Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0263 | 0.234 | 0.7561 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0286 | 0.0211 |
Echinococcus granulosus | CREB binding protein | 0.0075 | 0.0534 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0663 | 0.2024 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0111 | 0.0877 | 0.0877 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0225 | 0.0578 |
Schistosoma mansoni | tar DNA-binding protein | 0.034 | 0.3079 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0048 | 0.0266 | 0.0711 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0225 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.9235 | 0.9235 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.0841 | 0.2158 |
Echinococcus multilocularis | GPCR, family 2 | 0.005 | 0.0286 | 0.0286 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0877 | 0.2284 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0877 | 0.273 |
Loa Loa (eye worm) | RNA binding protein | 0.034 | 0.3079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1544 | 0.4931 |
Echinococcus multilocularis | musashi | 0.0089 | 0.0663 | 0.0663 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0131 | 0.1068 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0089 | 0.0663 | 0.0663 |
Schistosoma mansoni | tar DNA-binding protein | 0.034 | 0.3079 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0089 | 0.0663 | 0.2024 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0225 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.036 | 0.1022 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1544 | 0.4931 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0043 | 0.022 | 0.022 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0225 | 0.0719 |
Echinococcus multilocularis | tar DNA binding protein | 0.034 | 0.3079 | 0.3079 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0877 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0225 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0122 | 0.0985 | 0.0985 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0157 | 0.132 | 0.4192 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.1544 | 0.1544 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0225 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.034 | 0.3079 | 0.3079 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0286 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1299 | 0.4122 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0225 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0877 | 1 |
Brugia malayi | RNA binding protein | 0.034 | 0.3079 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0122 | 0.0985 | 0.2663 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.034 | 0.3079 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.0286 | 0.0776 |
Loa Loa (eye worm) | CBP-B | 0.0085 | 0.0625 | 0.1898 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.0286 | 0.0776 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0048 | 0.0266 | 0.0711 |
Onchocerca volvulus | 0.0089 | 0.0663 | 0.491 | |
Schistosoma mansoni | CREB-binding protein 2 | 0.0122 | 0.0985 | 0.2663 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0286 | 0.0286 |
Schistosoma mansoni | intermediate filament proteins | 0.0089 | 0.0663 | 0.1535 |
Brugia malayi | TAZ zinc finger family protein | 0.0122 | 0.0985 | 0.3087 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0225 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0286 | 0.0776 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0877 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.0841 | 0.2611 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0225 | 0.0578 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0131 | 0.1068 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0225 | 0.0578 |
Echinococcus multilocularis | CREB binding protein | 0.0084 | 0.0615 | 0.0615 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0286 | 0.0286 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0131 | 0.1068 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0225 | 0.1401 | |
Onchocerca volvulus | 0.0089 | 0.0663 | 0.491 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0286 | 0.0286 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0225 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0225 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0205 | 0.0509 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0225 | 0.0719 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0621 | 0.1883 |
Onchocerca volvulus | 0.0155 | 0.1299 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0286 | 0.0211 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0225 | 0.0719 |
Echinococcus granulosus | GPCR family 2 | 0.005 | 0.0286 | 0.0286 |
Schistosoma mansoni | tar DNA-binding protein | 0.034 | 0.3079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0225 | 0.0578 |
Loa Loa (eye worm) | intermediate filament protein | 0.0089 | 0.0663 | 0.2024 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | TAR-binding protein | 0.034 | 0.3079 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0111 | 0.0877 | 0.0877 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0111 | 0.0877 | 0.2284 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1544 | 0.4931 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.1544 | 0.1544 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0648 | 0.1972 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0225 | 0.0719 |
Brugia malayi | TAR-binding protein | 0.034 | 0.3079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.132 | 0.4192 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0841 | 0.2611 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0286 | 0.0211 |
Onchocerca volvulus | 0.0043 | 0.0225 | 0.1401 | |
Schistosoma mansoni | lamin | 0.0089 | 0.0663 | 0.1535 |
Schistosoma mansoni | tar DNA-binding protein | 0.034 | 0.3079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0225 | 0.0578 |
Echinococcus multilocularis | lamin dm0 | 0.0089 | 0.0663 | 0.0663 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.1068 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.2481 | 1 |
Echinococcus multilocularis | lamin | 0.0089 | 0.0663 | 0.0663 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0225 | 0.0225 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0059 | 0.0372 | 0.0372 |
Echinococcus granulosus | lamin dm0 | 0.0089 | 0.0663 | 0.0663 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0059 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0157 | 0.132 | 0.4192 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0205 | 0.0509 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0225 | 0.0578 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0225 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0225 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.034 | 0.3079 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0043 | 0.022 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1068 | 0.3359 |
Brugia malayi | hypothetical protein | 0.0131 | 0.1068 | 0.3359 |
Brugia malayi | RNA recognition motif domain containing protein | 0.034 | 0.3079 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0131 | 0.1068 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0263 | 0.234 | 0.7561 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0225 | 0.0719 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0372 | 0.0515 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0225 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0225 | 0.1719 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0225 | 0.0719 |
Schistosoma mansoni | lamin | 0.0089 | 0.0663 | 0.1535 |
Echinococcus granulosus | lamin | 0.0089 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0089 | 0.0663 | 0.2024 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0225 | 0.0719 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0225 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0225 | 0.0719 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0131 | 0.1068 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.0286 | 0.0776 |
Brugia malayi | intermediate filament protein | 0.0089 | 0.0663 | 0.2024 |
Onchocerca volvulus | 0.0043 | 0.0225 | 0.1401 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0157 | 0.132 | 0.4192 |
Echinococcus multilocularis | tumor protein p63 | 0.1059 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0225 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0225 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0263 | 0.234 | 0.7561 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0131 | 0.1068 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0225 | 0.0225 |
Entamoeba histolytica | hypothetical protein | 0.0111 | 0.0877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0225 | 0.0578 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0225 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0225 | 0.0578 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0225 | 0.0719 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0225 | 0.0719 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0225 | 0.0578 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0131 | 0.1068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.022 | 0.056 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0155 | 0.1299 | 0.3762 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.1544 | 0.1544 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.