Detailed information for compound 764521

Basic information

Technical information
  • TDR Targets ID: 764521
  • Name: 5-[(4-chloro-3,5-dimethylphenoxy)methyl]-3-(4 -nitrophenyl)-1,2,4-oxadiazole
  • MW: 359.764 | Formula: C17H14ClN3O4
  • H donors: 0 H acceptors: 4 LogP: 4.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)c1noc(n1)COc1cc(C)c(c(c1)C)Cl
  • InChi: 1S/C17H14ClN3O4/c1-10-7-14(8-11(2)16(10)18)24-9-15-19-17(20-25-15)12-3-5-13(6-4-12)21(22)23/h3-8H,9H2,1-2H3
  • InChiKey: CKOMVDDHXRSZPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4-chloro-3,5-dimethyl-phenoxy)methyl]-3-(4-nitrophenyl)-1,2,4-oxadiazole
  • ZINC01312636
  • STK117500

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi CXXC zinc finger family protein 0.0028 0.0033 0.011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0106 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0004 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.0651 0.22
Brugia malayi Latrophilin receptor protein 2 0.0081 0.016 0.0542
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0081 0.0274
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0071 0.0241
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0004 0.0012
Schistosoma mansoni endoplasmin 0.0045 0.0075 0.0254
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0502 0.1179 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Echinococcus granulosus snurportin 1 0.0613 0.1447 0.4891
Leishmania major hypothetical protein, conserved 0.0237 0.0538 1
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0004 0.0062
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0031 0.0578
Onchocerca volvulus 0.0028 0.0033 0.011
Schistosoma mansoni hypothetical protein 0.0029 0.0035 0.0116
Echinococcus granulosus jumonji domain containing protein 0.004 0.0062 0.0208
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0106 0.0356
Schistosoma mansoni ap endonuclease 0.0058 0.0106 0.0356
Schistosoma mansoni hypothetical protein 0.0682 0.1613 0.5452
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0038 0.0129
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0075 0.1395
Plasmodium falciparum histone acetyltransferase GCN5 0.0159 0.0349 0.9135
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Onchocerca volvulus Matrilysin homolog 0.0022 0.0018 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0108 0.0366
Trichomonas vaginalis set domain proteins, putative 0.0716 0.1696 1
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0068 0.0402
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0071 0.024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0106 0.2761
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0006 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0071 0.024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0071 0.0241
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0059 0.11
Brugia malayi polybromodomain protein 0.0014 0 0.0001
Brugia malayi hypothetical protein 0.0021 0.0015 0.0052
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0015 0.0051
Schistosoma mansoni lamin 0.0027 0.003 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0071 0.0241
Giardia lamblia Histone acetyltransferase GCN5 0.0159 0.0349 0.529
Loa Loa (eye worm) hypothetical protein 0.0029 0.0035 0.0117
Brugia malayi Matrixin family protein 0.0022 0.0018 0.006
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0199 0.0198
Brugia malayi tailless protein 0.0021 0.0015 0.0052
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0015 0.0052
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0192 0.0648
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0006 0.0006
Schistosoma mansoni zinc finger protein 0.0021 0.0015 0.0051
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0155 0.1274
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0004 0.0062
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0075 0.1957
Echinococcus multilocularis snurportin 1 0.0613 0.1447 0.1447
Echinococcus granulosus smad 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Brugia malayi TAR-binding protein 0.0389 0.0906 0.3061
Loa Loa (eye worm) hypothetical protein 0.0255 0.0581 0.1965
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0068 0.0534
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0017 0.0005 0.003
Echinococcus granulosus sodium bile acid cotransporter 0.1238 0.2958 1
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.0538 1
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0015 0.0052
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.0659 1
Mycobacterium tuberculosis Conserved protein 0.0079 0.0155 0.1274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0651 0.22
Brugia malayi nuclear receptor NHR-88 0.0044 0.0071 0.0241
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0104 0.1934
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0035 0.0116
Brugia malayi steroid hormone receptor 0.0044 0.0071 0.0241
Loa Loa (eye worm) intermediate filament protein 0.0027 0.003 0.0101
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0006 0.0019
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0031 0.0923
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0106 0.1959
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0016 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0174 0.0386 0.1305
Leishmania major cytochrome p450-like protein 0.0016 0.0004 0.0062
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0104 0.0104
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0071 0.0241
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0031 0.0105
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0284
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0068 0.0402
Plasmodium vivax SET domain containing protein 0.0018 0.001 0.0248
Brugia malayi Cytochrome P450 family protein 0.0016 0.0004 0.0012
Schistosoma mansoni sodium-bile acid cotransporter related 0.1238 0.2958 1
Schistosoma mansoni nuclear receptor 0.0021 0.0015 0.0051
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0049 0.0049
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0116 0.0392
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0155 0.1274
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Brugia malayi jmjC domain containing protein 0.0094 0.0192 0.0649
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0155 0.1274
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0155 0.4045
Toxoplasma gondii exonuclease III APE 0.0058 0.0106 0.2748
Echinococcus granulosus Smad4 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0072
Onchocerca volvulus Alhambra homolog 0.0029 0.0035 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0071 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0011 0.0207
Schistosoma mansoni sodium-bile acid cotransporter related 0.0502 0.1179 0.3985
Giardia lamblia Grp94/Hsp90 0.0043 0.0068 0.1036
Echinococcus multilocularis lamin dm0 0.0027 0.003 0.003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0173 0.0384 0.226
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Entamoeba histolytica hypothetical protein 0.0047 0.0078 0.118
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0155 0.4588
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0386 0.1306
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0588 0.1387 0.4689
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0031 0.0923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0651 0.22
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0031 0.0578
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0015
Brugia malayi polybromodomain protein 0.0014 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0071 0.0241
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0071 0.024
Echinococcus multilocularis endoplasmin 0.0043 0.0068 0.0068
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0015 0.0051
Schistosoma mansoni hypothetical protein 0.0613 0.1447 0.4891
Brugia malayi nuclear hormone receptor 0.0021 0.0015 0.0052
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Mycobacterium ulcerans hypothetical protein 0.0027 0.0031 0.0923
Brugia malayi hypothetical protein 0.0143 0.031 0.1048
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0014 0 0.0000011629
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0155 0.0155
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0004 0.0015
Echinococcus multilocularis sodium bile acid cotransporter 0.1238 0.2958 0.2958
Mycobacterium ulcerans hypothetical protein 0.0027 0.0031 0.0923
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Brugia malayi hypothetical protein 0.0023 0.0021 0.0072
Brugia malayi hypothetical protein 0.0023 0.0021 0.0072
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0029 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0071 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0389 0.0906 0.3061
Echinococcus granulosus cpg binding protein 0.0029 0.0036 0.0123
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0035 0.0117
Echinococcus multilocularis cpg binding protein 0.0029 0.0036 0.0036
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0071 0.0071
Brugia malayi BRM protein 0.0014 0 0.0001
Echinococcus multilocularis lamin 0.0027 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0173 0.0384 0.226
Onchocerca volvulus 0.0716 0.1696 0.5734
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0613 0.1447 0.4892
Onchocerca volvulus 0.0021 0.0015 0.0051
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0006 0.0147
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0014 0 0.00000034402
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0035 0.0896
Loa Loa (eye worm) hypothetical protein 0.1238 0.2958 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0071 0.0241
Echinococcus granulosus tar DNA binding protein 0.0389 0.0906 0.3061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0155 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0071 0.0241
Loa Loa (eye worm) bromodomain containing protein 0.0014 0 0.0001
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0029 0.0197
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0015 0.0051
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0015 0.0015
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0006 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0071 0.0071
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0068 0.1756
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0071 0.0241
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0015 0.0015
Brugia malayi MH2 domain containing protein 0.0237 0.0539 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0072
Brugia malayi nuclear receptor RXR 0.0021 0.0015 0.0052
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0045 0.0265
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0014
Echinococcus multilocularis sodium bile acid cotransporter 0.1238 0.2958 0.2958
Giardia lamblia PHD finger protein 15 0.0029 0.0035 0.0521
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0075 0.1139
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0021 0.0071
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0081 0.016 0.0541
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0059 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0071 0.0241
Plasmodium falciparum phd finger protein, putative 0.0029 0.0035 0.0901
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0015 0.0051
Echinococcus granulosus geminin 0.0682 0.1613 0.5452
Schistosoma mansoni ran 0.0042 0.0068 0.0228
Onchocerca volvulus 0.0091 0.0185 0.0624
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0155 0.2884
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0304 0.2544
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0525
Loa Loa (eye worm) hypothetical protein 0.0051 0.0088 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0389 0.0906 0.3061
Loa Loa (eye worm) hypothetical protein 0.0229 0.0519 0.1755
Echinococcus multilocularis geminin 0.0682 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Loa Loa (eye worm) BRM protein 0.0014 0 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0389 0.0906 0.3061
Leishmania major importin beta-1 subunit, putative 0.0047 0.0078 0.1445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0071 0.0241
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0185 0.0185
Mycobacterium tuberculosis Conserved protein 0.0027 0.0031 0.0217
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0021 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0071 0.024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Trichomonas vaginalis ran, putative 0.0042 0.0068 0.0397
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.0659 1
Echinococcus granulosus GPCR family 2 0.0081 0.016 0.0541
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0059 0.0898
Brugia malayi isocitrate dehydrogenase 0.0017 0.0006 0.002
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0075 0.1957
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0015
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0015 0.0052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0053 0.0178
Echinococcus multilocularis protein dispatched 1 0.0047 0.008 0.0079
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0062 0.0061
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0017 0.0005 0.003
Loa Loa (eye worm) TAR-binding protein 0.0389 0.0906 0.3061
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0029 0.0098
Toxoplasma gondii ABC1 family protein 0.0079 0.0155 0.4045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0173 0.0384 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0104 0.1934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.0651 0.0651
Brugia malayi Hemopexin family protein 0.0031 0.0039 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0155 0.2884
Trichomonas vaginalis esterase, putative 0.0079 0.0155 0.0914
Schistosoma mansoni hypothetical protein 0.0143 0.031 0.1047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0015 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Schistosoma mansoni ran 0.0042 0.0068 0.0228
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0155 0.5046
Schistosoma mansoni bromodomain containing protein 0.0016 0.0004 0.0013
Onchocerca volvulus Matrilysin homolog 0.0048 0.0081 0.0274
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0155 0.1274
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0015 0.0051
Brugia malayi hypothetical protein 0.0229 0.0519 0.1755
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0071 0.0071
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0006 0.0148
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0106 0.1599
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0155 0.0914
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0006 0.0006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0021 0.0071
Onchocerca volvulus 0.0079 0.0155 0.0524
Brugia malayi ATPase, AAA family protein 0.0014 0 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0071 0.024
Brugia malayi Bromodomain containing protein 0.0043 0.0069 0.0235
Schistosoma mansoni hypothetical protein 0.0081 0.016 0.0541
Brugia malayi heat shock protein 90 0.0045 0.0075 0.0254
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0015 0.0051
Brugia malayi acetyltransferase, GNAT family protein 0.0588 0.1387 0.4689
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0071 0.024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0015 0.0051
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0071 0.024
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0185 0.0624
Plasmodium vivax SET domain protein, putative 0.0091 0.0185 0.4815
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0199 0.3012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.0651 0.2201
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0071 0.024
Brugia malayi Bromodomain containing protein 0.0016 0.0004 0.0014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0071 0.024
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0068 0.1765
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0078 0.1445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0155 0.0524
Schistosoma mansoni ap endonuclease 0.0058 0.0106 0.0356
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0015 0.0052
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0071 0.024
Brugia malayi bromodomain containing protein 0.0014 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0071 0.0241
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0185 0.0185
Mycobacterium ulcerans lipase LipD 0.0079 0.0155 0.5046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0013 0.0042
Toxoplasma gondii bromodomain-containing protein 0.0014 0 0.00000023816
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0525
Echinococcus granulosus peregrin 0.0043 0.0069 0.0234
Echinococcus granulosus lamin 0.0027 0.003 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0071 0.0241
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0068 0.1252
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0106 0.1599
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0078 0.0458
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0006 0.0105
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0155 0.0525
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0071 0.024
Schistosoma mansoni cpg binding protein 0.0029 0.0036 0.0123
Loa Loa (eye worm) hypothetical protein 0.0041 0.0065 0.0221
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Brugia malayi Sodium Bile acid symporter family protein 0.1238 0.2958 1
Brugia malayi Hsp90 protein 0.003 0.0038 0.013
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0155 0.0914
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0059 0.11
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0075 0.0254
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0015 0.0051
Brugia malayi Matrixin family protein 0.0022 0.0018 0.006
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0065 0.0065
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0038 0.0995
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0071 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0071 0.0241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0098
Brugia malayi Cytochrome P450 family protein 0.0016 0.0004 0.0012
Schistosoma mansoni smad 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0091 0.0185 0.0625
Loa Loa (eye worm) DR-78 0.0021 0.0015 0.0052
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Loa Loa (eye worm) hypothetical protein 0.0097 0.0199 0.0671
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0006 0.0006
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0006 0.002
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0106 0.0628
Plasmodium vivax endoplasmin, putative 0.0045 0.0075 0.1957
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0078 0.0265
Onchocerca volvulus 0.0027 0.003 0.0101
Echinococcus granulosus lamin dm0 0.0027 0.003 0.0101
Onchocerca volvulus 0.0027 0.003 0.0101
Schistosoma mansoni lamin 0.0027 0.003 0.0101
Brugia malayi RNA recognition motif domain containing protein 0.0389 0.0906 0.3061
Brugia malayi Smad1 0.0016 0.0004 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0071 0.0241
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0004 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0155 0.2884
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0106 0.0621
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0038 0.0129
Schistosoma mansoni cpg binding protein 0.0028 0.0033 0.011
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0071 0.024
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0075 0.1957
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0038 0.0579
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0075 0.1395
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0525
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0155 0.1274
Brugia malayi intermediate filament protein 0.0027 0.003 0.0101
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0016 0.0004 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0155 0.0914
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.031 0.031
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0106 1
Onchocerca volvulus 0.0079 0.0155 0.0524
Brugia malayi RNA binding protein 0.0389 0.0906 0.3061
Echinococcus granulosus heat shock protein 90 0.0039 0.0059 0.02
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0071 0.0241
Schistosoma mansoni heat shock protein 0.0045 0.0075 0.0254
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0035 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0071 0.0071
Schistosoma mansoni coup transcription factor 0.0044 0.0071 0.024
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0006 0.0019
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0021 0.0072
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.0581 0.1965
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0035 0.0896
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.004 0.0062 0.0208
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0006 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0015 0.0051
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0068 0.127
Echinococcus multilocularis zinc finger protein 0.0016 0.0004 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0071 0.024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0071 0.0071
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0053 0.0178
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0053 0.0179
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0021 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0004 0.0012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0106 0.085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0071 0.0241
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0629 0.1486 0.5024
Schistosoma mansoni hypothetical protein 0.0081 0.016 0.0541
Brugia malayi ecdysone receptor 0.0021 0.0015 0.0052
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0068 0.1252
Entamoeba histolytica acetyltransferase, GNAT family 0.0159 0.0349 0.529
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0068 0.0067
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0299 0.0299
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Brugia malayi TAZ zinc finger family protein 0.0014 0 0.0001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0202 0.0683
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.016 0.0541
Entamoeba histolytica Ran family GTPase 0.0042 0.0068 0.1022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0304 1
Plasmodium vivax heat shock protein 90, putative 0.003 0.0038 0.0995
Brugia malayi Pre-SET motif family protein 0.0091 0.0185 0.0625
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0097
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0199 0.0671
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0006 0.0105
Leishmania major GTP-binding protein, putative 0.0042 0.0068 0.1252
Mycobacterium ulcerans hypothetical protein 0.0079 0.0155 0.5046
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0006 0.0147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0155 0.0525
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0106 0.1959
Echinococcus multilocularis peregrin 0.0043 0.0069 0.0069
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0075 0.1395
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0155 0.0914
Echinococcus granulosus zinc finger protein 0.0016 0.0004 0.0013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0106 0.3392
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0015 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0185 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0071 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0185 0.0624
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0068 0.1252
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0015 0.0052
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0004 0.0015
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0173 0.0384 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.016 0.016
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Loa Loa (eye worm) matrixin family protein 0.0048 0.0081 0.0275
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0015 0.0015
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0106 0.0357
Echinococcus granulosus sodium bile acid cotransporter 0.1238 0.2958 1
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0071 0.024
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Schistosoma mansoni hypothetical protein 0.0682 0.1613 0.5452
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0031 0.0578
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.003 0.0101
Mycobacterium ulcerans beta-lactamase 0.0079 0.0155 0.5046
Brugia malayi hypothetical protein 0.0021 0.0015 0.0052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0155 0.5046
Loa Loa (eye worm) RNA binding protein 0.0389 0.0906 0.3061
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0006 0.0105
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.0581 0.1965
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0104 0.0352
Schistosoma mansoni importin beta-1 0.0057 0.0104 0.0351
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0525
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0071 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Mycobacterium tuberculosis Conserved protein 0.0079 0.0155 0.1274
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0071 0.024
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.006
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0588 0.1387 0.1387
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0071 0.024
Brugia malayi Importin beta-1 subunit 0.0057 0.0104 0.0352
Schistosoma mansoni patched 1 0.0041 0.0065 0.0221
Plasmodium falciparum importin beta, putative 0.0057 0.0104 0.2725
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0031 0.0217
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.016 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.0539 0.182
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0071 0.024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.0651 0.2201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0071 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Brugia malayi nuclear hormone receptor 0.0044 0.0071 0.0241
Entamoeba histolytica ankyrin repeat protein, putative 0.0014 0 0.00000013857
Echinococcus granulosus heat shock protein 0.0045 0.0075 0.0254
Plasmodium falciparum heat shock protein 90 0.0045 0.0075 0.1966
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Onchocerca volvulus 0.0031 0.0039 0.0133
Loa Loa (eye worm) acetyltransferase 0.0588 0.1387 0.4689
Echinococcus multilocularis heat shock protein 90 0.0039 0.0059 0.0059
Brugia malayi PHD-finger family protein 0.0029 0.0035 0.0117
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0192 0.0192
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0155 0.1274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0072
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0075 0.1395
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0031 0.0031
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0015
Plasmodium vivax importin-beta 2, putative 0.0057 0.0104 0.2712
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0155 0.0914
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Loa Loa (eye worm) bromodomain containing protein 0.0014 0 0.0001
Schistosoma mansoni Smad4 0.0016 0.0004 0.0014
Entamoeba histolytica hypothetical protein 0.0143 0.031 0.4703
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0018 0.006
Brugia malayi nuclear receptor NHR-88 0.0021 0.0015 0.0052
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0072
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0068 0.0228
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0106 0.1959
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0038 0.0709
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0071 0.024
Brugia malayi Matrixin family protein 0.0052 0.0092 0.031
Echinococcus granulosus histone acetyltransferase KAT2B 0.0572 0.1347 0.4554
Schistosoma mansoni heat shock protein 0.003 0.0038 0.0129
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0014
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0015 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0071 0.0241
Brugia malayi Endoplasmin precursor 0.0045 0.0075 0.0254
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0045 0.0265
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0075 0.1395
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0021 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0065 0.0385
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0101
Onchocerca volvulus 0.0047 0.0078 0.0264
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0525
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0053 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0071 0.024
Schistosoma mansoni tar DNA-binding protein 0.0389 0.0906 0.3061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.0651 0.0651
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0519 0.1754
Loa Loa (eye worm) matrixin family protein 0.0052 0.0092 0.031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0033 0.011
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0078 0.0458
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0106 0.0357
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0071 0.0071
Onchocerca volvulus 0.0022 0.0018 0.0059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0106 0.2748
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0071 0.024
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0075 0.1395
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0299 0.1009
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0155 0.0524
Onchocerca volvulus 0.1238 0.2958 1
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0059 0.0349
Echinococcus granulosus histone acetyltransferase KAT2B 0.0173 0.0384 0.1296
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Toxoplasma gondii Hsp90 domain-containing protein 0.0172 0.0382 0.9952
Trypanosoma brucei hypothetical protein, conserved 0.0237 0.0538 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.0581 0.1965
Schistosoma mansoni hypothetical protein 0.004 0.0062 0.0208
Plasmodium falciparum bromodomain protein 1 0.0014 0 0.00000023931
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0015 0.0015
Plasmodium falciparum heat shock protein 90, putative 0.0172 0.0382 1
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0199 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0071 0.0241
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0015 0.0015
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0106 0.1959
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0072
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0065 0.0221
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Schistosoma mansoni endoplasmin 0.0045 0.0075 0.0254
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0031 0.0923
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.003 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0071 0.024
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.0015 0.0051
Entamoeba histolytica hypothetical protein 0.0143 0.031 0.4703
Plasmodium vivax heat shock protein, putative 0.0172 0.0382 0.9952
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0068 0.0228
Echinococcus granulosus expressed conserved protein 0.0091 0.0184 0.0623
Brugia malayi RNA, U transporter 1 0.0163 0.036 0.1217
Brugia malayi nuclear receptor NHR-67 0.0021 0.0015 0.0052
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0173 0.0384 1
Loa Loa (eye worm) CBP-B 0.0014 0 0.0001
Leishmania major hypothetical protein, conserved 0.0079 0.0155 0.2884
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0136 0.3533
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0021 0.0072
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0006 0.0147
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0075 0.1139
Schistosoma mansoni survival motor neuron protein 0.0047 0.0078 0.0264
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0078 0.0458
Entamoeba histolytica hypothetical protein 0.0143 0.031 0.4703
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0015
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0068 0.1022
Loa Loa (eye worm) hypothetical protein 0.0081 0.016 0.0542
Schistosoma mansoni cpg binding protein 0.0029 0.0036 0.0123
Schistosoma mansoni hypothetical protein 0.0081 0.016 0.0541
Brugia malayi jmjC domain containing protein 0.0036 0.0053 0.0179
Loa Loa (eye worm) hypothetical protein 0.0044 0.0071 0.0241
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0006 0.0105
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Trypanosoma brucei AAA ATPase, putative 0.0014 0 0.0000063983
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.016 0.0542
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0185 0.4815
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0065 0.0221
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0155 0.0524
Brugia malayi Matrixin family protein 0.0022 0.0018 0.006
Echinococcus granulosus intermediate filament protein 0.0027 0.003 0.0101
Loa Loa (eye worm) endoplasmin 0.0045 0.0075 0.0254
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0389 0.0906 0.3061
Echinococcus granulosus heat shock protein 90 0.0045 0.0075 0.0254
Leishmania major heat shock protein, putative 0.003 0.0038 0.0709
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0038 0.0038
Schistosoma mansoni bromodomain containing protein 0.0016 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.031 0.1047
Echinococcus multilocularis heat shock protein 0.0045 0.0075 0.0075
Echinococcus multilocularis heat shock protein 90 0.0045 0.0075 0.0075
Echinococcus multilocularis smad 0.0016 0.0004 0.0004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0175 0.0592
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Mycobacterium tuberculosis Conserved protein 0.0079 0.0155 0.1274
Brugia malayi CHE-14 protein 0.0041 0.0065 0.0221
Brugia malayi Pre-SET motif family protein 0.0629 0.1486 0.5024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.0651 0.22
Schistosoma mansoni intermediate filament proteins 0.0027 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0065 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0651 0.22
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0106 0.0621
Schistosoma mansoni hypothetical protein 0.004 0.0062 0.0208
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0071 0.0071
Mycobacterium ulcerans hydrolase 0.0026 0.0029 0.0846
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0015 0.0052
Brugia malayi conserved hypotetical protein 0.0021 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.006
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0029 0.0761
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.0659 1
Echinococcus multilocularis protein patched 0.0041 0.0065 0.0065
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0075 0.1395
Echinococcus multilocularis expressed conserved protein 0.0091 0.0184 0.0184
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.031 0.1047
Loa Loa (eye worm) hypothetical protein 0.0174 0.0386 0.1306
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0071 0.0241
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.0539 0.182
Schistosoma mansoni zinc finger protein 0.0016 0.0004 0.0013
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Brugia malayi PHD-finger family protein 0.0016 0.0004 0.0014
Echinococcus multilocularis tar DNA binding protein 0.0389 0.0906 0.0906
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0075 0.1395
Trypanosoma cruzi heat shock protein, putative 0.003 0.0038 0.0709
Loa Loa (eye worm) heat shock protein 75 0.003 0.0038 0.013
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Brugia malayi Matrixin family protein 0.0022 0.0018 0.006
Echinococcus granulosus endoplasmin 0.0043 0.0068 0.0231
Plasmodium vivax hypothetical protein, conserved 0.0014 0 0.00000023816
Schistosoma mansoni hypothetical protein 0.0031 0.0039 0.0133
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0018 0.0059
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0519 0.0519
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0043 0.0068 0.1434
Brugia malayi beta-lactamase 0.0079 0.0155 0.0525
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0185 0.0624
Brugia malayi beta-lactamase family protein 0.0079 0.0155 0.0525
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0185 0.0624
Brugia malayi nuclear receptor RXR 0.0023 0.0021 0.0072
Onchocerca volvulus 0.0079 0.0155 0.0524
Schistosoma mansoni sodium-bile acid cotransporter 0.0736 0.1745 0.5897
Leishmania major heat shock protein 83-1 0.0045 0.0075 0.1395
Brugia malayi ecdysteroid receptor 0.0044 0.0071 0.0241
Schistosoma mansoni hypothetical protein 0.0047 0.0078 0.0264
Schistosoma mansoni hypothetical protein 0.004 0.0062 0.0208
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0068 0.0228
Brugia malayi beta-lactamase family protein 0.0079 0.0155 0.0525
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0075 0.0442
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.0659 1
Entamoeba histolytica hypothetical protein 0.0143 0.031 0.4703
Trypanosoma brucei heat shock protein, putative 0.0045 0.0075 0.1395
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0035 0.0116
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0075 0.1139
Echinococcus multilocularis musashi 0.0027 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Loa Loa (eye worm) beta-lactamase 0.0079 0.0155 0.0525
Plasmodium falciparum endoplasmin, putative 0.0033 0.0045 0.1177
Onchocerca volvulus 0.0021 0.0015 0.0051
Loa Loa (eye worm) Smad1 0.0016 0.0004 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0145 0.0491
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Schistosoma mansoni heat shock protein 0.0045 0.0075 0.0254
Echinococcus multilocularis GPCR, family 2 0.0081 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0525
Mycobacterium leprae Probable lipase LipE 0.0079 0.0155 0.4588
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0068 0.1756
Schistosoma mansoni nuclear receptor 0.0021 0.0015 0.0051
Onchocerca volvulus 0.0044 0.0071 0.024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0071 0.024
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0068 0.2159
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0017 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0237 0.0538 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0052
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0014
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0031 0.0183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.016 0.0542
Schistosoma mansoni tar DNA-binding protein 0.0389 0.0906 0.3061
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0015 0.0052
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0071 0.024
Echinococcus granulosus sodium bile acid cotransporter 0.1238 0.2958 1
Echinococcus multilocularis sodium bile acid cotransporter 0.1238 0.2958 0.2958
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0155 0.1274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.0659 0.3884
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0104 0.2712
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0304 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.016 0.0541
Brugia malayi Bromodomain containing protein 0.0014 0 0.0001
Echinococcus granulosus importin subunit beta 1 0.0057 0.0104 0.0351
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0035 0.0896

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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