Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0127 | 0.0521 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0127 | 0.0521 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0112 | 0.0406 | 0.0467 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0406 | 0.0467 |
Schistosoma mansoni | integrin beta subunit | 0.0201 | 0.1088 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0749 | 0.1153 |
Echinococcus granulosus | integrin alpha 3 | 0.0128 | 0.0523 | 0.0414 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0122 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0127 | 0.0521 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.0122 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0372 | 0.2415 | 0.3718 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0406 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0256 | 0.1519 | 0.2338 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1354 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0462 | 0.3105 | 0.3025 |
Echinococcus granulosus | lamin dm0 | 0.0112 | 0.0401 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0122 | 0.0188 |
Loa Loa (eye worm) | matrixin family protein | 0.0901 | 0.6495 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0389 | 0.2543 | 0.3882 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.2415 | 0.3718 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.0115 | 0.0178 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus granulosus | integrin beta 2 | 0.0252 | 0.1488 | 0.139 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0127 | 0.0521 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0462 | 0.3105 | 0.3025 |
Brugia malayi | beta-lactamase | 0.0076 | 0.0122 | 0.0188 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0454 | 0.3042 | 0.4684 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.051 | 0.0785 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.0383 | 0.0589 |
Onchocerca volvulus | 0.0112 | 0.0401 | 0.0481 | |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0247 | 0.038 |
Schistosoma mansoni | integrin alpha | 0.0166 | 0.0823 | 0.1133 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0115 | 0.0003 |
Schistosoma mansoni | lamin | 0.0112 | 0.0401 | 0.0459 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0406 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0389 | 0.2543 | 0.3915 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0885 | 0.6372 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0122 | 0.0014 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0112 | 0.0401 | 0.0617 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0122 | 0.0188 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0462 | 0.3105 | 0.3025 |
Loa Loa (eye worm) | beta-lactamase | 0.0076 | 0.0122 | 0.0188 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Trichomonas vaginalis | esterase, putative | 0.0076 | 0.0122 | 0.5 |
Echinococcus multilocularis | transfer RNA-Trp | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0112 | 0.0406 | 0.0296 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0166 | 0.0823 | 0.1267 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0406 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.0383 | 0.0589 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0076 | 0.0122 | 0.0188 |
Loa Loa (eye worm) | TAR-binding protein | 0.0389 | 0.2543 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0383 | 0.0589 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0389 | 0.2543 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.3042 | 0.4684 |
Brugia malayi | Matrixin family protein | 0.0901 | 0.6495 | 1 |
Brugia malayi | intermediate filament protein | 0.0112 | 0.0401 | 0.0617 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | integrin alpha 3 | 0.0128 | 0.0523 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0521 | 0.0802 |
Onchocerca volvulus | 0.0528 | 0.3618 | 0.6029 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0484 | 0.3274 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0127 | 0.0521 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0372 | 0.2415 | 0.3677 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0385 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.2415 | 0.3718 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus granulosus | tumor protein p63 | 0.1071 | 0.7813 | 0.7787 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0127 | 0.0521 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0406 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0127 | 0.0521 | 1 |
Echinococcus granulosus | 5'partial|3'partial|non capsid protein NS 1 | 0.0462 | 0.3105 | 0.3025 |
Brugia malayi | RNA binding protein | 0.0389 | 0.2543 | 0.3915 |
Schistosoma mansoni | tar DNA-binding protein | 0.0389 | 0.2543 | 0.3882 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0256 | 0.1515 | 0.2332 |
Brugia malayi | hypothetical protein | 0.0127 | 0.0521 | 0.0802 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0341 | 0.217 | 0.3341 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0126 | 0.051 | 0.0785 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0076 | 0.0122 | 0.0188 |
Brugia malayi | TAR-binding protein | 0.0389 | 0.2543 | 0.3915 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.0383 | 0.0589 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0076 | 0.0122 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0406 | 0.0625 |
Loa Loa (eye worm) | matrixin family protein | 0.0826 | 0.592 | 0.9114 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0112 | 0.0406 | 0.0296 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.0122 | 0.0014 |
Brugia malayi | hypothetical protein | 0.0082 | 0.0172 | 0.0265 |
Schistosoma mansoni | lamin | 0.0112 | 0.0401 | 0.0459 |
Schistosoma mansoni | tar DNA-binding protein | 0.0389 | 0.2543 | 0.3882 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.0521 | 1 |
Onchocerca volvulus | 0.0372 | 0.2415 | 0.3955 | |
Brugia malayi | Matrixin family protein | 0.0372 | 0.2415 | 0.3718 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0122 | 0.0188 |
Echinococcus multilocularis | tar DNA binding protein | 0.0389 | 0.2543 | 0.2457 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0157 | 0.0749 | 0.1015 |
Loa Loa (eye worm) | integrin beta-2 | 0.0341 | 0.217 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0122 | 0.0188 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0547 | 0.0841 |
Brugia malayi | Matrixin family protein | 0.0372 | 0.2415 | 0.3718 |
Echinococcus multilocularis | musashi | 0.0112 | 0.0401 | 0.0291 |
Onchocerca volvulus | 0.0112 | 0.0401 | 0.0481 | |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus granulosus | lamin | 0.0112 | 0.0401 | 0.0291 |
Loa Loa (eye worm) | intermediate filament protein | 0.0112 | 0.0401 | 0.0617 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0462 | 0.3105 | 0.3025 |
Echinococcus granulosus | intermediate filament protein | 0.0112 | 0.0401 | 0.0291 |
Onchocerca volvulus | Matrilysin homolog | 0.0372 | 0.2415 | 0.3955 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0115 | 0.0178 |
Onchocerca volvulus | 0.0157 | 0.0749 | 0.1081 | |
Schistosoma mansoni | hypothetical protein | 0.0528 | 0.3618 | 0.5599 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0076 | 0.0122 | 0.0009 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0122 | 0.0188 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0122 | 0.0188 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0389 | 0.2543 | 0.3915 |
Echinococcus multilocularis | transfer RNA-Gly | 0.0957 | 0.6928 | 0.6893 |
Onchocerca volvulus | Matrilysin homolog | 0.0826 | 0.592 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | transfer RNA-Gly | 0.0957 | 0.6928 | 0.6893 |
Brugia malayi | Matrixin family protein | 0.0372 | 0.2415 | 0.3718 |
Echinococcus multilocularis | lamin dm0 | 0.0112 | 0.0401 | 0.0291 |
Echinococcus granulosus | tar DNA binding protein | 0.0389 | 0.2543 | 0.2457 |
Schistosoma mansoni | hypothetical protein | 0.0462 | 0.3105 | 0.478 |
Brugia malayi | Matrixin family protein | 0.0372 | 0.2415 | 0.3718 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.2415 | 0.3718 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0256 | 0.1515 | 0.2332 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Echinococcus multilocularis | integrin beta 2 | 0.0252 | 0.1488 | 0.139 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.0122 | 0.0188 |
Echinococcus multilocularis | tumor protein p63 | 0.1071 | 0.7813 | 0.7787 |
Brugia malayi | MH2 domain containing protein | 0.0256 | 0.1515 | 0.2332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0389 | 0.2543 | 0.3882 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0401 | 0.0617 |
Schistosoma mansoni | tar DNA-binding protein | 0.0389 | 0.2543 | 0.3882 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0122 | 0.0188 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Schistosoma mansoni | intermediate filament proteins | 0.0112 | 0.0401 | 0.0459 |
Echinococcus multilocularis | lamin | 0.0112 | 0.0401 | 0.0291 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0957 | 0.6928 | 0.6893 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0826 | 0.592 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0454 | 0.3042 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.0122 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0454 | 0.3042 | 1 |
Echinococcus multilocularis | transfer RNA-Gly | 0.0957 | 0.6928 | 0.6893 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0454 | 0.3042 | 0.9266 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0112 | 0.0401 | 0.0617 |
Brugia malayi | Hemopexin family protein | 0.0528 | 0.3618 | 0.557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.