Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.033 | 0.4466 | 0.4378 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0155 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0155 | 0.0348 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0155 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0155 | 0.5 |
Onchocerca volvulus | 0.0085 | 0.0853 | 0.7584 | |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0155 | 0.0226 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0703 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0155 | 0.5 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0418 | 0.0935 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0703 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0418 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0065 | 0.0562 | 0.1259 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.032 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1869 | 0.4185 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0098 | 0.1045 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1125 | 0.252 |
Echinococcus granulosus | lamin | 0.0085 | 0.0853 | 0.0709 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0155 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.0418 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.032 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0184 | 0.0411 |
Loa Loa (eye worm) | RNA binding protein | 0.033 | 0.4466 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.033 | 0.4466 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0257 | 0.3385 | 0.7581 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0155 | 0.0348 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0184 | 0.0411 |
Onchocerca volvulus | Matrilysin homolog | 0.006 | 0.0483 | 0.4293 |
Echinococcus multilocularis | lamin dm0 | 0.0085 | 0.0853 | 0.0709 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0103 | 0.1125 | 0.252 |
Brugia malayi | RNA recognition motif domain containing protein | 0.033 | 0.4466 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0155 | 0.0348 |
Echinococcus granulosus | tar DNA binding protein | 0.033 | 0.4466 | 0.4378 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0085 | 0.0853 | 0.1911 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.0703 | 0.0557 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0045 | 0.0273 | 0.0611 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4466 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0703 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0155 | 0.0348 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0703 | 0.1575 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0085 | 0.0853 | 0.1911 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1152 | 0.258 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0155 | 0.5 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0155 | 0.0226 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0098 | 0.1045 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0418 | 0.0935 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0155 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0155 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.032 | 0.0717 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.032 | 0.0717 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0155 | 0.0348 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0155 | 0.0226 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0154 | 0.1869 | 0.4185 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0041 | 0.0207 | 0.0052 |
Echinococcus multilocularis | lamin | 0.0085 | 0.0853 | 0.0709 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0154 | 0.1869 | 0.4185 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0207 | 0.0463 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0155 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0155 | 0.0348 |
Loa Loa (eye worm) | matrixin family protein | 0.006 | 0.0483 | 0.1082 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.033 | 0.4466 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.0418 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0154 | 0.1869 | 0.4185 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.032 | 0.0717 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0155 | 0.0348 |
Brugia malayi | Hemopexin family protein | 0.0038 | 0.0166 | 0.0371 |
Echinococcus multilocularis | transfer RNA-Gly | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.032 | 0.0168 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4466 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4466 | 1 |
Brugia malayi | TAR-binding protein | 0.033 | 0.4466 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4466 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0155 | 0.0226 |
Echinococcus multilocularis | musashi | 0.0085 | 0.0853 | 0.0709 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0155 | 0.0226 |
Loa Loa (eye worm) | intermediate filament protein | 0.0085 | 0.0853 | 0.1911 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.0703 | 0.0557 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0129 | 0.0289 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.1152 | 0.258 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0155 | 0.0226 |
Onchocerca volvulus | 0.0038 | 0.0166 | 0.1473 | |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0155 | 0.0348 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.1152 | 0.258 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0041 | 0.0207 | 0.0052 |
Schistosoma mansoni | lamin | 0.0085 | 0.0853 | 0.1911 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0703 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0065 | 0.0562 | 0.1259 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0155 | 0.0226 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0064 | 0.0545 | 0.1221 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0155 | 0.0348 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0045 | 0.0273 | 0.0611 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0155 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0155 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0257 | 0.3385 | 0.7581 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0155 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Onchocerca volvulus | 0.0103 | 0.1125 | 1 | |
Echinococcus multilocularis | transfer RNA-Gly | 0.005 | 0.0335 | 0.0183 |
Brugia malayi | intermediate filament protein | 0.0085 | 0.0853 | 0.1911 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Onchocerca volvulus | 0.0085 | 0.0853 | 0.7584 | |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.032 | 0.0168 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0418 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.032 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0166 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0853 | 0.1911 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.006 | 0.0483 | 0.4293 |
Brugia malayi | RNA binding protein | 0.033 | 0.4466 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0155 | 0.0226 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.032 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0155 | 0.0348 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.032 | 0.0168 |
Echinococcus multilocularis | transfer RNA-Gly | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.032 | 0.0168 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Brugia malayi | MH2 domain containing protein | 0.0257 | 0.3385 | 0.7581 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0155 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0418 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0239 | 0.3129 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.0418 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0155 | 0.0226 |
Echinococcus granulosus | intermediate filament protein | 0.0085 | 0.0853 | 0.0709 |
Schistosoma mansoni | intermediate filament proteins | 0.0085 | 0.0853 | 0.1911 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0155 | 0.0348 |
Echinococcus multilocularis | tumor protein p63 | 0.0705 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0155 | 0.0348 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | transfer RNA-Trp | 0.005 | 0.0335 | 0.0183 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.032 | 0.0168 |
Onchocerca volvulus | 0.0037 | 0.0155 | 0.138 | |
Schistosoma mansoni | lamin | 0.0085 | 0.0853 | 0.1911 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.032 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0086 | 0.0194 |
Onchocerca volvulus | 0.0037 | 0.0155 | 0.138 | |
Onchocerca volvulus | 0.0037 | 0.0155 | 0.138 | |
Brugia malayi | hypothetical protein | 0.0075 | 0.0703 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.083 | 0.186 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.005 | 0.0335 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0155 | 0.0348 |
Echinococcus granulosus | lamin dm0 | 0.0085 | 0.0853 | 0.0709 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.0703 | 0.1575 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0033 | 0.0086 | 0.0194 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0155 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.032 | 0.0717 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4466 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0155 | 0.0226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.