Detailed information for compound 765041

Basic information

Technical information
  • TDR Targets ID: 765041
  • Name: N-(6-methoxy-4H-indeno[3,2-d][1,3]thiazol-2-y l)-2-methylbenzamide
  • MW: 336.408 | Formula: C19H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)Cc1c2nc(s1)NC(=O)c1ccccc1C
  • InChi: 1S/C19H16N2O2S/c1-11-5-3-4-6-14(11)18(22)21-19-20-17-15-8-7-13(23-2)9-12(15)10-16(17)24-19/h3-9H,10H2,1-2H3,(H,20,21,22)
  • InChiKey: AXCFTELURDHJHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(6-methoxy-4H-indeno[3,2-d]thiazol-2-yl)-2-methyl-benzamide
  • N-(6-methoxy-4H-indeno[3,2-d]thiazol-2-yl)-2-methylbenzamide
  • N-(6-methoxy-4H-indeno[3,2-d][1,3]thiazol-2-yl)-2-methyl-benzamide
  • NCGC00101729-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0133 0.0127
Schistosoma mansoni smad 0.0023 0.0074 0.0059
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0223 0.0785
Echinococcus granulosus Smad4 0.0051 0.0247 0.0257
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0094 0.0388
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0077 0.233
Brugia malayi MH1 domain containing protein 0.0051 0.0247 0.0257
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0037 0.0058
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Schistosoma mansoni lamin 0.0087 0.0471 0.0512
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0133 0.0127
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.026 0.1419
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0053 0.0123
Giardia lamblia DINP protein human, muc B family 0.0023 0.0077 0.3081
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0247 0.0226
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Brugia malayi Bromodomain containing protein 0.0044 0.0203 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1 0.5883
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0228 0.0236
Trypanosoma brucei ISWI complex protein 0.0016 0.0032 0.0441
Giardia lamblia Pyruvate kinase 0.0017 0.0037 0.0828
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0074 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0133 0.0127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.233
Schistosoma mansoni bromodomain containing protein 0.007 0.0364 0.039
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0128 0.0723
Brugia malayi Sugar transporter family protein 0.0102 0.056 0.0613
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0284
Trypanosoma cruzi ISWI complex protein 0.0016 0.0032 0.0441
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0094 0.6977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0755
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0133 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0412 0.2472 0.2793
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0073 0.2169
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0134 1
Loa Loa (eye worm) DR-78 0.0015 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0073 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0133 0.0139
Schistosoma mansoni glucose transport protein 0.0102 0.056 0.0613
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.056 0.0613
Brugia malayi ecdysteroid receptor 0.0032 0.0133 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0133 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1476 0.8698
Loa Loa (eye worm) hypothetical protein 0.013 0.0737 0.0826
Echinococcus multilocularis General substrate transporter 0.0087 0.0472 0.0451
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0128 0.4451
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0196
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0055 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451
Echinococcus multilocularis musashi 0.0087 0.0471 0.045
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0055 1
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0133 0.0139
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0125 0.0104
Echinococcus multilocularis dna polymerase eta 0.0023 0.0077 0.0056
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0134 0.0438
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0055 0.0038
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0202 0.1469
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1 0.5883
Loa Loa (eye worm) TAR-binding protein 0.026 0.1535 0.1735
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0022 0.1615
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0165 0.0144
Brugia malayi latrophilin 2 splice variant baaae 0.0282 0.1669 0.1877
Schistosoma mansoni zinc finger protein 0.0016 0.0032 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0133 0.0127
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5067 0.5056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0022 0.0095
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0133 0.0127
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0094 0.6977
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0028 0.0006
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.056 0.0613
Brugia malayi nuclear receptor NHR-67 0.0015 0.0028 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0086
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0153 0.5491
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0128 0.0723
Trypanosoma brucei glucose transporter 2A 0.0032 0.0128 0.4451
Brugia malayi RNA recognition motif domain containing protein 0.026 0.1535 0.1724
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1482 0.1674
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0134 0.0141
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1696 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0945 0.556
Echinococcus granulosus lamin 0.0087 0.0471 0.0512
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0094 0.0388
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.1476 0.1667
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0202 0.0181
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0882 0.0863
Echinococcus granulosus smad 0.0051 0.0247 0.0257
Brugia malayi Cam kinase protein 1 0.0031 0.0125 0.0118
Echinococcus multilocularis Smad4 0.0051 0.0247 0.0226
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0024 0.0002
Schistosoma mansoni tar DNA-binding protein 0.026 0.1535 0.1724
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0028 0.0006
Schistosoma mansoni Smad4 0.0023 0.0074 0.0059
Entamoeba histolytica hypothetical protein 0.0023 0.0073 0.0186
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0125 0.0617
Loa Loa (eye worm) hypothetical protein 0.004 0.0181 0.0194
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0125 0.0617
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0077 0.0423
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0043 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.026 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0223 0.12
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0127 0.0724
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0121 0.5534
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0133 0.0127
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0028 0.0007
Echinococcus multilocularis pyruvate kinase 0.0033 0.0134 0.0113
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0125 0.0118
Brugia malayi tailless protein 0.0015 0.0028 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0074 0.0072
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0022 0.0095
Mycobacterium ulcerans sugar transporter 0.0014 0.0022 0.1615
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0094 0.6977
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0024 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0094 0.5046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0282 0.1669 0.1887
Brugia malayi hypothetical protein 0.0015 0.0028 0.0007
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0022 0.0012
Brugia malayi hypothetical protein 0.0017 0.0039 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0133 0.0112
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0125 0.0404
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0153 0.051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0133 0.0127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0133 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0079 0.0431
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0127 0.0629
Echinococcus granulosus flap endonuclease 1 0.0031 0.0127 0.012
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0077 0.5753
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0182 0.1057 0.1038
Schistosoma mansoni DNA polymerase eta 0.0023 0.0077 0.0063
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0077 0.233
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.026 1
Giardia lamblia Pyruvate kinase 0.0033 0.0134 0.6242
Schistosoma mansoni smad1 5 8 and 0.0051 0.0247 0.0257
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0055 0.1389
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0053 0.3964
Loa Loa (eye worm) Smad1 0.0051 0.0247 0.0269
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0094 0.6977
Brugia malayi hypothetical protein 0.0147 0.0837 0.0929
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0202 0.1162
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0275 0.1629 0.1611
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0125 0.0104
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0028 0.0007
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0247 0.0257
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0153 0.051
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0077 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0079 0.0431
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451
Schistosoma mansoni protein kinase 0.0031 0.0125 0.0118
Brugia malayi nuclear hormone receptor 0.0032 0.0133 0.0127
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0134 0.0128
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0223 0.023
Loa Loa (eye worm) RNA binding protein 0.026 0.1535 0.1735
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0077 0.0056
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0185 0.9075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0755
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0471 0.0524
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0147 0.5269
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0133 0.0127
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0125 0.013
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0028 0.0007
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0073 0.0308
Echinococcus granulosus sodium bile acid cotransporter 0.1439 0.8797 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0247 0.0257
Entamoeba histolytica protein kinase, putative 0.0031 0.0125 0.0704
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0125 0.0404
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0077 0.0423
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0082
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0055 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0222 0.024
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0196
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0134 0.0761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0092 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0108 0.0605
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0134 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0755
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0048
Schistosoma mansoni ap endonuclease 0.002 0.0055 0.0038
Echinococcus multilocularis pyruvate kinase 0.0026 0.0092 0.007
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.056 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Brugia malayi hypothetical protein 0.0034 0.0144 0.014
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0074 0.0052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013 0.0737 0.0717
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0028 0.0007
Loa Loa (eye worm) hypothetical protein 0.1439 0.8797 1
Schistosoma mansoni transcription factor LCR-F1 0.0182 0.1057 0.118
Trypanosoma cruzi hexose transporter, putative 0.0017 0.004 0.0759
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0022 0.1615
Echinococcus granulosus dna polymerase eta 0.0023 0.0077 0.0063
Echinococcus multilocularis pyruvate kinase 0.0017 0.0037 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1476 0.8698
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0028 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.233
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0024 0.0002
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0074 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0106
Echinococcus multilocularis GPCR, family 2 0.013 0.0737 0.0717
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0061 0.1631
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0077 0.4935
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0055 0.0038
Brugia malayi Smad1 0.0051 0.0247 0.0257
Plasmodium vivax CDK-related protein kinase 6, putative 0.0431 0.259 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0147 0.0837
Schistosoma mansoni ap endonuclease 0.002 0.0055 0.0038
Schistosoma mansoni tar DNA-binding protein 0.026 0.1535 0.1724
Brugia malayi hypothetical protein 0.024 0.1412 0.1584
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Schistosoma mansoni hypothetical protein 0.0022 0.0067 0.0051
Trypanosoma cruzi hexose transporter 0.0032 0.0128 0.4451
Onchocerca volvulus 0.0049 0.0235 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0106
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.0945 0.3595
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0045 0.0983
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0043 0.0025
Plasmodium falciparum pyruvate kinase 0.0033 0.0134 0.0438
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0043 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0202 0.1162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0094 0.6977
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0028 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0133 0.0127
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0202 0.7563
Schistosoma mansoni smad 0.0051 0.0247 0.0257
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.1476 0.1657
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0202 0.7563
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0125 0.0404
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0133 0.0112
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0094 0.5046
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0077 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0308 0.1829 0.2059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0133 0.0139
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0147 0.5269
Brugia malayi Calcitonin receptor-like protein seb-1 0.0412 0.2472 0.2793
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0047 0.2221
Entamoeba histolytica hypothetical protein 0.0182 0.1057 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0028 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0094 0.0082
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0125 0.0118
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0121 0.0665
Schistosoma mansoni nuclear receptor 0.0015 0.0028 0.0007
Schistosoma mansoni protein kinase 0.0031 0.0125 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0228 0.0207
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0746 0.453 0.5144
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0228 0.0236
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0037 0.0089
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0024 0.0082
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0121 0.8442
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0228 0.0236
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1412 0.1584
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0053 0.2801
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Schistosoma mansoni lamin 0.0087 0.0471 0.0512
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0202 0.0205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0755
Brugia malayi Pre-SET motif family protein 0.0036 0.0156 0.0153
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0133 0.0127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0133 0.0112
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0125 0.0404
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0039 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0073 0.0201
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0094 0.0082
Echinococcus granulosus muscleblind protein 0.0156 0.0896 0.0997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0133 0.0139
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0073 0.2572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0079 0.0431
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0121 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013 0.0737 0.0815
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0127 0.0133
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0024 0.0082
Schistosoma mansoni pyruvate kinase 0.0033 0.0134 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Brugia malayi Muscleblind-like protein 0.0156 0.0896 0.0997
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0077 0.233
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0073 0.2868
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0235 0.0243
Echinococcus granulosus tumor protein p63 0.1086 0.6623 0.7523
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0133 0.0127
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0055 0.2942
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0228 0.0236
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0128 0.4451
Loa Loa (eye worm) sugar transporter 0.0014 0.0022 0.0012
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.0945 0.5495
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0073 0.0059
Plasmodium falciparum protein kinase 6 0.0431 0.259 1
Schistosoma mansoni sodium-bile acid cotransporter 0.0855 0.5203 0.5904
Trypanosoma brucei unspecified product 0.0016 0.0033 0.0461
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0134 0.0128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0071
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0073 0.2169
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Schistosoma mansoni sodium-bile acid cotransporter related 0.1439 0.8797 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0121 0.0114
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0471 0.0512
Onchocerca volvulus 0.0286 0.1696 0.1908
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0133 0.0112
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0094 0.3019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0079 0.0431
Leishmania major hypothetical protein, conserved 0.0016 0.0032 0.0441
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Brugia malayi nuclear receptor NHR-88 0.0015 0.0028 0.0007
Entamoeba histolytica protein kinase, putative 0.0031 0.0125 0.0704
Schistosoma mansoni hypothetical protein 0.0275 0.1629 0.1832
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0125 0.013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.013
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0128 0.0723
Echinococcus granulosus pyruvate kinase 0.0017 0.0037 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0133 0.0127
Mycobacterium ulcerans hypothetical protein 0.0026 0.0094 0.6977
Echinococcus granulosus sodium bile acid cotransporter 0.1439 0.8797 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0153 0.0779
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0127 0.0411
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0055 0.0291
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0121 0.0114
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0133 0.0127
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0082
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0073 0.0059
Echinococcus granulosus zinc finger protein 0.0024 0.0083 0.0069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0127 0.072
Echinococcus granulosus intermediate filament protein 0.0087 0.0471 0.0512
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0121 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0133 0.0127
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.056 0.0539
Schistosoma mansoni smad1 5 8 and 0.0051 0.0247 0.0257
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5067 0.575
Echinococcus granulosus dna polymerase kappa 0.0023 0.0077 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0266 0.0244
Loa Loa (eye worm) hypothetical protein 0.0147 0.0837 0.0941
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0094 0.6977
Echinococcus multilocularis pyruvate kinase 0.0017 0.0037 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0133 0.0127
Leishmania major DNA polymerase kappa, putative 0.0023 0.0077 0.233
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0074 0.0059
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.026 0.0928
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0134 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0133 0.0139
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0128 0.4451
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0182 0.1057 0.118
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0094 0.6395
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0055 0.4082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0106
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0121 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0094 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0755
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0028 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0074 0.0059
Plasmodium falciparum protein kinase 7 0.0287 0.1702 0.6542
Echinococcus granulosus tar DNA binding protein 0.026 0.1535 0.1724
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0945 0.556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0092 0.0513
Brugia malayi nuclear receptor NHR-88 0.0032 0.0133 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0133 0.0127
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0185 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.043
Brugia malayi nuclear hormone receptor 0.0015 0.0028 0.0007
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0125 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Echinococcus multilocularis sodium bile acid cotransporter 0.1439 0.8797 0.8794
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0055 0.0033
Schistosoma mansoni survival motor neuron protein 0.0049 0.0235 0.0243
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0153 0.5491
Brugia malayi MH2 domain containing protein 0.0051 0.0247 0.0257
Brugia malayi MH2 domain containing protein 0.0051 0.0247 0.0257
Brugia malayi nuclear receptor RXR 0.0015 0.0028 0.0007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.013 0.0737 0.0717
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0228 0.0236
Loa Loa (eye worm) hypothetical protein 0.0086 0.0461 0.0513
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0039 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Brugia malayi steroid hormone receptor 0.0032 0.0133 0.0127
Schistosoma mansoni sodium-bile acid cotransporter related 0.0583 0.3527 0.3995
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0073 0.2169
Onchocerca volvulus 0.0147 0.0837 0.0929
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0113 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.026 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Brugia malayi nuclear receptor RXR 0.0017 0.0039 0.002
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0055 0.0291
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0121 0.0114
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0028 0.0007
Echinococcus multilocularis sodium bile acid cotransporter 0.1439 0.8797 0.8794
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0073 0.0401
Onchocerca volvulus 0.0015 0.0028 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.008 0.0067
Brugia malayi Bromodomain containing protein 0.0082 0.044 0.0476
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0945 0.556
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0412 0.2472 0.2802
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0147 0.0837
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0033 0.0461
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0028 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1476 0.8698
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0128 0.0723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.026 0.1535 0.1735
Brugia malayi MH1 domain containing protein 0.0028 0.0107 0.0097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0039 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0128 0.0723
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Toxoplasma gondii exonuclease III APE 0.002 0.0055 0.0197
Leishmania major glucose transporter, lmgt3 0.0032 0.0128 0.4451
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0841 0.0934
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0028 0.0007
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0043 0.0025
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0037 0.0058
Onchocerca volvulus 0.0036 0.0156 0.0153
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0147 0.5269
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.056 0.0539
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0056 0.0299
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0048
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0028 0.0007
Echinococcus granulosus lamin dm0 0.0087 0.0471 0.0512
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0077 0.5753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0147 0.0837
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0113 0.0105
Schistosoma mansoni tar DNA-binding protein 0.026 0.1535 0.1724
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Plasmodium vivax SET domain protein, putative 0.0036 0.0156 0.0522
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0125 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0133 0.0127
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0125 0.0118
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0094 0.6395
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0077 0.4935
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0074 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0094 0.0523
Schistosoma mansoni zinc finger protein 0.0024 0.0083 0.0069
Brugia malayi RNA binding protein 0.026 0.1535 0.1724
Trypanosoma brucei glucose transporter 1E 0.0032 0.0128 0.4451
Loa Loa (eye worm) hypothetical protein 0.0033 0.0134 0.0141
Plasmodium vivax hexose transporter 0.0102 0.056 0.2094
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0047 0.2221
Brugia malayi conserved hypotetical protein 0.0015 0.0028 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0133 0.0127
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0247 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0106
Brugia malayi MH2 domain containing protein 0.0746 0.453 0.5138
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1412 0.1393
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0094 0.0082
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0053 0.0123
Schistosoma mansoni coup transcription factor 0.0032 0.0133 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1476 0.8698
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0222 0.0228
Loa Loa (eye worm) acetyltransferase 0.0154 0.0882 0.0992
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0028 0.0019
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.056 0.3201
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0133 0.0127
Onchocerca volvulus 0.0159 0.0913 0.1016
Echinococcus multilocularis muscleblind protein 0.0156 0.0896 0.0876
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0074 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0945 0.556
Leishmania major hypothetical protein, conserved 0.0053 0.026 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0032 0.0441
Schistosoma mansoni hypothetical protein 0.0049 0.0235 0.0243
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0223 0.1288
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0079 0.0057
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0032
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0127 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0156 0.0153
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0094 0.3019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0107 0.0109
Echinococcus granulosus pyruvate kinase 0.0033 0.0134 0.0128
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0024 0.0015
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0022 0.0012
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0077 0.233
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0133 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.043
Onchocerca volvulus 0.0032 0.0133 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0033 0.0461
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0134 0.0128
Onchocerca volvulus 0.0087 0.0471 0.0512
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0128 0.4451
Schistosoma mansoni hypothetical protein 0.0102 0.056 0.0613
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0052 0.2723
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0024 0.0002
Onchocerca volvulus 0.0026 0.0094 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.233
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0028 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0147 0.0837
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0134 0.4721
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0193 0.0172
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0134 0.0128
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0185 0.1302
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0055 0.1389
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0156 0.0896 0.1008
Brugia malayi hypothetical protein 0.0015 0.0028 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0133 0.0127
Schistosoma mansoni glucose transport protein 0.0102 0.056 0.0613
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0127 0.4434
Onchocerca volvulus 0.0087 0.0471 0.0512
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.0126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Brugia malayi ecdysone receptor 0.0015 0.0028 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0055 0.1836
Brugia malayi MH1 domain containing protein 0.0051 0.0247 0.0257
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Leishmania major pyruvate kinase 0.0033 0.0134 0.4721
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.026 0.0928
Schistosoma mansoni intermediate filament proteins 0.0087 0.0471 0.0512
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0156 0.0153
Schistosoma mansoni tar DNA-binding protein 0.026 0.1535 0.1724
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0028 0.0006
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0882 0.0981
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0156 0.0134
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0153 0.5491
Brugia malayi PHD-finger family protein 0.003 0.0117 0.0109
Echinococcus granulosus pyruvate kinase 0.0017 0.0037 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0054 0.0266 0.029
Leishmania major protein kinase, putative 0.0031 0.0125 0.4348
Brugia malayi MH2 domain containing protein 0.0023 0.0074 0.0059
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0028 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0028 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0032
Echinococcus granulosus sodium bile acid cotransporter 0.1439 0.8797 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0266 0.0278
Brugia malayi Sodium Bile acid symporter family protein 0.1439 0.8797 1
Brugia malayi Latrophilin receptor protein 2 0.013 0.0737 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0202 0.1162
Brugia malayi Pre-SET motif family protein 0.0251 0.1482 0.1664
Echinococcus multilocularis lamin dm0 0.0087 0.0471 0.045
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0022 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0039 0.002
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0202 0.1469
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0087 0.0471 0.0524
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0133 0.0127
Leishmania major glucose transporter, lmgt1 0.0032 0.0128 0.4451
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0133 0.0127
Schistosoma mansoni Smad4 0.0023 0.0074 0.0059
Brugia malayi hypothetical protein 0.0182 0.1057 0.118
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0077 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0067 0.0064
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0073 0.0059
Echinococcus multilocularis tar DNA binding protein 0.026 0.1535 0.1516
Schistosoma mansoni glucose transport protein 0.0102 0.056 0.0613
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0094 0.3019
Plasmodium falciparum flap endonuclease 1 0.0031 0.0127 0.0411
Schistosoma mansoni pyruvate kinase 0.0033 0.0134 0.0128
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0073 0.5467
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0133 0.0127
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0073 0.5467
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0127 0.4434
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.0945 0.3595
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0128 0.4451
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0012
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0882 0.0981
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0945 0.556
Schistosoma mansoni hypothetical protein 0.0182 0.1057 0.118
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0028 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0133 0.0139
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0055 0.1389
Schistosoma mansoni hypothetical protein 0.0282 0.1669 0.1877
Schistosoma mansoni pyruvate kinase 0.0017 0.0037 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0163 0.0929
Schistosoma mansoni protein kinase 0.0031 0.0125 0.0118
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0134 0.4721
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0134 0.4721
Loa Loa (eye worm) hypothetical protein 0.0042 0.0193 0.0207
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0125 0.0104
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0341 0.0364
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.056 0.0613
Loa Loa (eye worm) hypothetical protein 0.0074 0.0389 0.0431
Echinococcus granulosus General substrate transporter 0.0087 0.0472 0.0513
Loa Loa (eye worm) sugar transporter 0.0102 0.056 0.0625
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0028 0.0019
Echinococcus multilocularis smad 0.0051 0.0247 0.0226
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.008 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0148 0.0143
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0028 0.0019
Echinococcus multilocularis tumor protein p63 0.1086 0.6623 0.6616
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0048
Trypanosoma brucei unspecified product 0.0023 0.0077 0.233
Leishmania major pyruvate kinase 0.0033 0.0134 0.4721
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0945 0.556
Echinococcus multilocularis lamin 0.0087 0.0471 0.045
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0202 0.7563
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0077 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0223 0.1288
Echinococcus multilocularis sodium bile acid cotransporter 0.1439 0.8797 0.8794
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0128 0.4451
Echinococcus granulosus pyruvate kinase 0.0033 0.0134 0.0128
Brugia malayi MH1 domain containing protein 0.0028 0.0107 0.0097
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5067 0.575
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0094 0.0523
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.056 0.0613
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0133 0.0127
Plasmodium falciparum hexose transporter 0.0102 0.056 0.2094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Leishmania major glucose transporter, lmgt2 0.0032 0.0128 0.4451
Schistosoma mansoni nuclear receptor 0.0015 0.0028 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0047 0.2221
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0133 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0077 0.233
Loa Loa (eye worm) hypothetical protein 0.0412 0.2472 0.2802
Onchocerca volvulus 0.0015 0.0028 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0202 0.0218
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0133 0.0112
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0341 0.032
Schistosoma mansoni Smad4 0.0051 0.0247 0.0257
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0077 0.0063
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0275 0.1629 0.1832
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0073 0.0052
Entamoeba histolytica hypothetical protein 0.0182 0.1057 1
Giardia lamblia GTOR 0.0044 0.0202 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0133 0.0112
Brugia malayi hypothetical protein 0.0053 0.026 0.0272
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0202 0.7563
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0033 0.0461
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0266 0.0278
Chlamydia trachomatis pyruvate kinase 0.0033 0.0134 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0022 0.1615
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0133 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0133 0.0127
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0896 0.0876
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.013 0.0737 0.0815
Echinococcus multilocularis pyruvate kinase 0.0017 0.0037 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0028 0.0007
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0134 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0133 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0755
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0055 0.005
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0125 0.0617
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0133 0.0664
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0125 0.0118
Schistosoma mansoni hypothetical protein 0.0024 0.008 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0228 0.0236
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0055 0.1389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0133 0.0139
Loa Loa (eye worm) MH2 domain-containing protein 0.0746 0.453 0.5144
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0077 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.056 0.3278
Trypanosoma brucei unspecified product 0.0016 0.0033 0.0461
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0247 0.0269
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0134 0.0761
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0128 0.4451
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0228 0.0207
Schistosoma mansoni zinc finger protein 0.0015 0.0028 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0047 0.2221
Loa Loa (eye worm) hypothetical protein 0.0046 0.0219 0.0237
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0019
Leishmania major DNA polymerase eta, putative 0.0023 0.0077 0.233
Brugia malayi intermediate filament protein 0.0087 0.0471 0.0512
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451
Schistosoma mansoni hypothetical protein 0.013 0.0737 0.0815
Brugia malayi Flap endonuclease-1 0.0031 0.0127 0.012
Loa Loa (eye worm) latrophilin receptor protein 2 0.013 0.0737 0.0826
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Echinococcus granulosus GPCR family 2 0.013 0.0737 0.0815
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0094 0.6977
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0078 0.043
Schistosoma mansoni hypothetical protein 0.013 0.0737 0.0815
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0247 0.0226
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.007 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.026 0.0928
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0125 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0266 0.0278
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0202 0.0205
Toxoplasma gondii protein kinase, putative 0.0287 0.1702 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1476 0.8698
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0128 0.0723
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0945 0.556
Loa Loa (eye worm) hypothetical protein 0.003 0.0121 0.0126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0165 0.0163
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0223 0.12
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0228 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0077 0.233
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0055 0.0129
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0133 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.233
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0127 0.4434
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0134 0.4721
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0134 0.067
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0079 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0133 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0133 0.0755
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0193 0.0195
Loa Loa (eye worm) nuclear factor I 0.0028 0.0107 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0127 0.5863
Loa Loa (eye worm) hypothetical protein 0.024 0.1412 0.1595
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0072
Schistosoma mansoni cellular tumor antigen P53 0.0159 0.0913 0.1016
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0133 0.0127
Schistosoma mansoni hypothetical protein 0.013 0.0737 0.0815
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0028 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0077 0.0063
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0153 0.5491
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0133 0.0127
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0028 0.0007
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0153 0.5491
Schistosoma mansoni hypothetical protein 0.013 0.0737 0.0815
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0471 0.0524
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0125 0.0708
Onchocerca volvulus 0.1439 0.8797 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Loa Loa (eye worm) hypothetical protein 0.0159 0.0913 0.1027
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0945 0.1053
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0073 0.0201
Entamoeba histolytica hypothetical protein 0.0182 0.1057 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0037 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0147 0.0837
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0156 0.0798
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0039 0.0032
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0128 0.0723
Echinococcus multilocularis thyroid hormone receptor alpha 0.0308 0.1829 0.1811
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0125 0.0404
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0121 0.0685
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0125 0.0404
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013 0.0737 0.0815
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Echinococcus multilocularis pyruvate kinase 0.0033 0.0134 0.0113
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0247 0.0269
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0079 0.0065
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0053 0.3964
Schistosoma mansoni flap endonuclease-1 0.0028 0.0109 0.0099
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0028 0.0007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0202 0.7563
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.056 0.0539
Schistosoma mansoni tar DNA-binding protein 0.026 0.1535 0.1724
Entamoeba histolytica hypothetical protein 0.0182 0.1057 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.0032 0.0133 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0012
Brugia malayi TAR-binding protein 0.026 0.1535 0.1724
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1476 0.8698
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0028 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0028 0.0007
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0125 0.0404
Loa Loa (eye worm) hypothetical protein 0.0048 0.0231 0.0251
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0134 0.0141
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0202 0.7563
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Schistosoma mansoni thyroid hormone receptor 0.0308 0.1829 0.2059
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0125 0.4348
Brugia malayi hypothetical protein 0.0017 0.0039 0.002
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0022 0.0095
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0134 0.0128
Schistosoma mansoni smad1 5 8 and 0.0051 0.0247 0.0257
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0202 0.0205
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0052 0.2723
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0156 0.0896 0.1008
Echinococcus multilocularis zinc finger protein 0.0024 0.0083 0.0061
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0074 0.0187
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0094 0.0388
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0073 0.5467
Trypanosoma brucei glucose transporter, putative 0.0032 0.0128 0.4451

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0028 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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