Detailed information for compound 764069

Basic information

Technical information
  • TDR Targets ID: 764069
  • Name: N-(2,6-diethylphenyl)-2-(1,1,3-trioxo-1,2-ben zothiazol-2-yl)acetamide
  • MW: 372.438 | Formula: C19H20N2O4S
  • H donors: 1 H acceptors: 4 LogP: 3.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1NC(=O)CN1C(=O)c2c(S1(=O)=O)cccc2)CC
  • InChi: 1S/C19H20N2O4S/c1-3-13-8-7-9-14(4-2)18(13)20-17(22)12-21-19(23)15-10-5-6-11-16(15)26(21,24)25/h5-11H,3-4,12H2,1-2H3,(H,20,22)
  • InChiKey: PPIJRMBUJBIMAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,6-diethylphenyl)-2-(1,1,3-triketo-1,2-benzothiazol-2-yl)acetamide
  • N-(2,6-diethylphenyl)-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)ethanamide
  • ZINC04163211
  • AH-487/42143393
  • BAS 08307160
  • ST058179

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.022 0.2945 0.3716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.01 0.0101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0211 0.0495
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0312 0.957
Echinococcus multilocularis smad 0.0029 0.0199 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.01 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0072 0.001
Mycobacterium tuberculosis Probable reductase 0.0501 0.7004 0.8958
Trichomonas vaginalis set domain proteins, putative 0.0239 0.3219 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.219 0.3665
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0482 0.0807
Onchocerca volvulus 0.0239 0.3219 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0018 0.0035 0.0107
Brugia malayi glutathione reductase 0.022 0.2945 0.4927
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0068 0.0068
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0068 0.0068
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0557 0.7811 1
Echinococcus granulosus glutamate synthase 0.002 0.0068 0.0068
Trichomonas vaginalis glutathione reductase, putative 0.0076 0.0875 0.256
Echinococcus multilocularis thioredoxin glutathione reductase 0.0222 0.2971 0.2971
Echinococcus multilocularis glutamate synthase 0.002 0.0068 0.0068
Trypanosoma brucei target of rapamycin kinase 3, putative 0.003 0.0212 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0103 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0211 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0103 0.0112
Brugia malayi Thioredoxin reductase 0.022 0.2945 0.4927
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0312 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0183 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0323 0.081
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0068 0.0219
Plasmodium vivax thioredoxin reductase, putative 0.022 0.2945 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0312 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0072 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.022 0.2945 1
Schistosoma mansoni tar DNA-binding protein 0.0228 0.3067 0.3067
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0212 0.0455
Schistosoma mansoni smad 0.0029 0.0199 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0323 0.081
Echinococcus multilocularis microtubule associated protein 2 0.0709 1 1
Schistosoma mansoni alpha-glucosidase 0.0144 0.1854 0.1854
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0557 0.7811 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0482 0.0807
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0076 0.0875 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0211 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0312 0.0849
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.219 0.219
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0212 0.0455
Echinococcus granulosus mothers against decapentaplegic 5 0.0029 0.0199 0.0199
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Brugia malayi TAR-binding protein 0.0228 0.3067 0.5131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0143 0.0239
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0214 0.0214
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0068 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0183 0.0365
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0068 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0211 0.0211
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.003 0.0212 0.05
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0076 0.0875 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0312 0.0775
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0068 0.0068
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0228 0.3067 0.5131
Toxoplasma gondii target of rapamycin (TOR), putative 0.0028 0.0183 0.04
Mycobacterium tuberculosis Probable oxidoreductase 0.0557 0.7811 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0501 0.7004 0.8958
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0312 0.0775
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0482 0.0807
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0323 0.0323
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0076 0.0875 0.2803
Brugia malayi MH1 domain containing protein 0.0029 0.0199 0.0333
Loa Loa (eye worm) programmed cell death 8 0.002 0.0068 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0132 0.0201
Brugia malayi Pre-SET motif family protein 0.003 0.0211 0.0352
Loa Loa (eye worm) MH1 domain-containing protein 0.0029 0.0199 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0243 0.0556
Trypanosoma brucei glucosidase, putative 0.0037 0.0312 0.1049
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0076 0.0875 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0312 0.0312
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2801 0.4686
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0072 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0029 0.0199 0.0333
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0068 0.0068
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0323 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0072 0.0012
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0068 0.0219
Entamoeba histolytica hypothetical protein 0.003 0.0214 0.5728
Schistosoma mansoni glutamate synthase 0.002 0.0068 0.0068
Brugia malayi RNA recognition motif domain containing protein 0.0228 0.3067 0.5131
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0501 0.7004 0.8958
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0068 0.0068
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0076 0.0875 0.1464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0323 0.081
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0076 0.0875 0.2961
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0323 0.0541
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0076 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.003 0.0211 0.0352
Trypanosoma brucei trypanothione reductase 0.022 0.2945 1
Echinococcus multilocularis tar DNA binding protein 0.0228 0.3067 0.3067
Brugia malayi Smad1 0.0029 0.0199 0.0333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0323 0.0541
Toxoplasma gondii thioredoxin reductase 0.022 0.2945 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0211 0.0211
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0312 0.0775
Schistosoma mansoni alpha-glucosidase 0.0144 0.1854 0.1854
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0056 0.0583 0.0976
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.002 0.0068 0.0219
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0076 0.0875 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0068 0.0114
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0323 0.0887
Loa Loa (eye worm) hypothetical protein 0.0049 0.0482 0.0807
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0076 0.0875 0.2961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0183 0.0365
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0076 0.0875 0.2803
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0038 0.0323 1
Schistosoma mansoni hypothetical protein 0.0033 0.0259 0.0259
Entamoeba histolytica hypothetical protein 0.003 0.0214 0.5728
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0312 0.0849
Schistosoma mansoni sulfide quinone reductase 0.002 0.0068 0.0068
Leishmania major trypanothione reductase 0.022 0.2945 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0076 0.0875 0.2803
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0211 0.0211
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0312 0.0775
Onchocerca volvulus 0.003 0.0211 0.0452
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0068 0.0114
Mycobacterium tuberculosis Probable dehydrogenase 0.0501 0.7004 0.8958
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0068 0.0219
Schistosoma mansoni Smad4 0.0029 0.0199 0.0199
Brugia malayi MH1 domain containing protein 0.0016 0.001 0.0018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0076 0.0875 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0076 0.0875 0.0875
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0076 0.0875 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0183 0.0365
Giardia lamblia NADH oxidase lateral transfer candidate 0.0076 0.0875 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0183 0.0365
Brugia malayi MH1 domain containing protein 0.0016 0.001 0.0018
Plasmodium vivax SET domain protein, putative 0.003 0.0211 0.0495
Schistosoma mansoni alpha glucosidase 0.0037 0.0312 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0103 0.0112
Loa Loa (eye worm) RNA binding protein 0.0228 0.3067 0.5131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0068 0.0068
Giardia lamblia GTOR 0.0038 0.0323 0.3163
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0076 0.0875 0.0875
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0323 0.0323
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0211 0.0211
Schistosoma mansoni hypothetical protein 0.003 0.0214 0.0214
Brugia malayi MH2 domain containing protein 0.0029 0.0199 0.0333
Echinococcus multilocularis mothers against decapentaplegic 5 0.0029 0.0199 0.0199
Brugia malayi MH2 domain containing protein 0.0029 0.0199 0.0333
Entamoeba histolytica hypothetical protein 0.003 0.0214 0.5728
Plasmodium falciparum thioredoxin reductase 0.022 0.2945 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0557 0.7811 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0076 0.0875 1
Loa Loa (eye worm) TAR-binding protein 0.0228 0.3067 0.5131
Brugia malayi MH1 domain containing protein 0.0029 0.0199 0.0333
Trypanosoma cruzi target of rapamycin kinase 3 0.003 0.0212 0.05
Trypanosoma cruzi trypanothione reductase, putative 0.0076 0.0875 0.2803
Schistosoma mansoni smad1 5 8 and 0.0029 0.0199 0.0199
Loa Loa (eye worm) nuclear factor I 0.0016 0.001 0.0018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0029 0.0199 0.0199
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0501 0.7004 0.8958
Echinococcus granulosus Smad4 0.0029 0.0199 0.0199
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0038 0.0323 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0212 0.0455
Brugia malayi glutamate synthase 0.002 0.0068 0.0114
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0068 0.0068
Schistosoma mansoni glutamate synthase 0.002 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0072 0.0012
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0056 0.0583 0.0976
Plasmodium falciparum glutathione reductase 0.0076 0.0875 0.2803
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.219 0.219
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0212 0.0455
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0259 0.0433
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0029 0.0199 0.0199
Schistosoma mansoni glutamate synthase 0.002 0.0068 0.0068
Treponema pallidum NADH oxidase 0.0076 0.0875 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0029 0.0199 0.0199
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0076 0.0875 0.2803
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0038 0.0323 0.1086
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0312 0.0312
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0076 0.0875 0.1042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0312 0.957
Schistosoma mansoni tar DNA-binding protein 0.0228 0.3067 0.3067
Brugia malayi MH2 domain containing protein 0.043 0.5977 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0501 0.7004 0.8958
Trichomonas vaginalis mercuric reductase, putative 0.0076 0.0875 0.256
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.219 0.219
Plasmodium falciparum thioredoxin reductase 0.0076 0.0875 0.2803
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0312 0.0775
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0211 0.0211
Brugia malayi RNA binding protein 0.0228 0.3067 0.5131
Schistosoma mansoni tar DNA-binding protein 0.0228 0.3067 0.3067
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0038 0.0323 0.1086
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0214 0.0214
Brugia malayi Pre-SET motif family protein 0.021 0.2801 0.4686
Loa Loa (eye worm) MH2 domain-containing protein 0.043 0.5977 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.219 0.3665
Loa Loa (eye worm) thioredoxin reductase 0.022 0.2945 0.4927
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0501 0.7004 0.8958
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0076 0.0875 0.2961
Echinococcus granulosus tar DNA binding protein 0.0228 0.3067 0.3067
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0072 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0072 0.001
Schistosoma mansoni smad1 5 8 and 0.0029 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0114
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0068 0.0068
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0195 0.0195
Schistosoma mansoni hypothetical protein 0.002 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0018
Schistosoma mansoni smad1 5 8 and 0.0029 0.0199 0.0199
Echinococcus granulosus smad 0.0029 0.0199 0.0199
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0068 0.0114
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0076 0.0875 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0228 0.3067 0.3067
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0312 0.0775
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0323 0.0887
Brugia malayi hypothetical protein 0.003 0.0214 0.0359
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0068 0.0219
Loa Loa (eye worm) glutathione reductase 0.022 0.2945 0.4927
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0076 0.0875 0.2961
Schistosoma mansoni microtubule-associated protein tau 0.0709 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0323 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0212 0.0455
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0312 0.0523
Plasmodium vivax glutathione reductase, putative 0.022 0.2945 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0068 0.0068
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0068 0.0068
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0312 0.0849
Entamoeba histolytica hypothetical protein 0.003 0.0214 0.5728
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0068 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0076 0.0875 0.2803
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0312 0.0775
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0312 0.0775
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Onchocerca volvulus 0.0097 0.1173 0.3506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0183 0.0365
Loa Loa (eye worm) transcription factor SMAD2 0.043 0.5977 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0312 0.0849
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0323 0.0323
Schistosoma mansoni tar DNA-binding protein 0.0228 0.3067 0.3067
Echinococcus granulosus thioredoxin glutathione reductase 0.0222 0.2971 0.2971
Loa Loa (eye worm) hypothetical protein 0.0033 0.0259 0.0433
Toxoplasma gondii NADPH-glutathione reductase 0.0076 0.0875 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0183 0.0365
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0076 0.0875 0.2803
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0076 0.0875 0.2803
Schistosoma mansoni sulfide quinone reductase 0.002 0.0068 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0076 0.0875 0.2803
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0214 0.0214
Plasmodium falciparum glutathione reductase 0.022 0.2945 1
Echinococcus multilocularis Smad4 0.0029 0.0199 0.0199
Loa Loa (eye worm) Smad1 0.0029 0.0199 0.0333
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0068 0.0068
Trypanosoma brucei NADH dehydrogenase 0.002 0.0068 0.0219

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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