TDR Targets

Basic information

Technical information

TDR Targets ID: 765019
Name: 2-furan-2-yl-5-[(4-propan-2-ylphenyl)methylid ene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
MW: 341.427 | Formula: C18H19N3O2S
H donors: 0 H acceptors: 3 LogP: 4.55 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C(=Cc2ccc(cc2)C(C)C)SC2N1NC(N2)c1ccco1
InChi: 1S/C18H15N3O2S/c1-11(2)13-7-5-12(6-8-13)10-15-17(22)21-18(24-15)19-16(20-21)14-4-3-9-23-14/h3-11H,1-2H3/b15-10-
InChiKey: ZYUUSBNZRUVIHC-GDNBJRDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-2-furan-2-yl-5-[(4-propan-2-ylphenyl)methylidene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
2-(2-furyl)-5-[(4-isopropylphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
(5Z)-2-(2-furyl)-5-[(4-isopropylphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
2-(2-furyl)-5-[(4-isopropylphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
(5Z)-2-(2-furyl)-5-[(4-isopropylphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
2-(2-furyl)-5-(4-isopropylbenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one
(5Z)-2-(2-furyl)-5-(4-isopropylbenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one
ZINC02705043

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0474	0.1336
Entamoeba histolytica	hypothetical protein	0.0111	0.0834	1
Entamoeba histolytica	hypothetical protein	0.0111	0.0834	1
Brugia malayi	MH2 domain containing protein	0.0259	0.2261	0.7713
Schistosoma mansoni	lamin	0.0112	0.0841	0.263
Brugia malayi	RNA recognition motif domain containing protein	0.0328	0.2932	1
Loa Loa (eye worm)	intermediate filament protein	0.0112	0.0841	0.2869
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0474	0.1618
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0054	0.0281	0.0187
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.0474	0.1094
Plasmodium falciparum	ataxin-2 like protein, putative	0.0129	0.1004	0.5
Echinococcus multilocularis	lamin dm0	0.0112	0.0841	0.0753
Loa Loa (eye worm)	RNA binding protein	0.0328	0.2932	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.0824	0.2812
Echinococcus multilocularis	lamin	0.0112	0.0841	0.0753
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0473	0.4335	1
Schistosoma mansoni	tar DNA-binding protein	0.0328	0.2932	1
Mycobacterium ulcerans	lipase LipD	0.0074	0.0474	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0129	0.1004	1
Schistosoma mansoni	intermediate filament proteins	0.0112	0.0841	0.263
Onchocerca volvulus		0.0112	0.0841	0.6692
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0474	0.5
Brugia malayi	cytoplasmic intermediate filament protein	0.006	0.0338	0.1153
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.006	0.0338	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0261	0.089
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0474	0.1336
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0054	0.0281	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0474	0.1618
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0474	0.1618
Brugia malayi	hypothetical protein	0.0129	0.1004	0.3424
Loa Loa (eye worm)	TAR-binding protein	0.0328	0.2932	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0474	0.5
Echinococcus granulosus	lamin dm0	0.0112	0.0841	0.0753
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.0824	0.2812
Mycobacterium ulcerans	beta-lactamase	0.0074	0.0474	1
Schistosoma mansoni	hypothetical protein	0.0075	0.0487	0.1381
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.0474	1
Brugia malayi	beta-lactamase family protein	0.0074	0.0474	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1004	0.3424
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0474	0.1618
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.0474	0.1094
Schistosoma mansoni	tar DNA-binding protein	0.0328	0.2932	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.0474	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0824	0.2812
Trypanosoma cruzi	PAB1-binding protein , putative	0.0129	0.1004	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0474	0.1618
Loa Loa (eye worm)	MH2 domain-containing protein	0.0259	0.2261	0.7713
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0474	0.1094
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.0474	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0474	0.1618
Onchocerca volvulus		0.0112	0.0841	0.6692
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0474	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1257	0.4287
Brugia malayi	beta-lactamase family protein	0.0074	0.0474	0.1618
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.0474	0.1094
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0474	1
Schistosoma mansoni	cellular tumor antigen P53	0.0155	0.1257	0.4096
Toxoplasma gondii	LsmAD domain-containing protein	0.0129	0.1004	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0474	0.5
Loa Loa (eye worm)	hypothetical protein	0.011	0.0821	0.2801
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0095	0.0325
Echinococcus granulosus	tar DNA binding protein	0.0328	0.2932	0.2864
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.0824	0.2812
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0474	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0474	0.5
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.0474	0.1094
Schistosoma mansoni	tar DNA-binding protein	0.0328	0.2932	1
Echinococcus granulosus	intermediate filament protein	0.0112	0.0841	0.0753
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0474	0.1618
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0111	0.0834	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0487	0.1661
Schistosoma mansoni	tar DNA-binding protein	0.0328	0.2932	1
Onchocerca volvulus		0.0155	0.1257	1
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0095	0.0325
Brugia malayi	RNA binding protein	0.0328	0.2932	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0129	0.1004	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0129	0.1004	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0281	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0261	0.089
Onchocerca volvulus		0.0074	0.0474	0.3773
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0474	0.0383
Schistosoma mansoni	lamin	0.0112	0.0841	0.263
Brugia malayi	hypothetical protein	0.0111	0.0834	0.2843
Brugia malayi	Intermediate filament tail domain containing protein	0.0112	0.0841	0.2869
Trichomonas vaginalis	esterase, putative	0.0074	0.0474	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0328	0.2932	1
Brugia malayi	intermediate filament protein	0.0112	0.0841	0.2869
Loa Loa (eye worm)	transcription factor SMAD2	0.0259	0.2261	0.7713
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0112	0.0841	0.2869
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.0474	0.1094
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0058	0.0317	0.0224
Leishmania major	hypothetical protein, conserved	0.0129	0.1004	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0328	0.2932	1
Echinococcus multilocularis	musashi	0.0112	0.0841	0.0753
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0058	0.0317	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0841	0.2869
Entamoeba histolytica	hypothetical protein	0.0111	0.0834	1
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0474	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0487	0.1661
Trypanosoma brucei	PAB1-binding protein , putative	0.0129	0.1004	1
Schistosoma mansoni	transcription factor LCR-F1	0.0111	0.0834	0.2603
Onchocerca volvulus		0.0074	0.0474	0.3773
Echinococcus granulosus	lamin	0.0112	0.0841	0.0753
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0474	1
Leishmania major	hypothetical protein, conserved	0.0074	0.0474	0.4724
Brugia malayi	hypothetical protein	0.0083	0.0562	0.1918
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0095	0.0325
Brugia malayi	TAR-binding protein	0.0328	0.2932	1
Schistosoma mansoni	hypothetical protein	0.0111	0.0834	0.2603
Brugia malayi	beta-lactamase	0.0074	0.0474	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0095	0.0325
Echinococcus multilocularis	tumor protein p63	0.1059	1	1
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0474	0.1618
Schistosoma mansoni	hypothetical protein	0.0058	0.0317	0.0781
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0111	0.0834	0.0745
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.0474	0.1094
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0474	0.0383
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0474	0.1094
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0474	0.1094
Echinococcus multilocularis	tar DNA binding protein	0.0328	0.2932	0.2864
Entamoeba histolytica	hypothetical protein	0.0111	0.0834	1
Onchocerca volvulus		0.0074	0.0474	0.3773

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 765019