Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.7967 | 0.7926 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0199 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0199 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0199 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7967 | 1 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.7967 | 0.7926 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7967 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0518 | 0.041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7967 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0199 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.7967 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0199 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.4897 | 0.6048 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0518 | 0.0559 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0199 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.7956 | 0.9985 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0199 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.7967 | 0.861 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0199 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0199 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0199 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1264 | 0.1086 |
Brugia malayi | RNA binding protein | 0.0069 | 0.7967 | 0.7926 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4024 | 0.4348 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7967 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.7967 | 0.861 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.7967 | 0.861 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.4897 | 0.4793 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3186 | 0.3845 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.7332 | 0.9182 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.4897 | 0.6048 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0199 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0199 | 0.0215 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0333 | 0.0173 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0851 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4357 | 0.4709 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.9254 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0199 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.4897 | 0.6048 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.7332 | 0.9182 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.3599 | 0.3469 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0851 | 0.0839 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.4897 | 0.6048 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0333 | 0.0173 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.4897 | 0.5292 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0199 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.4897 | 0.6048 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0199 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.4897 | 0.6048 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3611 | 0.3902 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3186 | 0.3845 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.7967 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.4897 | 0.6048 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0851 | 0.0839 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0333 | 0.0173 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0199 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.