Detailed information for compound 765110

Basic information

Technical information
  • TDR Targets ID: 765110
  • Name: 5-(3,4-diethoxyphenyl)-3-phenyl-1,2,4-oxadiaz ole
  • MW: 310.347 | Formula: C18H18N2O3
  • H donors: 0 H acceptors: 2 LogP: 4.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1OCC)c1onc(n1)c1ccccc1
  • InChi: 1S/C18H18N2O3/c1-3-21-15-11-10-14(12-16(15)22-4-2)18-19-17(20-23-18)13-8-6-5-7-9-13/h5-12H,3-4H2,1-2H3
  • InChiKey: JPPIQETUUBNFCC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • SMR000092531
  • ZINC04281395
  • 5-(3,4-Diethoxy-phenyl)-3-phenyl-[1,2,4]oxadiazole
  • BAS 07399798
  • MLS000115427

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0022 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Schistosoma mansoni ran 0.0021 0.0017 0.0019
Trichomonas vaginalis set domain proteins, putative 0.0722 0.4084 0.7555
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0112 0.0266
Echinococcus granulosus expressed conserved protein 0.0112 0.0541 0.0627
Loa Loa (eye worm) hypothetical protein 0.0146 0.0738 0.2063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0022 0.0063
Echinococcus granulosus snurportin 1 0.031 0.1693 0.1962
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Loa Loa (eye worm) hypothetical protein 0.023 0.123 0.3441
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0189 0.0528
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.013 0.0377
Schistosoma mansoni survival motor neuron protein 0.0047 0.0165 0.0192
Schistosoma mansoni peptidase Clp (S14 family) 0.0171 0.0882 0.1023
Onchocerca volvulus 0.0116 0.0567 0.1341
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0233 0.0652
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0022 0.0063
Echinococcus granulosus sodium bile acid cotransporter 0.0473 0.2638 0.3058
Echinococcus granulosus tar DNA binding protein 0.0388 0.2146 0.2488
Echinococcus multilocularis sodium bile acid cotransporter 0.0473 0.2638 0.2638
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0293 0.0339
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.0882 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0125 0.0297
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0125 0.1413
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0022 0.0063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0022 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0189 0.0219
Schistosoma mansoni hypothetical protein 0.011 0.0532 0.0617
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0567 0.1023
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0486 0.5509
Onchocerca volvulus 0.0116 0.0567 0.1341
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0034 0.0605
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0949 0.5401 1
Echinococcus granulosus lamin 0.011 0.0528 0.0613
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0486 0.5509
Loa Loa (eye worm) hypothetical protein 0.0062 0.0255 0.0714
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.0567 0.1586
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0532 0.1489
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0022 0.0063
Brugia malayi hypothetical protein 0.0113 0.0551 0.154
Echinococcus granulosus muscleblind protein 0.0146 0.0738 0.0855
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0022 0.0063
Treponema pallidum fructose-bisphosphate aldolase 0.0949 0.5401 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0268 0.0311
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0029 0.0515
Loa Loa (eye worm) hypothetical protein 0.0051 0.0189 0.0528
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0567 0.1023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.013 0.23
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0046
Echinococcus granulosus importin subunit beta 1 0.0029 0.0061 0.0071
Schistosoma mansoni hypothetical protein 0.0049 0.0178 0.0206
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0159 0.0159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0022 0.0026
Mycobacterium tuberculosis Probable reductase 0.0179 0.0931 0.2216
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0022 0.0026
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0199 0.0231
Entamoeba histolytica hypothetical protein 0.0113 0.0551 0.0992
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0203 0.0663
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0203 0.0347
Mycobacterium ulcerans beta-lactamase 0.0116 0.0567 0.2091
Schistosoma mansoni hypothetical protein 0.0049 0.0178 0.0206
Loa Loa (eye worm) hypothetical protein 0.0473 0.2638 0.7378
Echinococcus multilocularis tumor protein p63 0.1068 0.6094 0.6094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0022 0.0026
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0171 0.0882 0.1023
Brugia malayi Pre-SET motif family protein 0.0635 0.3576 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0189 0.0527
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0159 0.0184
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0189 0.0219
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0022 0.0026
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0017 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0022 0.0063
Loa Loa (eye worm) RNA binding protein 0.0388 0.2146 0.6003
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0583 0.1629
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0017 0.0188
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0022 0.0022
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.013 0.0365
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0189 0.0219
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0022 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0203 0.0663
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0879 0.0879
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0486 0.8568
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0421 0.0421
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.013 0.0365
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0125 0.1413
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0203 0.3583
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0022 0.0063
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0879 0.1019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0022 0.0063
Brugia malayi steroid hormone receptor 0.0022 0.0022 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0022 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0486 0.8568
Loa Loa (eye worm) hypothetical protein 0.0102 0.0486 0.1359
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.005 0.0886
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0059 0.0233 0.0127
Brugia malayi Sodium Bile acid symporter family protein 0.0473 0.2638 0.7378
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0189 0.0219
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0179 0.0931 0.2216
Echinococcus granulosus sodium bile acid cotransporter 0.0473 0.2638 0.3058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0189 0.0528
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0293 0.0293
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0567 0.1023
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0268 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0022 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0421 0.0488
Echinococcus multilocularis geminin 0.0199 0.1046 0.1046
Plasmodium falciparum glutathione reductase 0.0078 0.0348 0.3943
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0349
Leishmania major trypanothione reductase 0.0078 0.0348 0.6133
Echinococcus multilocularis protein patched 0.0051 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0486 0.5509
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0022 0.0026
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0205 0.0574
Loa Loa (eye worm) hypothetical protein 0.0171 0.0882 0.2467
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0022 0.0063
Echinococcus multilocularis GPCR, family 2 0.0051 0.0189 0.0189
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.123 0.123
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0528 0.1478
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0022 0.0063
Loa Loa (eye worm) glutathione reductase 0.0078 0.0348 0.0973
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0189 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.1369 0.3828
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0179 0.0931 0.2216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0635 0.3576 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.023 0.023
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0112 0.0541 0.142
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0112 0.0266
Schistosoma mansoni hypothetical protein 0.0199 0.1046 0.1213
Schistosoma mansoni tar DNA-binding protein 0.0388 0.2146 0.2488
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0567 0.643
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0421 0.4769
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0022 0.0063
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0022 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0293 0.0819
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0203 0.0347
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0583 0.1051
Brugia malayi Cytochrome P450 family protein 0.0056 0.0216 0.0605
Onchocerca volvulus 0.0047 0.0165 0.0352
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0203 0.0568
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.0567 0.1349
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0022 0.0026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0017 0.0188
Brugia malayi ecdysteroid receptor 0.0022 0.0022 0.0063
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.005 0.0058
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0254 0.0254
Echinococcus granulosus microtubule associated protein 2 0.1505 0.8626 1
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0233 0.0652
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0022 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0029 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.005 0.0886
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0528 0.1478
Loa Loa (eye worm) hypothetical protein 0.0091 0.0421 0.1177
Schistosoma mansoni tar DNA-binding protein 0.0388 0.2146 0.2488
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0203 0.0663
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.005 0.0063
Echinococcus granulosus GPCR family 2 0.0051 0.0189 0.0219
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.0567 0.1349
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0293 0.0339
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.005 0.0141
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0022 0.0022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0199 0.1047 0.2491
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.013 0.0151
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0254 0.0863
Brugia malayi nuclear receptor NHR-88 0.0022 0.0022 0.0063
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0165 0.0462
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0292
Toxoplasma gondii exonuclease III APE 0.0041 0.013 0.1479
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.0354 0.041
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0388 0.2146 0.6003
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.005 0.0886
Schistosoma mansoni lamin 0.011 0.0528 0.0613
Onchocerca volvulus 0.011 0.0528 0.1246
Entamoeba histolytica hypothetical protein 0.0113 0.0551 0.0992
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0203 0.0568
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.011 0.0528 0.1478
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0022 0.0022
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.0203 0.0663
Brugia malayi Pre-SET motif family protein 0.0091 0.0421 0.1177
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0022 0.0063
Echinococcus granulosus peptidase Clp S14 family 0.0112 0.0541 0.0627
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0034 0.0096
Schistosoma mansoni ap endonuclease 0.0041 0.013 0.0151
Schistosoma mansoni hypothetical protein 0.0049 0.0178 0.0206
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Loa Loa (eye worm) TAR-binding protein 0.0388 0.2146 0.6003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.1693 0.4735
Brugia malayi intermediate filament protein 0.011 0.0528 0.1478
Onchocerca volvulus 0.0156 0.08 0.1915
Brugia malayi Cytochrome P450 family protein 0.0024 0.0034 0.0096
Loa Loa (eye worm) hypothetical protein 0.0108 0.0517 0.1445
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0171 0.0882 0.2853
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.0567 0.2091
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0022 0.0022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0464 0.2583 1
Echinococcus granulosus survival motor neuron protein 1 0.023 0.123 0.1426
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0078 0.0348 0.0828
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0034 0.0096
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.005 0.057
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0268 0.0638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0204 0.0204
Mycobacterium ulcerans hypothetical protein 0.0116 0.0567 0.2091
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.005 0.0886
Loa Loa (eye worm) hypothetical protein 0.0051 0.0188 0.0525
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0022 0.0026
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0254 0.0863
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0022 0.0026
Mycobacterium ulcerans lipase LipD 0.0116 0.0567 0.2091
Schistosoma mansoni hypothetical protein 0.031 0.1693 0.1962
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.005 0.0886
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.1369 0.3828
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0203 0.0568
Schistosoma mansoni hypothetical protein 0.0046 0.0159 0.0184
Brugia malayi Probable ClpP-like protease 0.0171 0.0882 0.2467
Echinococcus multilocularis tar DNA binding protein 0.0388 0.2146 0.2146
Brugia malayi Thioredoxin reductase 0.0078 0.0348 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0189 0.0319
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0464 0.2583 0.6146
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0268 0.0311
Schistosoma mansoni hypothetical protein 0.0051 0.0189 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0112 0.0541 0.0541
Onchocerca volvulus 0.0116 0.0567 0.1341
Loa Loa (eye worm) hypothetical protein 0.0053 0.0199 0.0558
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0567 0.0658
Schistosoma mansoni hypothetical protein 0.0049 0.0178 0.0206
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0061 0.0061
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0022 0.0026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0421 0.0421
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0349
Brugia malayi hypothetical protein 0.023 0.123 0.3441
Leishmania major hypothetical protein, conserved 0.0116 0.0567 1
Brugia malayi hypothetical protein 0.0066 0.0276 0.0771
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.005 0.0886
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0567 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0349
Echinococcus multilocularis sodium bile acid cotransporter 0.0473 0.2638 0.2638
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0203 0.0663
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.0567 0.0658
Toxoplasma gondii ABC1 family protein 0.0116 0.0567 0.643
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.013 0.23
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.013 0.1479
Schistosoma mansoni hypothetical protein 0.0051 0.0189 0.0219
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0125 0.0894
Loa Loa (eye worm) hypothetical protein 0.0116 0.0567 0.1586
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0421 0.0488
Loa Loa (eye worm) hypothetical protein 0.011 0.0532 0.1489
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0349
Echinococcus multilocularis musashi 0.011 0.0528 0.0528
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0022 0.0026
Echinococcus granulosus lamin dm0 0.011 0.0528 0.0613
Brugia malayi jmjC domain containing protein 0.0069 0.0293 0.0819
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0179 0.0931 0.3059
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0112 0.0541 0.1287
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.005 0.057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0022 0.0026
Onchocerca volvulus 0.0473 0.2638 0.644
Brugia malayi glutathione reductase 0.0078 0.0348 0.0973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0204 0.0204
Leishmania major cytochrome p450-like protein 0.0024 0.0034 0.0605
Brugia malayi hypothetical protein 0.0102 0.0486 0.1359
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0022 0.0026
Schistosoma mansoni importin beta-1 0.0029 0.0061 0.0071
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.0203 0.0663
Echinococcus granulosus intermediate filament protein 0.011 0.0528 0.0613
Plasmodium vivax thioredoxin reductase, putative 0.0078 0.0348 0.3943
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0292
Loa Loa (eye worm) hypothetical protein 0.0161 0.0829 0.2318
Loa Loa (eye worm) hypothetical protein 0.0054 0.0203 0.0568
Echinococcus multilocularis lamin dm0 0.011 0.0528 0.0528
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0046
Brugia malayi nuclear hormone receptor 0.0022 0.0022 0.0063
Echinococcus granulosus sodium bile acid cotransporter 0.0473 0.2638 0.3058
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0034 0.0605
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0268 0.0918
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0233 0.2646
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0189 0.0528
Brugia malayi beta-lactamase 0.0116 0.0567 0.1586
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0022 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0179 0.0931 0.2216
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.013 0.015
Echinococcus multilocularis snurportin 1 0.031 0.1693 0.1693
Brugia malayi RNA binding protein 0.0388 0.2146 0.6003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0189 0.0189
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0199 0.1047 0.3546
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.0567 0.1349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0022 0.0063
Loa Loa (eye worm) thioredoxin reductase 0.0078 0.0348 0.0973
Loa Loa (eye worm) hypothetical protein 0.0051 0.0189 0.0527
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0583 0.0675
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0171 0.0882 0.1555
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0268 0.0311
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.005 0.0886
Mycobacterium tuberculosis Probable oxidoreductase 0.0199 0.1047 0.2491
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0171 0.0882 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.0882 0.3326
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.005 0.012
Schistosoma mansoni microtubule-associated protein tau 0.1505 0.8626 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0179 0.0931 0.2216
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0254 0.0605
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.013 0.0212
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.0567 0.1349
Loa Loa (eye worm) hypothetical protein 0.0119 0.0583 0.1629
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.013 0.0212
Onchocerca volvulus 0.0091 0.0421 0.0981
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0268 0.4731
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0486 0.8568
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0008 0.0023
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.005 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0551 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0022 0.0063
Trypanosoma brucei trypanothione reductase 0.0078 0.0348 0.6133
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0171 0.0882 0.0882
Echinococcus multilocularis sodium bile acid cotransporter 0.0473 0.2638 0.2638
Schistosoma mansoni hypothetical protein 0.0051 0.0189 0.0219
Brugia malayi MH2 domain containing protein 0.0254 0.1369 0.3828
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0204 0.0236
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0293 0.0339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0022 0.0063
Schistosoma mansoni hypothetical protein 0.0047 0.0165 0.0192
Plasmodium falciparum thioredoxin reductase 0.0027 0.005 0.057
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0017 0.0292
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0034 0.0605
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0204 0.0236
Brugia malayi CHE-14 protein 0.0051 0.0189 0.0527
Brugia malayi RNA, U transporter 1 0.0083 0.0372 0.1041
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0204 0.057
Loa Loa (eye worm) intermediate filament protein 0.011 0.0528 0.1478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0421 0.0488
Plasmodium falciparum importin beta, putative 0.0029 0.0061 0.0693
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0061 0.1077
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0567 1
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0022 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0551 0.0638
Schistosoma mansoni intermediate filament proteins 0.011 0.0528 0.0613
Brugia malayi Cytochrome P450 family protein 0.0024 0.0034 0.0096
Brugia malayi Muscleblind-like protein 0.0146 0.0738 0.2063
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.005 0.0063
Loa Loa (eye worm) hypothetical protein 0.0116 0.0567 0.1586
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0583 0.0583
Loa Loa (eye worm) beta-lactamase 0.0116 0.0567 0.1586
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0593 0.0688
Mycobacterium ulcerans hypothetical protein 0.0054 0.0203 0.0663
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0204 0.057
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.005 0.0886
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.0829 0.2318
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.005 0.057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0421 0.0488
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0017 0.0019
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.0567 0.2091
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0199 0.0199
Onchocerca volvulus 0.0722 0.4084 1
Schistosoma mansoni patched 1 0.0051 0.0189 0.0219
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0061 0.1077
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.005 0.057
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.005 0.0063
Schistosoma mansoni ap endonuclease 0.0041 0.013 0.0151
Plasmodium falciparum thioredoxin reductase 0.0078 0.0348 0.3943
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.013 0.0212
Plasmodium falciparum glutathione reductase 0.0027 0.005 0.057
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.013 0.23
Schistosoma mansoni sodium-bile acid cotransporter related 0.0473 0.2638 0.3058
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.013 0.031
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0112 0.0541 0.1287
Toxoplasma gondii thioredoxin reductase 0.0078 0.0348 0.3943
Trypanosoma cruzi trypanothione reductase, putative 0.0078 0.0348 0.6133
Echinococcus granulosus geminin 0.0199 0.1046 0.1213
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.013 0.23
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0551 0.0638
Echinococcus multilocularis lamin 0.011 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0116 0.0567 0.1586
Brugia malayi TAR-binding protein 0.0388 0.2146 0.6003
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0203 0.3583
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0349
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0949 0.5401 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0421 0.0488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0022 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0022 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0949 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0203 0.0568
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0171 0.0882 1
Mycobacterium tuberculosis Conserved protein 0.0116 0.0567 0.1349
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0293 0.0339
Brugia malayi beta-lactamase family protein 0.0116 0.0567 0.1586
Brugia malayi Importin beta-1 subunit 0.0029 0.0061 0.0171
Mycobacterium leprae Probable lipase LipE 0.0116 0.0567 0.1529
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0116 0.0567 0.1586
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0293 0.0293
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.0203 0.0483
Plasmodium vivax importin-beta 2, putative 0.0029 0.0061 0.0693
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.005 0.0058
Schistosoma mansoni lamin 0.011 0.0528 0.0613
Schistosoma mansoni ran 0.0021 0.0017 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0216 0.0605
Giardia lamblia Fructose-bisphosphate aldolase 0.0949 0.5401 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.0567 0.0567
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.0567 0.1586
Brugia malayi beta-lactamase family protein 0.0116 0.0567 0.1586
Mycobacterium leprae conserved hypothetical protein 0.0116 0.0567 0.1529
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.0882 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0008 0.0023
Onchocerca volvulus 0.0024 0.0033 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0112 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0204 0.0236
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0029 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0112 0.0266
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0179 0.0931 0.2216
Onchocerca volvulus 0.0054 0.0203 0.0445
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.0882 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0029 0.0023
Loa Loa (eye worm) hypothetical protein 0.0054 0.0203 0.0568
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0464 0.2583 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0268 0.0918
Loa Loa (eye worm) hypothetical protein 0.0156 0.08 0.2238
Loa Loa (eye worm) hypothetical protein 0.0116 0.0567 0.1586
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.0354 0.0354
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0022 0.0026
Echinococcus granulosus tumor protein p63 0.1068 0.6094 0.7064
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.013 0.1479
Loa Loa (eye worm) hypothetical protein 0.0146 0.0738 0.2063
Plasmodium vivax glutathione reductase, putative 0.0078 0.0348 0.3943
Schistosoma mansoni sodium-bile acid cotransporter 0.0281 0.1525 0.1768
Entamoeba histolytica hypothetical protein 0.0113 0.0551 0.0992
Echinococcus multilocularis microtubule associated protein 2 0.1505 0.8626 0.8626
Schistosoma mansoni sodium-bile acid cotransporter related 0.0192 0.1006 0.1166
Loa Loa (eye worm) hypothetical protein 0.0029 0.0061 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0388 0.2146 0.2488
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0567 0.1023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0022 0.0063
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.005 0.0063
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.0567 0.1349
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.013 0.0212
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0125 0.0354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0204 0.0236
Entamoeba histolytica hypothetical protein 0.0113 0.0551 0.0992
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.0567 0.1349
Leishmania major hypothetical protein, conserved 0.0102 0.0486 0.8568
Schistosoma mansoni hypothetical protein 0.0113 0.0551 0.0638
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0022 0.0026
Entamoeba histolytica hypothetical protein 0.0024 0.0029 0.0023
Schistosoma mansoni cellular tumor antigen P53 0.0156 0.08 0.0928
Brugia malayi RNA recognition motif domain containing protein 0.0388 0.2146 0.6003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0268 0.0918
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0254 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0022 0.0063
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0254 0.4483
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0567 0.0658
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.005 0.057
Loa Loa (eye worm) hypothetical protein 0.0116 0.0567 0.1586
Loa Loa (eye worm) hypothetical protein 0.0051 0.0188 0.0525
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.0203 0.0663
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.0829 0.2318
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0293 0.0339
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0203 0.0483
Brugia malayi jmjC domain containing protein 0.0069 0.0293 0.0819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0022 0.0063
Trichomonas vaginalis esterase, putative 0.0116 0.0567 0.1023
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0061 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0567 0.1023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0022 0.0026
Toxoplasma gondii hypothetical protein 0.0059 0.0233 0.2646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0204 0.0236
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0171 0.0882 1
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0486 0.5509
Echinococcus multilocularis expressed conserved protein 0.0112 0.0541 0.0541
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.0567 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.005 0.057
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.0882 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.0829 0.2318
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.0882 0.3326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0022 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0063
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.0203 0.0347
Schistosoma mansoni hypothetical protein 0.0051 0.0189 0.0219
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.005 0.0063
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0401 0.0465
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0017 0.0188
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0254 0.0295
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.005 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0388 0.2146 0.2488
Mycobacterium tuberculosis Conserved protein 0.0116 0.0567 0.1349
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0203 0.3583
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0022 0.0026
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.013 0.0964
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.005 0.0886
Leishmania major GTP-binding protein, putative 0.0021 0.0017 0.0292
Schistosoma mansoni coup transcription factor 0.0022 0.0022 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0022 0.0022
Plasmodium vivax SET domain protein, putative 0.0091 0.0421 0.4769
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0199 0.1047 0.2491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0743 0.4204 1
Schistosoma mansoni hypothetical protein 0.0199 0.1046 0.1213
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.005 0.0886
Onchocerca volvulus 0.011 0.0528 0.1246
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.0567 0.1349
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0268 0.3042
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0233 0.0342
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0034 0.0096
Echinococcus multilocularis muscleblind protein 0.0146 0.0738 0.0738
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0254 0.0711
Schistosoma mansoni tar DNA-binding protein 0.0388 0.2146 0.2488
Leishmania major importin beta-1 subunit, putative 0.0024 0.0029 0.0515
Mycobacterium tuberculosis Conserved protein 0.0116 0.0567 0.1349
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0059 0.0233 0.2646
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0022 0.0026

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2617 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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