Detailed information for compound 765036

Basic information

Technical information
  • TDR Targets ID: 765036
  • Name: 5-[(5-methylfuran-2-yl)methylidene]-2-(4-prop -2-enoxyphenyl)-[1,3]thiazolo[2,3-e][1,2,4]tr iazol-6-one
  • MW: 369.437 | Formula: C19H19N3O3S
  • H donors: 0 H acceptors: 3 LogP: 4.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1ccc(cc1)C1NC2N(N1)C(=O)C(=Cc1ccc(o1)C)S2
  • InChi: 1S/C19H15N3O3S/c1-3-10-24-14-8-5-13(6-9-14)17-20-19-22(21-17)18(23)16(26-19)11-15-7-4-12(2)25-15/h3-9,11H,1,10H2,2H3/b16-11-
  • InChiKey: HWFQZRVQZBYGTN-WJDWOHSUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-5-[(5-methylfuran-2-yl)methylidene]-2-(4-prop-2-enoxyphenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 2-(4-allyloxyphenyl)-5-[(5-methyl-2-furyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-2-(4-allyloxyphenyl)-5-[(5-methyl-2-furyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 2-(4-allyloxyphenyl)-5-[(5-methyl-2-furyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
  • (5Z)-2-(4-allyloxyphenyl)-5-[(5-methyl-2-furyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
  • ZINC02703769

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0076 0.0028 0.0992
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0051 0.0351
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0484 0.0266 1
Onchocerca volvulus 0.0117 0.0052 0.005
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0076 0.0028 0.0028
Onchocerca volvulus 0.0119 0.0054 0.0051
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0326 0.0174 0.0174
Echinococcus granulosus zinc finger protein 0.0042 0.0009 0.0008
Entamoeba histolytica hypothetical protein 0.0437 0.0239 1
Schistosoma mansoni smad 0.0059 0.0019 0.0018
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0066 0.0022 0.0766
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0076 0.0028 0.0026
Entamoeba histolytica hypothetical protein 0.0437 0.0239 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0484 0.0266 0.0266
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0018 0.0016
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0003 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0071 0.2625
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0051 0.0051
Plasmodium vivax importin-beta 2, putative 0.0089 0.0036 0.1286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0003 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0003 0.0002
Leishmania major GTP-binding protein, putative 0.0066 0.0022 0.0766
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0018 0.0115
Mycobacterium leprae conserved hypothetical protein 0.0484 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.0266 0.0266
Echinococcus multilocularis beta LACTamase domain containing family member 0.0484 0.0266 0.0265
Mycobacterium leprae Probable lipase LipE 0.0484 0.0266 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0484 0.0266 0.1888
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0002 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0153 0.0073 0.9196
Trypanosoma cruzi PAB1-binding protein , putative 0.0259 0.0135 0.5034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0514 0.0284 0.0283
Trichomonas vaginalis set domain proteins, putative 0.243 0.14 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0081 0.0444
Brugia malayi Bromodomain containing protein 0.0055 0.0016 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0003 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0591 0.0329 0.0328
Trichomonas vaginalis ap endonuclease, putative 0.0153 0.0073 0.051
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0016 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0003 0.0001
Trypanosoma brucei DNA polymerase eta, putative 0.0059 0.0018 0.0612
Onchocerca volvulus 0.0053 0.0015 0.0013
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0002 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0003 0.0001
Echinococcus granulosus synaptojanin 1 0.0031 0.0002 0.0002
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0058 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.1045 0.0593 0.0593
Echinococcus multilocularis traf and tnf receptor associated protein 0.0031 0.0002 0.0002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0484 0.0266 0.148
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0076 0.0028 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0308 0.0164 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0003 0.0002
Brugia malayi Bromodomain containing protein 0.01 0.0042 0.004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0002 0.0008
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0051 0.2074
Echinococcus granulosus high affinity choline transporter 1 0.1081 0.0614 0.0613
Trypanosoma brucei unspecified product 0.004 0.0008 0.021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.0266 1
Schistosoma mansoni transcription factor LCR-F1 0.0437 0.0239 0.0239
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0051 0.0051
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0051 0.1862
Onchocerca volvulus 0.0308 0.0164 0.0162
Loa Loa (eye worm) hypothetical protein 0.0484 0.0266 0.0266
Brugia malayi beta-lactamase 0.0484 0.0266 0.0264
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.0169 0.6306
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0003 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0181 0.009 0.3323
Schistosoma mansoni sodium-bile acid cotransporter 1.0218 0.5939 0.5938
Echinococcus multilocularis importin subunit beta 1 0.0089 0.0036 0.0035
Schistosoma mansoni inositol transporter 0.0119 0.0054 0.0053
Trichomonas vaginalis importin beta-1, putative 0.0072 0.0026 0.0172
Schistosoma mansoni survival motor neuron protein 0.005 0.0013 0.0013
Brugia malayi MH2 domain containing protein 0.0059 0.0019 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0305 0.0162 0.0161
Trypanosoma brucei hypothetical protein, conserved 0.0484 0.0266 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0026 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0514 0.0284 0.0283
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0484 0.0266 0.0266
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0076 0.0028 0.0187
Brugia malayi MH1 domain containing protein 0.0033 0.0003 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0051 0.0351
Schistosoma mansoni tar DNA-binding protein 0.1184 0.0674 0.0674
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0002 0.5
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0076 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0008 0.021
Echinococcus granulosus intermediate filament protein 0.0059 0.0018 0.0018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0484 0.0266 0.0264
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0002 0.5
Trypanosoma brucei unspecified product 0.004 0.0008 0.021
Giardia lamblia DINP protein human, muc B family 0.0059 0.0018 0.2082
Brugia malayi MH1 domain containing protein 0.0059 0.0019 0.0017
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.0169 0.6306
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0018 0.0612
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0002 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.0059 0.0018 0.0612
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0002 0.0004
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0514 0.0284 0.0283
Schistosoma mansoni hypothetical protein 0.0437 0.0239 0.0239
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0002 0.0002
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0002 0.0005
Echinococcus multilocularis high affinity choline transporter 1 0.1081 0.0614 0.0613
Echinococcus multilocularis sodium bile acid cotransporter 1.7187 1 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0059 0.0019 0.0018
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0119 0.0054 0.0053
Brugia malayi MH2 domain containing protein 0.0872 0.0492 0.049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0484 0.0266 0.0265
Echinococcus multilocularis sodium bile acid cotransporter 1.7187 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0295 0.0156 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0326 0.0174 0.0174
Echinococcus granulosus cpg binding protein 0.0126 0.0057 0.0057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0003 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0484 0.0266 0.148
Schistosoma mansoni hypothetical protein 0.1045 0.0593 0.0593
Brugia malayi 6-phosphofructokinase 0.0115 0.0051 0.0049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0003 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0051 0.0351
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0051 0.1331
Schistosoma mansoni hypothetical protein 0.0273 0.0143 0.0143
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0003 0.0001
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0031 0.0002 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0008 0.0007
Plasmodium falciparum histone acetyltransferase GCN5 0.0164 0.008 0.5837
Loa Loa (eye worm) hypothetical protein 0.0074 0.0027 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0437 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0259 0.0135 0.0135
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0484 0.0266 0.0265
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0006 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0484 0.0266 0.0266
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0326 0.0174 0.0174
Schistosoma mansoni lamin 0.0059 0.0018 0.0018
Onchocerca volvulus 0.0484 0.0266 0.0264
Mycobacterium tuberculosis Conserved protein 0.0484 0.0266 0.148
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0018 0.0682
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Brugia malayi hypothetical protein 0.0259 0.0135 0.0133
Trichomonas vaginalis bromodomain-containing protein, putative 0.0181 0.009 0.0627
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0153 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0181 0.009 0.3323
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0076 0.0028 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0071 0.2625
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Schistosoma mansoni intermediate filament proteins 0.0059 0.0018 0.0018
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.001 0.0299
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0018 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.001 0.0299
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0153 0.0073 0.0073
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0002 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0437 0.0239 0.0238
Echinococcus multilocularis synaptojanin 1 0.0031 0.0002 0.0002
Onchocerca volvulus 0.243 0.14 0.1398
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0066 0.0022 0.0766
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0076 0.0028 0.0028
Schistosoma mansoni Smad4 0.0059 0.0019 0.0018
Brugia malayi beta-lactamase family protein 0.0484 0.0266 0.0264
Schistosoma mansoni smad1 5 8 and 0.0059 0.0019 0.0018
Mycobacterium ulcerans hypothetical protein 0.0484 0.0266 1
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0076 0.0028 0.197
Loa Loa (eye worm) hypothetical protein 0.018 0.0089 0.0089
Schistosoma mansoni thyroid hormone receptor 0.0305 0.0162 0.0161
Loa Loa (eye worm) TAR-binding protein 0.1184 0.0674 0.0674
Echinococcus multilocularis cpg binding protein 0.0126 0.0057 0.0057
Trypanosoma brucei PAB1-binding protein , putative 0.0259 0.0135 0.5034
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0018 0.0018
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0119 0.0054 0.0053
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0018 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0514 0.0284 0.0283
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0273 0.0143 0.0142
Schistosoma mansoni hypothetical protein 0.0031 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Brugia malayi Calcitonin receptor-like protein seb-1 0.1529 0.0875 0.0873
Echinococcus multilocularis dna polymerase eta 0.0059 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0119 0.0054 0.0054
Echinococcus granulosus dna polymerase kappa 0.0059 0.0018 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0484 0.0266 0.148
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0018 0.0091
Loa Loa (eye worm) beta-lactamase 0.0484 0.0266 0.0266
Brugia malayi MH1 domain containing protein 0.0059 0.0019 0.0017
Trypanosoma brucei importin beta-1 subunit, putative 0.0089 0.0036 0.1286
Brugia malayi hypothetical protein 0.0437 0.0239 0.0237
Trichomonas vaginalis penicillin-binding protein, putative 0.0484 0.0266 0.1888
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0002 0.0001
Plasmodium vivax SET domain containing protein 0.0031 0.0002 0.0005
Schistosoma mansoni sodium/solute symporter 0.0119 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0059 0.0018 0.0018
Trypanosoma brucei importin beta-1 subunit, putative 0.0089 0.0036 0.1286
Echinococcus granulosus sodium bile acid cotransporter 1.7187 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0153 0.0073 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.3655 0.2114 0.2114
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0003 0.0002
Schistosoma mansoni cpg binding protein 0.0126 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0245 0.0127 0.0127
Schistosoma mansoni bromodomain containing protein 0.0088 0.0035 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0002 0.0001
Mycobacterium tuberculosis Conserved protein 0.0484 0.0266 0.148
Brugia malayi steroid hormone receptor 0.0032 0.0003 0.0001
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0059 0.0019 0.0018
Schistosoma mansoni ap endonuclease 0.0153 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.004 0.0008 0.0008
Brugia malayi MH1 domain containing protein 0.0033 0.0003 0.0001
Brugia malayi TAR-binding protein 0.1184 0.0674 0.0672
Echinococcus granulosus sodium:glucose cotransporter 0.0119 0.0054 0.0053
Trypanosoma cruzi importin beta-1 subunit, putative 0.0072 0.0026 0.0913
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0437 0.0239 0.0238
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0119 0.0054 0.1949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0484 0.0266 0.0266
Echinococcus multilocularis musashi 0.0059 0.0018 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0872 0.0492 0.0492
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0514 0.0284 0.0284
Schistosoma mansoni hypothetical protein 0.0952 0.0539 0.0538
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0018 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.004 0.0008 0.0007
Echinococcus multilocularis tar DNA binding protein 0.1184 0.0674 0.0673
Onchocerca volvulus 0.0059 0.0018 0.0016
Brugia malayi phosphofructokinase 0.0115 0.0051 0.0049
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0051 0.1862
Loa Loa (eye worm) hypothetical protein 0.0484 0.0266 0.0266
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0013 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0003 0.0002
Mycobacterium ulcerans hypothetical protein 0.0167 0.0081 0.2542
Brugia malayi nuclear hormone receptor 0.0032 0.0003 0.0001
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0076 0.0028 0.1105
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0003 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0051 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Echinococcus granulosus histone lysine methyltransferase setb 0.0326 0.0174 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.0484 0.0266 1
Brugia malayi beta-lactamase family protein 0.0484 0.0266 0.0264
Trichomonas vaginalis D-aminoacylase, putative 0.0484 0.0266 0.1888
Echinococcus multilocularis sodium bile acid cotransporter 1.7187 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0047 0.0012 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0484 0.0266 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0514 0.0284 0.0283
Loa Loa (eye worm) hypothetical protein 0.0053 0.0015 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0484 0.0266 0.0266
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0066 0.0022 0.0766
Trichomonas vaginalis D-aminoacylase, putative 0.0484 0.0266 0.1888
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0051 0.0276
Echinococcus granulosus neutral sphingomyelinase 0.0031 0.0002 0.0002
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0076 0.0028 0.0992
Echinococcus multilocularis mixed lineage leukemia protein mll 0.004 0.0008 0.0007
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0002 0.0004
Onchocerca volvulus 0.0059 0.0018 0.0016
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0076 0.0028 0.0992
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0003 0.0002
Echinococcus multilocularis solute carrier family 5 0.0119 0.0054 0.0053
Echinococcus granulosus dna polymerase eta 0.0059 0.0018 0.0018
Echinococcus multilocularis smad 0.0059 0.0019 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0002 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.001 0.0299
Echinococcus multilocularis thyroid hormone receptor alpha 0.0305 0.0162 0.0161
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0003 0.0002
Schistosoma mansoni ran 0.0066 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0484 0.0266 0.0266
Loa Loa (eye worm) RNA binding protein 0.1184 0.0674 0.0674
Echinococcus granulosus dnaJ subfamily B 0.0852 0.0481 0.048
Echinococcus granulosus sodium:glucose cotransporter 2 0.0119 0.0054 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0153 0.0073 0.2702
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0051 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0002 0.0001
Toxoplasma gondii exonuclease III APE 0.0153 0.0073 0.2702
Schistosoma mansoni zinc finger protein 0.0042 0.0009 0.0008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0031 0.0002 0.0002
Onchocerca volvulus 0.005 0.0013 0.0011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0116 0.0052 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0003 0.0001
Brugia malayi Pre-SET motif family protein 0.0308 0.0164 0.0162
Echinococcus granulosus beta LACTamase domain containing family member 0.0484 0.0266 0.0265
Schistosoma mansoni tar DNA-binding protein 0.1184 0.0674 0.0674
Echinococcus granulosus solute carrier family 5 0.0119 0.0054 0.0053
Loa Loa (eye worm) acetyltransferase 0.0611 0.034 0.034
Schistosoma mansoni cript-related 0.0031 0.0002 0.0002
Echinococcus granulosus snurportin 1 0.0952 0.0539 0.0538
Giardia lamblia Histone acetyltransferase GCN5 0.0164 0.008 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0008 0.021
Echinococcus granulosus histone acetyltransferase KAT2B 0.0181 0.009 0.0089
Mycobacterium tuberculosis Probable hydrolase 0.0484 0.0266 0.148
Schistosoma mansoni hypothetical protein 0.0484 0.0266 0.0266
Schistosoma mansoni high-affinity choline transporter 0.1081 0.0614 0.0614
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0119 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.3655 0.2114 0.2114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0022 0.0766
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0116 0.0052 0.0051
Brugia malayi RNA binding protein 0.1184 0.0674 0.0672
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0051 0.2074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0484 0.0266 0.148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0852 0.0481 0.048
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0076 0.0028 0.0992
Echinococcus granulosus lamin 0.0059 0.0018 0.0018
Echinococcus multilocularis snurportin 1 0.0952 0.0539 0.0538
Loa Loa (eye worm) Smad1 0.0059 0.0019 0.0019
Echinococcus granulosus tumor protein p63 0.036 0.0194 0.0194
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0047 0.0012 0.0011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0022 0.0766
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0076 0.0028 0.0992
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0084 0.0033 0.0032
Brugia malayi RNA recognition motif domain containing protein 0.1184 0.0674 0.0672
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0002 0.0001
Echinococcus multilocularis lamin dm0 0.0059 0.0018 0.0018
Onchocerca volvulus 0.0484 0.0266 0.0264
Mycobacterium tuberculosis Probable esterase LipL 0.0484 0.0266 0.148
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0018 0.0018
Mycobacterium tuberculosis Probable lipase LipE 0.0484 0.0266 0.148
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0611 0.034 0.0339
Brugia malayi intermediate filament protein 0.0059 0.0018 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.0169 0.6306
Echinococcus granulosus smad 0.0059 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0116 0.0052 0.0051
Schistosoma mansoni ap endonuclease 0.0153 0.0073 0.0073
Echinococcus multilocularis lamin 0.0059 0.0018 0.0018
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0259 0.0135 0.0135
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0026 0.0172
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0484 0.0266 0.148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0308 0.0164 0.0163
Schistosoma mansoni smad1 5 8 and 0.0059 0.0019 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0003 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0018 0.0612
Trypanosoma cruzi PAB1-binding protein , putative 0.0259 0.0135 0.5034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Schistosoma mansoni inositol transporter 0.0119 0.0054 0.0053
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0031 0.0002 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0181 0.009 0.3323
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0484 0.0266 0.0266
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0153 0.0073 0.2227
Brugia malayi hypothetical protein 0.0245 0.0127 0.0125
Schistosoma mansoni lamin 0.0059 0.0018 0.0018
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0181 0.009 0.0627
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Entamoeba histolytica Ran family GTPase 0.0066 0.0022 0.0853
Echinococcus granulosus lamin dm0 0.0059 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0326 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Entamoeba histolytica hypothetical protein 0.0072 0.0026 0.1018
Loa Loa (eye worm) hypothetical protein 0.0484 0.0266 0.0266
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0003 0.0001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0002 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0484 0.0266 1
Schistosoma mansoni importin beta-1 0.0089 0.0036 0.0036
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0153 0.0073 0.2702
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0003 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0003 0.0003
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0076 0.0028 0.0028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0117 0.0052 0.0052
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0952 0.0539 0.0539
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0153 0.0073 0.5368
Echinococcus granulosus importin subunit beta 1 0.0089 0.0036 0.0035
Schistosoma mansoni DNA polymerase eta 0.0059 0.0018 0.0018
Plasmodium vivax SET domain protein, putative 0.0308 0.0164 0.6128
Loa Loa (eye worm) MH1 domain-containing protein 0.0059 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0117 0.0052 0.0052
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0002 0.0001
Echinococcus granulosus sodium bile acid cotransporter 1.7187 1 1
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0051 0.0051
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0058 0.0018 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0008 0.0007
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.0127 0.0126
Brugia malayi PHD-finger family protein 0.0048 0.0012 0.001
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0051 0.2074
Echinococcus multilocularis neutral sphingomyelinase 0.0031 0.0002 0.0002
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) bromodomain containing protein 0.0033 0.0004 0.0004
Echinococcus granulosus mothers against decapentaplegic 5 0.0059 0.0019 0.0018
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.0089 0.0087
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0076 0.0028 0.0992
Plasmodium falciparum ataxin-2 like protein, putative 0.0259 0.0135 1
Echinococcus multilocularis GPCR, family 2 0.0484 0.0266 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0003 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.025 0.013 0.4841
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0071 0.2625
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.0127 0.0126
Schistosoma mansoni tar DNA-binding protein 0.1184 0.0674 0.0674
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.001 0.0299
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Trypanosoma brucei unspecified product 0.0059 0.0018 0.0612
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0051 0.0051
Onchocerca volvulus 0.0032 0.0003 0.0001
Brugia malayi nuclear receptor NHR-88 0.0032 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0514 0.0284 0.0282
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0003 0.0002
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0031 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0051 0.0014 0.0444
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0002 0.0015
Brugia malayi ecdysteroid receptor 0.0032 0.0003 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1184 0.0674 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0003 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0059 0.0019 0.0019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0153 0.0073 0.04
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0003 0.0002
Leishmania major hypothetical protein, conserved 0.0259 0.0135 0.5034
Echinococcus granulosus mixed lineage leukemia protein mll 0.004 0.0008 0.0007
Leishmania major DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Loa Loa (eye worm) nuclear factor I 0.0033 0.0003 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0084 0.0033 0.0032
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0031 0.0002 0.0002
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0076 0.0028 0.0187
Loa Loa (eye worm) hypothetical protein 0.0033 0.0003 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0484 0.0266 0.0264
Schistosoma mansoni sodium-bile acid cotransporter related 0.6969 0.4045 0.4045
Schistosoma mansoni synaptojanin 0.0031 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0153 0.0073 0.051
Echinococcus multilocularis Smad4 0.0059 0.0019 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0153 0.0073 0.2702
Echinococcus granulosus Smad4 0.0059 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.005 0.0013 0.0013
Echinococcus granulosus GTP binding nuclear protein Ran 0.0066 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.0018 0.0018
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0002 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0003 0.0001
Leishmania major importin beta-1 subunit, putative 0.0072 0.0026 0.0913
Toxoplasma gondii ABC1 family protein 0.0484 0.0266 1
Mycobacterium ulcerans beta-lactamase 0.0484 0.0266 1
Schistosoma mansoni carbon catabolite repressor protein 0.0031 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0003 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0003 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0153 0.0073 0.3011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0514 0.0284 0.0283
Schistosoma mansoni ran 0.0066 0.0022 0.0022
Brugia malayi Sodium:solute symporter family protein 0.0119 0.0054 0.0051
Entamoeba histolytica hypothetical protein 0.0437 0.0239 1
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0051 0.1862
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0051 0.0051
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0066 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.1184 0.0674 0.0674
Trichomonas vaginalis esterase, putative 0.0484 0.0266 0.1888
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1529 0.0875 0.0873
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0003 0.0002
Schistosoma mansoni coup transcription factor 0.0032 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0153 0.0073 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.3091 0.1785 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0153 0.0073 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0013 0.0011
Brugia malayi RNA, U transporter 1 0.0254 0.0132 0.013
Brugia malayi acetyltransferase, GNAT family protein 0.0611 0.034 0.0338
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0059 0.0019 0.0018
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0003 0.0002
Echinococcus granulosus sodium:myo inositol cotransporter 0.0119 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0066 0.0022 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0003 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0153 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0089 0.0036 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0484 0.0266 0.0265
Schistosoma mansoni cpg binding protein 0.0126 0.0057 0.0057
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0119 0.0054 0.0053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0018 0.0018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0003 0.0003
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0066 0.0022 0.1521
Onchocerca volvulus 0.0484 0.0266 0.0264
Schistosoma mansoni neutral sphingomyelinase 0.0031 0.0002 0.0002
Schistosoma mansoni synaptojanin 0.0031 0.0002 0.0002
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0031 0.0002 0.0002
Toxoplasma gondii HEAT repeat-containing protein 0.0089 0.0036 0.1286
Brugia malayi Pre-SET motif family protein 0.2135 0.1228 0.1226
Toxoplasma gondii LsmAD domain-containing protein 0.0259 0.0135 0.5034
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0018 0.0016
Brugia malayi GH02984p 0.1081 0.0614 0.0612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0514 0.0284 0.0283
Plasmodium vivax hypothetical protein, conserved 0.0484 0.0266 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 1.4805 0.8612 0.8612
Echinococcus multilocularis dnaJ subfamily B 0.0852 0.0481 0.048
Schistosoma mansoni hypothetical protein 0.0484 0.0266 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0308 0.0164 0.0163
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0051 0.6889
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0003 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1529 0.0875 0.0875
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0003 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0872 0.0492 0.0492
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0018 0.0115
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0611 0.034 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0018 0.0612
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.2135 0.1228 0.1228
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0059 0.0019 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0259 0.0135 0.5034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0003 0.0002
Leishmania major hypothetical protein, conserved 0.0484 0.0266 1
Loa Loa (eye worm) hypothetical protein 1.7187 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0003 0.0001
Echinococcus granulosus traf and tnf receptor associated protein 0.0031 0.0002 0.0002
Schistosoma mansoni sodium-bile acid cotransporter related 1.7187 1 1
Echinococcus multilocularis zinc finger protein 0.0042 0.0009 0.0008
Brugia malayi hypothetical protein 0.0167 0.0081 0.0079
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0051 0.0351
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0153 0.0073 0.2702
Schistosoma mansoni nocturnin 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0484 0.0266 0.0266
Entamoeba histolytica acetyltransferase, GNAT family 0.0164 0.008 0.3274
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0308 0.0164 0.6128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0153 0.0073 0.2702
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0003 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0003 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Echinococcus granulosus tar DNA binding protein 0.1184 0.0674 0.0673
Brugia malayi latrophilin 2 splice variant baaae 0.1045 0.0593 0.0591
Brugia malayi CXXC zinc finger family protein 0.0117 0.0052 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0003 0.0002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0018 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0484 0.0266 0.0265
Brugia malayi MH2 domain containing protein 0.0059 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0066 0.0022 0.0022
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0002 0.0008
Plasmodium falciparum importin beta, putative 0.0089 0.0036 0.2554
Plasmodium falciparum ataxin-2 like protein, putative 0.0259 0.0135 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0018 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0018 0.0612
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0484 0.0266 0.1888
Echinococcus granulosus sodium bile acid cotransporter 1.7187 1 1
Brugia malayi 6-phosphofructokinase 0.0115 0.0051 0.0049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0003 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0008 0.021
Echinococcus multilocularis tumor protein p63 0.036 0.0194 0.0194
Loa Loa (eye worm) histone methyltransferase 0.0047 0.0012 0.0012
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0066 0.0022 0.2606
Echinococcus multilocularis deoxyribonuclease 1 2 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Brugia malayi Smad1 0.0059 0.0019 0.0017
Echinococcus granulosus TGF beta signal transducer SmadC 0.0059 0.0019 0.0018
Echinococcus granulosus geminin 0.3655 0.2114 0.2114
Loa Loa (eye worm) hypothetical protein 0.0484 0.0266 0.0266
Brugia malayi N-terminal motif family protein 0.018 0.0089 0.0087
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0003 0.0002
Mycobacterium ulcerans lipase LipD 0.0484 0.0266 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0273 0.0143 0.0142
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0018 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0003 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0003 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.1081 0.0614 0.0614
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0003 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0003 0.0001
Trichomonas vaginalis ran, putative 0.0066 0.0022 0.0145
Leishmania major DNA polymerase eta, putative 0.0059 0.0018 0.0612
Echinococcus granulosus GPCR family 2 0.0484 0.0266 0.0265
Echinococcus multilocularis geminin 0.3655 0.2114 0.2114
Loa Loa (eye worm) hypothetical protein 0.1529 0.0875 0.0875
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0002 0.0004
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0031 0.0002 0.0002
Brugia malayi Importin beta-1 subunit 0.0089 0.0036 0.0034
Schistosoma mansoni tar DNA-binding protein 0.1184 0.0674 0.0674
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0018 0.0612
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.0169 0.6306
Onchocerca volvulus 1.7187 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0003 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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