Detailed information for compound 764603

Basic information

Technical information
  • TDR Targets ID: 764603
  • Name: 2-[2-chloro-4-[[1-(4-ethylphenyl)-2,4,6-triox o-1,3-diazinan-5-ylidene]methyl]-6-methoxyphe noxy]acetic acid
  • MW: 458.848 | Formula: C22H19ClN2O7
  • H donors: 2 H acceptors: 5 LogP: 3.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)N1C(=O)NC(=O)C(=Cc2cc(Cl)c(c(c2)OC)OCC(=O)O)C1=O
  • InChi: 1S/C22H19ClN2O7/c1-3-12-4-6-14(7-5-12)25-21(29)15(20(28)24-22(25)30)8-13-9-16(23)19(17(10-13)31-2)32-11-18(26)27/h4-10H,3,11H2,1-2H3,(H,26,27)(H,24,28,30)/b15-8+
  • InChiKey: BVKMFBLZEPCEHG-OVCLIPMQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-chloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-6-methoxyphenoxy]acetic acid
  • 2-[2-chloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]-6-methoxy-phenoxy]acetic acid
  • 2-[2-chloro-4-[[1-(4-ethylphenyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]-6-methoxy-phenoxy]acetic acid
  • 2-[2-chloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]-6-methoxyphenoxy]acetic acid
  • 2-[2-chloro-4-[[1-(4-ethylphenyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]-6-methoxyphenoxy]acetic acid
  • 2-[2-chloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]-6-methoxy-phenoxy]acetic acid
  • 2-[2-chloro-4-[[1-(4-ethylphenyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]-6-methoxy-phenoxy]acetic acid
  • 2-[2-chloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-6-methoxy-phenoxy]ethanoic acid
  • 2-[2-chloro-4-[[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-6-methoxy-phenoxy]ethanoic acid
  • STK175230

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi larval opioid receptor 0.0046 0.0426 0.1138
Loa Loa (eye worm) RNA binding protein 0.0259 0.2936 0.8224
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Echinococcus multilocularis cpg binding protein 0.0064 0.0635 0.0613
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.2483 0.6945
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0017 0.0087 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Mycobacterium ulcerans beta-lactamase 0.0074 0.0757 0.1925
Schistosoma mansoni myosin xvIII 0.0046 0.0426 0.0426
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0479 0.1286
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0426 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0757 0.0757
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0075 0.0051
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0337 0.386 0.386
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0426 0.1138
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0549 0.1483
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.1836 0.1836
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0458 0.1229
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0087 0.0867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0087 0.0867
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0312 0.3562 0.3547
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0757 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0572 0.7485
Echinococcus granulosus g protein coupled receptor 0.0046 0.0426 0.0404
Loa Loa (eye worm) histone methyltransferase 0.002 0.0118 0.0267
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0426 0.1138
Brugia malayi G-protein coupled receptor 0.0046 0.0426 0.1138
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0757 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0426 0.0404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.0062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0757 0.0757
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Brugia malayi beta-lactamase family protein 0.0074 0.0757 0.207
Brugia malayi G-protein coupled receptor 0.0046 0.0426 0.1138
Giardia lamblia Alcohol dehydrogenase 0.0017 0.0087 0.1158
Schistosoma mansoni neuropeptide receptor 0.0046 0.0426 0.0426
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0087 0.1158
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0757 0.135
Schistosoma mansoni hypothetical protein 0.0046 0.0426 0.0426
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0503 0.1355
Loa Loa (eye worm) hypothetical protein 0.0074 0.0757 0.207
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0757 0.207
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0757 0.135
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0757 0.207
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2798 0.2781
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0426 0.0426
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0411 0.7057
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0426 0.1431
Schistosoma mansoni biogenic amine receptor 0.0046 0.0426 0.0426
Trichomonas vaginalis esterase, putative 0.0074 0.0757 0.207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0426 0.0426
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi CXXC zinc finger family protein 0.006 0.0595 0.1613
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0426 0.0404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0017 0.0087 0.018
Onchocerca volvulus 0.0046 0.0426 0.1431
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0118 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.0062
Echinococcus granulosus neuropeptide receptor 0.0046 0.0426 0.0404
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0426 0.0404
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0572 0.7485
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0757 0.1925
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.1292 0.3584
Mycobacterium ulcerans lipase LipD 0.0074 0.0757 0.1925
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0426 0.1138
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0075 0.0051
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus granulosus allatostatin A receptor 0.0046 0.0426 0.0404
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0757 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0087 0.0087
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0017 0.0087 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0473 0.5456 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.008 0.0161
Schistosoma mansoni hypothetical protein 0.0046 0.0426 0.0426
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0458 0.0436
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0017 0.0087 0.1158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0312 0.3562 0.9991
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0087 0.018
Loa Loa (eye worm) hypothetical protein 0.0074 0.0757 0.207
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0458 0.5934
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0017 0.0087 0.0226
Mycobacterium ulcerans glutaminase 0.0312 0.3565 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0312 0.3562 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0074 0.0757 0.207
Echinococcus granulosus geminin 0.0337 0.386 0.3846
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.1781 0.1762
Mycobacterium tuberculosis Conserved protein 0.0074 0.0757 0.135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0271 0.0271
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0458 0.1228
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0017 0.0087 0.0117
Mycobacterium tuberculosis Conserved protein 0.0074 0.0757 0.135
Schistosoma mansoni cpg binding protein 0.0064 0.0635 0.0635
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0271 0.0248
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.008 0.0161
Brugia malayi RNA binding protein 0.0259 0.2936 0.8224
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0426 0.0426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Brugia malayi neuropeptide F receptor 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0572 0.1549
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0426 0.0404
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0641 0.1593
Echinococcus multilocularis dnaJ subfamily B 0.0858 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0045 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0426 0.0404
Echinococcus granulosus sex peptide receptor 0.0046 0.0426 0.0404
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0426 0.0404
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0426 0.0404
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus granulosus fmrfamide receptor 0.0046 0.0426 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2936 0.2936
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0087 0.0867
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0017 0.0087 0.018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.0062
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0641 0.0619
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi TAR-binding protein 0.0259 0.2936 0.8224
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0087 0.0867
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0757 0.135
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0017 0.0087 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0572 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0757 0.207
Echinococcus granulosus serotonin receptor 0.0046 0.0426 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Brugia malayi G protein-coupled receptor 0.0046 0.0426 0.1138
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.008
Echinococcus granulosus orexin receptor type 2 0.0046 0.0426 0.0404
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.0426 0.0404
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0426 0.0404
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0426 0.1138
Brugia malayi aldehyde dehydrogenase 0.0017 0.0087 0.0179
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0426 0.0426
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0641 0.1745
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0312 0.3562 0.6514
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.008
Onchocerca volvulus 0.0046 0.0426 0.1431
Toxoplasma gondii ABC1 family protein 0.0074 0.0757 0.2072
Echinococcus granulosus g protein coupled receptor 0.0046 0.0426 0.0404
Schistosoma mansoni biogenic amine receptor 0.0046 0.0426 0.0426
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0087 0.1158
Brugia malayi sulfakinin receptor protein 0.0046 0.0426 0.1138
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0087 0.0867
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0426 0.0404
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0075 0.0075
Plasmodium vivax SET domain protein, putative 0.0033 0.0271 0.3372
Schistosoma mansoni hypothetical protein 0.0036 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0858 1 1
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0087 0.018
Loa Loa (eye worm) hypothetical protein 0.0074 0.0757 0.207
Onchocerca volvulus 0.0046 0.0426 0.1431
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0757 0.207
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.1836 0.5118
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0426 0.1138
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0312 0.3562 0.3547
Loa Loa (eye worm) hypothetical protein 0.0074 0.0757 0.207
Brugia malayi Dopamine receptor protein 1 0.0046 0.0426 0.1138
Schistosoma mansoni cpg binding protein 0.0064 0.0635 0.0635
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0757 0.135
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0426 0.0404
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0641 0.0641
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0271 0.0699
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0426 0.0404
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0757 0.0735
Onchocerca volvulus 0.006 0.0595 0.2029
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0017 0.0087 0.0064
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0115 0.0259
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0017 0.0087 0.0064
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0757 0.207
Onchocerca volvulus 0.0046 0.0426 0.1431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1542 0.4287
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0426 0.1431
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0757 0.207
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0426 0.0404
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0426 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Loa Loa (eye worm) glutaminase 2 0.0312 0.3565 1
Onchocerca volvulus 0.0046 0.0426 0.1431
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0017 0.0087 0.0117
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0241 0.0219
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0426 0.1138
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0426 0.0404
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0426 0.1138
Loa Loa (eye worm) glutaminase 0.0312 0.3565 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Trichomonas vaginalis glutaminase, putative 0.0312 0.3565 1
Onchocerca volvulus 0.0046 0.0426 0.1431
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0426 0.1138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0271 0.0271
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0087 0.0867
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0572 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Brugia malayi hypothetical protein 0.0247 0.2798 0.7833
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0312 0.3562 0.9991
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0087 0.0867
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0411 0.7057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0757 0.135
Echinococcus multilocularis serotonin receptor 0.0046 0.0426 0.0404
Onchocerca volvulus 0.005 0.0479 0.1617
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0757 0.207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0426 0.0404
Brugia malayi GnHR receptor homolog 0.0046 0.0426 0.1138
Schistosoma mansoni biogenic amine receptor 0.0046 0.0426 0.0426
Loa Loa (eye worm) beta-lactamase 0.0074 0.0757 0.207
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0426 0.0404
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0426 0.0404
Onchocerca volvulus 0.0046 0.0426 0.1431
Schistosoma mansoni synaptojanin 0.0012 0.0023 0.0023
Onchocerca volvulus 0.0046 0.0426 0.1431
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0426 0.0426
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0087 0.0087
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0426 0.0404
Onchocerca volvulus 0.0251 0.284 1
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0426 0.0404
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0426 0.0426
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0017 0.0087 0.0087
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0087 0.0867
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0023 0.0023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0641 0.1593
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0426 0.0426
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0426 0.0404
Brugia malayi putative neuropeptide receptor 0.0046 0.0426 0.1138
Schistosoma mansoni hypothetical protein 0.0046 0.0426 0.0426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.008 0.0057
Brugia malayi Dopamine receptor 0.0046 0.0426 0.1138
Echinococcus granulosus tar DNA binding protein 0.0259 0.2936 0.292
Brugia malayi Serotonin receptor 0.0046 0.0426 0.1138
Mycobacterium ulcerans hypothetical protein 0.0074 0.0757 0.1925
Treponema pallidum gamma-glutamyl phosphate reductase 0.0017 0.0087 0.1158
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0757 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.008 0.0057
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0426 0.0426
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0087 0.0867
Brugia malayi AKH receptor 0.0046 0.0426 0.1138
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0017 0.0087 0.018
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0572 0.7485
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0641 0.1743
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0426 0.0404
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0087 0.0867
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1405 0.1405
Onchocerca volvulus 0.0046 0.0426 0.1431
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0017 0.0087 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.008 0.0161
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1542 0.1522
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0426 0.1138
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0426 0.1138
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0426 0.0404
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0017 0.0087 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1542 0.1542
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Brugia malayi glutaminase DH11.1 0.0312 0.3565 1
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0087 0.0867
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0087 0.0087
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1542 0.4287
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0023 0.0023
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0017 0.0087 0.0179
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0087 0.018
Toxoplasma gondii aldehyde dehydrogenase 0.0312 0.3562 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0426 0.0404
Brugia malayi RE15519p 0.0046 0.0426 0.1138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0572 0.7485
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0426 0.0426
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0426 0.0404
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0426 0.0404
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0017 0.0087 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Echinococcus granulosus hypothetical protein 0.0046 0.0426 0.0404
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0572 0.101
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.008 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0087 0.0064
Echinococcus granulosus neuropeptide receptor 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0087 0.0867
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0017 0.0087 0.0117
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0426 0.0404
Schistosoma mansoni ap endonuclease 0.0058 0.0572 0.0572
Trichomonas vaginalis set domain proteins, putative 0.0251 0.284 0.7953
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0426 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2936 0.2936
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0426 0.0404
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0087 0.1158
Onchocerca volvulus 0.0074 0.0757 0.2603
Schistosoma mansoni opsin-like receptor 0.0046 0.0426 0.0426
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0426 0.0404
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0271 0.0248
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0017 0.0087 0.0179
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0017 0.0087 0.0064
Echinococcus multilocularis geminin 0.0337 0.386 0.3846
Schistosoma mansoni histamine h1 receptor 0.0046 0.0426 0.0426
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0075 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2936 0.2936
Schistosoma mansoni amine GPCR 0.0046 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) acetyltransferase 0.0166 0.1836 0.5118
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0087 0.0867
Schistosoma mansoni hypothetical protein 0.0017 0.0087 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2936 0.2936
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0595 0.1613
Loa Loa (eye worm) TAR-binding protein 0.0259 0.2936 0.8224
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0426 0.0404
Onchocerca volvulus 0.0074 0.0757 0.2603
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0757 0.1925
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0426 0.0404
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0426 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0259 0.2936 0.2936
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Echinococcus granulosus cpg binding protein 0.0064 0.0635 0.0613
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0572 1
Onchocerca volvulus 0.0046 0.0426 0.1431
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Onchocerca volvulus 0.0046 0.0426 0.1431
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0087 0.0867
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0118 0.0095
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Mycobacterium leprae Probable lipase LipE 0.0074 0.0757 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0572 0.1551
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0802
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0426 0.0404
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus multilocularis tar DNA binding protein 0.0259 0.2936 0.292
Schistosoma mansoni amine GPCR 0.0046 0.0426 0.0426
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0426 0.0404
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0426 0.0404
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0572 0.1549
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0426 0.0404
Onchocerca volvulus 0.0046 0.0426 0.1431
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0641 0.0619
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0757 0.0735
Schistosoma mansoni opsin-like receptor 0.0046 0.0426 0.0426
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0017 0.0087 0.0117
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0033 0.0271 0.0698
Onchocerca volvulus 0.0046 0.0426 0.1431
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0503 0.1355
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0572 1
Schistosoma mansoni synaptojanin 0.0012 0.0023 0.0023
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0087 0.0867
Echinococcus multilocularis GPCR, family 2 0.0017 0.008 0.0057
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0426 0.0426
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0426 0.0404
Mycobacterium ulcerans aldehyde dehydrogenase 0.0312 0.3562 0.9991
Onchocerca volvulus 0.0046 0.0426 0.1431
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi beta-lactamase family protein 0.0074 0.0757 0.207
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0087 0.0867
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0572 0.1549
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0017 0.0087 0.0179
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0017 0.0087 0.0117
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0426 0.0404
Schistosoma mansoni neuropeptide receptor 0.0046 0.0426 0.0426
Schistosoma mansoni aldehyde dehydrogenase 0.0312 0.3562 0.3562
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0179
Brugia malayi neuropeptide F receptor 0.0046 0.0426 0.1138
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0017 0.0087 0.0064
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0426 0.0404
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0426 0.0404
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0017 0.0087 0.0117
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0087 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.008 0.0057
Onchocerca volvulus 0.0046 0.0426 0.1431
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0075 0.0051
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.008
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0757 1
Brugia malayi ORL1-like opioid receptor 0.0046 0.0426 0.1138
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0426 0.0404
Brugia malayi Dopamine receptor protein 2 0.0046 0.0426 0.1138
Echinococcus multilocularis somatostatin receptor 0.0046 0.0426 0.0404
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0017 0.0087 0.0179
Brugia malayi follicle stimulating hormone receptor 0.0288 0.3281 0.9199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Schistosoma mansoni hypothetical protein 0.005 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0087 0.018
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0017 0.0087 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0757 0.135
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0572 0.055
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0426 0.0404
Schistosoma mansoni glutaminase 0.0312 0.3565 0.3565
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.2936 0.8224
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0017 0.0087 0.0117
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0426 0.1138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0426 0.0426
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0017 0.0087 0.0179
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0426 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1542 0.1522
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0426 0.0404
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0426 0.0404
Onchocerca volvulus 0.0046 0.0426 0.1431
Toxoplasma gondii exonuclease III APE 0.0058 0.0572 0.1551
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0087 0.0087
Schistosoma mansoni cript-related 0.0012 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0426 0.0404
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Echinococcus granulosus somatostatin receptor 0.0046 0.0426 0.0404
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0572 0.1549
Onchocerca volvulus 0.0074 0.0757 0.2603
Schistosoma mansoni amine GPCR 0.0046 0.0426 0.0426
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0271 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Schistosoma mansoni amine GPCR 0.0046 0.0426 0.0426
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0307 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Brugia malayi Aldehyde dehydrogenase protein 4 0.0017 0.0087 0.0179
Echinococcus granulosus GPCR family 2 0.0017 0.008 0.0057
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0271 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1542 0.1522
Loa Loa (eye worm) hypothetical protein 0.0074 0.0757 0.207
Mycobacterium tuberculosis Conserved protein 0.0074 0.0757 0.135
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0426 0.0426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0247 0.2798 0.7833
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0426 0.0404
Echinococcus multilocularis serotonin receptor 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0426 0.1138
Brugia malayi Pre-SET motif family protein 0.0221 0.2483 0.6945
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.0062
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0426 0.1138
Schistosoma mansoni aldehyde dehydrogenase 0.0312 0.3562 0.3562
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0757 0.135
Schistosoma mansoni neuropeptide receptor 0.0046 0.0426 0.0426
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0503 0.1355
Schistosoma mansoni survival motor neuron protein 0.005 0.0479 0.0479
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0017 0.0087 0.018
Brugia malayi Latrophilin receptor protein 2 0.0017 0.008 0.0161
Schistosoma mansoni amine GPCR 0.0046 0.0426 0.0426
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0411 0.7057
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0572 0.055
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0458 0.1229
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2798 0.2781
Schistosoma mansoni hypothetical protein 0.0337 0.386 0.386
Schistosoma mansoni hypothetical protein 0.0017 0.008 0.008
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0023 0.0023
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.0426 0.0426
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0426 0.0404
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0426 0.0404
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1542 0.1542
Loa Loa (eye worm) aldehyde dehydrogenase 0.0017 0.0087 0.0179
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0572 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0426 0.0404
Trichomonas vaginalis helicase, putative 0.0014 0.0045 0.0062
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0426 0.1138
Schistosoma mansoni hypothetical protein 0.0012 0.0023 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1542 0.1542
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0426 0.1138
Schistosoma mansoni neuropeptide receptor 0.0046 0.0426 0.0426
Onchocerca volvulus 0.0033 0.0271 0.0878
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0288 0.3281 0.9199
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi beta-lactamase 0.0074 0.0757 0.207
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0045 0.0062
Brugia malayi Melatonin receptor type 1A 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0053 0.0503 0.1355
Schistosoma mansoni opsin-like receptor 0.0046 0.0426 0.0426
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1542 0.1522
Schistosoma mansoni nocturnin 0.0012 0.0023 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0045 0.0062
Echinococcus multilocularis sex peptide receptor 0.0046 0.0426 0.0404
Brugia malayi hypothetical protein 0.0046 0.0426 0.1138
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0087 0.0867
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0426 0.1138
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.2936 0.8224
Schistosoma mansoni adenoreceptor 0.0046 0.0426 0.0426
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0458 0.1228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0045 0.0062
Onchocerca volvulus 0.0046 0.0426 0.1431
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0426 0.0404
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.1836 0.1817
Echinococcus granulosus g protein coupled receptor 0.0046 0.0426 0.0404
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0641 0.1137
Schistosoma mansoni cpg binding protein 0.006 0.0595 0.0595
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0426 0.0404
Schistosoma mansoni hypothetical protein 0.0046 0.0426 0.0426
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0426 0.0404
Leishmania major hypothetical protein, conserved 0.0074 0.0757 0.2072
Loa Loa (eye worm) hypothetical protein 0.0046 0.0426 0.1138
Brugia malayi Serotonin receptor 0.0046 0.0426 0.1138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0426 0.0426
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0426 0.0404
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0426 0.0404
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0426 0.0426
Brugia malayi Pre-SET motif family protein 0.0033 0.0271 0.0698
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0572 0.1395
Schistosoma mansoni ap endonuclease 0.0058 0.0572 0.0572

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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