Detailed information for compound 764488

Basic information

Technical information
  • TDR Targets ID: 764488
  • Name: butyl 2-amino-1'-(2-methoxy-2-oxoethyl)-2',5- dioxospiro[7,8-dihydro-6H-chromene-4,3'-indol e]-3-carboxylate
  • MW: 454.472 | Formula: C24H26N2O7
  • H donors: 1 H acceptors: 4 LogP: 2.14 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)C1=C(N)OC2=C(C31C(=O)N(c1c3cccc1)CC(=O)OC)C(=O)CCC2
  • InChi: 1S/C24H26N2O7/c1-3-4-12-32-22(29)20-21(25)33-17-11-7-10-16(27)19(17)24(20)14-8-5-6-9-15(14)26(23(24)30)13-18(28)31-2/h5-6,8-9H,3-4,7,10-13,25H2,1-2H3
  • InChiKey: YSZIORSFKIROOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • butyl 2-amino-1'-(2-methoxy-2-oxo-ethyl)-2',5-dioxo-spiro[7,8-dihydro-6H-chromene-4,3'-indoline]-3-carboxylate
  • 2-amino-1'-(2-methoxy-2-oxoethyl)-2',5-dioxo-3-spiro[7,8-dihydro-6H-chromene-4,3'-indoline]carboxylic acid butyl ester
  • 2-amino-2',5-diketo-1'-(2-keto-2-methoxy-ethyl)spiro[7,8-dihydro-6H-chromene-4,3'-indoline]-3-carboxylic acid butyl ester
  • butyl 2-amino-1'-(2-methoxy-2-oxo-ethyl)-2',5-dioxo-spiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0027 0.001 0.0001
Giardia lamblia Hypothetical protein 0.003 0.0012 0.2761
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0247 0.0189 0.0188
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.003 0.0012 0.0527
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0023 0.0023
Echinococcus granulosus MAM 0.0027 0.001 0.0008
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.003 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0001
Trypanosoma cruzi ABC transporter, putative 0.003 0.0012 0.0509
Brugia malayi Cytochrome P450 family protein 0.0051 0.0029 0.0026
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0247 0.0189 0.0189
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0037 0.0036
Leishmania major protein kinase, putative 0.006 0.0036 0.1577
Loa Loa (eye worm) hypothetical protein 0.0066 0.0042 0.004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0016 0.0697
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0102 0.4442
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0037 0.0036
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0027 0.001 0.001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0017 0.0731
Echinococcus granulosus hypothetical protein 0.0058 0.0035 0.0034
Echinococcus granulosus lamin 0.0026 0.0009 0.0007
Schistosoma mansoni cpg binding protein 0.0061 0.0037 0.0037
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.003 0.0012 0.0011
Leishmania major hypothetical protein, conserved 0.003 0.0012 0.0527
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0012 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0247 0.0189 0.8232
Echinococcus granulosus zinc finger protein 0.0023 0.0006 0.0005
Schistosoma mansoni cpg binding protein 0.0056 0.0033 0.0033
Brugia malayi Cytochrome P450 family protein 0.0022 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0023 0.0022
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0017 0.0015
Echinococcus granulosus mitogen activated protein kinase 14 0.0124 0.0088 0.0087
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0019 0.1012
Plasmodium falciparum ABC transporter G family member 2 0.003 0.0012 0.1804
Brugia malayi hypothetical protein 0.0035 0.0016 0.0013
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0062 0.2712
Leishmania major cytochrome p450-like protein 0.0022 0.0005 0.0239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0003 0.0127
Brugia malayi PHD-finger family protein 0.0029 0.0011 0.0008
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0021 0.0931
Echinococcus multilocularis sodium bile acid cotransporter 1.2252 1 1
Echinococcus multilocularis MAM 0.0027 0.001 0.0008
Brugia malayi Bromodomain containing protein 0.0039 0.0019 0.0016
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0012 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Echinococcus granulosus tar DNA binding protein 0.0061 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0058 0.0035 0.0034
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0017 0.0725
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0012 0.001
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0052 0.5
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0023 0.3446
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Toxoplasma gondii hypothetical protein 0.0079 0.0052 0.3016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Loa Loa (eye worm) hypothetical protein 0.0097 0.0067 0.0065
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0005 0.0004
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.003 0.0012 0.0009
Echinococcus multilocularis dual specificity protein kinase clk2 0.006 0.0036 0.0035
Loa Loa (eye worm) PDE1B protein 0.003 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0011
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.0088 0.0087
Mycobacterium ulcerans putative regulatory protein 0.0079 0.0052 0.4343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0023 0.1089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Leishmania major cAMP-specific phosphodiesterase, putative 0.003 0.0012 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0017 0.0015
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0109 0.0077 0.0074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0067 0.0064
Trypanosoma cruzi ATP-binding cassette protein, putative 0.003 0.0012 0.0509
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.003 0.0012 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0052 0.259
Echinococcus multilocularis 0.0058 0.0035 0.0034
Brugia malayi TAR-binding protein 0.0061 0.0037 0.0035
Plasmodium falciparum phosphodiesterase gamma, putative 0.003 0.0012 0.1889
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0003 0.0002
Echinococcus granulosus cpg binding protein 0.0061 0.0037 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0023 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0128 0.6658
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0061 0.0037 0.0036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0061 0.0037 0.0036
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0155 0.0114 0.0113
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.003 0.0012 0.0011
Leishmania major protein kinase, putative 0.006 0.0036 0.1577
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0079 0.0052 0.4343
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0189 0.9908
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0025 0.0024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Giardia lamblia hypothetical protein 0.003 0.0012 0.2761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0023 0.0022
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0017 0.0731
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0062 0.2712
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0011
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0003
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0021 0.0931
Schistosoma mansoni zinc finger protein 0.0023 0.0006 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0067 0.0064
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0012 0.001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0017 0.0015
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0128 0.6658
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis expressed protein 0.0046 0.0025 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0012 0.0011
Giardia lamblia GTOR 0.0044 0.0023 0.6143
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0037 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0793 0.0635 0.0634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0067 0.0065
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Echinococcus granulosus intermediate filament protein 0.0026 0.0009 0.0007
Schistosoma mansoni protein kinase 0.007 0.0045 0.0045
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.0088 0.3838
Loa Loa (eye worm) hypothetical protein 1.2252 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0023 0.1017
Echinococcus multilocularis lamin dm0 0.0026 0.0009 0.0007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0062 0.2712
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0003 0.0002
Plasmodium vivax phosphodiesterase gamma, putative 0.003 0.0012 0.1889
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0527
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.003 0.0012 0.0011
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0004 0.019
Toxoplasma gondii hypothetical protein 0.0217 0.0165 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0005 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Schistosoma mansoni hypothetical protein 0.0066 0.0042 0.0042
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0017 0.4124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0018 0.0808
Toxoplasma gondii GAF domain-containing protein 0.0079 0.0052 0.3016
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Echinococcus granulosus sodium bile acid cotransporter 1.2252 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0009 0.0007
Echinococcus multilocularis geminin 0.0164 0.0121 0.012
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.023 1
Echinococcus granulosus dnaJ subfamily B 0.0793 0.0635 0.0634
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0008
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0012 0.1889
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0005 0.0004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0003 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0008
Onchocerca volvulus 0.0027 0.001 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0007
Echinococcus multilocularis sodium bile acid cotransporter 1.2252 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0002 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.023 1
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.003 0.0012 0.0509
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.0088 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0316
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0316
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0012 0.0009
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Trypanosoma brucei ABC transporter, putative 0.003 0.0012 0.0509
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0169 0.0125 0.5433
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0079 0.0052 0.4343
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0204
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.0191 0.019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0023 0.1089
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.003 0.0012 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0003
Echinococcus granulosus lamin dm0 0.0026 0.0009 0.0007
Trypanosoma brucei ATP-binding cassette protein, putative 0.003 0.0012 0.0509
Loa Loa (eye worm) CMGC/CLK protein kinase 0.006 0.0036 0.0035
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0109 0.0077 0.391
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.006 0.0036 0.1577
Loa Loa (eye worm) hypothetical protein 0.0079 0.0052 0.005
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.003 0.0012 0.0011
Echinococcus granulosus sodium bile acid cotransporter 1.2252 1 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.006 0.0036 0.1577
Brugia malayi Protein kinase domain containing protein 0.006 0.0036 0.0034
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0023 0.1017
Onchocerca volvulus 0.0049 0.0027 0.0018
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0025 0.4523
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Brugia malayi ABC transporter family protein 0.0025 0.0008 0.0005
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Plasmodium falciparum protein serine/threonine kinase-1 0.006 0.0036 0.6842
Schistosoma mansoni intermediate filament proteins 0.0026 0.0009 0.0009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0164 0.0121 0.0121
Loa Loa (eye worm) ABC transporter 0.0025 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Loa Loa (eye worm) RNA binding protein 0.0061 0.0037 0.0036
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0008
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0025 0.0022
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0011
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0165 0.8588
Schistosoma mansoni sodium-bile acid cotransporter 0.7284 0.594 0.594
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0018
Echinococcus multilocularis cpg binding protein 0.0061 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0011
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0247 0.0189 0.8232
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0109 0.0077 0.0074
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.0088 0.0087
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0127
Schistosoma mansoni lamin 0.0026 0.0009 0.0009
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0012 0.001
Plasmodium vivax ABC transporter G family member 2, putative 0.003 0.0012 0.1804
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0115 1
Brugia malayi hypothetical protein 0.0035 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.0793 0.0635 0.0635
Plasmodium vivax serine/threonine kinase-1, putative 0.006 0.0036 0.6842
Brugia malayi protein C17H12.11 0.0059 0.0036 0.0033
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.003 0.0012 0.0527
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.003 0.0012 0.0509
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0011 0.0415
Mycobacterium ulcerans hypothetical protein 0.0157 0.0115 1
Brugia malayi intermediate filament protein 0.0026 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0027 0.001 0.001
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0025 0.0008 0.0427
Echinococcus granulosus microtubule associated protein 2 0.0679 0.0542 0.0541
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.0036 0.1577
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.0036 0.1577
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0019 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0012 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0165 0.8588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.023 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0012 0.001
Echinococcus granulosus dual specificity 0.0092 0.0062 0.0061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0023 0.0022
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0023 0.1017
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.0036 0.1577
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0009 0.0007
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Toxoplasma gondii hypothetical protein 0.0079 0.0052 0.3016
Brugia malayi hypothetical protein 0.0027 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0026
Onchocerca volvulus 1.2252 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0124 0.0088 0.3838
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0024
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0071 0.0045 0.0044
Echinococcus granulosus sodium bile acid cotransporter 1.2252 1 1
Brugia malayi Protein kinase domain containing protein 0.0229 0.0174 0.0172
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0062 0.2712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0012
Brugia malayi Bromodomain containing protein 0.0079 0.0052 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Leishmania major hypothetical protein, conserved 0.003 0.0012 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.004 0.0038
Brugia malayi Protein kinase domain containing protein 0.0092 0.0062 0.006
Echinococcus granulosus dual specificity protein kinase clk2 0.006 0.0036 0.0035
Schistosoma mansoni bromodomain containing protein 0.0068 0.0042 0.0042
Schistosoma mansoni ABC transporter 0.0025 0.0008 0.0008
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0012 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0102 0.4442
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0023 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0023 0.0021
Echinococcus multilocularis musashi 0.0026 0.0009 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0023 0.1017
Echinococcus granulosus activin receptor type 0.0072 0.0046 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0023 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0012
Brugia malayi RNA binding protein 0.0061 0.0037 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0002 0.0002
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0019 0.3355
Schistosoma mansoni sodium-bile acid cotransporter related 0.4968 0.4047 0.4047
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0109 0.0077 0.391
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0079 0.0052 0.4343
Loa Loa (eye worm) hypothetical protein 0.0109 0.0077 0.0075
Mycobacterium ulcerans putative regulatory protein 0.0079 0.0052 0.4343
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0169 0.0125 0.6487
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0012 0.0489
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.003 0.0012 0.0011
Loa Loa (eye worm) TK/ALK protein kinase 0.0229 0.0174 0.0173
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0016 0.0697
Schistosoma mansoni hypothetical protein 0.0164 0.0121 0.0121
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.003 0.0012 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0731
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0023 0.0022
Brugia malayi bone morphogenetic protein type 1 receptor 0.0155 0.0114 0.0111
Giardia lamblia ABC transporter 0.003 0.0011 0.2551
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0062 0.0061
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0017 0.0725
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0005 0.0239
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.003 0.0012 0.0527
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0003 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0005 0.023
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0005 0.0239
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0033 0.0031
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0012 0.0489
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0247 0.0189 0.8232
Echinococcus granulosus tumor protein p63 0.0332 0.0259 0.0258
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.003 0.0012 0.2761
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0036 0.0036
Entamoeba histolytica protein kinase, putative 0.0092 0.0062 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0023 0.1017
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0019 0.0017
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0102 0.4442
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0021 0.0931
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0247 0.0189 0.8232
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Plasmodium falciparum GAF domain-related protein, putative 0.0079 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0316
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0062 0.0062
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0012 0.1889
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0109 0.0077 0.391
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0017 0.0014
Echinococcus granulosus TGF beta receptor type 1 0.0156 0.0114 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0023 0.1089
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0023 0.0022
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0017 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Loa Loa (eye worm) hypothetical protein 0.009 0.0061 0.006
Echinococcus multilocularis lamin 0.0026 0.0009 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Entamoeba histolytica protein kinase, putative 0.0092 0.0062 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0015
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0019 0.3355
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.0036 0.1577
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0075 0.4487
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0121 0.0112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Echinococcus granulosus TGF-beta receptor type-1 0.0156 0.0114 0.0113
Echinococcus granulosus geminin 0.0164 0.0121 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0305
Echinococcus multilocularis zinc finger protein 0.0023 0.0006 0.0005
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0029 0.0028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0003 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Brugia malayi P38 map kinase family protein 2 0.0124 0.0088 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0023 0.1017
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0247 0.0189 0.0188
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Schistosoma mansoni sodium-bile acid cotransporter related 1.2252 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.02 0.0151 0.015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0021 0.0931
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0012 0.0783
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0052 1
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0124 0.0088 0.0087
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0012 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0023 0.0023
Onchocerca volvulus 0.0056 0.0033 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0036 0.1772
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0002 0.0099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Echinococcus multilocularis activin receptor type 0.0072 0.0046 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0305
Echinococcus granulosus expressed protein 0.0046 0.0025 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0169 0.0125 0.6487
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0014 0.0695
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0016 0.0697
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0023 0.3446
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0009 0.0006
Plasmodium falciparum phosphodiesterase delta, putative 0.003 0.0012 0.1889
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0127
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0017 0.0725
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Echinococcus granulosus GPCR family 2 0.0031 0.0012 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0012 0.0457
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.006 0.0036 0.2064
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0004
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0017 0.0017
Brugia malayi Protein kinase domain containing protein 0.0061 0.0037 0.0034
Toxoplasma gondii hypothetical protein 0.0048 0.0026 0.1456
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0002 0.0001
Schistosoma mansoni protein kinase 0.0156 0.0114 0.0114
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0017 0.2313
Giardia lamblia Kinase, CMGC CLK 0.006 0.0036 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0003 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0009 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.002
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.003 0.0012 0.0527
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0084 0.0084
Schistosoma mansoni lamin 0.0026 0.0009 0.0009
Entamoeba histolytica ABC transporter, putative 0.003 0.0012 0.1479
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0165 0.8588
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Entamoeba histolytica hypothetical protein 0.0092 0.0062 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0204
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0025 0.1364
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0025 0.1364
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0527
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0012 0.001
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.0191 0.0188
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.003 0.0012 0.0527
Schistosoma mansoni cpg binding protein 0.0061 0.0037 0.0037
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0027 0.0027
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0247 0.0189 0.8232
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0025 0.4523
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0042 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0072 0.0046 0.0045
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Schistosoma mansoni hypothetical protein 0.0039 0.0019 0.0019
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.003 0.0012 0.0527
Echinococcus multilocularis sodium bile acid cotransporter 1.2252 1 1
Brugia malayi CXXC zinc finger family protein 0.0056 0.0033 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0204
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0009 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.0542 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Echinococcus multilocularis dual specificity 0.0092 0.0062 0.0061
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0017 0.0016
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0023 0.0022
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0109 0.0077 0.0075
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0109 0.0077 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0029 0.1256
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0037 0.0035
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0017 0.0725
Loa Loa (eye worm) hypothetical protein 0.0059 0.0036 0.0034
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.003 0.0012 0.0012
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.0088 0.0087
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0005 0.0239
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.004 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0012 0.001
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.0088 0.3838
Loa Loa (eye worm) hypothetical protein 0.009 0.0061 0.006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Echinococcus granulosus mitogen activated protein kinase 11 0.0124 0.0088 0.0087
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0109 0.0077 0.0075
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0124 0.0088 0.3838
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0017 0.0015
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0017 0.0015
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Echinococcus multilocularis TGF beta receptor type 1 0.0156 0.0114 0.0113
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.003 0.0012 0.0011
Brugia malayi hypothetical protein 0.0059 0.0036 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0002 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0062 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Echinococcus multilocularis tumor protein p63 0.0332 0.0259 0.0258
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0012 0.0527
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0012 0.0783
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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