Detailed information for compound 765368

Basic information

Technical information
  • TDR Targets ID: 765368
  • Name: 1-[4-(4-methoxyphenyl)piperazin-1-yl]-3-(4-pr opylphenoxy)propan-2-ol
  • MW: 384.512 | Formula: C23H32N2O3
  • H donors: 1 H acceptors: 1 LogP: 4.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1ccc(cc1)OCC(CN1CCN(CC1)c1ccc(cc1)OC)O
  • InChi: 1S/C23H32N2O3/c1-3-4-19-5-9-23(10-6-19)28-18-21(26)17-24-13-15-25(16-14-24)20-7-11-22(27-2)12-8-20/h5-12,21,26H,3-4,13-18H2,1-2H3
  • InChiKey: PAYUOFDMBSMDOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(4-methoxyphenyl)-1-piperazinyl]-3-(4-propylphenoxy)propan-2-ol
  • Oprea1_262996
  • Oprea1_402855

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0077 0.7967 1
Brugia malayi PHD-finger family protein 0.003 0.1264 0.1086
Brugia malayi RNA binding protein 0.0077 0.7967 0.7926
Schistosoma mansoni tar DNA-binding protein 0.0077 0.7967 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0199 0.0215
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0851 0.0839
Schistosoma mansoni hypothetical protein 0.0025 0.0518 0.041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0199 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0199 0.5
Loa Loa (eye worm) RNA binding protein 0.0077 0.7967 0.861
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0199 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0199 0.5
Echinococcus granulosus zinc finger protein 0.0024 0.0333 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.4897 0.6048
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.7332 0.9182
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0199 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0056 0.4897 0.5292
Schistosoma mansoni tar DNA-binding protein 0.0077 0.7967 1
Schistosoma mansoni tar DNA-binding protein 0.0077 0.7967 1
Echinococcus granulosus tar DNA binding protein 0.0077 0.7967 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.9254 1
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0518 0.0559
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.3186 0.3845
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0199 0.5
Schistosoma mansoni tar DNA-binding protein 0.0077 0.7967 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.4897 0.6048
Toxoplasma gondii exonuclease III APE 0.0023 0.0199 0.5
Brugia malayi Bromodomain containing protein 0.0047 0.3599 0.3469
Loa Loa (eye worm) hypothetical protein 0.0052 0.4357 0.4709
Brugia malayi RNA recognition motif domain containing protein 0.0077 0.7967 0.7926
Schistosoma mansoni bromodomain containing protein 0.0077 0.7956 0.9985
Schistosoma mansoni zinc finger protein 0.0024 0.0333 0.0173
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0199 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.4897 0.6048
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0851 0.0839
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0077 0.7967 0.861
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.4897 0.6048
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.3186 0.3845
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.4897 0.6048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0199 0.5
Echinococcus multilocularis zinc finger protein 0.0024 0.0333 0.0173
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0199 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.4897 0.6048
Brugia malayi TAR-binding protein 0.0077 0.7967 0.7926
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0199 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.4024 0.4348
Loa Loa (eye worm) TAR-binding protein 0.0077 0.7967 0.861
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0199 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0056 0.4897 0.4793
Echinococcus multilocularis tar DNA binding protein 0.0077 0.7967 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0199 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0199 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0199 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.7332 0.9182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.4897 0.6048
Loa Loa (eye worm) hypothetical protein 0.0047 0.3611 0.3902
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0851 0.0839

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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