Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0278 | 0.3914 | 0.3901 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0195 | 0.0611 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0195 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0122 | 0.0311 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0682 | 0.1742 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0261 | 0.0666 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0195 | 0.0611 |
Onchocerca volvulus | 0.0036 | 0.0195 | 0.1686 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0195 | 0.5 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0195 | 0.0611 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0682 | 0.1697 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0682 | 0.1742 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0195 | 0.0174 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0194 | 0.0174 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0195 | 0.0611 |
Echinococcus multilocularis | lamin dm0 | 0.0087 | 0.0978 | 0.0959 |
Brugia malayi | MH2 domain containing protein | 0.0245 | 0.3409 | 0.871 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0195 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0122 | 0.0101 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0042 | 0.0285 | 0.0265 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0042 | 0.0285 | 0.0265 |
Schistosoma mansoni | intermediate filament proteins | 0.0087 | 0.0978 | 0.2459 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0491 | 0.1254 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0195 | 0.397 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.1164 | 0.2975 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0122 | 0.0259 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0122 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1164 | 0.2975 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0491 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0087 | 0.0978 | 0.25 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0087 | 0.0978 | 0.25 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0122 | 0.0259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0278 | 0.3914 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0122 | 0.0259 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0047 | 0.0356 | 0.0911 |
Echinococcus multilocularis | lamin | 0.0087 | 0.0978 | 0.0959 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0195 | 0.0447 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0195 | 0.0611 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0491 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.0491 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0195 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0195 | 0.0498 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0195 | 0.0498 |
Echinococcus granulosus | lamin | 0.0087 | 0.0978 | 0.0959 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0122 | 0.0311 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0195 | 0.0498 |
Echinococcus multilocularis | tumor protein p63 | 0.0673 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.0491 | 1 |
Brugia malayi | intermediate filament protein | 0.0087 | 0.0978 | 0.25 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0195 | 0.0611 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0231 | 0.319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0195 | 0.0498 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 0.3409 | 0.871 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0195 | 0.0611 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0194 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0194 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0195 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0195 | 0.0498 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0195 | 0.0498 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0194 | 0.0497 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0195 | 0.5 |
Echinococcus multilocularis | musashi | 0.0087 | 0.0978 | 0.0959 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.0491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0491 | 0.1254 |
Schistosoma mansoni | tar DNA-binding protein | 0.0278 | 0.3914 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0491 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0122 | 0.0101 |
Onchocerca volvulus | 0.0087 | 0.0978 | 0.8466 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0278 | 0.3914 | 1 |
Schistosoma mansoni | lamin | 0.0087 | 0.0978 | 0.2459 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0194 | 0.0445 |
Echinococcus multilocularis | tar DNA binding protein | 0.0278 | 0.3914 | 0.3901 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0195 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0285 | 0.0729 |
Echinococcus granulosus | lamin dm0 | 0.0087 | 0.0978 | 0.0959 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0122 | 0.0101 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0195 | 0.0498 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 0.3409 | 0.871 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0278 | 0.3914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0122 | 0.0311 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0122 | 0.0259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0278 | 0.3914 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0195 | 0.0174 |
Schistosoma mansoni | lamin | 0.0087 | 0.0978 | 0.2459 |
Onchocerca volvulus | 0.0087 | 0.0978 | 0.8466 | |
Echinococcus granulosus | intermediate filament protein | 0.0087 | 0.0978 | 0.0959 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0047 | 0.0356 | 0.0911 |
Onchocerca volvulus | 0.0036 | 0.0195 | 0.1686 | |
Onchocerca volvulus | 0.0099 | 0.1156 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0194 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0491 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0195 | 0.0498 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0194 | 0.0445 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0491 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0195 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0195 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0954 | 0.2437 |
Loa Loa (eye worm) | TAR-binding protein | 0.0278 | 0.3914 | 1 |
Brugia malayi | RNA binding protein | 0.0278 | 0.3914 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0278 | 0.3914 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0278 | 0.3914 | 1 |
Brugia malayi | TAR-binding protein | 0.0278 | 0.3914 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0195 | 0.0498 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0195 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0195 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0195 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1156 | 0.2953 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0122 | 0.0311 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0194 | 0.0174 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0195 | 0.0611 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0195 | 0.0611 |
Loa Loa (eye worm) | RNA binding protein | 0.0278 | 0.3914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0261 | 0.0666 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0195 | 0.0498 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0195 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0099 | 0.1156 | 0.2915 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0122 | 0.0101 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0087 | 0.0978 | 0.25 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0122 | 0.0101 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.1164 | 0.2975 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0195 | 0.0498 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0195 | 0.0498 |
Onchocerca volvulus | 0.0036 | 0.0195 | 0.1686 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0194 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0189 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0978 | 0.25 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.1164 | 0.2975 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.