Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1866 | 0.4226 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0056 | 0.0445 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0191 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0191 | 0.0431 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0191 | 0.0431 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0154 | 0.1866 | 0.4226 |
Loa Loa (eye worm) | intermediate filament protein | 0.0086 | 0.0877 | 0.1984 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1161 | 0.2629 |
Schistosoma mansoni | lamin | 0.0086 | 0.0877 | 0.1985 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0041 | 0.0236 | 0.0236 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0191 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0191 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0343 | 0.0777 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0191 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0191 | 0.0431 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0191 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0154 | 0.1866 | 0.4226 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4415 | 1 |
Brugia malayi | RNA binding protein | 0.033 | 0.4415 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.033 | 0.4415 | 1 |
Brugia malayi | TAR-binding protein | 0.033 | 0.4415 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0191 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0302 | 0.0681 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0343 | 0.0343 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0343 | 0.0343 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0191 | 0.06 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0056 | 0.0445 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4415 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0154 | 0.1866 | 0.4226 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0056 | 0.0445 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0343 | 0.0777 |
Schistosoma mansoni | lamin | 0.0086 | 0.0877 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0213 | 0.0481 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0343 | 0.0775 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0343 | 0.0343 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.0711 | 0.0711 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0445 | 0.1006 |
Onchocerca volvulus | 0.0105 | 0.1155 | 1 | |
Echinococcus multilocularis | lamin | 0.0086 | 0.0877 | 0.0877 |
Brugia malayi | intermediate filament protein | 0.0086 | 0.0877 | 0.1984 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0191 | 0.06 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0343 | 0.0343 |
Echinococcus multilocularis | tar DNA binding protein | 0.033 | 0.4415 | 0.4415 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.0711 | 0.0711 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.033 | 0.4415 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0086 | 0.0877 | 0.1984 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0191 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0711 | 0.1611 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.0445 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0877 | 0.1984 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.0711 | 0.1611 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0259 | 0.3386 | 0.767 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0191 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0343 | 0.0775 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4415 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0191 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0191 | 0.0431 |
Echinococcus granulosus | tar DNA binding protein | 0.033 | 0.4415 | 0.4415 |
Brugia malayi | RNA recognition motif domain containing protein | 0.033 | 0.4415 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0191 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1155 | 0.2614 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4415 | 1 |
Echinococcus granulosus | lamin | 0.0086 | 0.0877 | 0.0877 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0056 | 0.0445 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0213 | 0.0481 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0244 | 0.3172 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0343 | 0.0775 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0259 | 0.3386 | 0.767 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0343 | 0.0343 |
Echinococcus multilocularis | tumor protein p63 | 0.0716 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0041 | 0.0236 | 0.0236 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0343 | 0.0777 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0159 | 0.0358 |
Onchocerca volvulus | 0.0086 | 0.0877 | 0.759 | |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0711 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0191 | 1 |
Onchocerca volvulus | 0.0038 | 0.0191 | 0.1649 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0191 | 0.06 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0191 | 0.0433 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0191 | 0.06 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0191 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0191 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0191 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0086 | 0.0877 | 0.0877 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0191 | 0.0433 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 0.4415 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0191 | 0.0431 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0056 | 0.0445 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0086 | 0.0877 | 0.0877 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0191 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0191 | 0.0191 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0191 | 0.0431 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0191 | 0.4282 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0191 | 0.06 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0711 | 0.1609 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0711 | 1 |
Onchocerca volvulus | 0.0086 | 0.0877 | 0.759 | |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0711 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0056 | 0.0445 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0191 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0191 | 0.0431 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0105 | 0.1155 | 0.2615 |
Brugia malayi | MH2 domain containing protein | 0.0259 | 0.3386 | 0.767 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0056 | 0.0445 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0191 | 0.0431 |
Onchocerca volvulus | 0.0038 | 0.0191 | 0.1649 | |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0711 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0086 | 0.0877 | 0.1985 |
Echinococcus granulosus | lamin dm0 | 0.0086 | 0.0877 | 0.0877 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0191 | 0.0431 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.1161 | 0.263 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0343 | 0.0775 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0236 | 0.0532 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0191 | 1 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0445 | 0.1006 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0854 | 0.1933 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0191 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0191 | 0.0431 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0191 | 0.06 |
Loa Loa (eye worm) | RNA binding protein | 0.033 | 0.4415 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0302 | 0.0681 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.1161 | 0.2629 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0343 | 0.0777 |
Onchocerca volvulus | 0.0038 | 0.0191 | 0.1649 | |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0191 | 0.06 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0086 | 0.0877 | 0.1984 |
Echinococcus multilocularis | musashi | 0.0086 | 0.0877 | 0.0877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.