Detailed information for compound 765021

Basic information

Technical information
  • TDR Targets ID: 765021
  • Name: 5-[(4-diethylaminophenyl)methylidene]-2-furan -2-yl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-on e
  • MW: 370.469 | Formula: C19H22N4O2S
  • H donors: 0 H acceptors: 3 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)C=C1SC2N(C1=O)NC(N2)c1ccco1)CC
  • InChi: 1S/C19H18N4O2S/c1-3-22(4-2)14-9-7-13(8-10-14)12-16-18(24)23-19(26-16)20-17(21-23)15-6-5-11-25-15/h5-12H,3-4H2,1-2H3/b16-12-
  • InChiKey: NGQRMDHCLHTKLI-VBKFSLOCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[(4-diethylaminophenyl)methylidene]-2-furan-2-yl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 5-[(4-diethylaminophenyl)methylene]-2-(2-furyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-5-[(4-diethylaminophenyl)methylene]-2-(2-furyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • 5-[(4-diethylaminophenyl)methylene]-2-(2-furyl)-6-thiazolo[2,3-e][1,2,4]triazolone
  • (5Z)-5-[(4-diethylaminophenyl)methylene]-2-(2-furyl)-6-thiazolo[2,3-e][1,2,4]triazolone
  • 5-(4-diethylaminobenzylidene)-2-(2-furyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-5-(4-diethylaminobenzylidene)-2-(2-furyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • ZINC02703188

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0369 0.112
Loa Loa (eye worm) RNA binding protein 0.0389 0.3296 1
Echinococcus multilocularis tumor protein p63 0.1109 1 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0414 0.1257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0414 0.1257
Brugia malayi TAR-binding protein 0.0389 0.3296 1
Schistosoma mansoni lamin 0.0112 0.0726 0.2203
Echinococcus granulosus tar DNA binding protein 0.0389 0.3296 0.3296
Schistosoma mansoni tar DNA-binding protein 0.0389 0.3296 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0414 0.5
Entamoeba histolytica hypothetical protein 0.0117 0.0766 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0414 0.0414
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.0766 0.2324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0688 0.2086
Mycobacterium leprae Probable lipase LipE 0.0079 0.0414 0.5
Onchocerca volvulus 0.0112 0.0726 0.4008
Entamoeba histolytica hypothetical protein 0.0117 0.0766 0.5
Brugia malayi hypothetical protein 0.0117 0.0766 0.2324
Echinococcus granulosus geminin 0.0182 0.1371 0.1371
Loa Loa (eye worm) hypothetical protein 0.0079 0.0414 0.1257
Loa Loa (eye worm) hypothetical protein 0.0052 0.0167 0.0506
Schistosoma mansoni hypothetical protein 0.0059 0.0228 0.0691
Schistosoma mansoni lamin 0.0112 0.0726 0.2203
Schistosoma mansoni hypothetical protein 0.0182 0.1371 0.4159
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0414 0.5
Schistosoma mansoni intermediate filament proteins 0.0112 0.0726 0.2203
Loa Loa (eye worm) hypothetical protein 0.0079 0.0414 0.1257
Loa Loa (eye worm) hypothetical protein 0.0052 0.0167 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0389 0.3296 1
Schistosoma mansoni hypothetical protein 0.0117 0.0766 0.2324
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.2045 0.6205
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0899 0.5
Leishmania major hypothetical protein, conserved 0.0131 0.0899 1
Schistosoma mansoni cellular tumor antigen P53 0.0162 0.1192 0.3616
Trypanosoma brucei PAB1-binding protein , putative 0.0131 0.0899 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0503 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0707 0.2145
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0414 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.0414 0.1257
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0899 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0186 0.0563
Loa Loa (eye worm) intermediate filament protein 0.0112 0.0726 0.2203
Echinococcus multilocularis geminin 0.0182 0.1371 0.1371
Schistosoma mansoni tar DNA-binding protein 0.0389 0.3296 1
Entamoeba histolytica hypothetical protein 0.0117 0.0766 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0414 0.1257
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0414 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0059 0.0228 0.0228
Trypanosoma cruzi PAB1-binding protein , putative 0.0131 0.0899 1
Schistosoma mansoni hypothetical protein 0.0182 0.1371 0.4159
Schistosoma mansoni hypothetical protein 0.0074 0.0369 0.112
Loa Loa (eye worm) hypothetical protein 0.0108 0.0688 0.2086
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0054 0.0186 0.0186
Echinococcus granulosus intermediate filament protein 0.0112 0.0726 0.0726
Brugia malayi beta-lactamase family protein 0.0079 0.0414 0.1257
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0389 0.3296 1
Brugia malayi MH2 domain containing protein 0.0254 0.2045 0.6205
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0414 0.0414
Mycobacterium ulcerans hypothetical protein 0.0079 0.0414 0.5
Brugia malayi RNA binding protein 0.0389 0.3296 1
Brugia malayi beta-lactamase 0.0079 0.0414 0.1257
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.0766 0.0766
Mycobacterium ulcerans lipase LipD 0.0079 0.0414 0.5
Mycobacterium ulcerans beta-lactamase 0.0079 0.0414 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0131 0.0899 1
Onchocerca volvulus 0.0162 0.1192 1
Brugia malayi beta-lactamase family protein 0.0079 0.0414 0.1257
Brugia malayi cytoplasmic intermediate filament protein 0.006 0.0241 0.0732
Toxoplasma gondii LsmAD domain-containing protein 0.0131 0.0899 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0414 0.1257
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.0766 0.0766
Schistosoma mansoni tar DNA-binding protein 0.0389 0.3296 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0414 0.1257
Loa Loa (eye worm) beta-lactamase 0.0079 0.0414 0.1257
Echinococcus multilocularis lamin dm0 0.0112 0.0726 0.0726
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0688 0.2086
Echinococcus granulosus lamin 0.0112 0.0726 0.0726
Echinococcus multilocularis tar DNA binding protein 0.0389 0.3296 0.3296
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0112 0.0726 0.2203
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0414 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0414 0.1257
Echinococcus granulosus lamin dm0 0.0112 0.0726 0.0726
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.2045 0.6205
Echinococcus multilocularis musashi 0.0112 0.0726 0.0726
Entamoeba histolytica hypothetical protein 0.0117 0.0766 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0414 0.5
Loa Loa (eye worm) TAR-binding protein 0.0389 0.3296 1
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0414 0.5
Brugia malayi hypothetical protein 0.0131 0.0899 0.2727
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0054 0.0186 0.0186
Trichomonas vaginalis esterase, putative 0.0079 0.0414 0.5
Brugia malayi hypothetical protein 0.0084 0.0467 0.1418
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0059 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0162 0.1192 0.3616
Schistosoma mansoni tar DNA-binding protein 0.0389 0.3296 1
Brugia malayi Intermediate filament tail domain containing protein 0.0112 0.0726 0.2203
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0414 0.5
Echinococcus multilocularis lamin 0.0112 0.0726 0.0726
Brugia malayi intermediate filament protein 0.0112 0.0726 0.2203
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.006 0.0241 0.0732
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0688 0.2086
Loa Loa (eye worm) hypothetical protein 0.0112 0.0726 0.2203
Loa Loa (eye worm) hypothetical protein 0.0131 0.0899 0.2727
Onchocerca volvulus 0.0112 0.0726 0.4008
Loa Loa (eye worm) hypothetical protein 0.0079 0.0414 0.1257
Loa Loa (eye worm) hypothetical protein 0.0074 0.0369 0.112
Plasmodium falciparum ataxin-2 like protein, putative 0.0131 0.0899 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0389 0.3296 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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