Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0076 | 0.047 | 0.3759 | |
Mycobacterium ulcerans | hypothetical protein | 0.0076 | 0.047 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.1088 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.0224 | 0.0645 |
Brugia malayi | intermediate filament protein | 0.0113 | 0.0816 | 0.2351 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0159 | 0.1249 | 0.36 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0224 | 0.0645 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0114 | 0.0825 | 0.0615 |
Brugia malayi | hypothetical protein | 0.0083 | 0.0534 | 0.1538 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.026 | 0.2199 | 0.6337 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0159 | 0.125 | 0.3161 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0076 | 0.047 | 0.1354 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0294 | 0.0217 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.026 | 0.2199 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0775 | 0.2233 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.047 | 0.0758 |
Mycobacterium leprae | conserved hypothetical protein | 0.0076 | 0.047 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0076 | 0.047 | 0.1079 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0055 | 0.0264 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.047 | 0.1354 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0058 | 0.0294 | 0.0072 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.047 | 0.1354 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.047 | 0.1354 |
Loa Loa (eye worm) | beta-lactamase | 0.0076 | 0.047 | 0.1354 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.047 | 0.1079 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0129 | 0.0964 | 1 |
Onchocerca volvulus | 0.0159 | 0.125 | 1 | |
Brugia malayi | RNA binding protein | 0.0395 | 0.3469 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0395 | 0.3469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0264 | 0.0761 |
Brugia malayi | TAR-binding protein | 0.0395 | 0.3469 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0395 | 0.3469 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0395 | 0.3469 | 1 |
Echinococcus multilocularis | musashi | 0.0113 | 0.0816 | 0.0605 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0076 | 0.047 | 0.1354 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0076 | 0.047 | 0.1079 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0061 | 0.0321 | 0.0924 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0159 | 0.1249 | 0.36 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0061 | 0.0321 | 0.0924 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0114 | 0.0825 | 0.1852 |
Brugia malayi | beta-lactamase family protein | 0.0076 | 0.047 | 0.1354 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.047 | 0.4873 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0076 | 0.047 | 0.1079 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.047 | 0.1354 |
Mycobacterium leprae | Probable lipase LipE | 0.0076 | 0.047 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0113 | 0.0816 | 0.2351 |
Schistosoma mansoni | tar DNA-binding protein | 0.0395 | 0.3469 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0113 | 0.0816 | 0.1823 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.0775 | 0.2233 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.047 | 0.1354 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0058 | 0.0294 | 0.0072 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0076 | 0.047 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.047 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0129 | 0.0964 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0076 | 0.047 | 0.1079 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0395 | 0.3469 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.0775 | 0.1697 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0244 | 0.0705 |
Schistosoma mansoni | lamin | 0.0113 | 0.0816 | 0.1823 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0129 | 0.0964 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0129 | 0.0964 | 1 |
Echinococcus granulosus | lamin | 0.0113 | 0.0816 | 0.0605 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0816 | 0.2351 |
Onchocerca volvulus | 0.0113 | 0.0816 | 0.6526 | |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0055 | 0.0264 | 0.0041 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0159 | 0.1249 | 0.36 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0129 | 0.0964 | 1 |
Onchocerca volvulus | 0.0076 | 0.047 | 0.3759 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0113 | 0.0816 | 0.2351 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.047 | 0.1079 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.0224 | 0.0645 |
Brugia malayi | beta-lactamase | 0.0076 | 0.047 | 0.1354 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.125 | 0.3602 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0076 | 0.047 | 0.1079 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0076 | 0.047 | 1 |
Echinococcus multilocularis | lamin | 0.0113 | 0.0816 | 0.0605 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1249 | 0.36 |
Onchocerca volvulus | 0.0076 | 0.047 | 0.3759 | |
Echinococcus multilocularis | lamin dm0 | 0.0113 | 0.0816 | 0.0605 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0076 | 0.047 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.0964 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0395 | 0.3469 | 0.332 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0129 | 0.0964 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0825 | 0.1852 |
Schistosoma mansoni | lamin | 0.0113 | 0.0816 | 0.1823 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0489 | 0.4352 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0076 | 0.047 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.047 | 0.1354 |
Echinococcus granulosus | lamin dm0 | 0.0113 | 0.0816 | 0.0605 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0796 | 0.2295 |
Echinococcus granulosus | intermediate filament protein | 0.0113 | 0.0816 | 0.0605 |
Mycobacterium ulcerans | beta-lactamase | 0.0076 | 0.047 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0395 | 0.3469 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0076 | 0.047 | 0.0251 |
Loa Loa (eye worm) | intermediate filament protein | 0.0113 | 0.0816 | 0.2351 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.0224 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.047 | 0.1354 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0395 | 0.3469 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0076 | 0.047 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0129 | 0.0964 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0076 | 0.047 | 0.1079 |
Echinococcus granulosus | tar DNA binding protein | 0.0395 | 0.3469 | 0.332 |
Mycobacterium ulcerans | lipase LipD | 0.0076 | 0.047 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0114 | 0.0825 | 0.0615 |
Onchocerca volvulus | 0.0113 | 0.0816 | 0.6526 | |
Brugia malayi | hypothetical protein | 0.0114 | 0.0825 | 0.2378 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0076 | 0.047 | 0.0758 |
Brugia malayi | hypothetical protein | 0.0129 | 0.0964 | 0.2779 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0076 | 0.047 | 0.1079 |
Mycobacterium tuberculosis | Conserved protein | 0.0076 | 0.047 | 0.1079 |
Brugia malayi | MH2 domain containing protein | 0.026 | 0.2199 | 0.6337 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0395 | 0.3469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0244 | 0.0705 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0076 | 0.047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0964 | 0.2779 |
Schistosoma mansoni | tar DNA-binding protein | 0.0395 | 0.3469 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.