Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0827 | 1 |
Echinococcus multilocularis | musashi | 0.0087 | 0.0609 | 0.0528 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0239 | 0.0214 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0042 | 0.0172 | 0.0087 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0243 | 0.2115 | 0.9847 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0137 | 0.0418 |
Loa Loa (eye worm) | intermediate filament protein | 0.0087 | 0.0609 | 0.1989 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1391 | 0.4596 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0247 | 0.2148 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0087 | 0.0609 | 0.2019 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0243 | 0.2115 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0.0085 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0239 | 0.0155 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0137 | 0.0732 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0033 | 0.0085 | 0.0945 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0219 | 0.1879 | 0.8742 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0107 | 0.0793 | 0.9584 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0137 | 1 |
Onchocerca volvulus | 0.0039 | 0.0137 | 0.1005 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0042 | 0.0172 | 0.0087 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0085 | 0.0945 |
Trypanosoma brucei | trypanothione reductase | 0.0096 | 0.0691 | 0.8561 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0137 | 0.0732 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0107 | 0.0793 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0137 | 0.0732 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.0137 | 0.0732 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0137 | 1 |
Echinococcus granulosus | lamin | 0.0087 | 0.0609 | 0.0528 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0239 | 0.0759 |
Plasmodium vivax | glutathione reductase, putative | 0.0096 | 0.0691 | 0.8579 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.2321 | 0.7693 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0096 | 0.0691 | 0.3182 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0791 | 0.2597 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0137 | 0.1608 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0137 | 0.0732 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0336 | 0.3014 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0778 | 0.7282 | 1 |
Brugia malayi | RNA binding protein | 0.0336 | 0.3014 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3014 | 0.4069 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0137 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0107 | 0.0793 | 0.2631 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.0137 | 0.0588 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0106 | 0.0791 | 0.2625 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0137 | 0.0418 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0827 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0047 | 0.0216 | 0.0718 |
Treponema pallidum | NADH oxidase | 0.0033 | 0.0085 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0336 | 0.3014 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0793 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0793 | 1 |
Leishmania major | trypanothione reductase | 0.0096 | 0.0691 | 0.8697 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0792 | 0.2598 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0793 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0793 | 1 |
Onchocerca volvulus | 0.0155 | 0.1262 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.011 | 0.0827 | 0.1031 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.0793 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.2321 | 0.7702 |
Echinococcus multilocularis | lamin | 0.0087 | 0.0609 | 0.0528 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0137 | 0.0052 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0219 | 0.1879 | 0.8742 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0219 | 0.1879 | 0.8742 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.1391 | 0.4617 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0137 | 0.0588 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0137 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0156 | 0.0482 |
Echinococcus granulosus | tar DNA binding protein | 0.0336 | 0.3014 | 0.2954 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0033 | 0.0085 | 0.5875 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0033 | 0.0085 | 0.0283 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0137 | 0.0588 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0225 | 0.0194 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0137 | 0.0597 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.1391 | 0.1317 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0792 | 0.2626 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0137 | 0.0734 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0107 | 0.0793 | 0.0714 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0273 | 0.2658 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0155 | 0.1262 | 0.1635 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0033 | 0.0085 | 0.0945 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.0137 | 0.0588 |
Onchocerca volvulus | 0.0039 | 0.0137 | 0.1005 | |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.1391 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0609 | 0.1989 |
Echinococcus granulosus | transcription factor eb | 0.0122 | 0.094 | 0.0862 |
Brugia malayi | TAR-binding protein | 0.0336 | 0.3014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0934 | 0.3073 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0137 | 1 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0827 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.1391 | 0.1317 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3014 | 0.4069 |
Brugia malayi | intermediate filament protein | 0.0087 | 0.0609 | 0.2019 |
Echinococcus multilocularis | lamin dm0 | 0.0087 | 0.0609 | 0.0528 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3014 | 0.4069 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0048 | 0.0225 | 0.0141 |
Echinococcus multilocularis | tar DNA binding protein | 0.0336 | 0.3014 | 0.2954 |
Echinococcus granulosus | lamin dm0 | 0.0087 | 0.0609 | 0.0528 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0793 | 0.0983 |
Echinococcus granulosus | geminin | 0.0191 | 0.161 | 0.1538 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0827 | 0.1031 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0106 | 0.0792 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0047 | 0.0216 | 0.0683 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0778 | 0.7282 | 0.7259 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0106 | 0.0792 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0219 | 0.1879 | 0.8878 |
Loa Loa (eye worm) | RNA binding protein | 0.0336 | 0.3014 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.0137 | 0.0588 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3014 | 0.4069 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0107 | 0.0793 | 0.2603 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0137 | 0.0455 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.2321 | 0.7693 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0107 | 0.0793 | 0.0714 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.161 | 0.2119 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0048 | 0.0225 | 0.0141 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0239 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1266 | 0.418 |
Echinococcus multilocularis | tumor protein p63 | 0.1059 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0107 | 0.0793 | 1 |
Giardia lamblia | Kinase, PLK | 0.0107 | 0.0793 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0137 | 0.0732 |
Schistosoma mansoni | kinase | 0.0054 | 0.0287 | 0.028 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0096 | 0.0691 | 0.8561 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0156 | 0.0482 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0011 | 0.0038 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0239 | 0.0155 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0106 | 0.0792 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0106 | 0.0792 | 0.9979 |
Schistosoma mansoni | lamin | 0.0087 | 0.0609 | 0.0727 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0106 | 0.0792 | 0.9979 |
Schistosoma mansoni | intermediate filament proteins | 0.0087 | 0.0609 | 0.0727 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0096 | 0.0691 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0137 | 0.0418 |
Plasmodium falciparum | thioredoxin reductase | 0.0096 | 0.0691 | 0.8579 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0137 | 0.0732 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0137 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0172 | 0.0533 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0137 | 0.0732 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1391 | 0.4596 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0033 | 0.0085 | 0.5875 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0137 | 0.0418 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0033 | 0.0085 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.011 | 0.0827 | 0.0748 |
Onchocerca volvulus | 0.0039 | 0.0137 | 0.1005 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0011 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0427 | 0.1418 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3014 | 0.4069 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0087 | 0.0609 | 0.1989 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.0137 | 0.0588 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0033 | 0.0085 | 0.0945 |
Mycobacterium tuberculosis | Probable reductase | 0.0219 | 0.1879 | 0.8742 |
Onchocerca volvulus | 0.0087 | 0.0609 | 0.4774 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0106 | 0.0792 | 0.9979 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0239 | 0.0794 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0239 | 0.0214 |
Plasmodium falciparum | glutathione reductase | 0.0096 | 0.0691 | 0.8579 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.0137 | 0.0588 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0121 | 0.0934 | 0.3073 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0239 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1262 | 0.4166 |
Leishmania major | hypothetical protein, conserved | 0.0106 | 0.0792 | 0.9981 |
Brugia malayi | Thioredoxin reductase | 0.0096 | 0.0691 | 0.2293 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0137 | 0.0052 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0243 | 0.2115 | 0.9847 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0097 | 0.0697 | 0.0617 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0137 | 0.0597 |
Onchocerca volvulus | 0.0087 | 0.0609 | 0.4774 | |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.161 | 0.2119 |
Echinococcus multilocularis | transcription factor eb | 0.0122 | 0.094 | 0.0862 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.011 | 0.0827 | 0.0748 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.0239 | 0.0155 |
Brugia malayi | hypothetical protein | 0.011 | 0.0827 | 0.2744 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0239 | 0.0759 |
Schistosoma mansoni | lamin | 0.0087 | 0.0609 | 0.0727 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0137 | 0.0072 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0106 | 0.0792 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0137 | 0.0732 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0273 | 0.2658 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0033 | 0.0085 | 0.5875 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0137 | 0.0418 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0336 | 0.3014 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0137 | 0.0418 |
Echinococcus multilocularis | geminin | 0.0191 | 0.161 | 0.1538 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0239 | 0.0214 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0239 | 0.0794 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0219 | 0.1879 | 0.8742 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0122 | 0.094 | 0.3119 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0137 | 0.0734 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0243 | 0.2115 | 0.9847 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0239 | 0.0155 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0137 | 0.0455 |
Echinococcus granulosus | intermediate filament protein | 0.0087 | 0.0609 | 0.0528 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0011 | 0.0038 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0033 | 0.0085 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0096 | 0.0691 | 0.8579 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0791 | 0.0981 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0107 | 0.0793 | 0.6249 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0137 | 0.0455 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.1266 | 0.418 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0033 | 0.0085 | 0.0346 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.0827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0593 | 0.1937 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0096 | 0.0691 | 0.8579 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0097 | 0.0697 | 0.0617 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0137 | 0.0455 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0778 | 0.7282 | 0.7259 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0137 | 0.0588 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0137 | 0.0418 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.0137 | 0.0588 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0219 | 0.1879 | 0.8742 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0107 | 0.0793 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0239 | 0.0155 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0107 | 0.0793 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.0137 | 0.0588 |
Loa Loa (eye worm) | glutathione reductase | 0.0096 | 0.0691 | 0.2264 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0156 | 0.1266 | 0.4202 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.1266 | 0.4202 |
Brugia malayi | glutathione reductase | 0.0096 | 0.0691 | 0.2293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.