Detailed information for compound 765103

Basic information

Technical information
  • TDR Targets ID: 765103
  • Name: N-(2-methoxyethyl)-2-[3-(thiophene-2-carbonyl )indol-1-yl]acetamide
  • MW: 342.412 | Formula: C18H18N2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.66 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)Cn1cc(c2c1cccc2)C(=O)c1cccs1
  • InChi: 1S/C18H18N2O3S/c1-23-9-8-19-17(21)12-20-11-14(13-5-2-3-6-15(13)20)18(22)16-7-4-10-24-16/h2-7,10-11H,8-9,12H2,1H3,(H,19,21)
  • InChiKey: SPYVUJSKUUMUCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxyethyl)-2-[3-[oxo-(2-thienyl)methyl]-1-indolyl]acetamide
  • N-(2-methoxyethyl)-2-(3-thiophen-2-ylcarbonylindol-1-yl)ethanamide
  • ST061736
  • MLS000122650
  • SMR000120108
  • ZINC02846798
  • BAS 07323589
  • N-(2-Methoxy-ethyl)-2-[3-(thiophene-2-carbonyl)-indol-1-yl]-acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0034 0.0039
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0353 0.0351
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0288 0.0355
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0121 0.0959
Loa Loa (eye worm) Smad1 0.01 0.0331 0.0411
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0042
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0061 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.1195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.013 0.0158
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0022 0.0192
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0419 0.0417
Schistosoma mansoni glucose transport protein 0.0106 0.0353 0.0436
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0097 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0214 0.2127
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0048 0.0056
Schistosoma mansoni Smad4 0.01 0.0331 0.0408
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0022 0.0024
Loa Loa (eye worm) glutaminase 0.0265 0.0996 0.1238
Echinococcus granulosus General substrate transporter 0.0091 0.0293 0.0361
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0121 0.0959
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0054 0.0522
Brugia malayi hypothetical protein 0.0024 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0025
Entamoeba histolytica Ran family GTPase 0.0022 0.0016 0.0162
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0353 0.0436
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.013 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0616 0.6181
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0034 0.0039
Echinococcus granulosus lamin dm0 0.011 0.0372 0.0459
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.013 0.0158
Schistosoma mansoni smad 0.0045 0.0107 0.013
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0061 0.0588
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.013 0.0161
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0048 0.0185
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0619 0.2423 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0121 0.1463
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.0616 0.5431
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0616 0.6181
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0654 0.6555
Mycobacterium ulcerans hypothetical protein 0.0048 0.0121 0.0959
Toxoplasma gondii protein kinase, putative 0.0299 0.1132 1
Entamoeba histolytica hypothetical protein 0.0024 0.0022 0.0234
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0121 0.0959
Schistosoma mansoni lamin 0.011 0.0372 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0195 0.1939
Schistosoma mansoni Smad4 0.0045 0.0107 0.013
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0022 0.002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0016 0.0118
Loa Loa (eye worm) acetyltransferase 0.0143 0.0505 0.0628
Schistosoma mansoni ap endonuclease 0.0037 0.0075 0.009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.013 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.013 0.0158
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0022 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0022 0.002
Loa Loa (eye worm) RNA binding protein 0.0454 0.1758 0.2187
Trichomonas vaginalis glutaminase, putative 0.0265 0.0996 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0235 0.2339
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.013 0.0127
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.002 0.0216
Echinococcus multilocularis microtubule associated protein 2 0.1418 0.565 0.5649
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.013 0.0127
Brugia malayi RNA binding protein 0.0454 0.1758 0.2184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0195 0.1939
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0149 0.0776
Loa Loa (eye worm) hypothetical protein 0.0032 0.0057 0.0071
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.0616 0.3486
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0061 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.013 0.0158
Echinococcus multilocularis snurportin 1 0.0321 0.1224 0.1221
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0045 0.0107 0.0106
Echinococcus granulosus geminin 0.0328 0.1249 0.155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.013 0.0158
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0978 0.9822
Loa Loa (eye worm) hypothetical protein 0.011 0.0372 0.0462
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1758 0.2184
Schistosoma mansoni eyes absent homolog 0.0085 0.0271 0.0334
Plasmodium falciparum protein kinase 7 0.0299 0.1132 0.6483
Brugia malayi Cam kinase protein 1 0.0032 0.0057 0.0068
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.0328 0.1249 0.155
Echinococcus granulosus smad 0.01 0.0331 0.0408
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0072 0.0327
Schistosoma mansoni smad1 5 8 and 0.01 0.0331 0.0408
Entamoeba histolytica hypothetical protein 0.022 0.0814 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0075 0.5
Schistosoma mansoni protein kinase 0.0032 0.0057 0.0068
Schistosoma mansoni ap endonuclease 0.0037 0.0075 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0195 0.1939
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0026 0.003
Brugia malayi hypothetical protein 0.0036 0.007 0.0084
Schistosoma mansoni hypothetical protein 0.0106 0.0353 0.0436
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0061 0.0072
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0288 0.3513
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0022 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.1198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0064 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.013 0.0158
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0057 0.0068
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0003 0.0002
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0061 0.047
Echinococcus multilocularis tar DNA binding protein 0.0454 0.1758 0.1756
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0061 0.4697
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.013 0.0158
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0022 0.0024
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0121 0.1463
Schistosoma mansoni coup transcription factor 0.005 0.013 0.0158
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0149 0.0606
Trypanosoma brucei glucose transporter 1E 0.0033 0.0059 0.0232
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0057 0.024
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0022 0.0024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0121 0.0959
Schistosoma mansoni hypothetical protein 0.0271 0.1022 0.1268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0064 0.0496
Schistosoma mansoni protein kinase 0.0032 0.0057 0.0068
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0076 0.0301
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0048 0.0056
Schistosoma mansoni hypothetical protein 0.0025 0.0026 0.003
Echinococcus multilocularis smad 0.01 0.0331 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0353 0.353
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.013 0.0158
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.022 0.0814 0.0811
Echinococcus granulosus pyruvate kinase 0.0033 0.0061 0.0072
Plasmodium falciparum hexose transporter 0.0106 0.0353 0.1959
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0288 0.2871
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0353 0.0436
Brugia malayi TAR-binding protein 0.0454 0.1758 0.2184
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0075 0.0587
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0149 0.0776
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0057 0.0068
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0054 0.0064
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.009
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0082 0.0983
Schistosoma mansoni hypothetical protein 0.0328 0.1249 0.155
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0288 0.0285
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0097 0.0833
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0132 0.0161
Schistosoma mansoni intermediate filament proteins 0.011 0.0372 0.0459
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.013 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0057 0.0549
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0071 0.0214 0.0873
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0034 0.0039
Schistosoma mansoni sodium-bile acid cotransporter related 0.2011 0.804 1
Plasmodium falciparum importin beta, putative 0.003 0.0048 0.0186
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0061 0.0241
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0149 0.0606
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0076 0.0647
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0072 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0075 0.03
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0353 0.0436
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0049 0.0046
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0034 0.0042
Schistosoma mansoni nuclear receptor 0.0024 0.0022 0.0024
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.001 0.0074
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0288 0.1178
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0059 0.0566
Leishmania major glucose transporter, lmgt3 0.0033 0.0059 0.0232
Brugia malayi ecdysteroid receptor 0.005 0.013 0.0158
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0195 0.1705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.013 0.0161
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.013 0.0158
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0585 0.0582
Brugia malayi ecdysone receptor 0.0024 0.0022 0.0024
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Brugia malayi hypothetical protein 0.0024 0.0022 0.0024
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0054 0.0064
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0016 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0673 0.0834
Plasmodium vivax importin-beta 2, putative 0.003 0.0048 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0142 0.1407
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0271 0.1022 0.1268
Loa Loa (eye worm) DR-78 0.0024 0.0022 0.0028
Brugia malayi Sodium Bile acid symporter family protein 0.2011 0.804 1
Brugia malayi hypothetical protein 0.0027 0.0034 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0022 0.002
Schistosoma mansoni hypothetical protein 0.0321 0.1224 0.1519
Echinococcus multilocularis thyroid hormone receptor alpha 0.0173 0.0623 0.062
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0016 0.0054
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0048 0.0185
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0048 0.0187
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0057 0.024
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0022 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.014 0.1385
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0022 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0858 0.3388 0.4213
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0353 0.0436
Schistosoma mansoni nuclear receptor 0.0024 0.0022 0.0024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0121 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0022 0.0024
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0034 0.0039
Schistosoma mansoni hypothetical protein 0.0271 0.1022 0.1268
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1758 0.2184
Leishmania major pyruvate kinase 0.0033 0.0061 0.0241
Brugia malayi MH1 domain containing protein 0.01 0.0331 0.0408
Schistosoma mansoni survival motor neuron protein 0.0051 0.0132 0.0161
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0022 0.1258
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0025 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0978 0.9822
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0288 0.2871
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0022 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0121 0.0148
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0071 0.0214 0.0873
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0059 0.0566
Schistosoma mansoni nuclear hormone receptor 0.005 0.013 0.0158
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.1108 0.4567
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0353 0.0351
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.013 0.0127
Trypanosoma cruzi hexose transporter 0.0033 0.0059 0.0232
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0277 0.1135
Echinococcus multilocularis pyruvate kinase 0.0033 0.0061 0.0058
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.013 0.0158
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0042
Loa Loa (eye worm) hypothetical protein 0.0055 0.015 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0586 0.2293 0.2852
Schistosoma mansoni zinc finger protein 0.0024 0.0022 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0271 0.1022 0.1271
Brugia malayi Calcitonin receptor-like protein seb-1 0.0858 0.3388 0.4213
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0061 0.0588
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0061 0.0076
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0059 0.0232
Echinococcus granulosus microtubule associated protein 2 0.1418 0.565 0.7026
Echinococcus multilocularis General substrate transporter 0.0091 0.0293 0.029
Leishmania major importin beta-1 subunit, putative 0.0024 0.0025 0.0092
Toxoplasma gondii hypothetical protein 0.01 0.0329 0.2891
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0076 0.0305
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0288 0.0355
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0061 0.0076
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0022 0.0024
Schistosoma mansoni hypothetical protein 0.0271 0.1022 0.1268
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.013 0.0127
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0022 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0214 0.2127
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0505 0.0625
Brugia malayi MH1 domain containing protein 0.0055 0.015 0.0183
Brugia malayi hypothetical protein 0.0027 0.0034 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.005 0.013 0.0127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0121 0.0959
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0075 0.0587
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0048 0.0185
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0061 0.0262
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0937 0.1162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.013 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0673 0.0834
Leishmania major pyruvate kinase 0.0033 0.0061 0.0241
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0057 0.0483
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.013 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0064 0.0496
Brugia malayi nuclear receptor RXR 0.0027 0.0034 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0937 0.0934
Echinococcus granulosus tumor protein p63 0.1732 0.6917 0.8602
Brugia malayi MH2 domain containing protein 0.01 0.0331 0.0408
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0057 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.1195
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0022 0.0024
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0288 0.1178
Loa Loa (eye worm) hypothetical protein 0.0048 0.0121 0.0151
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.0978 0.1216
Brugia malayi MH2 domain containing protein 0.147 0.586 0.7287
Loa Loa (eye worm) hypothetical protein 0.0858 0.3388 0.4214
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0054 0.0064
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0054 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0022 0.0024
Onchocerca volvulus 0.0051 0.0132 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1758 0.2184
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0372 0.0459
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0059 0.0566
Echinococcus granulosus sodium bile acid cotransporter 0.2011 0.804 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.013 0.0158
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0057 0.0483
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0016 0.0461
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Leishmania major glucose transporter, lmgt1 0.0033 0.0059 0.0232
Brugia malayi RNA recognition motif domain containing protein 0.0454 0.1758 0.2184
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0059 0.0232
Onchocerca volvulus 0.005 0.013 0.0134
Echinococcus granulosus pyruvate kinase 0.0033 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0165 0.0205
Echinococcus granulosus sodium bile acid cotransporter 0.2011 0.804 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0075 0.0073
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0022 0.0024
Schistosoma mansoni pyruvate kinase 0.0033 0.0061 0.0072
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0505 0.0625
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0076 0.0301
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0057 0.024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.1198
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0057 0.0054
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0616 0.0741
Loa Loa (eye worm) transcription factor SMAD2 0.147 0.586 0.7288
Schistosoma mansoni TGF-beta signal transducer Smad2 0.01 0.0331 0.0408
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0097 0.0391
Brugia malayi Importin beta-1 subunit 0.003 0.0048 0.0056
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0059 0.0232
Schistosoma mansoni hypothetical protein 0.022 0.0814 0.1009
Loa Loa (eye worm) hypothetical protein 0.0108 0.0363 0.0452
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0022 0.0078
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0133 0.0165
Loa Loa (eye worm) sugar transporter 0.0106 0.0353 0.0439
Echinococcus multilocularis pyruvate kinase 0.0026 0.0033 0.003
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0048 0.0185
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Brugia malayi MH2 domain containing protein 0.0045 0.0107 0.013
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0022 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.013 0.0161
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0048 0.0402
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0049 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0271 0.1022 0.1019
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0061 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0057 0.024
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0022 0.0028
Leishmania major GTP-binding protein, putative 0.0022 0.0016 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.013 0.0158
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0034 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0586 0.2293 0.285
Plasmodium vivax CDK-related protein kinase 6, putative 0.0449 0.1737 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0195 0.1939
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0061 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0978 0.9822
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0121 0.0959
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0121 0.0491
Onchocerca volvulus 0.2011 0.804 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.006
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0022 0.0034
Toxoplasma gondii exonuclease III APE 0.0037 0.0075 0.0645
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0042
Echinococcus granulosus Smad4 0.01 0.0331 0.0408
Loa Loa (eye worm) nuclear factor I 0.0055 0.015 0.0186
Echinococcus multilocularis TGF beta signal transducer SmadC 0.01 0.0331 0.0328
Schistosoma mansoni thyroid hormone receptor 0.0173 0.0623 0.0771
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0057 0.0068
Echinococcus granulosus mothers against decapentaplegic 5 0.01 0.0331 0.0408
Echinococcus granulosus intermediate filament protein 0.011 0.0372 0.0459
Brugia malayi MH2 domain containing protein 0.01 0.0331 0.0408
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0121 0.0148
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0858 0.3388 0.4214
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0048 0.0453
Echinococcus granulosus importin subunit beta 1 0.003 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0022 0.0024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0353 0.0351
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0059 0.0232
Schistosoma mansoni transcription factor LCR-F1 0.022 0.0814 0.1009
Echinococcus multilocularis sodium bile acid cotransporter 0.2011 0.804 0.804
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0061 0.047
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0022 0.0034
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0057 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0048 0.0453
Loa Loa (eye worm) glutaminase 2 0.0265 0.0996 0.1238
Echinococcus multilocularis musashi 0.011 0.0372 0.0369
Loa Loa (eye worm) hypothetical protein 0.0053 0.0141 0.0176
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0059 0.0566
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0003 0.0002
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0016 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0619 0.2423 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0061 0.0048
Mycobacterium tuberculosis Conserved hypothetical protein 0.0326 0.1241 1
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.013 0.0158
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.1108 0.4567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.1195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Brugia malayi tailless protein 0.0024 0.0022 0.0024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.013 0.0158
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0072 0.056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0025 0.0092
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.022 0.0814 0.1009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0022 0.002
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0022 0.0024
Echinococcus multilocularis muscleblind protein 0.0163 0.0585 0.0582
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0141 0.0139
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0165 0.0202
Onchocerca volvulus 0.011 0.0372 0.0436
Loa Loa (eye worm) hypothetical protein 0.0033 0.0061 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0142 0.1407
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0057 0.024
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0149 0.13
Loa Loa (eye worm) TAR-binding protein 0.0454 0.1758 0.2187
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.009
Schistosoma mansoni pyruvate kinase 0.0033 0.0061 0.0072
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0075 0.0733
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0121 0.0491
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0057 0.024
Trypanosoma brucei glucose transporter 2A 0.0033 0.0059 0.0232
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0057 0.0068
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0048 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0075 0.0733
Plasmodium falciparum protein kinase 6 0.0449 0.1737 1
Echinococcus granulosus muscleblind protein 0.0163 0.0585 0.0724
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0057 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.013 0.0158
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0022 0.0078
Schistosoma mansoni microtubule-associated protein tau 0.1418 0.565 0.7026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0271 0.1022 0.1019
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0007 0.0037
Echinococcus granulosus TGF beta signal transducer SmadC 0.01 0.0331 0.0408
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0075 0.03
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0059 0.0566
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0288 0.1178
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0293 0.1108 0.4567
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0075 0.0346
Onchocerca volvulus 0.0254 0.095 0.1157
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0097 0.0833
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0616 0.6181
Brugia malayi hypothetical protein 0.022 0.0814 0.1009
Schistosoma mansoni cellular tumor antigen P53 0.0254 0.095 0.1178
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0978 0.9822
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0048 0.0187
Echinococcus multilocularis Smad4 0.01 0.0331 0.0328
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.0353 0.3104
Schistosoma mansoni ran 0.0022 0.0016 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0075 0.03
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0022 0.0024
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0288 0.3513
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0054 0.4129
Loa Loa (eye worm) hypothetical protein 0.0055 0.0149 0.0186
Schistosoma mansoni hypothetical protein 0.0051 0.0132 0.0161
Leishmania major glucose transporter, lmgt2 0.0033 0.0059 0.0232
Giardia lamblia Pyruvate kinase 0.0033 0.0061 0.2042
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0048 0.0453
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.013 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.013 0.0158
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0016 0.0054
Onchocerca volvulus 0.0153 0.0543 0.0649
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.0616 0.3486
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0076 0.0301
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0059 0.0232
Brugia malayi nuclear hormone receptor 0.0024 0.0022 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.014 0.1385
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.013 0.0158
Loa Loa (eye worm) hypothetical protein 0.025 0.0937 0.1165
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0195 0.1939
Brugia malayi nuclear hormone receptor 0.005 0.013 0.0158
Trypanosoma cruzi target of rapamycin kinase 3 0.0071 0.0214 0.0873
Chlamydia trachomatis pyruvate kinase 0.0033 0.0061 0.7777
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0489 0.0605
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0075 0.03
Loa Loa (eye worm) hypothetical protein 0.0153 0.0543 0.0675
Echinococcus granulosus mothers against decapentaplegic 2 0.0045 0.0107 0.013
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0022 0.0169
Schistosoma mansoni smad1 5 8 and 0.01 0.0331 0.0408
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.013 0.0158
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0048 0.0045
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0505 0.0503
Schistosoma mansoni glucose transport protein 0.0106 0.0353 0.0436
Entamoeba histolytica hypothetical protein 0.022 0.0814 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0454 0.1758 0.2187
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0149 0.0606
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0059 0.0232
Leishmania major hypothetical protein, conserved 0.0055 0.0149 0.0606
Brugia malayi MH1 domain containing protein 0.0055 0.015 0.0183
Schistosoma mansoni glucose transport protein 0.0106 0.0353 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0059 0.0566
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0068
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0076 0.0347
Echinococcus multilocularis sodium bile acid cotransporter 0.2011 0.804 0.804
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0022 0.002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0121 0.0959
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0016 0.0054
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0277 0.1135
Echinococcus granulosus snurportin 1 0.0321 0.1224 0.1519
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0673 0.0671
Echinococcus granulosus sodium bile acid cotransporter 0.2011 0.804 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0372 0.0462
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0419 0.0519
Giardia lamblia GTOR 0.009 0.0288 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0064 0.0496
Brugia malayi nuclear receptor RXR 0.0024 0.0022 0.0024
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0097 0.0469
Loa Loa (eye worm) intermediate filament protein 0.011 0.0372 0.0462
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0121 0.0491
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0057 0.0071
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0121 0.0959
Brugia malayi nuclear receptor NHR-67 0.0024 0.0022 0.0024
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0022 0.002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0034 0.0031
Entamoeba histolytica protein kinase, putative 0.0032 0.0057 0.067
Echinococcus multilocularis mothers against decapentaplegic 2 0.0045 0.0107 0.0104
Echinococcus granulosus GPCR family 2 0.0271 0.1022 0.1268
Loa Loa (eye worm) hypothetical protein 0.0163 0.0585 0.0727
Echinococcus multilocularis pyruvate kinase 0.0033 0.0061 0.0058
Echinococcus granulosus tar DNA binding protein 0.0454 0.1758 0.2184
Schistosoma mansoni importin beta-1 0.003 0.0048 0.0056
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.013 0.0158
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0057 0.0225
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0072 0.056
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0121 0.0148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Brugia malayi glutaminase DH11.1 0.0265 0.0996 0.1236
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0057 0.0054
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0075 0.0094
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0121 1
Trichomonas vaginalis ran, putative 0.0022 0.0016 0.0134
Entamoeba histolytica hypothetical protein 0.022 0.0814 1
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Echinococcus multilocularis GPCR, family 2 0.0271 0.1022 0.1019
Schistosoma mansoni glutaminase 0.0265 0.0996 0.1236
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.013 0.0158
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0072 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0195 0.1939
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0025 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1758 0.2184
Entamoeba histolytica hypothetical protein 0.0024 0.0025 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0214 0.2127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.013 0.0158
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0075 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0107 0.0133
Echinococcus multilocularis lamin 0.011 0.0372 0.0369
Echinococcus granulosus lamin 0.011 0.0372 0.0459
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0616 0.6181
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0616 0.6181
Onchocerca volvulus 0.011 0.0372 0.0436
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0057 0.024
Loa Loa (eye worm) MH2 domain-containing protein 0.01 0.0331 0.0411
Echinococcus multilocularis tumor protein p63 0.1732 0.6917 0.6916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0142 0.1407
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.0978 0.1214
Loa Loa (eye worm) hypothetical protein 0.0051 0.0133 0.0165
Brugia malayi hypothetical protein 0.0153 0.0543 0.0672
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0022 0.0024
Schistosoma mansoni protein kinase 0.0032 0.0057 0.0068
Echinococcus multilocularis importin subunit beta 1 0.003 0.0048 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0214 0.2127
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0121 0.0959
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0141 0.0172
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0288 0.0358
Loa Loa (eye worm) hypothetical protein 0.2011 0.804 1
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0059 0.0566
Loa Loa (eye worm) MH2 domain-containing protein 0.147 0.586 0.7288
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0061 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0616 0.6181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.013 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0616 0.6181
Echinococcus granulosus mothers against decapentaplegic 6 0.0045 0.0107 0.013
Leishmania major protein kinase, putative 0.0032 0.0057 0.0225
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0022 0.0153
Onchocerca volvulus 0.0048 0.0121 0.0124
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0007 0.0037
Schistosoma mansoni sodium-bile acid cotransporter related 0.0815 0.3216 0.3999
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.013 0.0158
Brugia malayi RNA, U transporter 1 0.0086 0.0272 0.0335
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0082 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0048 0.0453
Echinococcus multilocularis mothers against decapentaplegic 5 0.01 0.0331 0.0328
Echinococcus multilocularis lamin dm0 0.011 0.0372 0.0369
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0454 0.1758 0.2184
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0288 0.0355
Brugia malayi steroid hormone receptor 0.005 0.013 0.0158
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.0353 0.0351
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0271 0.1022 0.1268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.1198
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0277 0.1135
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0354 0.1452
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.002 0.0025
Echinococcus granulosus FTZ F1 alpha 0.005 0.013 0.0158
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0107 0.0133
Brugia malayi hypothetical protein 0.025 0.0937 0.1162
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0097 0.0947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0673 0.0834
Brugia malayi nuclear receptor NHR-88 0.005 0.013 0.0158
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Loa Loa (eye worm) steroid hormone receptor 0.005 0.013 0.0161
Loa Loa (eye worm) hypothetical protein 0.0045 0.0107 0.0133
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0075 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0121 0.1198
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0075 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0023 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0288 0.2871
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0057 0.0054
Brugia malayi Muscleblind-like protein 0.0163 0.0585 0.0724
Entamoeba histolytica protein kinase, putative 0.0032 0.0057 0.067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.013 0.0161
Schistosoma mansoni sodium-bile acid cotransporter 0.1195 0.475 0.5907
Schistosoma mansoni ran 0.0022 0.0016 0.0016
Schistosoma mansoni Smad4 0.0045 0.0107 0.013
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0288 0.1178
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.013 0.0158
Loa Loa (eye worm) MH1 domain-containing protein 0.01 0.0331 0.0411
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0022 0.0028
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0048 0.0185
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0288 0.1178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0673 0.0671
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.0673 0.0834
Schistosoma mansoni hypothetical protein 0.0122 0.0419 0.0519
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0097 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0173 0.0623 0.0771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0673 0.0834
Brugia malayi mothers against decapentaplegic homolog 3 0.0045 0.0107 0.013
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0026 0.0024
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Brugia malayi Sugar transporter family protein 0.0106 0.0353 0.0436
Schistosoma mansoni smad 0.01 0.0331 0.0408
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0025 0.0226
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0076 0.0301
Brugia malayi intermediate filament protein 0.011 0.0372 0.0459
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0061 0.0076
Mycobacterium ulcerans glutaminase 0.0265 0.0996 0.8017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.013 0.0158
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.1224 0.1522
Schistosoma mansoni hypothetical protein 0.0586 0.2293 0.285
Loa Loa (eye worm) hypothetical protein 0.0085 0.0271 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0195 0.1939
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0288 0.1178
Loa Loa (eye worm) hypothetical protein 0.0048 0.0121 0.0151
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0057 0.024
Brugia malayi Smad1 0.01 0.0331 0.0408
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0022 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0075 0.255
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.013 0.0158
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0048 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.013 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.013 0.0158
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0061 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0214 0.2127
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0057 0.0054
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0082 0.2798
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.013 0.0161
Loa Loa (eye worm) hypothetical protein 0.0271 0.1022 0.1271
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0075 0.009
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0054 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.0673 0.0837
Brugia malayi Steroid receptor seven-up type 2 0.005 0.013 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0978 0.9822
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0169 0.1673
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0054 0.1815
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0149 0.0776
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0121 0.0151
Schistosoma mansoni lamin 0.011 0.0372 0.0459
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0673 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0048 0.0453
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.0978 0.9822
Loa Loa (eye worm) hypothetical protein 0.0254 0.095 0.1181
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0076 0.0301
Echinococcus multilocularis sodium bile acid cotransporter 0.2011 0.804 0.804
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0271 0.1022 0.1268
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0076 0.0347
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0619 0.2423 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0161 0.1595
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0022 0.0024
Brugia malayi hypothetical protein 0.0055 0.0149 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0654 0.6555
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0075 0.5
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0059 0.0232
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0057 0.0483
Schistosoma mansoni smad1 5 8 and 0.01 0.0331 0.0408
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.013 0.0158
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0061 0.0072
Brugia malayi nuclear receptor NHR-88 0.0024 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0163 0.0585 0.0727
Brugia malayi hypothetical protein 0.0085 0.0271 0.0334
Plasmodium falciparum pyruvate kinase 0.0033 0.0061 0.0262
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0121 0.1463
Schistosoma mansoni hypothetical protein 0.0271 0.1022 0.1268
Mycobacterium ulcerans hypothetical protein 0.0326 0.1241 1
Brugia malayi Latrophilin receptor protein 2 0.0271 0.1022 0.1268
Echinococcus multilocularis geminin 0.0328 0.1249 0.1246
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.013 0.0158
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0016 0.0016
Brugia malayi MH1 domain containing protein 0.01 0.0331 0.0408
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.009
Leishmania major mitochondrial DNA polymerase beta 0.0619 0.2423 1
Onchocerca volvulus Bile acid receptor homolog 0.005 0.013 0.0134
Loa Loa (eye worm) hypothetical protein 0.0085 0.0271 0.0337
Brugia malayi conserved hypotetical protein 0.0024 0.0022 0.0024
Plasmodium vivax hexose transporter 0.0106 0.0353 0.1959
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0277 0.1135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.013 0.0158
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0054 0.0052
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0022 0.0665
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0022 0.0078
Entamoeba histolytica hypothetical protein 0.022 0.0814 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0057 0.0071
Trypanosoma brucei glucose transporter, putative 0.0033 0.0059 0.0232
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0054 0.0638
Echinococcus multilocularis mothers against decapentaplegic 6 0.0045 0.0107 0.0104

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3981 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.8078 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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