Detailed information for compound 764492

Basic information

Technical information
  • TDR Targets ID: 764492
  • Name: 3-[[2-chloro-5-(trifluoromethyl)phenyl]amino] -3H-2-benzofuran-1-one
  • MW: 327.686 | Formula: C15H9ClF3NO2
  • H donors: 1 H acceptors: 1 LogP: 4.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1NC1OC(=O)c2c1cccc2)C(F)(F)F
  • InChi: 1S/C15H9ClF3NO2/c16-11-6-5-8(15(17,18)19)7-12(11)20-13-9-3-1-2-4-10(9)14(21)22-13/h1-7,13,20H
  • InChiKey: DUALRDFUFSFIMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[2-chloro-5-(trifluoromethyl)phenyl]amino]-3H-isobenzofuran-1-one
  • STOCK3S-45886

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0006 0.0517
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.003 0.003
Echinococcus multilocularis mitogen activated protein kinase 3 0.0156 0.0119 0.0119
Echinococcus multilocularis sodium bile acid cotransporter 1.2404 1 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0009 0.0727
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0009 0.0009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0023 0.1946
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0082 0.4255
Echinococcus granulosus microtubule associated protein 2 0.2114 0.1698 0.1698
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0032 0.2666
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0006 0.1938
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0043 0.0043
Brugia malayi hypothetical protein 0.0126 0.0094 0.0094
Schistosoma mansoni inositol monophosphatase 0.0038 0.0023 0.0023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.003 0.003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0007 0.0111
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0006 0.0517
Loa Loa (eye worm) hypothetical protein 0.0147 0.0111 0.0111
Onchocerca volvulus 0.0147 0.0111 0.0096
Loa Loa (eye worm) hypothetical protein 0.0126 0.0094 0.0094
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0009 0.0000093111 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0097 0.0097
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0000093111 0.0000093111
Echinococcus granulosus sodium bile acid cotransporter 1.2404 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0195 1
Giardia lamblia PHD finger protein 15 0.0028 0.0015 0.0833
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0119 0.0119
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0097 0.0097
Echinococcus multilocularis microtubule associated protein 2 0.2114 0.1698 0.1698
Plasmodium falciparum thioredoxin reductase 0.0017 0.0006 0.1938
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.0188 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0097 0.0097
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0023 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0022 0.0922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.003 0.003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0003 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0183 1
Echinococcus multilocularis sodium bile acid cotransporter 1.2404 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0727
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0009 0.0132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0007 0.0007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0133 0.6694
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0000093111 0.0008
Brugia malayi AF-10 protein 0.0009 0.0000093111 0.0000093111
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0517
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0022 0.0022
Mycobacterium tuberculosis Probable reductase 0.011 0.0082 0.4255
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0022 0.0363
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0195 1
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.0188 0.0188
Echinococcus multilocularis sodium bile acid cotransporter 1.2404 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0006 0.0517
Plasmodium falciparum phd finger protein, putative 0.0028 0.0015 0.4903
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0727
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0195 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0091 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0007 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0022 0.0864
Loa Loa (eye worm) RNA binding protein 0.0129 0.0097 0.0097
Echinococcus multilocularis peregrin 0.0028 0.0015 0.0015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0023 1
Schistosoma mansoni hypothetical protein 0.0009 0.0000093111 0.0000093111
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0119 0.5943
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0119 0.5943
Trypanosoma brucei unspecified product 0.0014 0.0004 0.0308
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0043 0.2062
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0195 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0727
Leishmania major DNA polymerase eta, putative 0.002 0.0009 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Echinococcus granulosus tar DNA binding protein 0.0129 0.0097 0.0097
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0007 0.2333
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0022 0.0922
Echinococcus granulosus geminin 0.0165 0.0126 0.0126
Brugia malayi hypothetical protein 0.0242 0.0188 0.0188
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0022 0.0864
Toxoplasma gondii thioredoxin reductase 0.0048 0.0032 0.2666
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0022 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0009 0.0727
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0015 0.1307
Loa Loa (eye worm) hypothetical protein 1.2404 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0126 0.6316
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0023 0.0896
Mycobacterium leprae Probable lipase LipE 0.0037 0.0022 0.0363
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0156 0.0119 0.0119
Brugia malayi MAP kinase sur-1 0.0156 0.0119 0.0119
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0022 0.0922
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0126 0.6316
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0043 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0097 0.0097
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.0195 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0022 0.0022
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0015 0.0015
Plasmodium falciparum glutathione reductase 0.0017 0.0006 0.1938
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0015 0.1307
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0000093111 0.0000093111
Brugia malayi Bromodomain containing protein 0.0028 0.0015 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0006 0.0517
Brugia malayi Raf kinase 0.0214 0.0165 0.0165
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0119 0.5943
Mycobacterium ulcerans hypothetical protein 0.0037 0.0022 0.4472
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0023 0.1946
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0023 0.1946
Trichomonas vaginalis esterase, putative 0.0037 0.0022 0.0864
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0000093111 0.0008
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0015 0.0015
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0006 0.0517
Echinococcus granulosus mitogen activated protein kinase 0.0156 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) glutathione reductase 0.0048 0.0032 0.0032
Brugia malayi TAR-binding protein 0.0129 0.0097 0.0097
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0009 0.0793
Brugia malayi hypothetical protein 0.0147 0.0111 0.0111
Schistosoma mansoni sodium-bile acid cotransporter 0.7374 0.5942 0.5942
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0156 0.0119 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.165 0.1324 0.1324
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0009 0.0009
Echinococcus granulosus sodium bile acid cotransporter 1.2404 1 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.002 0.0776
Trypanosoma brucei unspecified product 0.0014 0.0004 0.0308
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0043 0.36
Loa Loa (eye worm) hypothetical protein 0.0049 0.0032 0.0032
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0156 0.0119 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0126 0.6316
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0009 0.0141
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.0195 0.0195
Schistosoma mansoni hypothetical protein 0.0049 0.0032 0.0032
Loa Loa (eye worm) beta-lactamase 0.0037 0.0022 0.0022
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Onchocerca volvulus Huntingtin homolog 0.0126 0.0094 0.0079
Toxoplasma gondii ABC1 family protein 0.0037 0.0022 0.1896
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0007 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0022 0.0022
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0006 0.0517
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0043 0.0043
Brugia malayi jmjC domain containing protein 0.0034 0.002 0.002
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0043 0.36
Loa Loa (eye worm) hypothetical protein 0.0126 0.0094 0.0094
Brugia malayi jmjC domain containing protein 0.0093 0.0068 0.0068
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0007 0.0622
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.003 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0043 0.0043
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0022 0.0922
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0022 0.0864
Schistosoma mansoni microtubule-associated protein tau 0.2114 0.1698 0.1698
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0043 1
Brugia malayi beta-lactamase family protein 0.0037 0.0022 0.0022
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0156 0.0119 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0091 0.4815
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0195 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0009 0.0727
Loa Loa (eye worm) hypothetical protein 0.0242 0.0188 0.0188
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Mycobacterium tuberculosis Conserved protein 0.0037 0.0022 0.0922
Echinococcus granulosus neuropeptide s receptor 0.0473 0.0374 0.0374
Mycobacterium tuberculosis Conserved protein 0.0037 0.0022 0.0922
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0007 0.0066
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0068 0.0068
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0156 0.0119 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0308
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0022 0.0922
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0032 0.0032
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0009 0.0682
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.0374 0.0374
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0006 0.5
Brugia malayi beta-lactamase 0.0037 0.0022 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Echinococcus multilocularis dna polymerase kappa 0.002 0.0009 0.0009
Brugia malayi Thioredoxin reductase 0.0048 0.0032 0.0032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0068 0.0068
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0156 0.0119 1
Brugia malayi PHD-finger family protein 0.0028 0.0015 0.0015
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0023 0.0896
Schistosoma mansoni sodium-bile acid cotransporter related 1.2404 1 1
Echinococcus granulosus sodium bile acid cotransporter 1.2404 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0727
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0000093111 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.002 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.003 0.003
Giardia lamblia Kinase, CMGC MAPK 0.0156 0.0119 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0082 0.8614
Mycobacterium tuberculosis Conserved protein 0.0037 0.0022 0.0922
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0022 0.0864
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0024 0.0024
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0007 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0126 0.6316
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0133 0.6694
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0022 0.0922
Brugia malayi glutathione reductase 0.0048 0.0032 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0156 0.0119 0.5943
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.002 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0022 0.0922
Leishmania major hypothetical protein, conserved 0.0037 0.0022 0.1896
Onchocerca volvulus 0.0037 0.0022 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.003 0.003
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0006 0.0517
Toxoplasma gondii exonuclease III APE 0.0018 0.0007 0.0622
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0727
Loa Loa (eye worm) raf kinase 0.022 0.017 0.017
Echinococcus multilocularis dna polymerase eta 0.002 0.0009 0.0009
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0082 0.4255
Schistosoma mansoni hypothetical protein 0.0165 0.0126 0.0126
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0009 0.0682
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0003 0.0003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0023 0.4635
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0007 0.007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.002 0.002
Brugia malayi Inositol-1 0.0038 0.0023 0.0023
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0024 0.0024
Onchocerca volvulus 0.0049 0.0032 0.0017
Plasmodium falciparum thioredoxin reductase 0.0048 0.0032 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.004 0.004
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0000093111 0.0008
Loa Loa (eye worm) inositol-1 0.0038 0.0023 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0006 0.0517
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0043 0.0043
Schistosoma mansoni DNA polymerase eta 0.002 0.0009 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0009 0.0009
Schistosoma mansoni sodium-bile acid cotransporter related 0.503 0.4051 0.4051
Mycobacterium ulcerans lipase LipD 0.0037 0.0022 0.4472
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0007 0.0622
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0009 0.0009
Brugia malayi RNA binding protein 0.0129 0.0097 0.0097
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0082 0.4255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0023 0.0896
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0009 0.0727
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0022 0.1896
Echinococcus multilocularis geminin 0.0165 0.0126 0.0126
Trypanosoma brucei unspecified product 0.002 0.0009 0.0727
Mycobacterium ulcerans beta-lactamase 0.0037 0.0022 0.4472
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0007 0.0342
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.0171 0.0171
Echinococcus granulosus dna polymerase kappa 0.002 0.0009 0.0009
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0156 0.0119 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0006 0.1938
Onchocerca volvulus 1.2404 1 1
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0097 0.0097
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0022 0.7111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0000093111 0.0000093111
Plasmodium vivax glutathione reductase, putative 0.0048 0.0032 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0007 0.0737
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0023 0.1946
Schistosoma mansoni hypothetical protein 0.0165 0.0126 0.0126
Leishmania major trypanothione reductase 0.0048 0.0032 0.2666
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0006 0.1938
Trypanosoma brucei trypanothione reductase 0.0048 0.0032 0.2666
Echinococcus multilocularis mitogen activated protein kinase 0.0156 0.0119 0.0119
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.0374 0.0374
Schistosoma mansoni survival motor neuron protein 0.0049 0.0032 0.0032
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0000093111 0.0008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0022 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0195 1
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.0007
Echinococcus granulosus mitogen activated protein kinase 3 0.0156 0.0119 0.0119
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0023 0.1946
Trypanosoma brucei protein kinase, putative 0.0156 0.0119 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0043 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0022 0.4472
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0082 0.4255
Brugia malayi beta-lactamase family protein 0.0037 0.0022 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0022 0.4472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.003 0.003
Plasmodium falciparum glutathione reductase 0.0048 0.0032 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0006 0.1938
Echinococcus granulosus dna polymerase eta 0.002 0.0009 0.0009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0009 0.0141
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0009 0.0132
Onchocerca volvulus 0.0037 0.0022 0.0007
Schistosoma mansoni inositol monophosphatase 0.0038 0.0023 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0097 0.0097
Onchocerca volvulus 0.0037 0.0022 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0015 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0126 0.6316
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0007 0.0007
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0156 0.0119 1
Echinococcus granulosus peregrin 0.0028 0.0015 0.0015
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0023 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0097 0.0097
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0006 0.0517
Echinococcus granulosus raf serine:threonine protein kinase 0.0221 0.0171 0.0171
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0032 0.0032
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0126 0.011
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0022 0.0864
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0032 0.0032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0082 0.4255
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0022 0.1896
Giardia lamblia DINP protein human, muc B family 0.002 0.0009 0.0222
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0007 0.2333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.003 0.003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0032 0.1437
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0091 0.4815
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0727
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0007 0.0622
Onchocerca volvulus Huntingtin homolog 0.0126 0.0094 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0032 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0126 0.0094 0.0094
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0091 0.4815
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.003 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0022 0.1896
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0097 0.0097
Schistosoma mansoni ap endonuclease 0.0018 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0006 0.0517
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0009 0.0009
Echinococcus multilocularis raf serine:threonine protein kinase 0.0221 0.0171 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0727
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0006 0.0006
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.0374 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0126 0.6316
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0097 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0015 0.4903
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0126 0.6316
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0007 0.0622
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0156 0.0119 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0006 0.0006
Brugia malayi PHD-finger family protein 0.0009 0.0000093111 0.0000093111
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0009 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0727
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0032 0.0032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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