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0331 0.0425
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0466 0.6101
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0533 0.0876
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.6373 0.8182
Entamoeba histolytica hypothetical protein 0.0072 0.1257 1
Echinococcus multilocularis cysteine protease 0.0033 0.0377 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0331 0.0425
Toxoplasma gondii thioredoxin reductase 0.0145 0.2881 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0331 0.0331
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0331 0.0519
Schistosoma mansoni ferritin light chain 0.0017 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0331 0.0519
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0114 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.0309
Leishmania major cathepsin L-like protease 0.0033 0.0377 0.1015
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0114 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0533 0.6998
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0185 0.0185
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0367 0.7875 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0094 0.0641
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.4262 0.5471
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0331 0.0425
Loa Loa (eye worm) thioredoxin reductase 0.0145 0.2881 0.3699
Toxoplasma gondii cathepsin CPL 0.0033 0.0377 0.1128
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.2479 0.8596
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0377 0.0592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0301 0.6406 0.8224
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0457 0.0587
Trichomonas vaginalis ran, putative 0.0021 0.0094 0.0137
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0466 0.0764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.013 0.0197
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.1773 0.2783
Entamoeba histolytica hypothetical protein 0.0072 0.1257 1
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0331 0.0519
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0415 0.5412
Brugia malayi RNA, U transporter 1 0.008 0.1426 0.183
Trichomonas vaginalis esterase, putative 0.0035 0.0415 0.0677
Leishmania major importin beta-1 subunit, putative 0.0023 0.0142 0.017
Leishmania major trypanothione reductase 0.0145 0.2881 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0331 0.0519
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0114 0.0114
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.1257 0.1257
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0756 0.2587
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3777 0.6339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0331 0.0425
Plasmodium falciparum glutathione reductase 0.0145 0.2881 1
Leishmania major cathepsin L-like protease 0.0033 0.0377 0.1015
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0114 0.0169
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0114 0.0345
Mycobacterium tuberculosis Probable dehydrogenase 0.033 0.7047 0.8947
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0331 0.0425
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0261 0.086
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0533 0.0684
Mycobacterium ulcerans hypothetical protein 0.0035 0.0415 0.5412
Onchocerca volvulus 0.0047 0.0676 0.1496
Mycobacterium tuberculosis Conserved protein 0.0035 0.0415 0.0512
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0331 0.0331
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0331 0.0331
Brugia malayi Cathepsin L-like precursor 0.0033 0.0377 0.0484
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0533 0.1575
Brugia malayi Calcitonin receptor-like protein seb-1 0.0301 0.6406 0.8224
Echinococcus granulosus cathepsin l1 0.0022 0.013 0.0204
Mycobacterium tuberculosis Putative ferredoxin reductase 0.033 0.7047 0.8947
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.005 0.0756 0.1187
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0261 0.0716
Loa Loa (eye worm) hypothetical protein 0.0301 0.6406 0.8224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2587
Schistosoma mansoni ets-related 0.024 0.5024 0.5024
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0114 0.0146
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0331 0.0519
Brugia malayi Thioredoxin reductase 0.0145 0.2881 0.3699
Leishmania major acetoin dehydrogenase e3 component-like protein 0.005 0.0756 0.2375
Schistosoma mansoni apoferritin-2 0.0017 0.0013 0.0013
Schistosoma mansoni pyruvate kinase 0.0037 0.0466 0.0466
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.1773 0.2277
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0331 0.0551
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Brugia malayi MH1 domain containing protein 0.0025 0.0185 0.0238
Giardia lamblia Pyruvate kinase 0.0037 0.0466 0.5844
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0377 0.0592
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0415 0.0512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Onchocerca volvulus 0.0031 0.0331 0.0551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Brugia malayi Cathepsin L-like precursor 0.0033 0.0377 0.0484
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0415 0.0512
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0114 0.0146
Onchocerca volvulus 0.0035 0.0415 0.0782
Loa Loa (eye worm) hypothetical protein 0.0022 0.013 0.0167
Echinococcus granulosus dna polymerase kappa 0.0022 0.0114 0.0178
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0377 0.0377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.5038 0.5038
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0676 0.0676
Leishmania major pyruvate kinase 0.0037 0.0466 0.1335
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0094 0.0506
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0182 0.0582
Schistosoma mansoni ferritin light chain 0.0017 0.0013 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0185 0.0238
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0377 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0331 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Brugia malayi Ets-domain containing protein 0.0079 0.1406 0.1805
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0114 0.0178
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.5038 0.6468
Leishmania major cathepsin L-like protease 0.0033 0.0377 0.1015
Brugia malayi Cathepsin L-like precursor 0.0033 0.0377 0.0484
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0185 0.0238
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0377 0.0678
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0142 0.0217
Loa Loa (eye worm) glutathione reductase 0.0145 0.2881 0.3699
Trypanosoma brucei unspecified product 0.0022 0.0114 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Loa Loa (eye worm) cysteine protease 0.0033 0.0377 0.0484
Onchocerca volvulus 0.0027 0.024 0.0303
Onchocerca volvulus 0.0033 0.0377 0.0678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Brugia malayi Ets-domain containing protein 0.0079 0.1406 0.1805
Giardia lamblia NADH oxidase lateral transfer candidate 0.005 0.0756 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0533 0.1809
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.013 0.0928
Schistosoma mansoni hypothetical protein 0.0181 0.3697 0.3697
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0533 0.0684
Schistosoma mansoni ran 0.0021 0.0094 0.0094
Echinococcus multilocularis lamin dm0 0.0027 0.024 0.0377
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0331 0.0425
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0466 0.1444
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0415 0.1397
Brugia malayi Cathepsin L-like precursor 0.0033 0.0377 0.0484
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.005 0.0756 0.0945
Brugia malayi Cathepsin L-like precursor 0.0033 0.0377 0.0484
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0094 0.0278
Schistosoma mansoni pyruvate kinase 0.0019 0.0059 0.0059
Plasmodium vivax vivapain-2 0.0033 0.0377 0.1265
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3777 0.6339
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0185 0.0291
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0331 0.0519
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0415 0.1397
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.033 0.7047 0.8947
Brugia malayi nuclear hormone receptor 0.0031 0.0331 0.0425
Echinococcus granulosus geminin 0.0181 0.3697 0.58
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0331 0.0425
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0114 0.0797
Schistosoma mansoni hypothetical protein 0.03 0.6373 0.6373
Brugia malayi Smad1 0.0025 0.0185 0.0238
Echinococcus multilocularis Smad4 0.0025 0.0185 0.0291
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0114 0.1354
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3777 0.6339
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0274
Brugia malayi MH2 domain containing protein 0.0025 0.0185 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0676 0.0676
Echinococcus granulosus cysteine protease 0.0017 0.0015 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0331 0.0425
Echinococcus multilocularis pyruvate kinase 0.0037 0.0466 0.0732
Treponema pallidum NADH oxidase 0.005 0.0756 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0114 0.0169
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0114 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0331 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2587
Loa Loa (eye worm) hypothetical protein 0.0022 0.013 0.0167
Schistosoma mansoni smad1 5 8 and 0.0025 0.0185 0.0185
Plasmodium falciparum glutathione reductase 0.005 0.0756 0.2587
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2375
Schistosoma mansoni intermediate filament proteins 0.0027 0.024 0.024
Plasmodium vivax importin-beta 2, putative 0.0028 0.0261 0.086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2587
Onchocerca volvulus 0.0035 0.0415 0.0782
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2587
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0331 0.0425
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0213 0.1598
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.5038 0.7905
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0331 0.0425
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0415 0.0512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.5038 0.7905
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.005 0.0756 1
Leishmania major hypothetical protein, conserved 0.0025 0.0182 0.0313
Schistosoma mansoni coup transcription factor 0.0031 0.0331 0.0331
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0415 0.0677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Echinococcus granulosus GPCR family 2 0.0095 0.1773 0.2783
Schistosoma mansoni smad 0.0025 0.0185 0.0185
Brugia malayi nuclear receptor NHR-88 0.0031 0.0331 0.0425
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0093
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0142 0.0217
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0114 0.0069
Brugia malayi steroid hormone receptor 0.0031 0.0331 0.0425
Mycobacterium tuberculosis Probable oxidoreductase 0.0367 0.7875 1
Echinococcus granulosus ferritin 0.0017 0.0013 0.002
Echinococcus multilocularis lamin 0.0027 0.024 0.0377
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.3935 0.6175
Loa Loa (eye worm) hypothetical protein 0.0035 0.0415 0.0533
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.5951 0.764
Leishmania major DNA polymerase kappa, putative 0.0022 0.0114 0.0069
Brugia malayi beta-lactamase family protein 0.0035 0.0415 0.0533
Plasmodium vivax vivapain-2 0.0033 0.0377 0.1265
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.2479 0.8596
Onchocerca volvulus 0.0033 0.0377 0.0678
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.1773 0.2277
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0466 0.1576
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.5038 0.7905
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.1257 0.1973
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.5038 0.5038
Loa Loa (eye worm) hypothetical protein 0.0068 0.1148 0.1474
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0094 0.0278
Entamoeba histolytica hypothetical protein 0.0072 0.1257 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Loa Loa (eye worm) ctsf protein 0.0033 0.0377 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.5951 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0415 0.5412
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.005 0.0756 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2587
Loa Loa (eye worm) hypothetical protein 0.0047 0.0676 0.0867
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.082 0.1287
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0756 0.2375
Echinococcus granulosus thioredoxin glutathione reductase 0.0145 0.2881 0.4521
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0377 0.1265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0331 0.0519
Loa Loa (eye worm) intermediate filament protein 0.0027 0.024 0.0309
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.5951 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0015 0.0015
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0093
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0533 0.1809
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0331 0.0519
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0466 0.0923
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0331 0.0331
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0533 0.1809
Leishmania major pyruvate kinase 0.0037 0.0466 0.1335
Trichomonas vaginalis glutathione reductase, putative 0.005 0.0756 0.1252
Onchocerca volvulus 0.0033 0.0377 0.0678
Brugia malayi ecdysteroid receptor 0.0031 0.0331 0.0425
Entamoeba histolytica cysteine protease, putative 0.0033 0.0377 0.2918
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0415 0.0533
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0331 0.0331
Brugia malayi intermediate filament protein 0.0027 0.024 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Schistosoma mansoni hypothetical protein 0.0095 0.1773 0.1773
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.005 0.0756 0.2587
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0415 0.0651
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0533 0.0836
Echinococcus granulosus snurportin 1 0.03 0.6373 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0331 0.0425
Schistosoma mansoni importin beta-1 0.0028 0.0261 0.0261
Echinococcus granulosus lamin 0.0027 0.024 0.0377
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0331 0.0425
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0093
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0114 0.1354
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.082 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Brugia malayi MH2 domain containing protein 0.0025 0.0185 0.0238
Brugia malayi beta-lactamase 0.0035 0.0415 0.0533
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0466 0.0599
Loa Loa (eye worm) hypothetical protein 0.0028 0.0261 0.0335
Brugia malayi MH1 domain containing protein 0.0025 0.0185 0.0238
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.024 0.0309
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.082 0.1053
Brugia malayi Latrophilin receptor protein 2 0.0095 0.1773 0.2277
Echinococcus multilocularis snurportin 1 0.03 0.6373 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0146
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0415 0.0512
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0676 0.0676
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.024 0.0309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Schistosoma mansoni smad1 5 8 and 0.0025 0.0185 0.0185
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.005 0.0756 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0114 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Plasmodium falciparum importin beta, putative 0.0028 0.0261 0.086
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0261 0.086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0415 0.0512
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0377 0.2918
Brugia malayi glutathione reductase 0.0145 0.2881 0.3699
Schistosoma mansoni smad1 5 8 and 0.0025 0.0185 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0114 0.0345
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.5951 1
Schistosoma mansoni Smad4 0.0025 0.0185 0.0185
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0466 0.1576
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0533 0.6998
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0756 0.2587
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0415 0.0677
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0415 0.1397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.033 0.7047 0.8947
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.082 0.1287
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0331 0.0425
Echinococcus multilocularis GPCR, family 2 0.0095 0.1773 0.2783
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 0.0582
Brugia malayi Importin beta-1 subunit 0.0028 0.0261 0.0335
Giardia lamblia DINP protein human, muc B family 0.0022 0.0114 0.0783
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0415 0.0677
Echinococcus multilocularis cathepsin L 0.0017 0.0015 0.0023
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0094 0.0121
Loa Loa (eye worm) hypothetical protein 0.0033 0.0377 0.0484
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0377 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.5038 0.5038
Schistosoma mansoni lamin 0.0027 0.024 0.024
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0377 0.1265
Onchocerca volvulus 0.0027 0.024 0.0303
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0094 0.0125
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0466 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3777 0.6339
Echinococcus multilocularis dna polymerase eta 0.0022 0.0114 0.0178
Brugia malayi mbt repeat family protein 0.0047 0.0676 0.0867
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.005 0.0756 0.0971
Brugia malayi hypothetical protein 0.0025 0.0182 0.0233
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0533 0.6998
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0331 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Echinococcus multilocularis pyruvate kinase 0.0037 0.0466 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.1773 0.2783
Toxoplasma gondii NADPH-glutathione reductase 0.005 0.0756 0.247
Loa Loa (eye worm) hypothetical protein 0.0022 0.013 0.0167
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0331 0.0331
Leishmania major cathepsin L-like protease 0.0033 0.0377 0.1015
Schistosoma mansoni apoferritin-2 0.0017 0.0013 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0415 0.0677
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0331 0.0519
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0331 0.0519
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3777 0.6339
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0331 0.0519
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0142 0.0443
Echinococcus granulosus Smad4 0.0025 0.0185 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0466 0.1576
Onchocerca volvulus 0.0035 0.0415 0.0782
Schistosoma mansoni pyruvate kinase 0.0037 0.0466 0.0466
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.465 0.5898
Leishmania major cathepsin L-like protease 0.0033 0.0377 0.1015
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.1869 0.6469
Plasmodium vivax glutathione reductase, putative 0.0145 0.2881 1
Schistosoma mansoni hypothetical protein 0.0206 0.4262 0.4262
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0415 0.1397
Toxoplasma gondii ABC1 family protein 0.0035 0.0415 0.1262
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0377 0.0613
Echinococcus granulosus intermediate filament protein 0.0027 0.024 0.0377
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0142 0.0217
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.005 0.0756 0.2587
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.005 0.0756 0.2587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.2479 0.8596
Mycobacterium tuberculosis Probable reductase 0.033 0.7047 0.8947
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0377 0.1265
Schistosoma mansoni DNA polymerase eta 0.0022 0.0114 0.0114
Plasmodium falciparum thioredoxin reductase 0.005 0.0756 0.2587
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0676 0.106
Onchocerca volvulus 0.0033 0.0377 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0331 0.0425
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0466 0.0923
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0377 0.0592
Echinococcus granulosus dna polymerase eta 0.0022 0.0114 0.0178
Entamoeba histolytica hypothetical protein 0.0023 0.0142 0.1022
Loa Loa (eye worm) MH2 domain-containing protein 0.0363 0.7789 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0533 0.0876
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.005 0.0756 0.2587
Loa Loa (eye worm) fli-1 protein 0.024 0.5024 0.645
Entamoeba histolytica hypothetical protein 0.0072 0.1257 1
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0059 0.0155
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0185 0.0291
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0415 0.0512
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3777 0.6339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.013 0.0197
Mycobacterium ulcerans lipase LipD 0.0035 0.0415 0.5412
Echinococcus multilocularis expressed protein 0.0017 0.0013 0.002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0094 0.0121
Mycobacterium ulcerans beta-lactamase 0.0035 0.0415 0.5412
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0114 0.0146
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0377 0.0592
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.3777 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0377 0.1265
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0377 0.0377
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0095 0.1773 0.1773
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.5951 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0533 0.0836
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0331 0.0331
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0466 0.0923
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Brugia malayi Cathepsin L-like precursor 0.0022 0.013 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3777 0.6339
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0377 0.0484
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.005 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0035 0.0415 0.0533
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0756 0.2587
Schistosoma mansoni lamin 0.0027 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.5038 0.6468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0015 0.0003
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0676 0.106
Schistosoma mansoni ap endonuclease 0.004 0.0533 0.0533
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0094 0.0148
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0094 0.0278
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.005 0.0756 0.1187
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0015 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0377 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0114 0.0345
Loa Loa (eye worm) hypothetical protein 0.0035 0.0415 0.0533
Loa Loa (eye worm) hypothetical protein 0.0095 0.1773 0.2277
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0015 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.4 0.6715
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0466 0.0599
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0466 0.1576
Brugia malayi hypothetical protein 0.0072 0.1257 0.1614
Leishmania major hypothetical protein, conserved 0.0035 0.0415 0.1152
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.1773 0.2783
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0466 0.1576
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0377 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Brugia malayi Cathepsin L-like precursor 0.0033 0.0377 0.0484
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0466 0.0599
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0425
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0094 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0377 0.0613
Echinococcus granulosus cathepsin L 0.0017 0.0015 0.0023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.082 0.1287
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.082 0.082
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0331 0.0331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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