Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0132 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0132 | 0.0612 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0132 | 0.0612 |
Onchocerca volvulus | 0.0038 | 0.0132 | 0.1052 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0132 | 0.0612 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0132 | 0.0064 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0132 | 0.0612 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0132 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.2159 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.027 | 0.088 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0258 | 0.2307 | 0.7516 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0235 | 0.0124 |
Echinococcus multilocularis | tumor protein p63 | 0.1035 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0235 | 0.0767 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0132 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0167 | 0.0544 |
Echinococcus multilocularis | lamin | 0.0086 | 0.0608 | 0.05 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.008 | 0.0552 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0132 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0132 | 1 |
Schistosoma mansoni | lamin | 0.0086 | 0.0608 | 0.1673 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.043 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0132 | 0.043 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0132 | 0.0612 |
Brugia malayi | hypothetical protein | 0.008 | 0.0552 | 0.18 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.0552 | 1 |
Echinococcus multilocularis | musashi | 0.0086 | 0.0608 | 0.05 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0132 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0335 | 0.3069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.043 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0506 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.008 | 0.0552 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0086 | 0.0608 | 0.05 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0086 | 0.0608 | 0.198 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1255 | 0.409 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0552 | 0.18 |
Schistosoma mansoni | intermediate filament proteins | 0.0086 | 0.0608 | 0.1673 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0506 | 0.0397 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0132 | 0.0612 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0132 | 0.043 |
Onchocerca volvulus | 0.0152 | 0.1255 | 1 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0258 | 0.2307 | 0.7516 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0506 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0132 | 0.0612 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0132 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0235 | 0.0414 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0235 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0792 | 0.258 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0132 | 0.0019 |
Onchocerca volvulus | 0.0086 | 0.0608 | 0.4841 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0132 | 0.0612 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0086 | 0.0608 | 0.198 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0235 | 0.0767 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0042 | 0.0167 | 0.0054 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0132 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0132 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0592 | 0.1929 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0506 | 0.0397 |
Schistosoma mansoni | tar DNA-binding protein | 0.0335 | 0.3069 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0132 | 0.0612 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0235 | 0.0414 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0152 | 0.1255 | 0.3864 |
Echinococcus granulosus | lamin | 0.0086 | 0.0608 | 0.05 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0212 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.043 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0153 | 0.1271 | 0.4143 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0132 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0506 | 0.1328 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0132 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0608 | 0.198 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1271 | 0.4143 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0132 | 0.043 |
Onchocerca volvulus | 0.0038 | 0.0132 | 0.1052 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0212 | 0.0692 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0235 | 0.0767 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0235 | 0.0124 |
Onchocerca volvulus | 0.0038 | 0.0132 | 0.1052 | |
Brugia malayi | hypothetical protein | 0.0076 | 0.0506 | 0.1647 |
Schistosoma mansoni | tar DNA-binding protein | 0.0335 | 0.3069 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0235 | 0.0124 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0132 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0132 | 0.0612 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0132 | 0.043 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0153 | 0.1271 | 0.4143 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.043 |
Brugia malayi | TAR-binding protein | 0.0335 | 0.3069 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0335 | 0.3069 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0335 | 0.3069 | 0.299 |
Brugia malayi | RNA binding protein | 0.0335 | 0.3069 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0132 | 0.2392 |
Onchocerca volvulus | 0.0086 | 0.0608 | 0.4841 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0235 | 0.0124 |
Echinococcus granulosus | tar DNA binding protein | 0.0335 | 0.3069 | 0.299 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0552 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0153 | 0.1271 | 0.4143 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0132 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.0235 | 0.0124 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0506 | 1 |
Schistosoma mansoni | lamin | 0.0086 | 0.0608 | 0.1673 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0235 | 0.0767 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0042 | 0.0167 | 0.0054 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0552 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.0235 | 0.0124 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0506 | 0.1328 |
Loa Loa (eye worm) | intermediate filament protein | 0.0086 | 0.0608 | 0.198 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.0792 | 0.258 |
Brugia malayi | MH2 domain containing protein | 0.0258 | 0.2307 | 0.7516 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0132 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0235 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.043 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0132 | 0.043 |
Schistosoma mansoni | tar DNA-binding protein | 0.0335 | 0.3069 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0335 | 0.3069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0493 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0792 | 0.2296 |
Loa Loa (eye worm) | TAR-binding protein | 0.0335 | 0.3069 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0335 | 0.3069 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0506 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0086 | 0.0608 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0493 |
Schistosoma mansoni | tar DNA-binding protein | 0.0335 | 0.3069 | 1 |
Brugia malayi | intermediate filament protein | 0.0086 | 0.0608 | 0.198 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.008 | 0.0552 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0132 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0552 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0086 | 0.0608 | 0.05 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0552 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.